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LaMnO_(3)/Co_(3)O_(4) nanocomposite for enhanced triethylamine sensing properties

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Journal of Rare Earths 2024年第4期42卷 733-742页

作者： Jian Zhang Yanping Chen ling li Xue Chen Wenya An Xiujuan Qian Yuye Tao School of Science Shandong Jianzhu UniversityJinan250100China

LaMnO_(3) modified Co_(3)O_(4) nanocomposites were prepared by simple hydrothermal method co mbined with sol-gel method.The gas sensitivity properties of pure Co_(3)O_(4) and LaMnO_(3)/Co_(3)O_(4) with different composite proportions are compared.It is found that 0.6-LMO/Co_(3)O_(4) sensor has higher sensitivity to triethylamine(TEA)than pure Co_(3)O_(4) sensor,which is improved by 9.27 times.And the working temperature is reduced from 150 to 130℃.Besides,it has excellent gas selectivity and repeatability.The improvement of the gas sensitivity of LaMnO_(3)/Co_(3)O_(4) sensor may be due to the fact that LaMnO_(3) is an effective catalyst,and the catalytic performance perhaps is beneficial to improving the sensing performance.In addition,the formation of p-p heterojunctions may be the key factor to improve the gas sensing performance.This work provides a new Co_(3)O_(4)-based gas sensing material for the detection of TEA.

关键词： Gas sensing Co_(3)O_(4) LaMnO_(3) Triethylamine Rareearths

Regulating Signal Pathway Triggers Circular Reactive Oxygen Species Production to Augment Oxidative Stress with Enzyme-Activated Nanoparticles

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CCS Chemistry 2024年第3期6卷 693-708页

作者： Benkai Bao Qiong Yuan Qian Feng ling li Meiqi li Yanli Tang Key Laboratory of Analytical Chemistry for life Science of Shaanxi Province Key Laboratory of Applied Surface and Colloid ChemistryMinistry of EducationSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’anShaanxi Province 710119

Regulating antioxidative stress pathways to augment oxidative stress and enhance antitumor therapy is highly desirable but very challenging.Herein,we initiated a multifunctional nanoparticle to regulate the Keap1-Nrf2 antioxidative stress pathway to promote cancer cell apoptosis.The OPFV-SnMP@GE11 nanoparticles were assembled by enzyme-activated OPFV-TLQ,tin mesoporphyrin(SnMP),and DSPEPEG-GE11.OPFV-SnMP@GE11 accumulated at tumor sites through specific targeting with GE11.OPFV-TLQ was specifically reduced to a photosensitizer OPFVNH2 by endocellular NAD(P)H:quinone oxidoreductase 1(NQO1).Under irradiation,OPFV-NH2 greatly produced reactive oxygen species(ROS)through a type I mechanism,which activated the Keap1-Nrf2 signal pathway and enhanced the transcription of NQO1,resulting in a continuous and explosive generation of ROS.Additionally,SnMP inhibited the activity of heme oxygenase-1(HO-1),further depressing antioxidative stress.This strategy provides insight into the regulation of the signal pathway to amplify oxidative stress,paving the way to studying the molecular mechanisms of cellular activities to enhance cancer therapy.

关键词： Keap1-Nrf2 pathway enzyme-activated probe reactive oxygen species oxidative stress antitumor therapy

Large porewater exchange reshapes saltmarsh carbon and greenhouse gas budgets on local and global scales

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Science China Earth Sciences 2024年第7期67卷 2195-2209页

作者： Xiaogang CHEN Isaac RSANTOS Lucheng ZHAN Yu Yan YAU Yan ZHANG ling li Key Laboratory of Coastal Environment and Resources of Zhejiang Province School of EngineeringWestlake UniversityHangzhou 310024China Department of Marine Sciences University of GothenburgGothenburg 41319Sweden College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210024China

Saltmarshes are carbon-rich ecosystems that play a role in climate regulation by efficiently sequestrating atmospheric CO_(2).Climate change is a major threat to saltmarshes and will impact saltmarsh carbon sequestration.Notably,porewater-derived carbon outwelling emerges as a crucial pathway for carbon sequestration,but it has been largely overlooked in saltmarshes.Here,we assessed the drivers of dissolved carbon exports and greenhouse gas emissions in a saltmarsh and placed those observations into a global context.In our study site,porewater exchange(PEX)was the major process controlling dissolved carbon and greenhouse gas dynamics.Combining our results with 33 other studies in saltmarshes worldwide,porewater-derived carbon fluxes were equivalent to~48% of average global saltmarsh primary productivity and 2.2 times greater than global organic carbon burial.Hence,our local observations and global upscaling demonstrate the major role played by PEX in saltmarsh carbon budgets.While part of dissolved inorganic carbon returns to the atmosphere as CO_(2),the remaining bicarbonate fraction is stored in the ocean over long time scales.Our findings strengthen global blue carbon assessments and build arguments for the use of saltmarshes as nature-based solutions for global climate change.

关键词： Coastal carbon Global carbon budget Carbon neutrality Nature-based solutions Coastal wetlands Submarine groundwater discharge

Toughened (Ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)Ta_(0.2))B_(2)–SiC composites fabricated by one-step reactive sintering with a unique SiB_(6) additive

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Journal of Advanced Ceramics 2024年第1期13卷 86-100页

作者： Wei Hao Xinzhe Lu ling li Tao Wang Guoliang Ren Huangyue Cai Xiaofeng Zhao Dongyun Wang Na Ni Zhejiang Provincial Key Laboratory of Urban Rail Transit Intelligent Operation and Maintenance Technology&Equipment Zhejiang Normal UniversityZhejiang 321004China Key Lab of Education Ministry for Power Machinery and Engineering School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

High-entropy diboride has been arousing considerable interest in recent years.However,the low toughness and damage tolerance limit its applications as ultra-high-temperature structural materials.Here we report that a unique SiB_(6) additive has been first incorporated as boron and silicon sources to fabricate a high-entropy boride(Ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)Ta_(0.2))B_(2)–SiC composite though one-step boro/carbothermal reduction reactive sintering.A synergetic effect of high-entropy sluggish diffusion and SiC secondary phase retarded the grain growth of the(Ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)Ta_(0.2))B_(2)–51SiC composites.The small grain size was beneficial to shorten the diffusion path for mass transport,thereby enhancing the relative density to~99.3%.These results in an increase of fracture toughness from~5.2 in HEBS-1900 to~7.7 MPa·m^(1/2) in HEBS-2000,which corresponded to a large improvement of 48%.The improvement was attributed to a mixed mode of intergranular and transgranular cracking for offering effective pinning in crack propagation,resulting from balanced grain boundary strength collectively affected by improved densification,solid solution strengthening,and incorporation of SiC secondary phase.

关键词： high-entropy diboride silicon hexaboride boro/carbothermal reduction reactive sintering fracture toughness

Predictive value of angiopoietin-like protein 8 in metabolic dysfunction-associated fatty liver disease and its progression:A case-control study

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World Journal of Diabetes 2024年第3期15卷 418-428页

作者： Lu-Lu Gan Can Xia Xuan Zhu Yue Gao Wen-Chang Wu Qi li ling li Zhe Dai Yi-Min Yan Medical College Wuhan University of Science and TechnologyWuhan 430071Hubei ProvinceChina Department of Endocrinology Xiaogan Hospital Affiliated with Wuhan University of Science and TechnologyThe Central Hospital of XiaoganXiaogan 432000Hubei ProvinceChina Department of Endocrinology Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina

BACKGROUND The prevalence of metabolic dysfunction-associated fatty liver disease(MAFLD)is rapidly increasing,currently affecting approximately 25%of the global population.liver fibrosis represents a crucial stage in the development of MAFLD,with advanced liver fibrosis elevating the risks of cirrhosis and hepatocellular carcinoma.Simple serum markers are less effective in diagnosing liver fibrosis compared to more complex markers.However,imaging techniques like transient elastography face limitations in clinical application due to equipment and technical constraints.Consequently,it is imperative to identify a straightforward yet effective method for assessing MAFLD-associated liver fibrosis.AIM To investigate the predictive value of angiopoietin-like protein 8(ANGPTL8)in MAFLD and its progression.METHODS We analyzed 160 patients who underwent abdominal ultrasonography in the Endocrinology Department,Xiaogan Central Hospital affiliated to Wuhan University of Science and Technology,during September 2021-July 2022.Using abdominal ultrasonography and MAFLD diagnostic criteria,among the 160 patients,80 patients(50%)were diagnosed with MAFLD.The MAFLD group was divided into the liver fibrosis group(n=23)and non-liver fibrosis group(n=57)by using a cut-off fibrosis-4 index≥1.45.Logistical regression was used to analyze the risk of MAFLD and the risk factors for its progression.Receiver operating characteristic curves were used to evaluate the predictive value of serum ANGPTL8 in MAFLD and its progression.RESULTS Compared with non-MAFLD patients,MAFLD patients had higher serum ANGPTL8 and triglyceride-glucose(TyG)index(both P<0.05).Serum ANGPTL8(r=0.576,P<0.001)and TyG index(r=0.473,P<0.001)were positively correlated with MAFLD.Serum ANGPTL8 was a risk factor for MAFLD[odds ratio(OR):1.123,95%confidence interval(CI):1.066-1.184,P<0.001).Serum ANGPTL8 and ANGPTL8+TyG index predicted MAFLD[area under the curve(AUC):0.832 and 0.886,respectively;both P<0.05].Compared with MAFLD patients without fibrosis,those with fibrosis

关键词： Angiopoietin-like protein 8 Metabolic dysfunction-associated fatty liver disease Fibrosis-4 index liver fibrosis

Vitamin D-binding protein in plasma microglia-derived extracellular vesicles as a potential biomarker for major depressive disorder

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Genes & Diseases 2024年第2期11卷 1009-1021页

作者： Gaojia Zhang ling li Yan Kong Dandan Xu Yu Bao Zhiting Zhang Zhixiang liao Jiao Jiao Dandan Fan Xiaojing Long Ji Dai Chunming Xie Zhiqiang Meng Zhijun Zhang Department of Neurology Affiliated Zhongda HospitalResearch Institution of NeuropsychiatrySchool of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Biochemistry and Molecular Biology School of MedicineSoutheast UniversityNanjingJiangsu 210009China Shenzhen Key Laboratory of Drug Addiction Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of Sciences (CAS)ShenzhenGuangdong 518000China CAS Key Laboratory of Brain Connectome and Manipulation The Brain Cognition and Brain Disease Institute (BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China Lauterbur Research Center for Biomedical Imaging Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China Shenzhen-Hong Kong Institute of Brain Sciences-Shenzhen Fundamental Research Institutions ShenzhenGuangdong 518000China Brain Cognition and Brain Disease Institute Department of Mental Health and Public HealthFaculty of Life and Health SciencesShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China

No well-established biomarkers are available for the clinical diagnosis of major depressive disorder(MDD).Vitamin D-binding protein(VDBP)is altered in plasma and postmortem dorsolateral prefrontal cortex(DLPFC)tissues of MDD patients.Thereby,the role of VDBP as a potential biomarker of MDD diagnosis was further assessed.Total extracellular vesicles(EVs)and brain cell-derived EVs(BCDEVs)were isolated from the plasma of first-episode drug-naïve or drug-free MDD patients and well-matched healthy controls(HCs)in discovery(20 MDD patients and 20 HCs)and validation cohorts(88 MDD patients and 38 HCs).VDBP level in the cerebrospinal fluid(CSF)from chronic glucocorticoid-induced depressed rhesus macaques or prelimbic cortex from lipopolysaccharide(LPS)-induced depressed mice and wild control groups was measured to evaluate its relationship with VDBP in plasma microglia-derived extracellular vesicles(MDEVs).VDBP was significantly decreased in MDD plasma MDEVs compared to HCs,and negatively correlated with HAMD-24 score with the highest diagnostic accuracy among BCDEVs.VDBP in plasma MDEVs was decreased both in depressed rhesus macaques and mice.A positive correlation of VDBP in MDEVs with that in CSF was detected in depressed rhesus macaques.VDBP levels in prelimbic cortex microglia were negatively correlated with those in plasma MDEVs in depressed mice.The main results suggested that VDBP in plasma MDEVs might serve as a prospective candidate biomarker for MDD diagnosis.

关键词： Biomarker Cerebrospinal fluid Major depressive disorder Microglia derived extracellular vesicles Vitamin-D binding protein

Revealing the specific regulations of nitric oxide on the postharvest ripening and senescence of bitter melon fruit

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aBIOTECH 2024年第1期5卷 29-45页

作者： Hongwei Wang ling li lili Ma Alisdair R.Fernie Anzhen Fu Chunmei Bai Zhaoze Sang Susu Guo Fan Zhang Qing Wang Yanyan Zheng Jinhua Zuo Key Laboratory of Vegetable Postharvest Processing Ministry of AgricultureBeijing Key Laboratory of Fruits and Vegetable Storage and ProcessingKey Laboratory of Biology and Genetic Improvement of Horticultural Crops(North China)of Ministry of AgricultureKey Laboratory of Urban Agriculture(North)of Ministry of AgricultureBeijing Vegetable Research CenterInstitute of Agro-Products Processing and Food NutritionBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China College of Food Science and Biotechnology Tianjin Agricultural UniversityTianjin 300392China Max Planck Institute of Molecular Plant Physiology 14476 Potsdam GolmGermany Institute of Food Science and Technology Chinese Academy of Agricultural SciencesBeijingChina

Bitter melon fruit is susceptible to yellowing,softening,and rotting under room-temperature storage conditions,resulting in reduced commercial value.Nitric oxide(NO)is an important signaling molecule and plays a crucial role in regulating the fruit postharvest quality.In this study,we investigated the effects of NO treatment on changes in sensory and firmness of bitter melon fruit during postharvest storage.Moreover,transcriptomic,metabolomic,and proteomic analyses were performed to elucidate the regulatory mechanisms through which No treatment delays the ripening and senescence of bitter melon fruit.Our results show that differentially expressed genes(DEGs)were involved in fruit texture(CSLE,β-Gal,and PME),plant hormone signal transduction(ACS,JAR4,and AUX28),and fruit flavor and aroma(SUS2,LOX,and GDH2).In addition,proteins differentially abundant were associated with fruit texture(PLY,PME,and PGA)and plant hormone signal transduction(PBL15,JAR1,and PYL9).Moreover,No significantly increased the abundance of key enzymes involved in the phenylpropanoid biosynthetic pathway,thus enhancing the disease resistance and alleviating softening of bitter melon fruit.Finally,differential metabolites mainly included phenolic acids,terpenoids,and flavonoids.These results provide a theoretical basis for further studies on the physiological changes associated with postharvest ripening and senescence of bitter melon fruit.

关键词： Bitter melon NO treatment Postharvest Ripening and senescence

Coupling metal-organic frameworks and wood-based carbon for water remediation

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Nano Research 2024年第6期17卷 5661-5669页

作者： Akhter Zia Manish Neupane Aidan McGlone Rui He Ruikun Xin Yifeng liu Qiangu Yan Jinwu Wang ling li Zhiyong Cai Pei Dong Yingchao Yang Department of Mechanical Engineering University of MaineOronoME 04469USA Department of Mechanical and Aerospace Engineering University of MissouriColumbiaMO 65211USA Department of Mechanical Engineering George Mason UniversityFairfaxVA 22030USA Department of Civil and Environmental Engineering Rice UniversityHoustonTX 77005USA Department of Materials Science and NanoEngineering Rice UniversityHoustonTX 77005USA Forest Products Laboratory USDAMadisonWI 53726USA School of Forestry Resources University of MaineOronoME 04469USA

Fresh and clean water is highly demanded throughout the world.To effectively address the need,nanomaterials enabled nanotechnology has been explored as a means of more efficient,reliable,and environmentally friendly approach towards water treatment practices.One concern in adopting nanomaterials is how to retrieve them from water body to avoid secondary contamination.In this work,the earth abundant and sustainable wood,e.g.,basswood,was selected and carbonized into porous carbon as host skeleton,and metal-organic frameworks(MOFs),e.g.,MOF-199 with extremely high surface area,were grown throughout all channels in the porous basswood carbon.Targeting the traditional organic pollutant,methyl orange(MO),the combination of MOFs and basswood carbon(MOFs@carbon)demonstrates a remarkable adsorption capacity,which is 243%and 454%higher than basswood carbon and MOF-199,respectively.Such an outstanding adsorption performance originates from that the positively charged carbon pulls MO molecules close to carbon surface,leading to a high MO molecule concentration,and then the concentration gradient drives the MO molecules to be stored inside MOFs,functioning like pockets.These findings highlight the potential application of coupled MOFs and biomass carbon in addressing water remediation.

关键词： metal-organic framework(MOF)-199 basswood carbon MOFs@carbon methyl orange

Deamidation enables pathogenic SMAD6 variants to activate the BMP signaling pathway

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Science China life Sciences 2024年

作者： ling li Lei Lu Ziqi Xiao Jingyi Lv Hefeng Huang Bo Wu Tongjin Zhao Chengtao li Weimin Wang Hongyan Wang Obstetrics and Gynecology Hospital State Key Laboratory of Genetic Engineering Institute of Reproduction and Development and Children's Hospital Fudan University Shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative Biology Fudan University Prenatal Diagnosis Center of Shenzhen Maternity & Child Healthcare Hospital Shanghai Medical College Fudan University Department of Pharmacy College of Life Sciences China Jiliang University

The BMP signaling pathway plays a crucial role in regulating early embryonic development and tissue homeostasis. SMAD6 encodes a negative regulator of BMP, and rare variants of SMAD6 are recurrently found in individuals with birth defects. However, we observed that a subset of rare pathogenic variants of SMAD6 consistently exhibited positive regulatory effects instead of the initial negative effects on the BMP signaling pathway. We sought to determine whether these SMAD6 variants have common pathogenic mechanisms. Here, we showed that pathogenic SMAD6 variants accompanying this functional reversal exhibit similar increases in deamidation. Mechanistically, increased deamidation of SMAD6 variants promotes the accumulation of the BMP receptor BMPR1A and the formation of new complexes, both of which lead to BMP signaling pathway activation. Specifically, two residues, N262 and N404, in SMAD6 were identified as the crucial sites of deamidation, which was catalyzed primarily by glutamine-fructose-6-phosphate transaminase 2(GFPT2). Additionally, treatment of cells harboring SMAD6 variants with a deamidase inhibitor restored the inhibitory effect of SMAD6 on the BMP signaling pathway. Conversely,when wild-type SMAD6 was manually simulated to mimic the deamidated state, the reversed function of activating BMP signaling was reproduced. Taken together, these findings show that deamidation of SMAD6 plays a crucial role in the functional reversal of BMP signaling activity, which can be induced by a subset of various SMAD6 variants. Our study reveals a common pathogenic mechanism shared by these variants and provides a potential strategy for preventing birth defects through deamidation regulation, which might prevent the off-target effects of gene editing.

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