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Synthesis of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives

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Chinese Chemical Letters 2007年第4期18卷 380-382页

作者： Xue Fei Yang ling yi kong Department of Natural Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China

A series of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives have been synthesized by utilizing the coupling of methyl 3- methoxy-4hydroxy-5-bromocinnamate with cuprous phenylacetylide as the key step. The structures of the new compounds were confirmed by 1H NMR, IR and MS. The structure of compound 14 was further confirmed by single crystal X-ray. Compound 17 showed cytotoxic activity against human lung carcinoma A549.

关键词： 2-Aryl-5-alkyl-7-methoxylbenzo[b]furan Neolignans Synthesis Cytotoxicity

Sebiferone,a New Triterpenoid from Stem Bark of Sapium sebiferum (L.)Roxb.

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Chinese Chemical Letters 2002年第11期13卷 1079-1082页

作者： Run Hui LIU ling yi kong Department of Natural Medicinal Chemistry China Pharmaceutical UniversityNanjing 210038

From the stem bark of Sapium sebiferum a new triterpenoid, named sebiferone (1), was isolated. The structure of the new compound was elucidated as 3β-acetoxy-D-friedoolen-14-en -1-one-28-oic acid on the basis of spe... 详细信息

关键词： Sapium sebiferum Euphorbiaceae sebiferone.

Steroids from the Roots of Asparagus officinalis and Their Cytotoxic Activity

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Journal of Integrative Plant Biology 2008年第6期50卷 717-722页

作者： Xue-Feng Huang Yu-ying Lin ling-yi kong Department of Natural Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China

One new （Sarsasapogenin O） and seven known steroids were isolated from the roots of Asparagus offlcinalis L. Their structures were elucidated on the basis of spectroscopic analysis, including various 2D-NMR techniques, hydrolysis, and by comparison of spectral data of known compounds. These compounds together with nine steroids which were previously isolated from this plant, were tested for cytotoxic activity. Among them, eight compounds displayed significant cytotoxiciUes against human A2780, HO-8910, Eca-109, MGC-803, CNE, LTEP-a-2, KB and mouse L1210 tumor cells.

关键词： Asparagus officinalis cytotoxic activity Sarsasapogenin O steroid

Biotransformation of 4-Hydroxybenzen Derivatives by Hairy Root Cultures of Polygonum multiflorum Thunb

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Journal of Integrative Plant Biology 2007年第2期49卷 207-212页

作者： Chun-Yan Yan Rong-Min Yu Zhang Zhang ling-yi kong Department of Natural Medicinal Chemistry College of Traditional Chinese Medicines China Pharmaceutical University Nanjing 210038 China Department of Natural Medicinal Chemistry and Pharmacognosy College of Pharmacy Jinan University Guangzhou 510632 China

The biotransformation of four 4-hydroxybenzen derivatives （1,4-benzenediol （compound 1）, 4-hydroxybenzaldehyde （compound 2）, 4-hydroxybenzyl alcohol （compound 3） and 4-hydroxybenzoic acid （compound 4）） by the hairy root cultures of Polygonum multiflorum Thunb. as a new biocatalyst was investigated. It was found that the substrates were transformed to their corresponding glucosides, 4-hydroxyphenyl β-D-glucopyranoside （arbutin, compound la）, 4-hydroxymethylphenyl β-D-glucopyranoside （gastrodin, compounds 2a, 3a） and 4-carboxyphenyl α-D- glucopyranoside （compound 4a）, respectively. In the meantime, the hairy roots of P. multiflorum were able to stereoselectively and regioselectively glucosylate phenolic hydroxyl groups of compounds 1-4, but the cultures could not glucosylate the aldehyde group of compound 2 or the benzyllc hydroxyl group of compound 3, and no glucosyl esterification of carboxyl groups of compound 4 was detected. On the other hand, the result also showed that the hairy roots of P. multiflorum were able to reduce the 4-hydroxybenzaldehyde to its corresponding alcohol. This is the first report that substrate 4 has been converted into its α-D-glucopyranoside by a plant biotransformα- tion system.

关键词： 4-hydroxybenzen derivatives arbutin biotransformation gastrodin hairy root cultures Polygonum multiflorum.

A new steroidal alkaloid from Beaumontia grandiflora

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Chinese Chemical Letters 2009年第9期20卷 1094-1096页

作者： Li Ma Jian Guang Luo Yu Cheng Gu ling yi kong Department of Natural Medicinal Chemistry China Pharmaceutical University 24 Tong Jia Xiang Nanjing 210009 People's Republic of China Syngenta Jealott's Hill International Research Centre Bracknell Berkshire RG42 6EY United Kingdom

A new steroidal alkaloid, beaumontamine （1）, was isolated from the stems of Beaumontia grandiflora. The structure was elucidated on the basis of spectral analysis. 2009 L.Y. kong. Published by Elsevier B.V. on beh... 详细信息

关键词： Beaumontia grandiflora Beaurnontamine Alkaloid

A Steroidal Glycoside from Cynanchum versicolor Bunge

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Chinese Chemical Letters 2006年第7期17卷 919-921页

作者： Zhao Guang ZHENG Run Hui LIU ling yi kong Wei Dong ZHANG Department of Phytochemistry Second Military Medical University Shanghai 200433 Departmentof Natural Medicinal Chemistry China Pharmaceutical University Nanjing 210038 School of Pharmacy Shanghai Jiaotong University Shanghai 200030

A new C21 steroidal glycoside, named cynanversicoside F （1）, was isolated from the root of Cynanchum versicolor Bunge. Its structure was established as glaucogenin-A 3-O-β-D- digitoxopyranosyl-（1→4）-β-D-cymarop... 详细信息

关键词： Cynanchum versicolor C21 steroidal glycoside cynanversicoside F.

New Coumarins From Peacedanum Decursivum

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Chinese Chemical Letters 1999年第6期10卷 477-480页

作者： Nian Huan YAO ling yi kong(Department of phytochemistry. China Pharmaceutical University. Nan-ling 210038) China Pharmaceut Univ Dept Phytochem Nanjing 210038 Peoples R China

Four new Coumarins named Decursitin B, C, D. F have been isolated from traditional Chinese medicine - the root of Peacedanum decursivum. Their structures were elucidated by chemical evidences and spectral analysis.

关键词： Peacedanum decursivum decursitin B decursitin C decursitin D decursitin F

The Genus Alpinia:A Review of Its Phytochemistry and Pharmacology

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World Journal of Traditional Chinese Medicine 2016年第1期2卷 26-41页

作者： Wei-Jie Zhang Jian-Guang Luo ling-yi kong State Key Laboratory of Natural Medicines Department of Natural Medicinal Chemistry China Pharmaceutical University Department of Natural Medicinal Chemistry China Pharmaceutical University

Genus Alpinia consists of over 250 species, which are widely distributed in south and southeast Asia. Many plants of genus Alpinia have been used for thousands of years to treat digestive system diseases and as anti-inflammatory drugs. Phytochemical research on this genus has led to the isolation of different kinds of diarylheptanoids, terpenes triterpenoids, phenylbutanoids, lignans, and flavonoids. Experimental evidences revealed that both the crude extracts and pure constituents isolated from the genus Alpinia exhibit a wide range of bioactivities such as anticancer, anti-oxidant, anti-bacterial, anti-viral, cardiovascular, and digestive system protective effects. Here, we summarize the phytochemistry and pharmacology investigation of the genus Alpinia, which can provide reference for further research and drug development.

关键词： Genus Alipinia phytochemistry pharmacology a review

Coumarin-glycoside and Ferulate from Peucedanum decursivum

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Chinese Chemical Letters 2000年第4期11卷 315-318页

作者： ling yi kong Nian Huan YAO (Department of Natural Medicinal Chemistry, China Pharmaceutical University. Nanjing 210038) China Pharmaceut Univ Dept Nat Med Chem Nanjing 210038 Peoples R China

Two new compounds named decuroside VI(1) and decursidate (2) were isolated from the roots of Peucedanum decursivum - a traditional Chinese medicine. Their structures were elucidated on the basis of chemical evidence a... 详细信息

关键词： Peucedanum decursivum decuroside VI decursidate