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Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain

Journal of Sport and Health Science 2024年第2期13卷 245-255页

作者： Cecilie Skarstad Norevik Aleksi M.Huuha Ragnhild N.RФsbjФrgen linda hildegard bergersen Kamilla Jacobsen Rodrigo Miguel-dos-Santos Liv Ryan Belma Skender Jose Bianco N.Moreira Asgeir Kobro-Flatmoen Menno P.Witter Nathan Scrimgeour Atefe R.Tari Cardiac Exercise Research Group(CERG) Department of Circulation and Medical ImagingNorwegian University of Science and Technology7491TrondheimNorway Department of Neurology and Clinical Neurophysiology St.Olavs University Hospital7030TrondheimNorway Institute of Oral Biology University of Oslo0372OsloNorway Department of Physiology Federal University of SergipeS~ao Cristov~ao49100-000SergipeBrazil Centre of Molecular Inflammation Research Department of Clinical and Molecular MedicineNorwegian University of Science and Technology7491TrondheimNorway Kavli Institute for Systems Neuroscience Centre for Neural Computationand Egil and Pauline Braathen and Fred Kavli Centre for Cortical MicrocircuitsNorwegian University of Science and Technology7030TrondheimNorway K.G.Jebsen Centre for Alzheimer’s Disease Norwegian University of Science and Technology7030TrondheimNorway

Background:Exercise training promotes brain plasticity and is associated with protection against cognitive impairment and Alzheimer’s disease(AD).These beneficial effects may be partly mediated by blood-borne *** we used an in vitro model of AD to investigate effects of blood plasma from exercise-trained donors on neuronal viability,and an in vivo rat model of AD to test whether such plasma impacts cognitive function,amyloid pathology,and ***:Mouse hippocampal neuronal cells were exposed to AD-like stress using amyloid-βand treated with plasma collected from human male donors 3 h after a single bout of high-intensity *** in vivo studies,blood was collected from exercise-trained young male Wistar rats(high-intensity intervals 5 days/week for 6 weeks).Transgenic AD rats(McGill-R-Thyl-APP)were inj ected 5 times/fortnight for 6 weeks at2 months or 5 months of age with either(a)plasma from the exercise-trained rats,(b)plasma from sedentary rats,or(c)*** function,amyloid plaque pathology,and neurogenesis were *** plasma used for the treatment was analyzed for 23 ***:Plasma from exercised donors enhanced cell viability by 44.1%(p=0.032)and reduced atrophy by 50.0%(p<0.001)in amyloid-β-treated *** vivo exercised plasma treatment did not alter cognitive function or amyloid plaque pathology but did increase hippocampal neurogenesis by~3 fold,regardless of pathological stage,when compared to saline-treated *** of 7 cytokines were significantly reduced in exercised plasma compared to sedentary ***:Our proof-of-concept study demonstrates that plasma from exercise-trained donors can protect neuronal cells in culture and promote adult hippocampal neurogenesis in the AD rat *** effect may be partly due to reduced pro-inflammatory signaling molecules in exercised plasma.

关键词： Cytokines High-intensity interval training Inflammation Neurons Plasma transfusion

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单羧酸转运蛋白在低氧培养脑和乳腺肿瘤细胞膜上的密度变化

单羧酸转运蛋白在低氧培养脑和乳腺肿瘤细胞膜上的密度变化

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中国解剖学会2012年年会

作者：常成 linda bergersen 高晓群郑州大学医学院解剖学教研室挪威奥斯陆大学解剖学系

＜正＞肿瘤细胞的一个基本特征是无氧糖酵解,可以促进细胞增殖并通过单羧酸转运蛋白转运乳酸等物质,引起细胞外环境的改变。杂乱的肿瘤血管系统,为肿瘤细胞造成了不同的氧环境,影响到了细胞的生存和代谢。为了探究不同肿瘤细胞在不同氧...

＜正＞肿瘤细胞的一个基本特征是无氧糖酵解,可以促进细胞增殖并通过单羧酸转运蛋白转运乳酸等物质,引起细胞外环境的改变。杂乱的肿瘤血管系统,为肿瘤细胞造成了不同的氧环境,影响到了细胞的生存和代谢。为了探究不同肿瘤细胞在不同氧状态下的单羧酸转运能力,乳腺癌T-47D细胞和脑胶质细胞瘤T98G细胞,分别在4%和20%氧浓度环境下培养,并通过免疫颗粒金标记透射电镜技术,

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