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Microfluidic assisted 90%loading CL-20 spherical particles:Enhancing self-sustaining combustion performance

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Defence Technology（防务技术） 2023年第4期22卷 176-184页

作者： ling-feng yang Xian-rui Shi Chun-zhi Li Bo Wu Chong-hua Pei State Key Laboratory of Environment-friendly Energy Materials Southwest University of Science and TechnologyMianyang621010PR China Xi'an Modern Chemistry Research Institute Xi'anShaanxi710065PR China Luzhou North Chemical Industries Co. Ltd.Luzhou646003PR China

The performance of the chemical fuel determines the altitude,range and longevity of spacecraft in air and space *** alternatives(e.g.,hypergolic ionic liquids or high-energy composites)with high-energy density,heat of formation and fast initial rate are considered as potential chemical *** the high-energy density material,hexanitrohexaazaisowurtzitane(CL-20)often serves as secondary explosive with poor self-propagating combustion ***,90%loading CL-20 microspheres with uniform particle sizes are precisely prepared by microfluid method,which exhibit unique hierarchical *** morphology,thermal behaviors,as well as combustion performance were further *** results demonstrated that as-prepared spherical particles exhibit prominent thermal compatibility,and the enhanced self-sustaining combustion *** work provides an efficient method achieving the uniform high-energy density particles with excellent self-sustaining combustion performance.

关键词： Microfluidics Hexanitrohexaazaisowurtzitane Spherical particles Thermal behavior Self-sustaining combustion

Synthesis,Crystal Structure and Its Application in Living Cells Imaging of Benz(c)acridine-1,2,3-triazole Derivatives

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Chinese Journal of Structural Chemistry 2021年第10期40卷 1309-1316页

作者： YAN Zhen-Shuo KANG Yan-Hui CHEN yang-ling HUO Li-Ni Guangxi University of Chinese Medicine Nanning 530001China Hebei University of Engineering Handan 056038China

A highly selective iron ions fluorescent probe based on the benz(c)acridine-1,2,3-triazole derivatives was produced by multi-step reactions. 1-(7-Benz[c]acridinyl)-4-(4-methylphenyl)-1,2,3-triazole(4 a), C_(26)H_(18)N_(4), was structurally determined by single-crystal X-ray diffraction. It crystallizes in the trigonal system, space group R-3 with a = 36.230(10), b = 36.230(10), c = 7.993(3)Å, β = 90°, V = 9086(6)Å^(3), Z = 18, D_(c)= 1.271 g/cm^(3), F(000) = 3636, μ = 0.602 mm^(-1), the final R = 0.0865 and wR = 0.1619 for 3951 observed reflections(I > 2σ(I)). X-ray analysis indicated that all four rings of benz(c)acridine are in the same plane, and the 1,2,3-triazole ring and the corresponding linked benzene(C(1)–C(6)–C(7)–C(8)–C(9)–N(1)) are approximately perpendicular with a dihedral angle of 106.5°. The crystal packing of the compound was stabilized by two weak interactions between C(11)–H(10)…N(4) and C(18)–H(18)…N(1). In fluorescence spectra studies, compound 4 c was exhibited good selectivity and sensitivity towards iron ions in DMSO: mops buffer solution. Furthermore, 4 c was successfully used for imaging iron ions in living He La cervical cancer cells.

关键词： benz(c)acridine-1 2 3-triazole crystal structure fluorescent probe iron ions

Downregulation of Astrocyte Elevated Gene-1 Expression Combined with All-Trans Retinoic Acid Inhibits Development of Vasculogenic Mimicry and Angiogenesis in Glioma

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Current Medical Science 2022年第2期42卷 397-406页

作者： Chen LIANG ling yang Shi-wen GUO Rui-chun LI Department of Neurosurgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China Department of Aeromedical Physical Examination Xi’an Civil Aviation HospitalXi’an710082China

Objective This study aimed to investigate the effects of downregulating astrocyte elevated gene-1(AEG-1)expression combined with all-trans retinoic acid(ATRA)on vasculogenic mimicry(VM)formation and angiogenesis in *** U87 glioma cells were transfected with AEG-1 shRNA lentiviral vectors(U87-siAEG-1)and incubated in a medium containing 20µmol/L ***-based tube formation assay was performed to evaluate VM formation,and the cell counting kit-8(CCK-8)assay was used to analyze the proliferation of glioma cells in *** transcription-quantitative polymerase chain reaction and Western blot analysis were used to investigate the mRNA and protein expression of related genes,*** xenograft models were generated via subcutaneous implantation of glioma cells in nude ***-bearing mice received an intraperitoneal injection of ATRA(10 mg/kg per day).Immunohistochemistry was used to evaluate the expression of related genes and the microvessel density(MVD)in glioma xenograft ***34/periodic acid-Schiff double staining was performed to detect VM channels in *** volume and weight of tumors were measured,and a tumor growth curve was drawn to evaluate tumor *** A combination of ATRA intervention and downregulation of AEG-1 expression significantly inhibited the proliferation of glioma cells in vitro and glioma VM formation in vitro and in *** also significantly decreased MVD and inhibited tumor ***,the expression levels of matrix metalloproteinase(MMP)-2,MMP-9,vascular endothelial-cadherin(VE-cadherin),and vascular endothelial growth factor(VEGF)in glioma significantly decreased in vivo and in *** Hence,a combinatorial approach might be effective in treating glioma through regulating MMP-2,MMP-9,VEGF,and VE-cadherin expression.

关键词： astrocyte elevated gene-1 glioma all-trans retinoic acid vasculogenic mimicry angiogenesis

A 640×640 ISFET array for detecting cell metabolism

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Journal of Semiconductors 2023年第2期44卷 84-91页

作者： ling yang Yizheng Huang Zhigang Song Manqing Tan Yude Yu Zhao Li Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China Beijing Key Laboratory of Genome and Precision Medicine Technologies Beijing 100101China

Ion sensitive field effect transistor(ISFET)devices are highly accurate,convenient,fast and low-cost in the detection of ions and biological macromolecules,such as DNA molecules,antibodies,enzymatic substrates and cellular *** high-throughput cell metabolism detection,we successfully designed a very large-scale biomedical sensing application specific integrated circuit(ASIC)with a 640×640 ISFET *** circuit design is highly integrated by compressing the size of a pixel to 7.4×7.4μm^(2)and arranging the layout of even and odd columns in an interdigital pattern to maximize the utilization of *** chip can operate at a speed of 2.083M pixels/s and the dynamic process of the fluid flow on the surface of the array was monitored through ion *** pH sensitivity is 33±4 mV/pH and the drift rate is 0.06 mV/min after 5 h,indicating the stability and robustness of the ***,the chip was applied to monitor pH changes in CaSki cells metabolism,with pH shifting from 8.04 to 7.40 on *** platform has the potential for continuous and parallel monitoring of cell metabolism in single-cell culture arrays.

关键词： ASIC ISFET array pH monitoring ion imaging cell metabolism

Relationship between H_(2)O_(2) accumulation and NO synthesis during osmotic stress:promoted somatic embryogenesis of Fraxinus mandshurica

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Journal of Forestry Research 2021年第3期32卷 917-925页

作者： ling yang Hanyang Guo Yingying Liu Dongyan Zhang Hongnan Liu Hailong Shen State Key Laboratory of Tree Genetics and Breeding Northeast Forestry UniversityHarbin 150040People’s Republic of China

Osmotic stress promotes somatic embryogenesis of Fraxinus mandshurica,which leads to accumulation of reactive oxygen species(ROS).The single pieces of cotyledons of *** were used as explants to induce somatic embryogenesis in osmotic-stress ***,the hydrogen peroxide H_(2)O_(2) content of explanted cells was varied by adding exogenous H_(2)O_(2) or catalase solution to assess the effects of the exogenous H_(2)O_(2)on somatic embryogenesis,intracellular H_(2)O_(2)accumulation,and the relationship between signaling mediated by ROS or reactive nitrogen *** results revealed that exogenous H_(2)O_(2)(100?300μmol L^(–1))increased the number of somatic *** 60th day of exogenous H_(2)O_(2)(200μmol L^(–1))treatment,the number of somatic embryos of explants treated,which was 136.54%,was higher than the ***,exogenous H_(2)O_(2)(100μmol L^(–1))significantly increased the intracellular H_(2)O_(2)content and enhanced the activities of superoxidase dismutase and ***,exogenous H_(2)O_(2)(100μmol L^(–1))activated the intracellular non-enzymatic pathway for nitric oxide(NO)*** somatic embryogenesis in broadleaf trees increases with the change of endogenic ROS content,and depends on the upregulation of antioxidant *** H_(2)O_(2)and NO,as signaling molecules,were found to be involved in the process of somatic embryogenesis in broadleaf *** the process of exogenous H_(2)O_(2)promoting somatic embryogenesis,NO synthesis depended on non-enzymatic *** results provide a scientific basis for resolving the mechanism by which ROS levels are regulated during somatic embryogenesis of broadleaf trees and establish a reasonable and efficient technology system for regulating somatic embryogenesis of trees.

关键词： Fraxinus mandshurica Somatic embryogenesis Hydrogen peroxide Nitric oxide Osmotic stress

A Deep Learning Method for Statistical Downscaling of CLDAS Relative Humidity with Different Sources of Data:Sensitivity Analysis

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Journal of Meteorological Research 2023年第6期37卷 878-895页

作者： Bin BAI Chunxiang SHI ling yang lingling GE Luhui YUE Guangyu LIU College of Electronic Engineering Chengdu University of Information TechnologyChengdu610225China Key Laboratory of Atmospheric Sounding of China Meteorological Administration Chengdu610225China National Meteorological Information Centre China Meteorological AdministrationBeijing100081China School of Computer and Software Nanjing University of Information Science&TechnologyNanjing210044China

High-resolution relative humidity(RH)data are essential in studies of climate change and in numerical meteorological ***,because high-resolution meteorological grid data require a large number of stations,the sparse distribution of ground meteorological stations in China before 2008 has limited the development of long-term and high-resolution RH products in the China Meteorological Administration’s Land Assimilation System(CLDAS)*** retrieve high-quality and high-resolution RH data before 2008,we propose a statistical downscaling model(SDM)based on a generative adversarial network(GAN)to transform the original RH data from a resolution of0.05°to 0.01°.The GAN-based SDM(GSDM)is trained with the RH of the CLDAS(0.05°)dataset after 2008 as its input,and the RH of the high-resolution CLDAS(HRCLDAS,0.01°)dataset after 2008 as its target for ***2-m air temperature data from the HRCLDAS dataset are also included in the input,and the station observations of RH are incorporated in the target for *** select the optimum data combination for the model,we compared three methods:(1)incorporating without auxiliary data(GSDM),(2)incorporating air temperature as an additional input(GSDM_T),and(3)incorporating air temperature as an additional input and the RH data at stations as an additional target for training(GSDM_TO).Taking the Beijing–Tianjin–Hebei region as an example,we trained the GSDM by using data from 2018 and tested the model performance in *** experimental results showed that the GSDM_TO algorithm achieved the lowest root-mean-square error(3.85%),followed by the GSDM_T(4.01%)and GSDM(4.95%)*** proposed models showed a competitive performance and captured more local details of the RH fields than other deep learning models and traditional bilinear *** general,the GSDM_TO algorithm using a combination of different sources of data(air temperature and observed RH)achieved the best results among the various d

关键词： relative humidity statistical downscaling generative adversarial network(GAN) temperature

Solvent-driven reversible transformation between electrically neutral thiolate protected Ag_(25)and Ag_(26)clusters

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Science China Chemistry 2021年第6期64卷 948-952页

作者： Yu-ling Tan ling yang Tian-Chen Yu Hong Yu Xin-Yao Wang Ying-Lin Song Zheng Niu Jian-Ping Lang College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China School of Physical Science and Technology Soochow UniversitySuzhou 215006China

Two atom-precise silver nanoclusters[Ag_(25)Cl_2(Tab)_(14)(Ph COO)_(11)(DMF)_4](PF_6)_(12)(Ag_(25),DMF=N,N-dimethylformamide)and[Ag_(26)Cl_2(Tab)_(14)(Ph COO)_(13)(DMAc)_4](PF_6)_(11)(Ag_(26),DMAc=N,N-dimethylacetamide)were synthesized based on the electrically neutral thiolate protective ligand,4-(trimethylammonio)benzenethiolate(Tab).The weak Ag–S interaction in Tab-protected silver nanoclusters allows to insert or leave a single silver atom in the Ag–S skeleton through solvent-trigger core fragmentation and re-arrangement,thereby realizing the reversible conversion of Ag_(25)and Ag_(26)for the first time.

关键词： silver nanocluster electrically neutral thiolate reversible transformation

Reversed ethane/ethylene adsorption in a metal–organic framework via introduction of oxygen

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Chinese Journal of Chemical Engineering 2020年第2期28卷 593-597页

作者： ling yang Wei Zhou Hao Li Ali Alsalme Litao Jia Jiangfeng yang Jinping Li Libo Li Banglin Chen College of Chemistry and Chemical Engineering Shanxi Key Laboratory of Gas Energy Efficient and Clean UtilizationTaiyuan University of TechnologyTaiyuan 030024China NIST Center for Neutron Research National Institute of Standards and TechnologyGaithersburgMD 20899-6102United States Department of Chemistry University of Texas at San AntonioOne UTSA CircleSan AntonioTX 78249-0698United States Chemistry Department College of ScienceKing Saud UniversityP O Box 2455Riyadh 11451Saudi Arabia State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030024China Key Laboratory of Coal Science and Technology Taiyuan University of TechnologyTaiyuan 030024China Shanxi Key Laboratory of Gas Energy Efficient and Clean Utilization Taiyuan 030024China

Separation of ethane from ethylene is a very important but challenging process in the petrochemical *** an alternative method would reduce the energy needed to make 170 million tons of ethylene manufactured worldwide each *** separation using C2H6-selective porous materials to directly produce high-purity C2H4 is more *** herein report the"reversed C2H6/C2H4 adsorption"in a metal–organic framework Cr-BTC via the introduction of oxygen on its open metal *** oxidized Cr-BTC(O2)can bind C2H6 over C2H4 through the active Cr-superoxo sites,which was elucidated by the gas sorption isotherms and density functional theory *** material thus exhibits a good performance for the separation of 50/50 C2H6/C2H4 mixtures to produce 99.99%pure C2H4 in a single separation operation.

关键词： Metal–organic frameworks Adsorptive separation Open metal sites Reversed ethane/ethylene adsorption Density-functional theory calculation Breakthrough curves

LRG1 promotes corneal angiogenesis and lymphangiogenesis in a corneal alkali burn mouse model

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International Journal of Ophthalmology(English edition) 2020年第3期13卷 365-373页

作者： Shan Song Jun Cheng Bing-Jie Yu Li Zhou Hai-Feng Xu ling-ling yang Weifang Medical University Weifang 261053Shandong ProvinceChina Qingdao Eye Hospital Shandong Eye InstituteShandong First Medical University&Shandong Academy of Medical SciencesQingdao 266071Shandong ProvinceChina Medical College Qingdao UniversityQingdao 266071Shandong ProvinceChina State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of OphthalmologyShandong Eye InstituteShandong First Medical University&Shandong Academy of Medical SciencesQingdao 266071Shandong ProvinceChina

AIM:To investigate the potential effect and mechanism of leucine-richα-2-glycoprotein-1(LRG1)on corneal angiogenesis and ***:Corneal neovascularization and lymphatics were induced by establishing alkali burn mouse *** staining was performed to detect the location of LRG1 in cornea tissues and to verify the source of LRG1-positive *** whole-mount staining for CD31(a panendothelial cell marker)and lymphatic endothelial hyluronan receptor-1(LYVE-1;lymphatic marker)was performed to detect the growth of blood and lymphatic vessels after local application of exogenous LRG1 protein or LRG1 si *** addition,expressions of the proangiogenic vascular endothelial growth factor(VEGF)related proteins were detected using Western blot ***:LRG1 was dramatically increased in alkali burned corneal stroma in both the limbal and central ***1-positive cells in the corneal stroma were mainly derived from Vimentin-positive *** application ofexogenous LRG1 protein not only aggravated angiogenesis but also lymphangiogenesis significantly(P<0.01).LRG1 group upregulated the levels of VEGF and the vascular endothelial growth factor receptor(VEGFR)family when compared with the phosphate-buffered saline(PBS)control *** also found that LRG1-specific si RNA could suppress corneal angiogenesis and lymphangiogenesis when compared with the scramble si RNA-treated group(P<0.01).CONCLUSION:LRG1 can facilitate corneal angiogenesis and lymphangiogenesis through heightening the stromal expression of VEGF-A,B,C,D and VEGFR-1,2,3;LRG1-specific si RNA can suppress corneal angiogenesis and lymphangiogenesis in corneal alkali burn mice.

关键词： leucine-richα-2-glycoprotein-1 angiogenesis lymphangiogenesis cornea alkali burn vascular endothelial growth factor