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应用免疫电镜技术检查猪传染性胃肠炎病毒和轮状病毒(下)

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中国畜牧兽医 1980年第3期 48-49页

作者：李成 linda j.saif

轮状病毒的间接IEM——直接IEM样品加入抗球蛋白(家免抗猪IgG)时,产生了由宽抗体缘围绕的病毒颗粒所构成的病毒凝聚物,使病毒的结构变为不太清楚(图6A)。间接IEM提高了诊断的敏感性,即可使轮状病毒凝聚物在某些直接用IEM检查为阴性的样品

关键词：轮状病毒抗原性 IEM 特异性检出家免病毒颗粒 TGE 技术检查

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肠病毒疫苗的设计及应用策略(二)

今日养猪业 2016年第12期 64-65页

作者：张坤 kuldeep s.chattha james a.roth linda j.saif 成都天邦生物制品有限公司不详

许多生物制品公司致力于开发安全有效的PEDv疫苗来替代返饲诱导免疫。然而,返饲和疫苗两者间没解决的问题是后备母猪和经常母猪间不同的乳源性免疫诱发水平。改策略对配种前的后备猪未必有效,因为肠-乳腺淋巴细胞的转运与妊娠激素有关。

关键词：疫苗研制后备母猪肠病毒后备猪应用策略诱导免疫生物制品公司黏膜免疫传染性腹泻生物安全措施

Integrated Risk Identification, Analysis, and Assessment:A Dynamic Household Economy Analysis Methodology and Example

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International journal of Disaster Risk Science 2013年第2期4卷 77-88页

作者： Bob Alexander linda j.Cox junko Mochizuki Rural Livelihood Risk Management Consulting P.O.Box 1251HonoluluHI 96807USA Department of Natural Resource and Environmental Management University of Hawai`i at ManoaHonoluluHI 96822USA

Many methodologies identify, analyze, and assess static risks to quantify potential disaster losses based on past and current events. Static methodologies will not, however, capture how climate change and adaptation are rapidly affecting the natural and social systems in many areas. Local and global changes such as those associated with development investments, livelihood pressures, political stability, and demographic trends are also affecting many areas, especially in emerging economies. Risk identification, analysis, and assessment methodologies must integrate all changes dynamically so that risk reduction and development decisions can be based on future needs. After a theoretical explanation of how to integrate dynamic changes, a static Household Economy Analysis(HEA) completed for a rapidly changing area of East Timor was altered using current trends to make the analysis more dynamic. Some inherent difficulties exist with a more dynamic approach and recommendations for overcoming them are presented. Research, government, and nongovernment personnel interested in integrated approaches to risk reduction and development decision-making in areas subject to rapid change will find the study useful.

关键词： integrate disaster interested

Closed 3-stop Center and Periphery in Graphs

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Acta Mathematica Sinica,English Series 2012年第3期28卷 439-452页

作者： linda EROH Ralucca GERA Steven j. WINTERS Department of Mathematics University of Wisconsin Oshkosh Department of Applied Mathematics Naval Postgraduate School

A delivery person must leave the central location of the business, deliver packages at a number of addresses, and then return. Naturally, he/she wishes to reduce costs by finding the most efficient route. This motivates the following： Given a set of k distinct vertices S = {x1, x2,..., xk } in a simple graph G, the closed k-stop-distance of set S is defined to be

关键词： Central appendage number peripheral appendage number Steiner distance

Case-control study of factors that trigger inflammatory bowel disease flares

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World journal of Gastroenterology 2014年第15期20卷 4329-4334页

作者： linda A Feagins Ramiz Iqbal Stuart j Spechler VA North Texas Healthcare System DallasTX 75216United States Division of Gastroenterology University of Texas Southwestern Medical CenterDallasTX 75216United States

AIM: To explore the association between inflammatory bowel diseases (IBD) flares and potential triggers.

关键词： Inflammatory bowel diseases, Flare, Non-adherence, Crohn’ s disease, Ulcerative colitis

A primer on stochastic epidemic models:Formulation,numerical simulation,and analysis

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Infectious Disease Modelling 2017年第2期2卷 128-142页

作者： linda j.S.Allen Department of Mathematics and Statistics Texas Tech UniversityLubbockTX 79409-1042USA

Some mathematical methods for formulation and numerical simulation of stochastic epidemic models are ***,models are formulated for continuous-time Markov chains and stochastic differential *** well-known examples are used for illustration such as an SIR epidemic model and a host-vector malaria *** methods for approximating the probability of a disease outbreak are also discussed.

关键词： Branching process Continuous-time Markov chain Minor outbreak Stochastic differential equation

Harnessing memory adaptive regulatory T cells to control autoimmunity in type 1 diabetes

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分子细胞生物学报:英文版 2012年第1期4卷 38-47页

作者： Cheng-Rui Li Bas j.G.Baaten linda M.Bradley Infectious and Inflammatory Disease Center Sanford-Burnham Medical Research Institute10901 North Torrey Pines RoadLa JollaCA 92037USA

Type 1 diabetes(T1D)results from autoimmune destruction of insulin-producing b-cells in the pancreatic *** is an immediate need to restore both b-cell function and immune tolerance to control disease progression and ultimately cure ***,there is no effective treatment strategy to restore glucose regulation in patients with ***3-expressing CD4^(+) regulatory T cells(Tregs)are potential candidates to control autoimmunity because they play a central role in maintaining ***,deficiencies in either naturally occurring Tregs(nTregs)themselves and/or their ability to control pathogenic effector T cells have been associated with ***,we hypothesize that nTregs can be replaced by FoxP3^(+) adaptive Tregs(aTregs),which are uniquely equipped to combat autoreactivity in *** nTregs,aTregs are stable and provide long-lived *** this review,we summarize the current understanding of aTregs and their potential for use as an immunological intervention to treat T1D.

关键词： type 1 diabetes adaptive regulatory T cells autoimmunity immunotherapy

Probability of a zoonotic spillover with seasonal variation

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Infectious Disease Modelling 2021年第1期6卷 514-531页

作者： Aadrita Nandi linda j.S.Allen Department of Mathematics and Statistics Texas Tech UniversityLubbockTX79409-1042USA Department of Microbiology and Immunology University of Michigan Medical SchoolAnn ArborMI48108-5260USA

Zoonotic infectious diseases are spread from animals to *** is estimated that over 60%of human infectious diseases are zoonotic and 75%of them are emerging *** majority of emerging zoonotic infectious diseases are caused by viruses including avian influenza,rabies,Ebola,coronaviruses and *** of infection from animals to humans depends on a complex transmission pathway,which is influenced by epidemiological and environmental *** this investigation,the focus is on direct transmission between animals and humans and the effects of seasonal variations on the transmission and recovery *** in transmission and recovery,besides being influenced by physiological processes and behaviors of pathogen and host,are driven by seasonal variations in temperature,humidity or rainfall.A new time-nonhomogeneous stochastic process is formulated for infectious disease spread from animals to humans when transmission and recovery rates are time-periodic.A branching process approximation is applied near the disease-free state to predict the probability of the first spillover event from animals to *** probability is a periodic function of the time when infection is introduced into the animal *** is shown that the highest risk of a spillover depends on a combination of animal to human transmission,animal to animal transmission and animal *** results are applied to a stochastic model for avian influenza with spillover from domestic poultry to humans.

关键词： Branching process Markov chain Seasonal fluctuations Spillover Zoonoses

The Long Road to Understanding the Baculovirus P10 Protein

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Virologica Sinica 2009年第4期24卷 227-242页

作者： David C. j. Carpentier linda A. King School of Life Sciences Oxford Brookes University Headington Campus Oxford United Kingdom Oxford Expression Technologies Ltd Oxford Brookes University Headington Campus Oxford United Kingdom

The baculovirus P 10 protein has always represented a mystery in the field of insect virology. Like the baculovirus polyhedrin protein it is expressed at high levels very late in infection. Homologues of the Autographa californica nucleopolyhedrovirus p10 gene are conserved in all Alphabaculoviruses and in other viruses of lepidopteran hosts yet is completely dispensable for virus replication and transmission. PIO is a microtubule interacting protein whose expression has been associated with the formation of a variety of complex and extensive cytoplasmic and nuclear structures. PIO has been associated with a number of roles during infection ranging from the formation of virus occlusion bodies, to affecting the rate of cellular and/or nuclear lysis during the final stages of the virus replication cycle. In this article we review recent work aimed at understanding the role of this enigmatic protein, putting them into context with recent advances in understanding of protein structure and function. We look back at a number of historical studies and observations, reanalysing their conclusions based on recent data and our own observations. The role of the P 10 protein during baculovirus replication remains elusive, however, novel avenues of investigation have been identified that will, we are sure, eventually lead to an understanding of this protein.

关键词： Baculovirus P10 microtubule Polyhedral occlusion body Fibrous body/fibrillar structure