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Fac.ors affec.ing use of ballistic. gelatin in laboratory studies of bac.erial c.ntamination in projec.ile wounds

Military Medic.l Researc. 2018年第4期5卷 304-313页

作者： Jessic. J. Evans Aaron Bost Karim H. Muc.-Küc.ler linda c. deveaux Biomedic.l Engineering Program South Dakota School of Mines and Technology Mec.anic.l Engineering Department South Dakota School of Mines and Technology Department of Biology New Mexico Institute of Mining and Technology

Bac.ground: Ballistic. gelatin is a c.mmon tissue surrogate used in bac.erial c.ntamination models for projec.ile wounds. Although these studies have demonstrated that bac.eria are transferred from the surfac. of the gelatin to the wound trac. by a projec.ile, quantifiable results have been inc.nsistent and not repeatable in suc.essive ***: In this study, five areas of a typic.l c.ntamination model in whic. bac.erial rec.very or survival are affec.ed were identified for optimization. The first was a c.ntaminated "skin" surrogate, where the novel use of vac.um filtration of a bac.erial c.lture and buffer onto filter paper was employed. The other possibly problematic.areas of the bac.erial distribution model inc.uded the determination of bac.erial survival when the c.ntamination model is dried, survival in solid and molten gelatin, and the effec. of high-intensity lights used for rec.rding high-speed ***: Vac.um filtration of bac.eria and buffer resulted in a c.nsistent bac.erial distribution and rec.very. The use of phosphate buffer M9(pH 7) aided in neutralizing the ballistic. gelatin and improving bac.erial survival in solid gelatin. Additionally, the use of high-intensity lights to rec.rd high-speed video and the use of a 42℃ water bath to melt the gelatin were found to be bac.eric.dal for gram-positive and gram-negative ***: Multiple areas of a typic.l c.ntamination model in whic. bac.erial survival may be impeded were identified, and methods were proposed to improve survival in eac. area. These methods may be used to optimize the results of bac.erial c.ntamination models for medic.l applic.tions, suc. as understanding the progression of infec.ion in penetrating wounds and to identify possible sourc.s of c.ntamination for forensic.purposes.

关键词： Ballistic. gelatin Wound c.ntamination Bac.erial model

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A c.mprehensive Survey for Privac.-Preserving Biometric.: Rec.nt Approac.es, c.allenges, and Future Direc.ions

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c.mputers, Materials & c.ntinua 2024年第2期78卷 2087-2110页

作者： Shahriar Md Arman Tao Yang Shahadat Shahed Alanoud AlMazroa Afraa Attiah linda Mohaisen Sc.ool of c.mputer Sc.enc. and Tec.nology Zhejiang Gongshang UniversityHangzhou310018China Sc.ool of c.mputer Sc.enc. and Tec.nology Hangzhou Dianzi UniversityHangzhou310018China c.llege of c.mputer and Information Sc.enc.s Princess Nourah bint Abdulrahman UniversityRiyadh84428Saudi Arabia Fac.lty of c.mputing and Information Tec.nology King Abdulaziz UniversityJeddah21589Saudi Arabia

The rapid growth of smart tec.nologies and servic.s has intensified the c.allenges surrounding identity authenti-c.tion *** c.edentials are inc.easingly being used for verific.tion due to their advantages over traditional methods,making it c.uc.al to safeguard the privac. of people’s biometric.data in various *** paper offers an in-depth exploration for privac.-preserving tec.niques and potential threats to biometric.*** proposes a noble and thorough taxonomy survey for privac.-preserving tec.niques,as well as a systematic.framework for c.tegorizing the field’s existing *** review the state-of-the-art methods and address their advantages and limitations in the c.ntext of various biometric.modalities,suc. as fac.,fingerprint,and eye *** survey enc.mpasses various c.tegories of privac.-preserving mec.anisms and examines the trade-offs between sec.rity,privac.,and rec.gnition performanc.,as well as the issues and future researc. *** aims to provide researc.ers,professionals,and dec.sion-makers with a thorough understanding of the existing privac.-preserving solutions in biometric.rec.gnition systems and serves as the foundation of the development of more sec.re and privac.-preserving biometric.tec.nologies.

关键词： Biometric.modalities biometric.rec.gnition biometric.sec.rity privac.-preserving sec.rity threats

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Shear-wave elastography to predic. hepatoc.llular c.rc.noma after hepatitis c.virus eradic.tion:A systematic.review and meta-analysis

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World Journal of Gastroenterology 2024年第10期30卷 1450-1460页

作者： Giorgio Esposto Paolo Santini linda Galasso Irene Mignini Maria Elena Ainora Antonio Gasbarrini Maria Assunta Zoc.o c.MAD Digestive Disease c.nter Fondazione Policlinico Universitario“A.Gemelli”IRCCSCatholic University of RomeRome 00168Italy Fondazione Polic.inic. Universitario Agostino Gemelli IRc.S Fondazione Policlinico Universitario Agostino Gemelli IRCCS-UniversitàCattolica del Sacro CuoreRome 00168Italy Medic.na Interna e Gastroenterologia CEMAD Digestive Disease CenterUniversitàCattolica del Sacro CuoreFondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy

BAc.GROUND Direc.-ac.ing antiviral agents(DAAs)are highly effec.ive treatment for c.ronic.hepatitis c.c.c.with a signific.nt rate of sustained virologic.response(SVR).The ac.ievement of SVR is c.uc.al to prevent additional liver damage and slow down fibrosis *** assessment of fibrosis degree c.n be performed with transient elastography,magnetic.resonanc. elastography or shear-wave elastography(SWE).Liver elastography c.uld func.ion as a predic.or for hepato-c.llular c.rc.noma(Hc.)in c.c.patients treated with *** To explore the predic.ive value of SWE for Hc. development after c.mplete c.earanc. of hepatitis c.virus(Hc.).METHODS A c.mprehensive literature searc. of c.inic.l studies was performed to identify the ability of SWE to predic. Hc. oc.urrenc. after Hc. *** ac.ordanc. with the study protoc.l,a qualitative and quantitative analysis of the evidenc. was *** At baseline and after 12 wk of follow-up,a trend was shown towards greater liver stiffness(LS)in those who go on to develop Hc. c.mpared to those who do not[baseline LS standardized mean differenc.(SMD):1.15,95%c.nfidenc. interval(95%c.):020-2.50;LS SMD after 12 wk:0.83,95%c.:0.33-1.98].The absenc. of a statistic.lly signific.nt differenc. between the mean LS in those who developed Hc. or not may be related to the inability to c.rrec. for c.nfounding fac.ors and the absenc. of raw sourc. *** was a statist-ic.lly signific.nt LS SMD at 24 wk of follow-up between patients who developed Hc. vs not(0.64;95%c.:0.04-1.24).c.Nc.USION SWE c.uld be a promising tool for predic.ion of Hc. oc.urrenc. in patients treated with *** studies with larger c.horts and standardized timing of elastographic.evaluation are needed to c.nfirm these data.

关键词： Shear-wave elastography Hepatoc.llular c.rc.noma Hepatitis c.virus Sustained virologic.response

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Exerc.sed blood plasma promotes hippoc.mpal neurogenesis in the Alzheimer's disease rat brain

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Journal of Sport and Health Sc.enc. 2024年第2期13卷 245-255页

作者： c.c.lie Skarstad Norevik Aleksi M.Huuha Ragnhild N.RФsbjФrgen linda Hildegard Bergersen Kamilla Jac.bsen Rodrigo Miguel-dos-Santos Liv Ryan Belma Skender Jose Bianc. N.Moreira Asgeir Kobro-Flatmoen Menno P.Witter Nathan Sc.imgeour Atefe R.Tari c.rdiac.Exerc.se Researc. Group(c.RG) Department of Circulation and Medical ImagingNorwegian University of Science and Technology7491TrondheimNorway Department of Neurology and c.inic.l Neurophysiology St.Olavs University Hospital7030TrondheimNorway Institute of Oral Biology University of Oslo0372OsloNorway Department of Physiology Federal University of SergipeS~ao Cristov~ao49100-000SergipeBrazil c.ntre of Molec.lar Inflammation Researc. Department of Clinical and Molecular MedicineNorwegian University of Science and Technology7491TrondheimNorway Kavli Institute for Systems Neurosc.enc. Centre for Neural Computationand Egil and Pauline Braathen and Fred Kavli Centre for Cortical MicrocircuitsNorwegian University of Science and Technology7030TrondheimNorway K.G.Jebsen c.ntre for Alzheimer’s Disease Norwegian University of Science and Technology7030TrondheimNorway

Bac.ground:Exerc.se training promotes brain plastic.ty and is assoc.ated with protec.ion against c.gnitive impairment and Alzheimer’s disease(AD).These benefic.al effec.s may be partly mediated by blood-borne *** we used an in vitro model of AD to investigate effec.s of blood plasma from exerc.se-trained donors on neuronal viability,and an in vivo rat model of AD to test whether suc. plasma impac.s c.gnitive func.ion,amyloid pathology,and ***:Mouse hippoc.mpal neuronal c.lls were exposed to AD-like stress using amyloid-βand treated with plasma c.llec.ed from human male donors 3 h after a single bout of high-intensity *** in vivo studies,blood was c.llec.ed from exerc.se-trained young male Wistar rats(high-intensity intervals 5 days/week for 6 weeks).Transgenic.AD rats(Mc.ill-R-Thyl-APP)were inj ec.ed 5 times/fortnight for 6 weeks at2 months or 5 months of age with either(a)plasma from the exerc.se-trained rats,(b)plasma from sedentary rats,or(c.*** func.ion,amyloid plaque pathology,and neurogenesis were *** plasma used for the treatment was analyzed for 23 ***:Plasma from exerc.sed donors enhanc.d c.ll viability by 44.1%(p=0.032)and reduc.d atrophy by 50.0%(pc.sed plasma treatment did not alter c.gnitive func.ion or amyloid plaque pathology but did inc.ease hippoc.mpal neurogenesis by~3 fold,regardless of pathologic.l stage,when c.mpared to saline-treated *** of 7 c.tokines were signific.ntly reduc.d in exerc.sed plasma c.mpared to sedentary ***:Our proof-of-c.nc.pt study demonstrates that plasma from exerc.se-trained donors c.n protec. neuronal c.lls in c.lture and promote adult hippoc.mpal neurogenesis in the AD rat *** effec. may be partly due to reduc.d pro-inflammatory signaling molec.les in exerc.sed plasma.

关键词： c.tokines High-intensity interval training Inflammation Neurons Plasma transfusion

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The Long Road to Understanding the Bac.lovirus P10 Protein

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Virologic. Sinic. 2009年第4期24卷 227-242页

作者： David c. J. c.rpentier linda A. King Sc.ool of Life Sc.enc.s Oxford Brookes University Headington Campus Oxford United Kingdom Oxford Expression Tec.nologies Ltd Oxford Brookes University Headington Campus Oxford United Kingdom

The bac.lovirus P 10 protein has always represented a mystery in the field of insec. virology. Like the bac.lovirus polyhedrin protein it is expressed at high levels very late in infec.ion. Homologues of the Autographa c.lifornic. nuc.eopolyhedrovirus p10 gene are c.nserved in all Alphabac.loviruses and in other viruses of lepidopteran hosts yet is c.mpletely dispensable for virus replic.tion and transmission. PIO is a mic.otubule interac.ing protein whose expression has been assoc.ated with the formation of a variety of c.mplex and extensive c.toplasmic.and nuc.ear struc.ures. PIO has been assoc.ated with a number of roles during infec.ion ranging from the formation of virus oc.lusion bodies, to affec.ing the rate of c.llular and/or nuc.ear lysis during the final stages of the virus replic.tion c.c.e. In this artic.e we review rec.nt work aimed at understanding the role of this enigmatic.protein, putting them into c.ntext with rec.nt advanc.s in understanding of protein struc.ure and func.ion. We look bac. at a number of historic.l studies and observations, reanalysing their c.nc.usions based on rec.nt data and our own observations. The role of the P 10 protein during bac.lovirus replic.tion remains elusive, however, novel avenues of investigation have been identified that will, we are sure, eventually lead to an understanding of this protein.

关键词： Bac.lovirus P10 mic.otubule Polyhedral oc.lusion body Fibrous body/fibrillar struc.ure

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Endosc.pic.ultrasound-guided tec.niques for diagnosing panc.eatic.mass lesions: c.n we do better?

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World Journal of Gastroenterology 2016年第39期22卷 8658-8669页

作者： Andrew c.Storm linda S Lee Division of Gastroenterology Hepatology and Endoscopy Brigham and Women’s Hospital Harvard Medical School

The diagnostic.approac. to a possible panc.eatic.mass lesion relies first upon various non-invasive imaging modalities, inc.uding c.mputed tomography, ultrasound, and magnetic.resonanc. imaging tec.niques. Onc. a suspec. lesion has been identified, tissue ac.uisition for c.arac.erization of the lesion is often paramount in developing an individualized therapeutic.approac.. Given the high prevalenc. and mortality assoc.ated with panc.eatic.c.nc.r, an ideal approac. to diagnosing panc.eatic.mass lesions would be safe, highly sensitive, and reproduc.ble ac.oss various prac.ic. settings. Tools, in addition to radiologic.imaging, c.rrently employed in the initial evaluation of a patient with a panc.eatic.mass lesion inc.ude serum tumor markers, endosc.pic.retrograde c.olangiopanc.eatography, and endosc.pic.ultrasound-guided fine needle aspiration(EUS-FNA). EUS-FNA has grown to bec.me the gold standard in tissue diagnosis of panc.eatic.lesions.

关键词： Endosc.pic.ultrasound Fine needle aspiration Panc.eatic.c.nc.r Panc.eatic.mass Endosc.py

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利妥昔单抗联合GDP方案治疗非霍奇金淋巴瘤患者的效果及对免疫功能的影响

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临床医学研究与实践 2024年第23期9卷 38-41页

作者：钟林达河南科技大学第一附属医院血液内科河南洛阳471000

目的探讨利妥昔单抗联合吉西他滨+顺铂+地塞米松(GDP)方案治疗非霍奇金淋巴瘤患者的效果及对免疫功能的影响。方法选取2020年3月至2022年8月我院收治的106例非霍奇金淋巴瘤患者,根据治疗方案不同将其分为对照组(53例)和观察组(53例)。... 详细信息

目的探讨利妥昔单抗联合吉西他滨+顺铂+地塞米松(GDP)方案治疗非霍奇金淋巴瘤患者的效果及对免疫功能的影响。方法选取2020年3月至2022年8月我院收治的106例非霍奇金淋巴瘤患者,根据治疗方案不同将其分为对照组(53例)和观察组(53例)。对照组采用GDP方案治疗,观察组在对照组基础上加用利妥昔单抗治疗。比较两组的治疗效果。结果观察组的疾病控制率(Dc.)为96.23%,高于对照组的84.91%,差异具有统计学意义(Pc.、补体c.、血管内皮生长因子(VEGF)及胸苷激酶-1(TK-1)水平均低于对照组,差异具有统计学意义(P0.05)。结论利妥昔单抗联合GDP方案治疗非霍奇金淋巴瘤患者效果显著,可改善免疫功能,降低血清肿瘤标志物水平,且用药安全性高。

关键词：非霍奇金淋巴瘤利妥昔单抗免疫功能

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Bone marrow mononuc.ear c.lls for joint therapy: The role of mac.ophages in inflammation resolution and tissue repair

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World Journal of Stem c.lls 2021年第7期13卷 825-840页

作者： Bruno c.Menarim James N Mac.eod linda A Dahlgren Gluc. Equine Researc. c.nter Department of Veterinary ScienceCollege of AgricultureFood and EnvironmentUniversity of KentuckyLexingtonKY 40546United States Department of Large Animal c.inic.l Sc.enc.s Virginia-Maryland College of Veterinary MedicineVirginia TechBlacksburgVA 24060United States

Osteoarthritis(OA)is the most prevalent joint disease c.using major disability and medic.l *** is a c.ntral feature of OA and is primarily driven by *** mac.ophages not only drive inflammation but also its resolution,through a c.ordinated,simultaneous expression of pro-and anti-inflammatory mec.anisms that are essential to c.unterac. damage and rec.ver *** OA therapies are largely based on anti-inflammatory princ.ples and therefore bloc. pro-inflammatory mec.anisms suc. as prostaglandin E2 and Nuc.ear fac.or-kappa B signaling ***,suc. mec.anisms are also innately required for mounting a pro-resolving response,and their bloc.age often results in c.ronic.low-grade *** minor injury,mac.ophages shield the damaged area and drive tissue *** the damage is more extensive,mac.ophages inc.te inflammation rec.uiting more mac.ophages from the bone marrow to maximize tissue repair and ultimately resolve ***,sustained damage and inflammation often overwhelms pro-resolving mec.anisms of synovial mac.ophages leading to the c.ronic.inflammation and related tissue degeneration observed in ***,experimental and c.inic.l studies have shown that joint injec.ion with autologous bone marrow mononuc.ear c.lls replenishes inflamed joints with mac.ophage and hematopoietic.progenitors,enhanc.ng mec.anisms of inflammation resolution,providing remarkable and long-lasting *** c.eating an ideal environment for resolution with high c.nc.ntrations of interleukin-10 and anabolic.growth fac.ors,mac.ophage progenitors also have a direc. role in tissue *** c.nstitute a large part of the early granulation tissue,and further transdifferentiate from myeloid into a mesenc.ymal *** c.lls,c.arac.erized as fibroc.tes,are essential for repairing osteoc.ondral ***“omic.”studies foc.sed on identifying key drivers of mac.ophagemediated resolution of j

关键词： Osteoarthritis Arthropathy Synovitis Hematopoietic.progenitor Homeostasis c.ll therapy

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Harmonic. Mitigation Using MMc.Based UPFc.and Partic.e Swarm Optimization

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Intelligent Automation & Soft c.mputing 2023年第3期35卷 3429-3445页

作者： c.Gnana Thilaka M.Mary linda Ponjesly c.llege of Engineering Nagercoil629003India

The applic.tion of non-linear loads in the power elec.ronic.devic. c.uses serious harmonic.issues in the power system sinc. it has the intrinsic.prop-erty of retrieving harmonic.c.rrent and reac.ive power from Alternating c.rrent(Ac.supply that leads to voltage *** maintain a reliable powerﬂow in the power system,an innovative Uniﬁed Power Flow c.nverter(UPFc.is uti-lized in this proposed *** c.nventional series c.nverter is replac.d with the Modular Multilevel c.nverter(MMc.that improves the power handling c.pability and ac.ieves higher modular level with minimized *** shunt c.mpensator assists in minimizing the voltageﬂuc.uations and maximizing the voltage stability under different load *** Direc. Quadrature(DQ)theory is utilized in this study to separate the harmonic.c.mponents by generating referenc. frame *** Proportional Integral(PI)c.ntroller aids in maintain-ing the direc. c.rrent potential differenc. in the c.nstant mode whereas the Pulse Width Modulation(PWM)generator helps in delivering optimized output to the *** gain parameters of PI c.ntroller are optimized with the aid of employ-ing Partic.e Swarm Optimization(PSO).The entire work is validated using MATLAB simulink and the obtained outc.mes proves that this new UPFc.is highly beneﬁc.al in minimizing the distortions with reduc.d Total Harmonic.Distortion(THD)of 2.21%.

关键词： UPFc PI c.ntroller PSO MMc DQ theory STATc.M

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Stem c.lls for c.rdiac.repair: an introduc.ion

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Journal of Geriatric.c.rdiology 2013年第2期10卷 186-197页

作者： Bastiaan c.du Pr(e) Pieter A Doevendans linda W van Laake Departments of c.rdiology and Medic.l Physiology Division of Heart and Lungs University Medical Center Utrecht P.O. box 85500 3508 GA Utrecht the Netherlands Departments of c.rdiology and Medic.l Physiology Division of Heart and Lungs University Medical Center Utrecht P.O. box 85500 3508 GA Utrecht the Netherlands Inter university Cardiology Institute of the Netherlands P.O. box 19258 2501 DG Utrecht the Netherlands Departments of c.rdiology and Medic.l Physiology Division of Heart and Lungs University Medical Center Utrecht P.O. box 85500 3508 GA Utrecht the Netherlands Hubrecht Institute P.O box 85164 3508 AD Utrecht the Netherlands

c.rdiovasc.lar disease is a major c.use of morbidity and mortality throughout the world. Most c.rdiovasc.lar diseases, suc. as isc.emic.heart disease and c.rdiomyopathy, are assoc.ated with loss of func.ional c.rdiomyoc.tes. Unfortunately, the heart has a limited regenerative c.pac.ty and is not able to replac. these c.rdiomyoc.tes onc. lost. In rec.nt years, stem c.lls have been put forward as a potential sourc. for c.rdiac.regeneration. Pre-c.inic.l studies that use stem c.ll-derived c.rdiac.c.lls show promising results. The mec.anisms,though, are not well understood, results have been variable, sometimes transient in the long term, and often without a mec.anistic.*** are still severalmajor hurdles to be taken. Stem c.ll-derived c.rdiac.c.lls should resemble original c.rdiac.c.ll types and be able to integrate in the damaged heart. Integration requires administration of stem c.ll-derived c.rdiac.c.lls at the right time using the right mode of delivery. Onc. delivered, transplanted c.lls need vasc.larization, elec.rophysiologic.l c.upling with the injured heart, and prevention of immunologic.l rejec.ion. Finally, stem c.ll therapy needs to be safe, reproduc.ble, and affordable. In this review, we will give an introduc.ion to the princ.ples of stem c.ll based c.rdiac.repair.

关键词： c.rdiomyoc.tes Heart Regeneration Stem c.ll

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