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Differences in insomnia-related self-reported outcomes among elderly hospitalized patients

World Journal of Psychiatry 2024年第5期14卷 686-694页

作者： xia Ding ling-xia Qi Dong-Yun Sun Department of Gangzha General Medical Center The Affiliated Hospital of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Anesthesiology and Surgery The Affiliated Hospital of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Ophthalmic Surgery Room The Affiliated Hospital of Nantong UniversityNantong 226000Jiangsu ProvinceChina

Insomnia is among the most common sleep disorders *** in older adults is a social and public health *** affects the physical and mental health of elderly hospitalized patients and can aggravate or induce physical *** subjective feelings and providing reasonable and standardized care for elderly hospitalized patients with insomnia are urgent *** To explore the differences in self-reported outcomes associated with insomnia among elderly hospitalized *** One hundred patients admitted to the geriatric unit of our hospital between June 2021 and December 2021 were included in this ***-reported symptoms were assessed using the Athens Insomnia Scale(AIS),Generalized Anxiety Disorder Scale-7(GAD-7),Geriatric Depression Scale-15(GDS-15),Memorial University of Newfoundland Scale of Happiness(MUNSH),Barthel Index Evaluation(BI),Morse Fall Scale(MFS),Mini-Mental State Examination,and the Short Form 36 Health Survey Questionnaire(SF-36).Correlation coefficients were used to analyze the correlation between sleep quality and self-reported *** of insomnia was analyzed using Logistic regression *** Nineteen patients with AIS≥6 were included in the insomnia group,and the incidence of insomnia was 19%(19/100).The remaining 81 patients were assigned to the non-insomnia *** were significant differences between the two groups in the GDA-7,GDS-15,MUNSH,BI,MFS,and SF-36 items(Pling(P<0.05).Subjective well-being and quality of life were poorer in the insomnia group than in the control *** AIS scores positively correlated with the GAD-7,GDS-15,and MFS scores in elderly hospitalized patients with insomnia(P<0.05).Logistic regression analysis showed that GDS-15≥5 was an independent risk factor for ins

关键词： Elderly hospitalized patients Insomnia Self-reported outcomes Symptoms Subjective feelings Correlation

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Ferroptosis mechanism and Alzheimer's disease

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Neural Regeneration Research 2024年第8期19卷 1741-1750页

作者： Lina Feng Jingyi Sun ling xia Qiang Shi Yajun Hou Lili Zhang Mingquan Li Cundong Fan Baoliang Sun Shandong Key Laboratory of TCM Multi-Target Intervention and Disease Control the Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Internal Medicine Taian Traffic HospitalTaianShandong ProvinceChina Department of Neurology the Third Affiliated Clinical Hospital of Changchun University of Chinese MedicineChangchunJilin ProvinceChina

Regulated cell death is a genetically determined form of programmed cell death that commonly occurs during the development of living *** process plays a crucial role in modulating homeostasis and is evolutionarily conserved across a diverse range of living *** is a classic regulatory mode of cell *** studies of regulatory cell death in Alzheimer’s disease have yielded increasing evidence that fe rroptosis is closely related to the occurrence,development,and prognosis of Alzheimer’s *** review summarizes the molecular mechanisms of ferroptosis and recent research advances in the role of ferro ptosis in Alzheimer’s *** findings are expected to serve as a theoretical and experimental foundation for clinical research and targeted therapy for Alzheimer’s disease.

关键词： Alzheimer’s disease apolipoprotein E Fe^(2+) ferroptosis glial cell glutathione peroxidase 4 imbalance in iron homeostasis lipid peroxidation regulated cell death system Xc^(-)

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Status,outcome,and related factors of postpartum hypertension in the Shanghai community

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World Journal of Clinical Cases 2024年第21期12卷 4632-4641页

作者： ling-xia Wu Man Jin Jian Yang Department of Women's Health Xuhui District Maternal and Child Health HospitalShanghai 200235China

BACKGROUND Postpartum hypertension poses a considerable health *** research on gestational hypertension,comprehensive studies focusing on postpartum hypertension in communities are *** its prevalence and associated risk factors is crucial for effective prevention and *** To provide insights for postpartum hypertension’s prevention and *** In total,3297 women who gave birth between June 2021 and December 2022 in Xuhui District,Shanghai were *** pressure was measured thrice within one month post-delivery during home ***-six women with hypertension were followed up for four months to analyze hypertension persistence and its related risk factors.A predictive model for persistent postpartum hypertension was established and verified using the Nomo diagram *** Hypertension prevalence 1 month post-delivery was 2.61%(86/3297).Among the 86 pregnant women,32(37.21%)had persistent hypertension at four months *** logistic regression analysis revealed that older age[odds ratio(OR)=1.212;95%confidence interval(CI):1.065–1.380]and higher pre-pregnancy body mass index(BMI)(OR=1.188;95%CI:1.006–1.404)were associated with hypertension(OR=10.781;95%CI:1.006–1.404)during pregnancy.A 95%CI of 1.243–93.480 is a risk factor for persistent postpartum *** Nomograph model accurately predicted the risk of persistent postpartum hypertension,demonstrating high *** In Xuhui,older age,higher pre-pregnancy BMI,and gestational hypertension are risk factors for persistent postpartum *** prediction model can identify high-risk individuals,thereby improving patient quality of life.

关键词： Postpartum High blood pressure Shanghai community Hypertensive diseases during pregnancy Risk factors Nomo diagram model

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Bibliometric analysis of research in epilepsy and comorbid depression from 2014 to 2023

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World Journal of Psychiatry 2024年第6期14卷 985-998页

作者： ling Chen xiao-Hui He xia-ling Li Juan Yang Hao Huang Department of Neurology The Affiliated Hospital of Zunyi Medical UniversityZunyi 563003Guizhou ProvinceChina Department of Neurology Xinqiao Hospital and the Second Affiliated HospitalArmy Medical University(Third Military Medical University)Chongqing 400010China

BACKGROUND Epilepsy and depression have complicated bidirectional *** study aimed to explore the field of epilepsy comorbid with depression in a bibliometric perspective from *** To improve our understanding of epilepsy and depression by evaluating the relationship between epilepsy and depression,bibliometric analyses were *** Epilepsy and depression-related publications from the last decade were retrieved from the Web of Science Core *** conducted bibliometric and visual analysis using VOSviewer and CiteSpace,examining authorships,countries,institutions,journals of publication,co-citations of references,connections between keywords,clusters of keywords,and keywords with citation *** Over the past ten years,we collected 1045 research papers focusing on the field of epilepsy and comorbid *** on epilepsy and depression have shown a general upward trend over time,though with some *** United States,with 287 articles,and the University of Melbourne,contributing 34 articles,were the top countries and institutions,*** addition,in the field of epilepsy and depression,Professor Lee,who has published 30 articles,was the most contributing *** hot topics pay attention to the quality of life in patients with epilepsy and *** We reported that quality of life and stigma in patients with epilepsy comorbid with depression are possible future hot topics and directions in the field of epilepsy and depression research.

关键词： Epilepsy Depression Bibliometrics VOSviewer CiteSpace Visualization analysis

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Nomogram to predict severe retinopathy of prematurity in Southeast China

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 282-288页

作者： Dan Liu Xing-Yong Li Hong-Wu He Ka-Lu Jin ling-xia Zhang Yang Zhou Zhi-Min Zhu Chen-Chen Jiang Hai-Jian Wu Sui-Lian Zheng Department of Ophthalmology the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Taizhou Optometry Hospital Taizhou 318001Zhejiang ProvinceChina Department of Ophthalmology Jiaxing Maternity and Child Health Care HospitalJiaxing 314009Zhejiang ProvinceChina Department of Ophthalmology Taizhou Women and Children’s Hospital of Wenzhou Medical UniversityTaizhou 318001Zhejiang ProvinceChina Clinical Medical Research Center the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Department of Ophthalmology Taizhou Municipal HospitalTaizhou 318099Zhejiang ProvinceChina

AIM:To define the predictive factors of severe retinopathy of prematurity(ROP)and develop a nomogram for predicting severe ROP in southeast ***:Totally 554 infants diagnosed with ROP hospitalized in the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University and hospitalized in Taizhou Women and Children’s Hospital were *** data and 43 candidate predictive factors of ROP infants were collected *** regression model was used to identify predictive factors of severe ROP and to propose a nomogram for individual risk prediction,which was compared with WINROP model and Digirop-Birth ***:Infants from the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University(n=478)were randomly allocated into training(n=402)and internal validation group(n=76).Infants from Taizhou Women and Children’s Hospital were set as external validation group(n=76).Severe ROP were found in 52 of 402 infants,12 of 76 infants,and 7 of 76 infants in training group,internal validation group,and external validation group,*** weight[odds ratio(OR),0.997;95%confidence interval(CI),0.996-0.999;P<0.001],multiple births(OR,1.885;95%CI,1.013-3.506;P=0.045),and non-invasive ventilation(OR,0.288;95%CI,0.146-0.570;P<0.001)were identified as predictive factors for the prediction of severe ROP,by univariate analysis and multivariate *** predicting severe ROP based on the internal validation group,the areas under receiver operating characteristic curve(AUC)was 78.1(95%CI,64.2-92.0)for the nomogram,32.9(95%CI,15.3-50.5)for WINROP model,70.2(95%CI,55.8-84.6)for Digirop-Birth *** external validation group,AUC of the nomogram was also higher than that of WINROP model and Digirop-Birth model(80.2 versus 51.1 and 63.4).The decision curve analysis of the nomogram demonstrated better clinical efficacy than that of WINROP model and Digirop-Birth *** calibration curves demonst

关键词： retinopathy of prematurity nomogram predictive factor birth weight multiple births non-invasive ventilation

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Personalized and continuous care intervention affects rehabilitation,living quality,and negative emotions of patients with breast cancer

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World Journal of Psychiatry 2024年第6期14卷 876-883页

作者： ling-xia Kong Yan-Hong Zhao Zhi-Lin Feng Ting-Ting Liu Department of Breast Surgery The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Operating Room The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina

BACKGROUND Breast cancer is among the most common malignancies *** progress in treatment methods and levels,the overall survival period has been prolonged,and the demand for quality care has *** To investigate the effect of individualized and continuous care intervention in patients with breast *** Two hundred patients with breast cancer who received systemic therapy at The First Affiliated Hospital of Hebei North University(January 2021 to July 2023)were retrospectively selected as research *** them,134 received routine care intervention(routing group)and 66 received personalized and continuous care(intervention group).Self-rating anxiety scale(SAS),self-rating depression scale(SDS),and Functional Assessment of Cancer Therapy-Breast(FACT-B)scores,including limb shoulder joint activity,complication rate,and care satisfaction,were compared between both groups after *** SAS and SDS scores were lower in the intervention group than in the routing group at one and three months after *** total FACT-B scores and five dimensions in the intervention group were higher than those in the routing group at three months of *** range of motion of shoulder anteflexion,posterior extension,abduction,internal rotation,and external rotation in the intervention group was higher than that in the routing group one month after *** incidence of postoperative complications was 18.18%lower in the intervention group than in the routing group(34.33%;P<0.05).Satisfaction with care was 90.91% higher in the intervention group than in the routing group(78.36%;P<0.05).CONCLUSION Personalized and continuous care can alleviate negative emotions in patients with breast cancer,quicken rehabilitation of limb function,decrease the incidence of complications,and improve living quality and care satisfaction.

关键词： Breast cancer Personalized care Continuous care Negative emotions Living quality Rehabilitation effect

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数字主权安全的理论内涵、现实挑战与应对路径

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陕西师范大学学报（哲学社会科学版） 2024年第1期53卷 122-133页

作者：刘玲霞陕西师范大学马克思主义学院陕西西安710119 商洛学院马克思主义学院陕西商洛726000

数字主权指国家对数字空间的最高统治权,数字主权安全指国家数字主权不受侵害,以国家在数字领域的管辖权、独立权、平等权及防卫权不受侵害为标志,由数字事务管辖能力、数字规则主导能力及数字防卫能力来保障。当前国家数字主权安全面... 详细信息

数字主权指国家对数字空间的最高统治权,数字主权安全指国家数字主权不受侵害,以国家在数字领域的管辖权、独立权、平等权及防卫权不受侵害为标志,由数字事务管辖能力、数字规则主导能力及数字防卫能力来保障。当前国家数字主权安全面临着三大挑战:一国扩展数字主权对他国数字主权的削弱、数字平台实施技术垄断对国家数字主权的威胁和个人不当运用数字技术对国家数字主权的弱化。国家应对数字主权安全挑战的路径是:加强国家数字能力建设,以因应他国数字主权扩展;秉持国家安全至上理念,以规制数字平台垄断行为;坚持全球合作原则,以价值共识导引个人数字技术运用。

关键词：数字主权数字主权安全国家主权国家主权安全

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High-efficiency gene editing in Anopheles sinensis using ReMOT control

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Insect Science 2024年第1期31卷 307-312页

作者： xiao-lin Yang xia ling Quan Sun Pin-pin Qiu Kai xiang Jun-feng Hong Shu-lin He Jie Chen Xin Ding Hai Hu Zheng-bo He Cao Zhou Bin Chen Liang Qiao Chongqing Key Laboratory of Vector Insects Institute of Entomology and Molecular BiologyCollege of Life SciencesChongqing Normal UniversityChongqingChina Xunjian Life Science&Technology Co.Ltd. ChongqingChina State Key Laboratory of Resource Insects Southwest UniversityChongqingChina

Dear editor,Functional genomics studies of mosquito vectors are crucial for understanding their physiological behavior,pathogen transmission,and evolution,and for providing essential molecular targets for genetic control(Severson&Behura,201l;Alphey,2014;Ruzzante et al.,2019;Hong et al.,2022).The main methods involve clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)gene editing via embryo microinjection(Criscione et al.,2015;Kistler et al.,2015).

关键词： editor editing injection

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基于遗传算法-序列二次规划的磁共振被动匀场优化方法

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浙江大学学报（工学版） 2024年第6期58卷 1305-1314页

作者：赵杰刘锋夏灵范一峰杭州医学院医学影像学院浙江杭州310053 昆士兰大学信息技术与电气工程学院昆士兰布里斯班4072 浙江大学生物医学工程教育部重点实验室浙江杭州310027

为了解决磁共振成像(MRI)系统中固有的主磁场(B0)不均匀的问题,提出遗传算法-序列二次规划(GASQP)算法,以提高7 T磁共振的主磁场均匀性.从被动匀场数学模型的角度出发,该混合算法利用GA算法获得稳定的初始解,实现主磁场的第1次优化,再通... 详细信息

为了解决磁共振成像(MRI)系统中固有的主磁场(B0)不均匀的问题,提出遗传算法-序列二次规划(GASQP)算法,以提高7 T磁共振的主磁场均匀性.从被动匀场数学模型的角度出发,该混合算法利用GA算法获得稳定的初始解,实现主磁场的第1次优化,再通过SQP算法的快速求解,在较少的时间内实现主磁场的第2次优化,同时提高磁共振主磁场的均匀性.采用正则化方法减少磁场均匀所需的铁片质量,并且获得稀疏的铁片分布.在仿真建模的案例研究中,7 T磁共振裸磁场均匀度可以从462×10-6优化到4.5×10-6,并且在匀场空间上仅消耗0.8 kg的铁片.相比于传统的GA优化方法,新方案的磁场均匀性提高了96.7%,总铁片消耗质量减少了85.7%.实验结果表明,GA-SQP算法比其他优化算法具有更强的鲁棒性和竞争力.

关键词：磁共振成像被动匀场遗传算法-序列二次规划(GA-SQP) 正则化方法非线性优化

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经典名方中芡实的本草考证

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中国实验方剂学杂志 2024年第11期30卷 210-217页

作者：高子轩瞿城严辉夏玲郭盛詹志来南京中医药大学中药资源产业化与方剂创新药物国家地方联合工程研究中心江苏省中药资源产业化过程协同创新中心江苏省经典名方工程研究中心南京210023 中国中医科学院中药资源中心道地药材品质保障与资源持续利用全国重点实验室北京100700

通过查阅古代相关本草、医籍、方书及近现代文献资料,对经典名方中所用芡实的名称、基原、产地、品质评价、采收加工与炮制方法等进行了系统梳理并考证。结果表明芡实最早以“鸡头实”之名被本草收载,自明代以来以“芡实”为正名并延续... 详细信息

通过查阅古代相关本草、医籍、方书及近现代文献资料,对经典名方中所用芡实的名称、基原、产地、品质评价、采收加工与炮制方法等进行了系统梳理并考证。结果表明芡实最早以“鸡头实”之名被本草收载,自明代以来以“芡实”为正名并延续至今,另有“雁喙实”等别名;历代所用基原古今一致,为睡莲科植物芡Euryale ferox,然因长期的人工驯化,致使品种随产地的不同而不同,有北芡、苏芡之分;芡实入药部位为成熟种仁;古代著录的产地主要有山东、江苏、河南等地,自明清以来推崇苏州所产的苏芡;近代以来逐步总结形成芡实以颗粒饱满、断面白色、粉性足、无碎末者为佳的性状品质评价方法;历代采收时间主要为“八月”或“逢秋采实”;历代炮制方法主要有去皮作粉、蒸后舂粉、晒干、炒等,延续至今形成了净制、炒制两大主流炮制方法。基于考证结果,建议经典名方易黄汤中芡实选用芡***成熟种仁,结合原方炮制要求,建议参考现行版《中华人民共和国药典》炮制通则中清炒法炮制。

关键词：经典名方芡实本草考证基原种类产地变迁学名演变

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