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Retrospective analysis of complications related to endoscopic retrograde cholangio-pancreatography in patients with cirrhosis vs patients without cirrhosis

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World Journal of Hepatology 2021年第4期13卷 472-482页

作者： Michelle Bernshteyn linda hu Umair Masood Anuj Vikrant Sharma Danning huang Bishnu Sapkota Department of Medicine SUNY Upstate Medical UniversitySyracuseNY 13202United States Division of Gastroenterology and Hepatology State University of New York Upstate Medical UniversitySyracuseNY 13210United States Department of Public Health and Preventive Medicine SUNY Upstate Medical UniversitySyracuseNY 13202United States Division of Gastroenterology and Hepatology SUNY Upstate Medical University and Syracuse VA Medical CenterSyracuseNY 13210United States

BACKGROUND There is minimal objective data regarding adverse events related to endoscopic retrograde cholangio-pancreatography(ERCP)in patients with cirrhosis compared to those without cirrhosis and even fewer data comparing complications among cirrhosis patients based on severity of *** To determine if patients with cirrhosis are at increased risk of adverse events related to ERCP:mainly pancreatitis,bleeding,perforation,cholangitis,and mortality;And to see if higher Child-Pugh(CP)score and Model for End-Stage Liver Disease(MELD)score are associated with higher post-ERCP *** We performed a retrospective analysis of 692 patients who underwent ERCP and analyzed the impact of cirrhosis etiology,gender,type of sedation used during procedure,interventions performed,and co-morbidities on the rate of complications in cirrhosis patients as compared to non-cirrhosis *** Overall complications were higher in those with cirrhosis as compared to those without cirrhosis(P=0.015 at significance level of 0.05).CP class,especially CP class C,was shown to be associated with a significantly higher rate of ERCP complications as compared to CP class A and CP class B(P=0.010 at significance level of 0.05).CONCLUSION The results of our study reaffirm that liver cirrhosis has an impact on the occurrence of complications during *** study shows that CP class seems to be more reliable as compared to MELD score in predicting complications of ERCP in cirrhosis patients.

关键词： Cirrhosis Complications Advanced endoscopy Endoscopic retrograde cholangio-pancreatography

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浅谈美国的住房问题

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科技导报 1986年第2期 44-47页

作者：李玲瑶美国PSI公司副总裁

美国的住房工业(Housing Industry)是仅次于汽车工业的第二大工业。直接参与住房工业的人员,约占就业人口的4.2％,间接参与这个工业的人更是不计其数。整个社会用极大的人力、物力、财力来适应人们住房上的需求,住房工业规模庞大,说明... 详细信息

美国的住房工业(Housing Industry)是仅次于汽车工业的第二大工业。直接参与住房工业的人员,约占就业人口的4.2％,间接参与这个工业的人更是不计其数。整个社会用极大的人力、物力、财力来适应人们住房上的需求,住房工业规模庞大,说明美国社会对住房问题的重视。

关键词：住房问题社会问题银行贷款美元本位币住宅美国美利坚合众国北美洲开发商通货膨胀房子收入财政管理投资者利润

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高速铁路与经济增长的因果关系——基于时空理论视角下中国省域面板数据的计量分析

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长安大学学报（社会科学版） 2016年第4期18卷 31-43页

作者：李红昌 linda Tjia 胡顺香刘李红北京交通大学经济管理学院北京100044 香港城市大学亚洲及国际学院香港999077

针对中国高速铁路供给对经济增长和产业结构的影响,以及产业结构、城镇化率、人口密度如何决定高速铁路供给等问题,对高速铁路与经济增长的即时效应、快速效应和慢速效应机理进行分析。研究认为,从高速铁路对经济增长角度来看,2005~201... 详细信息

针对中国高速铁路供给对经济增长和产业结构的影响,以及产业结构、城镇化率、人口密度如何决定高速铁路供给等问题,对高速铁路与经济增长的即时效应、快速效应和慢速效应机理进行分析。研究认为,从高速铁路对经济增长角度来看,2005~2014年中国省域面板数据实证表明：高速铁路在十年间的即时效应和快速效应不断降低,高速铁路的高时间价值与高出行成本特性主导的慢速效应占据支配地位,导致高速铁路对全国和中部地区经济增长没有显著影响,对东部地区有显著正向影响,对西部地区有显著负向影响,说明总体上高速铁路并不是经济增长的原因;从经济增长对高速铁路角度来看,Logit模型计量经济增长对高速铁路触发的影响表明：经济增长本源性需求内生出对高速铁路的即时效应、快速效应和慢速效应的派生性需求,经济增长以及第三产业、城镇化率、人口密度变量显著决定高速铁路供给。

关键词：高速铁路经济增长城镇化率人口密度即时效应

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Effect of Honghua (Flos Carthami) on nitric oxide production in RAW 264.7 cells and α-glucosidase activity

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Journal of Traditional Chinese Medicine 2014年第3期34卷 362-368页

作者： hui Liao linda Banbury Hongping Liang Xiaomin Wang Xiaokai Lü Ling hu Jin Wu Department of Pharmacy Shanxi Provincial People's Hospital Southern Cross Plant Science Southern Cross University Department of Clinical Laboratory Shanxi Provincial People's Hospital Department of Pharmacy Shanxi DaYi Hospital Department of Endocrinology Shanxi Provincial People's Hospital Management of Hospital Shanxi Medical University Second Hospital

OBJECTIVE： To study the effects of extracts from Honghua （Flos Carthaml~ on lipopolysaccharide in- duced nitric oxide （NO） production in RAW 264.7 cells and the influence of the extracts on yeast a-glucosidase activity. The total flavonoid content of the extracts was also determined. METHODS： Cytotoxicity of the extracts to RAW 264.7 cells was evaluated by the ATPliteTM method. Inhibitory effects of the extracts on NO production were evaluated by Griess assay. Curcumin was used as a positive control. Screening of extracts for po- tential a-glucosidase inhibitors was done by a fiuo- rometric assay. The assay was based on the hydroly- sis of 4-methylumbelliferyl-a-D-glucopyranoside toform the fluorescent product, 4-methylumbellifer- one. Acarbose was used as a positive control. The total t3avonoid content was tested using kaempfer- ol as the standard. RESULTS： There were significant inhibitory effects on NO production when the extracts were 25-100 μg/ mL （P〈0.05） and curcumin was 2-4 μg/mL （P〈 0.001）. The extracts showed an inhibitory effect on a-glucosidase activity at the concentrations of 15.6-125 μg/mL with a half maximal （50%）inhibito- ry concentration （ICs0） of （32.8± 5.7） μg/mL, com- pared with the ICs0 of acarbose at （1.8±0.4） μg/mL. There was a significant difference between the two IC50 values （P〈0.001）. The total content of flavo- noids per gram of dried herb was 1.14 mg. CONCLUSION： Honghua （Flos Carthami） showed in- hibitory effects on NO production in activated RAW 264.7 macrophage cells and an inhibitory effect on yeast a-glucosidase. There might be a relationship between these pharmacological effects and its fla- vonoid content.

关键词： Carthamus tinctorius Nitric oxide AI-pha-glucosidases Flavonoids RAW 264.7 cells

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Physiological Responses of Dendrobium officinale under Exposure to Cold Stress with Two Cultivars

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Phyton-International Journal of Experimental Botany 2020年第3期89卷 599-617页

作者： Shuaishuai Zhang Jin Li Yongchang Shen linda Nartey Korkor Qian Pu Jin Lu Balock Shakeela Dedong Kong Ou Li Guohong Zeng Xiufang hu Zhejiang Province Key Laboratory of Plant Secondary Metabolism and Regulation College of Life ScienceZhejiang Sci-Tech UniversityHangzhou310018China College of Agriculture and Biology Zhejiang UniversityDeqing Ecoagriculture Biotechnology Co.Ltd.Hangzhou310018China

This study aimed to explore the cold tolerance of two cultivars of Dendrobium officinale(MG1,MG2)grown in different regions of ***-2℃ incubation,cultivar MG1 remained active after 3 d,and continued to grow after returning to room ***,MG2 could only maintain its activity after 2 d treatment at−2℃,and the seedlings died with the low temperature treatment *** of the characteristics of the plants grown in the south(Hangzhou)or north(Zhengzhou)of China indicated that the leaves of MG1 also had reduced stomatal density,the highest thickness,and a compact *** contents of proline and soluble sugars were higher in MG1 than those in *** cultivar MG1 had higher SOD enzyme activity than MG2,while CAT and POD activities in samples from Zhengzhou were higher than those from *** contents of polysaccharides and alkaloids in stems of in MG1 were higher than those in MG2,while the content of flavonoids in the Zhengzhou samples was higher than that in the Hangzhou *** addition,plant heights,stem diameters,and chlorophyll content were higher in ***,MG1 had better cold resistance than ***1 is a cold tolerant cultivar with thick leaves and reduced stomatal density,higher contents of soluble sugars,proline,CAT,POD,polysaccharides,flavonoids and alkaloids,which together make it more adaptable to low ***,the cultivar MG1,with its demonstrated cold tolerance,can accordingly be grown on a large scale in cold regions,thereby expanding the available planting area for this important traditional medicinal plant to meet the increasing commercial demand for it.

关键词： Dendrobium officinale cold stress microstructure characteristics physiological characteristics biochemical characteristics

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中国高速铁路对沿线城市经济集聚与均等化的影响

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数量经济技术经济研究 2016年第11期33卷 127-143页

作者：李红昌 linda Tjia 胡顺香北京交通大学经济管理学院香港大学

高速铁路对城市经济集聚与均等化影响重大。本文分析了高速铁路引起可达性变化,再引起集聚租金变化,进而引起城市经济与空间集聚的变化的作用机理。通过构建DID估计模型,分别以第三产业区位熵等4个指标作为集聚经济指数,计量分析高速铁... 详细信息

高速铁路对城市经济集聚与均等化影响重大。本文分析了高速铁路引起可达性变化,再引起集聚租金变化,进而引起城市经济与空间集聚的变化的作用机理。通过构建DID估计模型,分别以第三产业区位熵等4个指标作为集聚经济指数,计量分析高速铁路对城市集聚经济产生的影响。结果表明我国东部、中部、西部地区城市集聚经济的水平存在明显的梯度差异,高速铁路促进经济更向西部地区集聚,有益于我国经济趋向于均等化。

关键词：高速铁路城市可达性集聚经济均等化

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Evaluation of the Pharmacokinetics and Renal Excretion of Ma-Zi-Ren-Wan in Health Subjects

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World Journal of Traditional Chinese Medicine 2017年第2期3卷 8-15页

作者： Dong-Dong hu linda Li-Dan Zhong Kun Wai huai-Xue Mu Cheng-Yuan Lin Ling Zhao Liang Dai Tao huang Zhao-Xiang Bian Hong Kong Chinese Medicine Study Centre Hong Kong Baptist University School of Chinese Medicine Hong Kong Baptist University Hong Kong Baptist University Shenzhen Research Institute and Continuing Education

Background: Ma-Zi-Ren-Wan(MZRW) is a classic Chinese formula for treating human constipation. It is comprised of six *** previous studies have shown its great therapeutic effect. The absorbed compounds had been studied in rat, while there was no study about its components in human ***: To observe the components of MZRW absorbed in health subjects and study the pharmacokinetics of major compounds. At the same time, to observe the renal excretion of MZRW in health subjects based on the quantification of major ***: Health adults were randomly assigned to three dose groups(5 g, 7.5 g and 10 g q.d.) of MZRW. Blood samples were collected from the medial cubital vein just before and at 0.25, 0.5, 1, 2, 4, 8 and 12 h after administration. Urine samples were collected at 0 to 3 h, 3 to 6 h, 6 to 9 h and 9 to 12 h after MZRW administration, with the urine volume recorded for each time segment. Plasma and urine samples were analyzed by optimized LC-MSMS(Liquid chromatography-tandem mass spectrometry) method for pharmacokinetics and renal excretion study of ***: Ten compounds of MZRW were observed in 23 health subjects. Due to the low concentration in plasma at the current dose, only four compounds(Albiflorin, paeoniflorin, magnolol and rhein) were quantified in the plasma sample. Honokiol, aloe emodin and emodin could only meet the LLOQ at some time points of the high dose group. Hesperidin, naringin and amygdalin could not be detected in plasma sample. While seven compounds(Amygdalin, albiflorin, paeoniflorin, magnolol, honokiol, rhein and aloe emodin) could be quantified in urine, the renal excretion was well ***: MZRW was safe and well tolerated in this clinical study. Albiflorin, paeoniflorin, magnolol and rhein was well quantified in plasma. The renal excretion of paeoniflorin, albiflorin and rhein were dose dependent for doses ranging between 5 and 10 g.

关键词： Ma-Zi-Ren-Wan LC-MS/MS Pharmacokinetics human plasma Renal Excretion

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Chinese Herbal Medicine for Ulcerative Colitis:A Systematic Review Protocol

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World Journal of Traditional Chinese Medicine 2017年第2期3卷 16-19页

作者： Hong Mi linda Zhong Tao huang Cheng-yuan Lin Ling Zhao Dong-dong hu Hai-tao Xiao Zhao-xiang Bian Feng-bin Liu Department of Gastroenterology the First Affiliated Hospital of Guangzhou University of Chinese Medicine School of Chinese medicine Hong Kong Baptist University

Introduction: This manuscript aims to provide a protocol of systematic review to assess the safety and effectiveness of Chinese herbal medicine(CHM) for the treatment of ulcerative colitis(UC). Although CHM has been widely used for UC, its effectiveness and safety has not yet been well defined and *** and analysis: Seven electronic databases were searched, including China National Knowledge Infrastructure(CNKI), Chinese Biomedical literature(CBL), VIP database, Cochrane Library, MEDLINE, PubMed and China Journals Full-text Database. Related Chinese literature will be searched in other Chinese databases. All relevant randomized controlled literature of publication type will be *** of risk of bias, data synthesis and subgroup analysis will be carried out using Review Manager *** and dissemination: The results of the systematic review will be disseminated via publication in a peer-reviewed journal and presented at a relevant conference.

关键词： Chinese herbal medicine Ulcerative colitis Systematic review Protocol

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Metabolic abnormalities play a crucial role in non-obese people suffering from non-alcoholic fatty liver disease(NAFLD)

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Hepatobiliary Surgery and Nutrition 2022年第2期11卷 333-334页

作者： Qing Ye Takanori Ito linda Henry Mindie H.Nguyen Department of Hepatology of The Third Central Hospital of Tianjin TianjinChina Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoyaJapan Division of Gastroenterology and Hepatology Stanford University Medical CenterPalo AltoCAUSA

We read the article entitled“The presence of NAFLD in nonobese subjects increased the risk of metabolic abnormalities than obese subjects without NAFLD:A population-based cross-sectional study”by hu et al.(1),which was published in the latest issue of Hepatobiliary Surgery Nutrition,with great *** the authors described,due to rapid urbanization and sedentary lifestyles,the prevalence of non-alcoholic fatty liver disease(NAFLD)has *** this population-based,cross-sectional health survey study,in which the data were obtained from community health centers,the investigators reported that the prevalence of NAFLD in Shanghai,China grew from 15%in 2005 to 32.7%in 2017(1).To gain a better understanding of the prevalence of metabolic features in relation to NAFLD status,gender,and age,the authors quantified the risks of having different metabolic conditions between the following 4 groups:(I)the non-obese NAFLD group;(II)the non-obese non-NAFLD group;(III)the obese non-NAFLD group;and(IV)the obese NAFLD group(1).

关键词： NAFLD Surgery obese

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Effects of Benzo(a)pyrene on the Contractile Function of the Thoracic Aorta of Sprague-dawley Rats

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Biomedical and Environmental Sciences 2012年第5期25卷 549-556页

作者： GAN Tie Er XIAO Su Ping JIANG Ying hu hu WU Yi hua DUERKSEN-huGHES Penelope J SHENG Jian Zhong YANG Jun First Affiliated Hospital State Key Laboratory for Diagnosis and Treatment of Infectious DiseasesZhejiang UniversityHangzhou 310003ZhejiangChina Department of Pathology and Pathophysiology Zhejiang University School of MedicineHangzhou 310058ZhejiangChina Department of Basic Science Division of BiochemistryLoma Linda University School of MedicineLoma LindaCA 92354USA Department of Toxicology Hangzhou Normal University School of Public HealthHangzhou 310036ZhejiangChina

Abstract Objective To evaluate the possible vascular effects of an environment carcinogen benzo（a）pyrene （BaP）. Methods The cytotoxicit of BaP and rat liver S9 （0.25 mg/mL）-activated BaP were examined by MTT assay. Thoracic aortic rings were dissected from Sprague-Dawley rats. Contraction of aortic rings was induced by 60 mmol/L KCl or 10-6 mol/L phenylephrine （PE） in an ex-vivo perfusion system after BaP （100 tlmol/L） incubation for 6 h. [Ca^2＋]i was measured using Fluo-4/AM. For in-vivo treatment, rats were injected with BaP for 4 weeks （10 mg/kg, weekly, i.p.）. Results BaP （1-500 μm） did not significantly affect cell viability; S9-activated BaP stimulated cell proliferation. BaP did not affect the contractile function of endothelium-intact or -denuded aortic rings. BaP did not affect ATP-induced （[Ca2＋]i） increases in human umbilical vein endothelial cells. In BaP-treated rats, heart rate and the number of circulating inflammatory cells were not affected. Body weight decreased while blood pressure increased significantly. The maximum aortic contractile responses to PE and KCI and the maximum aortic relaxation response to acetylcholine were significantly decreased by 25.0%, 34.2%, and 10.4%, respectively. Conclusion These results suggest, in accordance with its DNA-damaging properties, that metabolic activation is a prerequisite for BaP-induced cardiovascular toxicity.

关键词： DNA damage Benzo(a)pyrene Cardiovascular toxicity Vascular contraction

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