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International Journal of Ophthalmology(English edition) 2024年第4期17卷 707-712页

作者： Qing-Jian Li Sheng-Mei Zhou ling-Yu Zhang An-Ni Lin Yang Zhang Jing Jiang Xin che.Yi-Wen Qian Yan Liu Zhi-Liang Wang Department of Ophthalmology Huashan HospitalFudan UniversityShanghai 200040China Eye Institute of Xiamen University Xiamen University School of MedicineXiamen 361005Fujian ProvinceChina Department of Gastroenterology Huashan HospitalFudan UniversityShanghai 200040China

AIM:To evaluate the relationship of overweight and obesity with retinal and choroidal thickness in adults without ocular symptoms by swept-source optical coherence tomography(SS-OCT).METHODS:According to the body mass index(BMI)results,the adults enrolled in the cross-sectional study were divided into the normal group(18.50≤BMIche. subjects each:normal,overweight,and *** mean BMI was 22.20±1.67,26.82±1.38,and 32.21±2.35 kg/m^(2) in normal,overweight and obesity groups,*** choroid was significantly thinner in both the overweight and obesity groups compared to the normal group(P<0.05 for all),while the retinal thickness of the three groups did not differ ***’s correlation analysis showed that BMI was significantly negatively correlated with choroidal thickness,but no significant correlation was observed between BMI and retinal ***:Choroidal thickness is decreased in people with overweight or *** on changes in choroidal thickness contributes to the understanding of the mechanisms of certain ocular disorders in overweight and obese adults.

关键词： overweight obesity body mass index choroidal thickness retinal thickness swept-source optical coherence tomography

Potential application of Nardostachyos Radix et Rhizoma-Rhubarb for the treatment of diabetic kidney disease based on network pharmacology and cell culture experimental verification

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World Journal of Diabetes 2024年第3期15卷 530-551页

作者： Meng-Ying che.ling Yuan Jiao Min Duo-Jie Xu Dou-Dou Lu Wen-Jing Liu Kai-Li Wang Yan-Yan Wang Yi Nan Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Endocrinology Yinchuan Hospital of Traditional Chinese MedicineYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Diabetic kidney disease(DKD)is one of the serious complications of diabetes mellitus,and the existing treatments cannot meet the needs of today's *** Chinese medicine has been validated for its efficacy in DKD after many years of clinical ***,the specific mechanism by which it works is still *** the molecular mechanism of the Nardostachyos Radix et Rhizoma-rhubarb drug pair(NRDP)for the treatment of DKD will provide a new way of thinking for the research and development of new *** To investigate the mechanism of the NRDP in DKD by network pharmacology combined with molecular docking,and then verify the initial findings by in vitro *** The Traditional Chinese Medicine Systems Pharmacology(TCMSP)database was used to screen active ingredient targets of *** for DKD were obtained based on the Genecards,OMIM,and TTD *** VENNY 2.1 database was used to obtain DKD and NRDP intersection targets and their Venn diagram,and Cytoscape 3.9.0 was used to build a"drug-component-target-disease"*** String database was used to construct protein interaction *** Encyclopedia of Genes and Genomes(KEGG)enrichment analysis and Gene Ontology analysis were performed based on the DAVID *** selecting the targets and the active ingredients,Autodock software was used to perform molecular *** experimental validation using renal tubular epithelial cells(TCMK-1),we used the Cell Counting Kit-8 assay to detect the effect of NRDP on cell viability,with glucose solution used to mimic a hyperglycemic *** cytometry was used to detect the cell cycle progression and *** blot was used to detect the protein expression of STAT3,p-STAT3,BAX,BCL-2,Caspase9,and *** A total of 10 active ingredients and 85 targets with 111 disease-related signaling pathways were obtained for *** analysis of KEGG pathways was performed to determ

关键词： Nardostachyos Radix et Rhizoma-rhubarb Diabetic kidney disease Molecular docking Network pharmacology Experimental validation

Functional dissection of parabrachial substrates in processing nociceptive information

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Zoological Research 2024年第3期45卷 633-647页

作者： Jin Ke Wei-che.g Lu Hai-Yang Jing Shen Qian Sun-Wook Moon Guang-Fu Cui Wei-Xin Qian Xiao-Jing che.Qian Zhang Shi-Shi Lai ling Zhang Ying-Jie Zhu Jing-Dun Xie Tian-Wen Huang Shenzhen Key Laboratory of Drug Addiction Shenzhen-Hong Kong Institute of Brain ScienceBrain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China CAS Key Laboratory of Brain Connectome and Manipulation Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China University of Chinese Academy of Sciences Beijing 100049China Department of Anesthesiology State Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China University of Science and Technology of China HefeiAnhui 230027China Department of Anesthesiology Shenzhen University General Hospital and Shenzhen University Academy of Clinical Medical SciencesShenzhen UniversityShenzhenGuangdong 518055China School of Medicine Yunnan UniversityKunmingYunnan 650091China

Painful stimuli elicit first-line reflexive defensive reactions and,in many cases,also evoke second-line recuperative behaviors,the latter of which reflects the sensing of tissue damage and the alleviation of *** lateral parabrachial nucleus(lPBN),composed of external-(elPBN),dorsal-(dlPBN),and central/superior-subnuclei(jointly referred to as slPBN),receives sensory inputs from spinal projection neurons and plays important roles in processing affective information from external threats and body integrity ***,the organizational rules of lPBN neurons that provoke diverse behaviors in response to different painful stimuli from cutaneous and deep tissues remain *** this study,we used region-specific neuronal depletion or silencing approache. combined with a battery of behavioral assays to show that slPBN neurons expressing substance P receptor(NK1R)(lPBNNK1R)are crucial for driving pain-associated self-care behaviors evoked by sustained noxious thermal and mechanical stimuli applied to skin or bone/muscle,while elPBN neurons are dispensable for driving such ***,lPBNNK1R neurons are specifically required for forming sustained somatic pain-induced negative teaching signals and aversive memory but are not necessary for fear-learning or escape behaviors elicited by external ***,both lPBNNK1R and elPBN neurons contribute to che.ical irritant-induced nocifensive *** results reveal the functional organization of parabrachial substrates that drive distinct behavioral outcomes in response to sustained pain versus external danger under physiological conditions.

关键词： Lateral parabrachial nucleus Substance P receptor Pain affect Defensive reaction Somatosensory

Antibacterial and angiogenic dual-functional fibrous membrane dressing for infected wound healing

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Biomedical Engineering Communications 2024年第1期3卷 4-14页

作者： Chao Zhou che.Zhao Hao-Yu Dai Tian-Jun Zhu Jia-Pei Yao Li che. Jing-Jing Wen Jia ling Celestine Loh Xin-Die Zhou Yong Huang School of Medical and Health Engineering Changzhou UniversityChangzhouJiangsu 213164China School of Aerospace and Mechanical Engineering Changzhou Institute of TechnologyChangzhouJiangsu 213032China Department of Orthopedics The Affiliated Changzhou Second People's Hospital of Nanjing Medical UniversityChangzhou Medical CenterNanjing Medical UniversityChangzhou 213000China Duke-NUS Graduate Medical School National University of SingaporeKent Ridge 169547Singapore

Background:Skin,being a vital organ that regulates physiological responses in the human body,is prone to injury from external environmental *** full-thickness skin defects becomes especially challenging when infections and vascular injuries are *** wound dressings with single functions,such as antibacterial or angiogenic properties,fall short in achieving rapid wound *** address this,there is a need to develop wound dressing materials that possess both effective antibacterial and angiogenic ***:In this study,we utilized electrospinning technology to fabricate hyaluronic acid-cellulose acetate fibrous membrane dressings,incorporating poly(ionic liquid)as an antibacterial polymer and deferoxamine as an angiogenic ***:The resulting fibrous membrane dressing contained poly(ionic liquid)and deferoxamin showcased a microporous structure,drug-releasing capabilities,and excellent air *** not only demonstrated highly effective antibacterial properties but also exhibited remarkable angiogenesis,thereby promoting the healing of full-thickness skin defect wounds in both in vitro and in vivo ***:These findings highlight the immense potential of this wound dressing material for future clinical applications.

关键词： electro spinning antibacterial polymer angiogenesis wound healing membrane dressing

Ferroptosis biomarkers predict tumor mutation burden's impact on prognosis in HER2-positive breast cancer

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World Journal of Clinical Oncology 2024年第3期15卷 391-410页

作者： Jin-Yu Shi Xin che.Rui Wen Si-Jia Hou Yu-Jia Xi Yi-Qian Feng ling-Xiao Wang Shi-Jia Liu Wen-Hao Lv Ya-Fen Zhang Department of Breast Surgery The Fifth Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina The Fifth Clinical Medical College Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Colorectal Surgery The Fifth Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina College of Pharmacy Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Neurology The First Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Urology The Second Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Breast Surgery The First Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina

BACKGROUND Ferroptosis has recently been associated with multiple degenerative *** induction in cancer cells is a feasible method for treating neoplastic ***,the association of iron proliferation-related genes with prognosis in HER2+breast cancer(BC)patients is *** To identify and evaluate fresh ferroptosis-related biomarkers for HER2+*** First,we obtained the mRNA expression profiles and clinical information of HER2+BC patients from the TCGA and METABRIC public databases.A four gene prediction model comprising PROM2,SLC7A11,FANCD2,and FH was subsequently developed in the TCGA cohort and confirmed in the METABRIC *** were stratified into high-risk and low-risk groups based on their median risk score,an independent predictor of overall survival(OS).Based on these findings,immune infiltration,mutations,and medication sensitivity were analyzed in various risk ***,we assessed patient prognosis by combining the tumor mutation burden(TMB)with risk ***,we evaluated the expression of critical genes by analyzing single-cell RNA sequencing(scRNA-seq)data from malignant vs normal epithelial *** We found that the higher the risk score was,the worse the prognosis was(P<0.05).We also found that the immune cell infiltration,mutation,and drug sensitivity were different between the different risk *** highrisk subgroup was associated with lower immune scores and high ***,we found that the combination of the TMB and risk score could stratify patients into three groups with distinct ***-HTMB patients had the worst prognosis,whereas LRisk-LTMB patients had the best prognosis(P<0.0001).Analysis of the scRNAseq data showed that PROM2,SLC7A11,and FANCD2 were significantly differentially expressed,whereas FH was not,suggesting that these genes are expressed mainly in cancer epithelial cells(P<0.01).CONCLUSION Our model helps guide the prognosis of HER2+breast cancer pa

关键词： HER2+breast cancer Ferroptosis Tumor mutation burden Single-cell RNA sequencing Prognosis

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聚焦老年心力衰竭患者的心脏康复管理

老年医学与保健 2024年第2期30卷 280-282页

作者：王怡恒车琳同济大学附属同济医院心血管内科上海200065

心力衰竭是心血管疾病的中晚期阶段,是老年人死亡的主要原因,我国6579岁和80岁及以上人群心衰患病率分别为3.86%和7.55%[1]。近年来,我国总体心衰住院死亡率呈现下降趋势;但同期老年心衰患者病死率较成年患者明显升高,针对老年心衰患者... 详细信息

心力衰竭是心血管疾病的中晚期阶段,是老年人死亡的主要原因,我国6579岁和80岁及以上人群心衰患病率分别为3.86%和7.55%[1]。近年来,我国总体心衰住院死亡率呈现下降趋势;但同期老年心衰患者病死率较成年患者明显升高,针对老年心衰患者的管理和康复策略尤其受到了业界的关注。

关键词：老年心力衰竭心脏康复运动训练

UAV-Assisted Data Offloading for Smart Container in Offshore Maritime Communications

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China Communications 2022年第1期19卷 153-165页

作者： Yanpeng Dai Bin Lin Yudi che.ling Lyu School of Information Science and Technology Dalian Maritime UniversityDalian 116026China Network Communication Research Centre Peng Cheng LaboratoryShenzhen 518052China State Key Laboratory of Integrated Services Networks Xidian UniversityShaanxi 710071China

Smart containers have been extensively applied in the maritime industry by embracing the Internet of Things to realize container status monitoring and data offloading without human ***, the offloading rate and delay in the offshore region are limited by the coverage of the onshore base station(BS). In this paper, we investigate the unmanned aerial vehicle(UAV)-assisted data offloading for smart containers in offshore maritime communications where the UAV is as a relay node between smart containers and onshore BS. We first consider the mobility of container vessel in the offshore region and establish a UAV-assisted data offloading model. Based on this model, a data offloading algorithm is proposed to reduce the average offloading delay under data-size requirements and available energy constraints of smart containers. Specifically, the convex-concave procedure is used to update time-slot assignment,offloading approach selection, and power allocation in an iterative manner. Simulation results show that the proposed algorithm can efficiently reduce average offloading delay and increase offloading success ***, it is shown that the UAV relay cannot always bring the performance gain on offloading delay especially in the close-to-shore area, which could give an insight on the deployment of UAV relay in offshore communications.

关键词： data offloading smart container unmanned aerial vehicle maritime Internet of Things

硅基纳米色素粒子的制备及在纺织品印花中的应用

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印染 2024年第6期50卷 39-43页

作者：凌嘉祺徐青青沈孟茹车映红瞿建刚南通大学纺织服装学院江苏南通226019 上海市纺织科学研究院有限公司上海200082 苏州大学纺织行业天然染料重点实验室江苏苏州215123

通过硅烷偶联剂KH550将活性染料反应到二氧化硅(SiO_(2))微球表面,制备了纳米色素粒子。研究了硅烷偶联剂用量、染料用量、反应温度和反应时间对染料吸附率的影响。采用红外光谱、透射电镜和Zeta电位对纳米色素粒子进行表征,并将纳米色... 详细信息

通过硅烷偶联剂KH550将活性染料反应到二氧化硅(SiO_(2))微球表面,制备了纳米色素粒子。研究了硅烷偶联剂用量、染料用量、反应温度和反应时间对染料吸附率的影响。采用红外光谱、透射电镜和Zeta电位对纳米色素粒子进行表征,并将纳米色素粒子应用于纺织品印花。结果表明,硅基纳米色素粒子较优的制备工艺为:KH550与SiO_(2)质量比为10%,活性黄145与SiO_(2)质量比为12.5%,反应温度为60℃,反应时间为140 min。吸附染料后的纳米色素粒子粒径由113.4 nm增加到135.1 nm,染料吸附率可达95.71%。印花织物的耐干摩擦色牢度均为4~5级,耐湿摩擦色牢度为3~4级,耐皂洗变色牢度为4~5级,耐日晒色牢度为4级。

关键词：硅基纳米色素粒子活性染料二氧化硅涂料印花

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重庆市新材料检验检测行业调研分析

实验室检测

实验室检测 2024年第6期2卷 90-93页

作者：车敏叶春玲席敏重庆化工建设工程质量监督站

本文对重庆市材料行业发展方向、规模、新材料检验检测能力情况进行调研，分析了新材料检验检测行业现状及存在的问题，提出了聚焦检测行业差异化发展，搭建完善的检测公共服务共享平台的发展路径。

关键词：新材料检验检测公共服务共享平台

非金属材料表面冷喷涂金属化的研究现状及展望

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中国材料进展 2024年第2期43卷 102-114,123页

作者：张志杰苏聪聪邵照峰廖红丽丁星星张玲车翰卿重庆大学材料科学与工程学院教育部轻合金材料国际合作联合实验室重庆400044

冷喷涂是一种快速发展的固态粉末沉积技术,具有喷涂温度低、沉积效率高、制造速度快等特点,在金属涂层制备、受损零部件修复、增材制造等方面已有广泛的研究与应用。传统冷喷涂工艺的基体材料一般是金属材料,其沉积过程的机理研究也较... 详细信息

冷喷涂是一种快速发展的固态粉末沉积技术,具有喷涂温度低、沉积效率高、制造速度快等特点,在金属涂层制备、受损零部件修复、增材制造等方面已有广泛的研究与应用。传统冷喷涂工艺的基体材料一般是金属材料,其沉积过程的机理研究也较为成熟。近年来,随着众多工业领域对复合材料的需求进一步提升,通过冷喷涂技术在非金属材料表面制备金属涂层(表面金属化)受到了不同领域众多研究者的关注。总结了目前已报道的使用冷喷涂工艺在高分子和陶瓷等非金属材料表面制备金属涂层的相关结果,围绕几种常用的高分子和陶瓷基体材料,分析了非金属基体材料上冷喷涂沉积金属涂层的结合机理,并在此基础上讨论了冷喷涂工艺参数和材料参数对非金属材料表面冷喷涂金属化的影响。

关键词：冷喷涂金属涂层非金属基体表面金属化结合机理

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