检索结果-南通市图书馆

An Undiscouered Scenic Town in Western China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Today 2002年第11期51卷 42-45页

作者： ai MEI

WE came across Fubao (fortune and trea-sure) Town by chance during a trip to Fobao (Buddhist Treasure) Mountain in Sichuan Province. Cloaked in dense forest, watered by rivers and waterfalls, and the habitat of various wild animals, the mountain is 46 kilometers from Hejiang County, Luzhou City. At its foot nestles the small secluded town of Fubao, little changed throughout the *** emerging in the late Song Dynasty, Fubao Town took shape during the Ming Dynasty.

关键词： An Undiscouered Scenic Town in Western China

Targeting histone deacetylase suppresses tumor growth through eliciting METTL14-modified m^(6)A RNA methylation in ocular melanoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2023年第11期43卷 1185-1206页

作者： ai Zhuang Xiang Gu Tongxin Ge Shaoyun Wang Shengfang Ge Peiwei Chai Renbing Jia Xianqun Fan Department of Ophthalmology Shanghai Ninth People's HospitalShanghai JiaoTong University School of MedicineShanghaiP. R. China Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology ShanghaiP. R. China

Background Diversified histone deacetylation inhibitors(HDACis)have demonstrated encouraging outcomes in multiple malignancies.N6-methyladenine(m6A)is the most prevalent messenger RNA modification that plays an essential role in the regulation of ***,an in-depth understanding of the crosstalk between histone acetylation and m6A RNA modifications remains *** study aimed to explore the role of histone acetylation and m6A modifications in the regulation of tumorigenesis of ocular *** Histone modification inhibitor screening was used to explore the effects of HDACis on ocular melanoma *** blot assay was used to detect the global m6A RNA modification ***-omics assays,including RNA-sequencing,cleavage under targets and tagmentation,single-cell sequencing,methylated RNA immunoprecipitation-sequencing(meRIP-seq),and m6A individual nucleotide resolution cross-linking and immunoprecipitation-sequencing(miCLIP-seq),were performed to reveal the mechanisms of HDACis on methyltransferase-like 14(METTL14)and FAT tumor suppressor homolog 4(FAT4)in ocular *** real-time polymerase chain reaction(qPCR),western blotting,and immunofluorescent staining were applied to detect the expression of METTL14 and FAT4 in ocular melanoma cells and *** models and orthotopic xenograft models were established to determine the roles of METTL14 and FAT4 in the growth of ocular ***-binding protein immunoprecipitation-qPCR,meRIP-seq,miCLIP-seq,and RNA stability assay were adopted to investigate the mechanism by which m6A levels of FAT4 were *** First,we found that ocular melanoma cells presented vulnerability towards *** triggered the elevation of m6A RNA modification in ocular *** studies revealed that METTL14 served as a downstream candidate for ***14 was silenced by the hypo-histone acetylation status,whereas HDACi restored the normal histone acetylation level of MET

关键词： epigenetics histone deacetylation inhibitors melanoma N6-methyladenine histone-RNA crosstalk

CPAFFC Confers Honor Medals on Arab Friends

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Voice of Friendship 2016年第1期 5-6页

作者： ai Lin

On Jan 20,with President Xi Jinping in attendance,the CPAFFC presented awards to 1Arab figures for their contribution to the development of the SinoArab *** received

关键词： figures translator ceremony hands honor president currently spoke friendly faced

Israeli Young Ambassadors Delegation Visits China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Voice of Friendship 2017年第2期 15-16页

作者： ai Lin

This year marks the 25th anniversary of the establishment of China-Israel diplomatic *** further strengthen friendly cooperative relations between the two countries,the CPAFFC invited a 38-member Young Ambassadors del... 详细信息

关键词： Israeli Young Ambassadors Delegation Visits China CRI School

An Analysis of Governmental Economic Activities on Non-point Source Pollution Treatment in Rural Areas 1 in China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An Analysis of Governmental Economic Activities on Non-point...

Development of resource-conserving society:from the perspective of circular economy

2006 International Conference on Public Administration

作者： CHEN Hong SHI Shu-ai SHANG Xin College of Economics & Management University of Northeast Forestry

ISBN: (纸本)7811142686

In this paper we analyze all levels of government’s activities in non-point source pollution treatment in rural areas from the perspective analysis of economics by starting from the economic characteristics of non-point source pollution in rural areas, besides, we discussed the dilemma between the rules and regulations of the central government when preventing and controlling the non-point source pollution in rural areas and the producers’ behavior which is protected by local governments. Thus we derive the government should reduce the direct administrative intervention, meanwhile by using more economical methods and incentive mechanisms which can control the input of natural resource and the output of the pollutants in the course of non-point source pollution treatment in rural areas, the market price system of green organic agricultural products will be formed, which will lead the behavior of producers and consumers to beneficial to environment.

关键词： Non-point source pollution Market failure Central government Incentive-mechanism Local governments

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Ecological Economy 2010年第2期6卷 140-151页

作者： YUAN ai-zhi Institute of Economics Shandong Academy of Social SciencesJinan 250002P.R.China

The purpose of building a resource-conserving society is to pursuit less resource consumption and less environmental pollution,and to accept greater economic and social benefits,and the ultimate goal is to ensure sustainable use of resources and economic and social sustainable *** circular economy is the inevitable choice and the basic way to build a resource-conserving *** economy is a resource-conserving production,initiate resource-conserving consumption,and it is the key to build resource-conserving *** study tries to clarify the relationship between them and bring forward a scientific index system which can measure the development level of a resource-conserving *** provides a new set of ideas for the evaluation of resourceconserving society,and it is important for the resource-conserving society assessment and construction,while further empirical research is made on China's eastern coastal Shandong Province.

关键词： Resource-conserving society Circular economy Evaluation index system

The effect of serum luteinizing hormone on trigger day with a GnRH antagonist protocol in IVF/ICSI treatment

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gynecology and Obstetrics Clinical Medicine 2021年第4期1卷 205-210页

作者： Yanru Hou Li Tian Huixin Liu Jiajia ai Yanbin Wang Huan Shen Department of Obstetrics and Gynecology Peking University People's HospitalChina Department of Clinical Epidemiology and Biostatistics Peking University People's HospitalChina

Objective:To investigate the effect of serum luteinizing hormone(LH)on trigger day with a Gonadotrophinreleasing hormone(GnRH)antagonist protocol in patients receiving in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI)treatment for pregnancy ***:We retrospectively reviewed the medical documents of patients receiving IVF/ICSI with fresh embryo transfers from the Reproductive Medicine Center of Peking University People's Hospital between January 2016 and December 2018.730 patients were included and divided into three groups by their serum LH level determined on trigger *** patients were categorized into Group A,Group B,and Group C based on LH concentrations<1.0 IU/L,1.0–5.0 IU/L,and from 5.0 to 10.0 IU/L on trigger day during the cycle,*** were made between the three ***:There was a significant difference in implantation rates between Group A and Group C(24.8%versus 40.1%,respectively,P<0.05).The clinical pregnancy rates(39.3%versus 54.3%,respectively,P=0.078)and live birth rate(LBR)(32.1%versus 46.5%,respectively,P=0.116),though the differences were not *** logistic regression analysis showed that the OR of Group C for clinical pregnancy(OR=1.849,P=0.040)and for LBR(OR=1.915,P=0.034)were significant using Group A as the base ***:Our study has demonstrated that patients with higher serum LH levels(5.0–10.0 IU/L)on trigger day in the GnRH antagonist protocol may confer better clinical outcomes than those with lower LH levels(<1.0 IU/L).

关键词： Gonadotrophin-releasing hormone antagonist Controlled ovarian stimulation Luteinizing hormone Live birth rate

Static and Dynamic Analysis of Lasing Action from Single and Coupled Photonic Crystal Nanocavity Lasers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letters 2017年第2期34卷 30-33页

作者： Peng-Chao Zhao Fan Qi ai-Yi Qi Yu-Fei Wang Wan-Hua Zheng State key Laboratory on Integrated Optoeleetronics Institute of Semiconductors Beijing 100083 Laboratory of Solid-state Optoelectronics Information Technology Institute of Semiconductors Beijing 100083

The single and coupled photonic crystal nanocavity lasers are fabricated in the InGaAsP material system and their static and dynamic features are compared. The coupled-cavity lasers show a larger lasing e^ciency and generate an output power higher than the single-cavity lasers, results that are consistent with the theoretical results obtained by rate equations. In dynamic regime, the single-cavity lasers produce pulses as short as 113 ps, while the coupled-cavity lasers show a significantly longer lasing duration. These results indicate that the photonic crystal laser is a promising candidate for the light source in high-speed photonic integrated circuit.

关键词： Static and Dynamic Analysis of Lasing Action from Single and Coupled Photonic Crystal Nanocavity Lasers

14,15-EET减轻脂多糖诱导的小鼠急性肺损伤的作用及其机制

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

临床和实验医学杂志 2024年第2期23卷 113-117页

作者：于悦杨霭琳何馨于刚刚王浩彦吴艳军首都医科大学附属北京友谊医院呼吸内科北京100050

目的探讨14,15-环氧二十碳三烯酸(14,15-EET)减轻脂多糖(LPS)诱导小鼠急性肺损伤(ALI)的作用及其机制。方法将32只6~8周的C57BL/6J雄性小鼠按照随机数字表法分为4组:对照组、LPS组、LPS+铁死亡抑制剂(Fer-1)组以及LPS+14,15-EET组,每组... 详细信息

目的探讨14,15-环氧二十碳三烯酸(14,15-EET)减轻脂多糖(LPS)诱导小鼠急性肺损伤(ALI)的作用及其机制。方法将32只6~8周的C57BL/6J雄性小鼠按照随机数字表法分为4组:对照组、LPS组、LPS+铁死亡抑制剂(Fer-1)组以及LPS+14,15-EET组,每组各8只。对照组小鼠气管内滴注无菌磷酸盐缓冲液(PBS)50μL,另外3组小鼠气管内分别滴注0.2 mg/mL LPS 50μL。气管内滴注LPS刺激6 h后,LPS+Fer-1组尾静脉注射Fer-1(0.8 mg/kg),LPS+14,15-EET组尾静脉注射14,15-EET(100 nmol/L),分别作用16 h。造模成功后取小鼠肺组织及支气管肺泡灌洗液(BALF),苏木精-伊红染色观察各组小鼠肺组织病理学变化,测量肺湿/干(W/D)比重;记录各组小鼠BALF中总蛋白浓度及总细胞数量;采用实时荧光定量聚合酶链式反应(RT-qPCR)检测小鼠肺组织白细胞介素(IL)-1β和单核细胞趋化蛋白-1(MCP-1)mRNA表达;采用冰冻切片活性氧簇(ROS)染色观察肺组织中ROS的生成;分别使用试剂盒检测肺组织丙二醛水平及铁含量;采用蛋白质印迹法检测铁死亡相关分子谷胱甘肽过氧化物酶4(GPX4)、环氧化物酶2(COX2)的表达水平。结果与对照组相比,LPS组肺损伤评分及W/D值均明显升高,差异均有统计学意义(P0.05)。结论14,15-EET可能通过抑制铁死亡减轻LPS诱导的小鼠ALI,发挥肺部保护作用。

关键词：小鼠脂多糖类 14,15-环氧二十碳三烯酸急性肺损伤铁死亡