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UAV-Assisted Data Offloading for Smart Container in Offshore Maritime Communications

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China Communications 2022年第1期19卷 153-165页

作者： Yanpeng Dai Bin Lin Yudi Che ling lyu School of Information Science and Technology Dalian Maritime UniversityDalian 116026China Network Communication Research Centre Peng Cheng LaboratoryShenzhen 518052China State Key Laboratory of Integrated Services Networks Xidian UniversityShaanxi 710071China

Smart containers have been extensively applied in the maritime industry by embracing the Internet of Things to realize container status monitoring and data offloading without human ***, the offloading rate and delay in the offshore region are limited by the coverage of the onshore base station(BS). In this paper, we investigate the unmanned aerial vehicle(UAV)-assisted data offloading for smart containers in offshore maritime communications where the UAV is as a relay node between smart containers and onshore BS. We first consider the mobility of container vessel in the offshore region and establish a UAV-assisted data offloading model. Based on this model, a data offloading algorithm is proposed to reduce the average offloading delay under data-size requirements and available energy constraints of smart containers. Specifically, the convex-concave procedure is used to update time-slot assignment,offloading approach selection, and power allocation in an iterative manner. Simulation results show that the proposed algorithm can efficiently reduce average offloading delay and increase offloading success ***, it is shown that the UAV relay cannot always bring the performance gain on offloading delay especially in the close-to-shore area, which could give an insight on the deployment of UAV relay in offshore communications.

关键词： data offloading smart container unmanned aerial vehicle maritime Internet of Things

Hydrogen Sulfide Promotes Platelet Autophagy via PDGFR-a/PI3K/Akt Signaling in Cirrhotic Thrombocytopenia

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 625-633页

作者： Hua-Xiang Yang Yang-Jie Li Yang-Lan He Ke-Ke Jin ling-Na lyu Hui-Guo Ding Department of Gastroenterology and Hepatology Beijing You’an Hospital Affiliated to Capital Medical UniversityBeijingChina

Background and Aims:The role of platelet autophagy in cirrhotic thrombocytopenia(CTP)remains *** study aimed to investigate the impact of platelet autophagy in CTP and elucidate the regulatory mechanism of hydrogen sulfide(H_(2)S)on platelet ***:Platelets from 56 cirrhotic patients and 56 healthy individuals were isolated for in vitro *** markers(ATG7,BECN1,LC3,and SQSTM1)were quantified using enzyme-linked immunosorbent assay,while autophagosomes were visualized through electron *** blotting was used to assess the autophagy-related proteins and the PDGFR/PI3K/Akt/mTOR pathway following treatment with NaHS(an H_(2)S donor),hydroxocobalamin(an H_(2)S scavenger),or AG 1295(a selective PDGFR-α/inhibitor).A carbon terachloride-induced cirrhotic BALB/c mouse model was *** mice with thrombocytopenia were randomly treated with normal saline,NaHS,or hydroxocobalamin for 15 *** in platelet count and aggregation rate were observed every three ***:Cirrhotic patients with thrombocytopenia exhibited significantly decreased platelet autophagy markers and endogenous H_(2)S levels,alongside increased platelet aggregation,compared to healthy *** vitro,NaHS treatment of platelets from severe CTP patients elevated LC3-II levels,reduced SQSTM1 levels,and decreased platelet aggregation in a dose-dependent manner.H_(2)S treatment inhibited PDGFR,PI3K,Akt,and mTOR *** vivo,NaHS significantly increased LC3-II and decreased SQSTM1 expressions in platelets of cirrhotic mice,reducing platelet aggregation without affecting the platelet ***:Diminished platelet autophagy potentially contributes to thrombocytopenia in cirrhotic patients.H_(2)S modulates platelet autophagy and functions possibly via the PDGFR-α/PI3K/Akt/mTOR signaling pathway.

关键词： Liver cirrhosis Thrombocytopenia Platelet Autophagy Hydrogen sulfide NaHS PDGFR-α PI3K/Akt/mTOR signaling

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皮肌炎伴发恶性肿瘤的研究进展

中华皮肤科杂志 2022年第3期55卷 276-279页

作者：吕玲吕小岩四川大学华西医院皮肤性病科成都610041

皮肌炎伴发恶性肿瘤是皮肌炎的一个亚型,伴发恶性肿瘤为皮肌炎预后不良的主要因素。恶性肿瘤高危发病时间为皮肌炎诊断前后1年内。与经典型皮肌炎相比,皮肌炎伴发恶性肿瘤具有患者年龄>50岁、Heliotrope征、皮肤坏死及肌炎特异性抗体抗... 详细信息

皮肌炎伴发恶性肿瘤是皮肌炎的一个亚型,伴发恶性肿瘤为皮肌炎预后不良的主要因素。恶性肿瘤高危发病时间为皮肌炎诊断前后1年内。与经典型皮肌炎相比,皮肌炎伴发恶性肿瘤具有患者年龄>50岁、Heliotrope征、皮肤坏死及肌炎特异性抗体抗转录中介因子1γ抗体、抗核基质蛋白2抗体阳性等典型的临床特点,这些特点提示需进行恶性肿瘤的筛查或密切监测随访。

关键词：皮肌炎肿瘤自身抗体诊断预后

Hepatoid adenocarcinoma of the lung accompanied with multiple systemic metastases

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Chinese Medical Journal 2021年第2期134卷 237-238页

作者： Jing-Xian Chen ling-ling lyu Wen-Hua Zhu Xiao-Yan Chen Lan Zheng Department of Traditional Chinese Medicine Ruijin HospitalShanghai Jiaotong UniversityShanghai 200025China Department of Pathology Ruijin HospitalShanghai Jiaotong UniversityShanghai 200025China

To the Editor:Hepatoid adenocarcinoma of the lung(HAL)is a rare malignant tumor,which can be defined as alph-fetoprotein(AFP)-producing primary lung *** hepatoid adenocarcinomas(HAC)have high AFP *** lacks effective t... 详细信息

关键词： adenocarcinoma lung expression.

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个体化免疫耐受的诱导与调节性T细胞

器官移植 2020年第1期11卷 8-12页

作者：吕凌倪绪浩南京医科大学第一附属医院肝胆中心

免疫耐受的诱导是器官移植免疫领域的重要组成部分和最高追求目标,它基于对移植抗原识别、提呈以及免疫系统的激活和应答等免疫学本质的认识。但是,在成功诱导免疫耐受之前,如何对器官移植受者实施个体化免疫耐受诱导,从而使免疫抑制剂... 详细信息

免疫耐受的诱导是器官移植免疫领域的重要组成部分和最高追求目标,它基于对移植抗原识别、提呈以及免疫系统的激活和应答等免疫学本质的认识。但是,在成功诱导免疫耐受之前,如何对器官移植受者实施个体化免疫耐受诱导,从而使免疫抑制剂和个体化治疗措施实现最优化的搭配,来达到预防和治疗排斥反应的效果最佳、不良反应最小的理想状态,仍然是移植工作者不断探索和仍未解决的难题。本文综合国际核心期刊报道内容,从免疫耐受诱导机制、可操作性免疫耐受的实现、个体化免疫耐受诱导新策略及调节性T细胞在个体化免疫耐受中的应用,并结合本中心调节性T细胞临床和基础研究成果综合讨论个体化免疫耐受诱导策略和未来展望。

关键词：器官移植免疫耐受可操作性免疫耐受免疫排斥反应移植免疫调节性T细胞转化医学

Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural Regeneration Research 2025年第1期20卷 67-81页

作者： Yubo Wang Tingli Yuan Tianjie lyu ling Zhang Meng Wang Zhiying He Yongjun Wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering Research Center of Stem Cells Translational Medicine ShanghaiChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

工业原料制备大孔拟薄水铝石及在异佛尔酮选择性加氢中的应用

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应用化学 2023年第1期40卷 79-90页

作者：林锦王芳珠吕灵灵中国石油大学(华东)化学化工学院青岛266580

以废催化裂化催化剂处理生产的工业级硫酸铝与偏铝酸钠为原料制备拟薄水铝石,探究制备工艺、扩孔和改性等对拟薄水铝石晶型、孔结构、表面酸性以及形貌的影响。用自制的拟薄水铝石经过挤条、焙烧等过程制备相应的催化剂载体,负载Pd活性... 详细信息

以废催化裂化催化剂处理生产的工业级硫酸铝与偏铝酸钠为原料制备拟薄水铝石,探究制备工艺、扩孔和改性等对拟薄水铝石晶型、孔结构、表面酸性以及形貌的影响。用自制的拟薄水铝石经过挤条、焙烧等过程制备相应的催化剂载体,负载Pd活性组分,研究改性Al_(2)O_(3)载体以及PdCl_(2)和Pd(acac)2前驱体制备的Pd/Al_(2)O_(3)催化剂对异佛尔酮C==C选择性加氢反应的活性与选择性。通过优化反应条件得到了比表面积为413 m^(2)/g,孔容为0.84 cm^(3)/g,孔径为6.84 nm的拟薄水铝石。加入扩孔剂碳酸铵和硅酸钠后,拟薄水铝石的孔容分别增大至0.98和1.53 cm^(3)/g,平均孔径分别增至7.70和12.34 nm。以碳酸铵扩孔得到的Al_(2)O_(3)为载体和以PdCl_(2)为前驱体制备得到的Pd/Al_(2)O_(3)催化剂对异佛尔酮C==C选择性加氢活性高,达到98.69%,3,3,5-三甲基环己酮选择性>99%,活性稳定性高。

关键词：拟薄水铝石制备改性异佛尔酮选择性加氢

线状硬斑病107例临床及影像学特点回顾性分析

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中华皮肤科杂志 2021年第9期54卷 798-803页

作者：周海燕唐鹤菡陈冲吕玲吕小岩四川大学华西医院皮肤科成都610041 四川大学华西医院放射科成都610041 四川大学华西公共卫生学院/华西第四医院皮肤科

目的分析不同亚型线状硬斑病(LM)的临床表现、实验室及影像学检查特点,对LM的诊断和病情评估方法提出建议。方法回顾性分析2018年1月至2019年12月四川大学华西医院皮肤科门诊经临床和/或病理确诊的LM患者的临床资料。结果共纳入107例LM... 详细信息

目的分析不同亚型线状硬斑病(LM)的临床表现、实验室及影像学检查特点,对LM的诊断和病情评估方法提出建议。方法回顾性分析2018年1月至2019年12月四川大学华西医院皮肤科门诊经临床和/或病理确诊的LM患者的临床资料。结果共纳入107例LM患者,肢体LM 63例,刀劈状硬斑病22例,进行性颜面偏侧萎缩和嗜酸性筋膜炎各11例。88例患者接受改良局限性硬皮病皮肤严重指数(mLoSSI)和皮肤损伤指数(LoSDI)评分,mLoSSI评分为0~51分,LoSDI评分为0~40分。10例嗜酸性筋膜炎患者行血常规检查,4例嗜酸性粒细胞增高。88例LM患者行抗核抗体检查,13例(14.8%)阳性(滴度≥1∶320)。4例进行性颜面偏侧萎缩患者行核磁共振成像(MRI)检查2例出现同侧大脑半球萎缩及对侧白质区T2高信号;肢体LM 28例中26例(92.9%)MRI表现为肌筋膜增厚,嗜酸性筋膜炎患者11例MRI均可见皮下脂肪间隔和肌筋膜增厚。结论mLoSSI和LoSDI可对LM的疾病活动性、严重程度及预后做出初步评估;对临床提示有深部受累的患者,建议行MRI检查。

关键词：线状硬斑病肢体线状硬斑病刀劈状硬斑病进行性颜面偏侧萎缩嗜酸性筋膜炎

甲状腺影像报告与数据系统分类和超声弹性成像技术及其联合诊断甲状腺结节研究进展

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中国医学影像技术 2021年第8期37卷 1238-1241页

作者：吕玲赵树樊牛惠萍长治医学院附属和平医院超声科山西长治046000

甲状腺影像报告与数据系统(TI-RADS)分类规范了超声诊断术语,有助于临床诊断甲状腺结节。超声弹性成像技术可定性、定量评估甲状腺结节软硬度,为诊断良恶性甲状腺结节提供依据。本文对TI-RADS分类、超声弹性成像技术及二者联合用于甲状... 详细信息

甲状腺影像报告与数据系统(TI-RADS)分类规范了超声诊断术语,有助于临床诊断甲状腺结节。超声弹性成像技术可定性、定量评估甲状腺结节软硬度,为诊断良恶性甲状腺结节提供依据。本文对TI-RADS分类、超声弹性成像技术及二者联合用于甲状腺结节进展进行综述。

关键词：甲状腺肿瘤超声检查弹性成像技术甲状腺影像报告与数据系统