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Forensic Sciences Research 2022年第2期7卷 265-271页

作者： Liang Meng Shuhai Ye Yilin Wu linda You Department of Forensic Science Fujian Police CollegeFuzhouChina Institute of Forensic Science Fujian Provincial Public Security DepartmentFuzhouChina

A new method was developed for pre-concentration and determination of multiple drugs of abuse in human urine using dispersive liquid–liquid microextraction(DLLME)and capillary electrophoresis(CE)with photodiode array *** method was based on the formation of tiny droplets of an organic extractant in the prepared sample solution using water-immiscible organic solvent(chloroform)dissolved in water-miscible organic dispersive solvent(isopropyl alcohol).The organic phase,which extracted eight drugs of abuse from the prepared urine solution,was separated by *** sedimented phase was transferred into a small volume CE auto-sampler vial with 10μL of 1%HCl methanol solution and evaporated to *** residue was reconstituted in lidocaine hydrochloride(internal standard)aqueous solution and introduced by electrokinetic injection into *** the optimum conditions,acceptable linear relationship was observed in the range of 3.0–500 ng/mL with the correlation coefficient(r)of 0.9982–0.9994 for spiked urine *** limit of detection(LOD)(S/N=3)was estimated to be 1.0 ng/mL.A recovery of 75.7%–90.6%was obtained for spiked *** mean relative error(MRE)was within±7.0%and the relative standard deviation(RSD)was less than 6.9%.The proposed DLLME-CE procedure offers an alternative analytical approach for the sensitive detection of drugs of abuse in real urine samples.

关键词： Forensic sciences forensic toxicology dispersive liquid-liquid microextraction capillary electrophoresis drugs of abuse urine sample

Isolation and identification of an isomeric sildenafil analogue as an adulterant in an instant coffee premix

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Forensic Sciences Research 2022年第2期7卷 290-298页

作者： Ahmad Yusri Mohd Yusop linda Xiao Shanlin Fu Centre for Forensic Science University of Technology SydneyUltimoAustralia Pharmacy Enforcement Division Ministry of HealthSelangorMalaysia

The proliferation of adulterated health foods and beverages in the market demands a comprehensive analytical strategy to identify the adulterants,particularly those of isomeric phosphodiesterase 5(PDE5)*** instant coffee premix(ICP)purchased from an online retailer was flagged for suspected adulteration through PDE5 inhibition *** ICP was then analysed using suspected-target and non-targeted screenings of a liquid chromatography-quadrupole time-of-flight mass *** on these findings,a PDE5 inhibitor initially assigned as compound X was isolated from the ICP by employing a liquid chromatography-diode array detection before its structural elucidation with liquid chromatography-ultraviolet(LC-UV)spectroscopy and nuclear magnetic resonance(NMR)*** suspected-target screening matched the protonated molecule([MþH]þ)precursor ion of compound X at m/z 499.2310 with two suspected analytes that are structural isomers of one *** fragmentation patterns of compound X were comparable to those analogues in the dithiocarbodenafil group through the non-targeted *** findings,complemented by the LC-UV and NMR spectroscopy data,together with the chromatographic separation of related structural isomers,conclude the identity of compound *** our best knowledge,this is the first study to report the presence of 3,5-dimethylpiperazinyl-dithiodesmethylcarbodenafil in an ICP sample.

关键词： Forensic sciences food adulteration non-targeted screening phosphodiesterase 5 inhibitors structural isomer suspected-target screening

Effect of Thunbergia laurifolia water extracts on hepatic insulin resistance in high-fat diet-induced obese mice

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Asian Pacific Journal of Tropical Biomedicine 2021年第3期11卷 97-104页

作者： Jarinyaporn Naowaboot Urarat Nanna linda Chularojmontri Pholawat Tingpej Patchareewan Pannangpetch Division of Pharmacology Department of Preclinical ScienceFaculty of MedicineThammasat UniversityPathum Thani 12120Thailand Division of Microbiology and Immunology Department of Preclinical ScienceFaculty of MedicineThammasat UniversityPathum Thani 12120Thailand Department of Pharmacology Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand

Objective:To examine the effect of water extract of Thunbergia laurifolia on hepatic insulin resistance in high-fat diet-induced obese ***:High-fat diet with 45 kcal%lard fat was used for obesity induction in ICR *** mice were fed with high-fat diet for 16 weeks,and during the last 8 weeks,they were treated with 200 mg/kg/day of water extracts from Thunbergia laurifolia leaf,stem and *** biochemistry,liver histology,and protein expression were examined after the ***:Extracts from all of the three parts of Thunbergia laurifolia significantly alleviated hyperglycemia,hyperlipidemia,hyperinsulinemia,and *** stem and flower extracts improved glucose *** of the extracts significantly reduced serum TNFαand monocyte chemoattractant protein-1 *** weight,triglyceride levels,and lipid accumulation were also ***,hepatic glucose-6-phosphatase level was significantly decreased,while the levels of PPARα,phosphorylated AMPK,and phosphorylated Akt were significantly increased with treatment of Thunbergia laurifolia ***:Thunbergia laurifolia extracts can ameliorate hepatic insulin resistance in high-fat diet-induced obese mice by improving glucose and lipid homeostasis,which may be associated with stimulating phosphorylation of AMPK and Akt pathways.

关键词： Thunbergia laurifolia Obesity Insulin resistance Inflammation

Drug resistance in the sexually transmitted protozoan Trichomonas vaginalis

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Cell Research 2003年第4期13卷 239-249页

作者： REBECCA L DUNNE,linda A DUNN,PETER UPCROFT,PETERJO’DONOGHUE,JACQUELINE A UPCROFT The Queensland Institute of Medical Research The Australian Centre for International and Tropical Health and Nutrition Brisbane Queensland 4029 Australia Tie School of Molecular and Microbial Science University of Queensland Brisbane Queensland 4072 Australia The Queensland Institute of Medical Research The Australian Centre for International and Tropical Health and Nutrition Brisbane Queensland 4029 Australia The Queensland Institute of Medical Research The Australian Centre for International and Tropical Health and Nutrition Brisbane Queensland 4029 Australia The School of Molecular and Microbial Science University of Queensland Brisbane Queensland 4072 Australia The Queensland Institute of Medical Research The Australian Centre for International and Tropical Health and Nutrition Brisbane Queensland 4029 Australia

Trichomoniasis is the most common, sexually transmitted infection. It is caused by the flagellated protozoan parasite Trichomonas vaginalis. Symptoms include vaginitis and infections have been associated with preterm delivery, low birth weight and increased infant mortality, as well as predisposing to HIV/AIDS and cervical cancer. Trichomoniasis has the highest prevalence and incidence of any sexually transmitted infection. The 5-nitroimidazole drugs, of which metronidazole is the most prescribed, are the only approved, effective drugs to treat trichomoniasis. Resistance against metronidazole is frequently reported and cross resistance among the family of 5-nitroimidazole drugs is common, leaving no alternative for treatment, with some cases remaining unresolved. The mechanism of metronidazole resistance in T. vaginalis from treatment failures is not well understood, unlike resistance which is developed in the laboratory under increasing metronidazole pressure. In the latter situation, hydrogenosomal fu

关键词： Trichomonas vaginalis metronidazole pyruvate: ferredoxin oxidoreductase ferredoxin hydrogenase drug resistance.

Life Cycle Assessment of Recycling High-Density Polyethylene Plastic Waste

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Journal of Renewable Materials 2021年第8期9卷 1463-1483页

作者： Neeti Gandhi Nicholas Farfaras Nien-Hwa linda Wang Wan-Ting Chen Department of Chemical Engineering Virginia Polytechnic and State InstituteBlacksburg24061USA Department of Plastics Engineering University of Massachusetts LowellLowell01854USA School of Chemical Engineering Purdue UniversityWest Lafayette47907USA

Increasing production and use of various novel plastics products,a low recycling rate,and lack of effective recycling/disposal methods have resulted in an exponential growth in plastic waste accumulation in landfills and in the *** better understand the effects of plastic waste,Life Cycle Analysis(LCA)was done to compare the effects of various production and disposal *** shows the specific effects of the cradle-to-grave or cradle-to-cradle scenarios for landfill,incineration,and mechanical *** analysis clearly indicates that increasing recycling of plastics can significantly save energy and eliminate harmful emissions of various carcinogens and GHGs into the *** recycling increases,the need for virgin-plastic production can be greatly ***,the results of this study may help improve current mechanical recycling processes as well as potential future recycling methods,such as chemical *** about the current recycling/disposal methods for plastics have brought increasing attention to the waste accumulation ***,with the current COVID-19 pandemic,plastic accumulation is expected to increase significantly in the near future.A better understanding of the quantitative effects of the various disposal methods can help guide policies and future research toward effective solutions of the plastic waste problem.

关键词： Life Cycle Analysis(LCA) mechanical recycling microplastic chemical recycling plastic policy

The Impact of Strategic Human Resource Management(SHRM)on the Wellbeing of Health Workers in Sierra Leone

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The Impact of Strategic Human Resource Management(SHRM)on th...

作者： linda Susan Kabba 山东大学

学位级别：硕士

人力资源管理通过投资于员工发展和承诺,在卫生部门发挥着重要作用。在政府补贴和管理者支付框架(Hunter,2013a)中,人力资源管理活动应有助于发现劳动力的适当均等(Kunnanatt,2013年),以及这些专业人员成功和高效运营的能力。此外,对于... 详细信息

人力资源管理通过投资于员工发展和承诺,在卫生部门发挥着重要作用。在政府补贴和管理者支付框架(Hunter,2013a)中,人力资源管理活动应有助于发现劳动力的适当均等(Kunnanatt,2013年),以及这些专业人员成功和高效运营的能力。此外,对于塞拉利昂等新兴国家的居民来说,获得高质量的社会保险管理是很困难的,因为这些居民可能无法获得或无法获得医疗人员和资源供应。卫生部门变革中的人力资源预计将推动行政管理和患者履行职责的性质,因此,战略人力资源管理被认为是在脚踏实地的环境中对卫生保健至关重要的,这是实现卫生部门变革的根本部分。这种做法包括建立有效的系统来监督自我激励的工作,报告进入和退出福利劳动力,并加强现有卫生工作者的传播和实施。关键的人力资产取决于承认,如果机构的人力资产受人力资源战略和活动的控制,这些人力资源战略和活动能够向正确的个人传达适当的活动、所需的技能和对机构的重要激励。本研究利用受访者(塞拉利昂的卫生工作者)的社会经济特征,讨论战略人力资源管理政策和实践,以确保他们的整体健康,同时从工作中获得最有效的承诺。它还揭示了他们在履行职责过程中面临的各种挑战的强度和顺序。这项研究采用了社会创造的哲学,其中大量的讨论、实施和结论都是从定量数据中得出的,这些数据是通过对受访者(塞拉利昂的卫生工作者)进行问卷调查获得的。统计获得的数据,并从收集的意见,更战略性的人力资源实践的基础上不同的管理领域进行了讨论。

关键词：战略人力资源管理卫生工作者福利激励战略人力资源政策塞拉利昂

Economic Growth in the East African Community Countries:the Role of FDIs and External Debt

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Economic Growth in the East African Community Countries:the ...

作者： NAMBASSA linda（琳达）东南大学

学位级别：硕士

外国直接投资(FDI)和外债正日益成为许多国家的最终融资解决方案,因为有限的国内收入需要补充以积累资本并增加循环收入流动的流动性。外商直接投资和外债的部署被认为有可能通过提供额外援助来为东非共同体的经济运作提供资金,从而弥... 详细信息

外国直接投资(FDI)和外债正日益成为许多国家的最终融资解决方案,因为有限的国内收入需要补充以积累资本并增加循环收入流动的流动性。外商直接投资和外债的部署被认为有可能通过提供额外援助来为东非共同体的经济运作提供资金,从而弥补国内储蓄和投资之间的差距。本文将深入研究1995年至2018年期间FDI和外债对东非共同体国家经济增长的影响。自变量是外国直接投资(FDI)、外债、官方发展援助(ODA)、官方外汇、贸易开放和出口,对经济增长进行回归,以国内生产总值(GDP)的年增长率为代表。此外,本研究进行固定效应回归分析并使用跨越23年的面板数据。结果显示,FDI正相关为9.74%,外债为10.2%,ODA为49.0%,官方外汇为89%,出口为5%。然而,贸易开放与增长的负相关为-0.29%,这可能归因于与持续实行保护主义的强大或工业化经济体在同一市场上的激烈和不健康的竞争。因此,本研究表明官方外汇和官方发展援助是影响东非国家增长的最有效因素。为了从经济增长中受益,政策制定者必须制定宏观经济战略,通过结合财政和货币政策,在适当的方向上成功利用外国资本流入。因此,这项研究的重要性在于调查外国直接投资和外债在东非共同体国家经济增长中的作用,并利用各种政策和创新设计可持续性指标。

关键词：外债外商直接投资经济增长

Marketing Strategies on the Internet （Internet Marketing） and Its Impact on Smes in Ghana

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Marketing Strategies on the Internet （Internet Marketing） ...

作者： Nyansah linda Afoley 浙江工商大学

学位级别：硕士

This study focused on Internet marketing and the impact on Ghana’s small and medium-sized *** objectives of the study were to determine the reach of internet marketing applications by SMEs in Ghana,to identify the challenges faced by SMEs in implementing internet marketing in Ghana and to determine the effect of internet marketing on the output of *** the last few decades,the growth and proliferation of the internet with an unprecedented speed has contributed to its expanded use for marketing purposes;this is internet *** Internet as a marketing tool provides businesses considerable opportunities to try and implement creative strategies to meet the rising customer *** inquiry was a descriptive study using a sample size of 150 *** data were obtained using SMEs’ top management *** data collected were analyzed using the frequencies,percentages,means and standard deviation as well as the study of factor and *** study found that internet marketing was used to a modest degree and that certain problems affected or prevented SMEs ability to apply internet *** small and medium-sized companies concluded that the greatest obstacle in internet marketing application was the fear of losing their existing customers who could not access *** lack of funds to invest in the introduction of internet marketing as well as the lack of skilled IT workers addressed the difficulties outlined in the *** marketing has had a positive effect on SME *** most used ways of internet marketing were the social media,mobile advertising and *** ability improved,market share increased and the ability to expand their market *** company’s reputation has been improved,an increased competitive advantage as well as greater loyalty and access to new markets as impacts of these SMEs ’ use of internet marketing.

关键词： small enterprises medium-sized enterprises Internet marketing Ghana

Stem cells for cardiac repair: an introduction

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Journal of Geriatric Cardiology 2013年第2期10卷 186-197页

作者： Bastiaan C du Pr(e) Pieter A Doevendans linda W van Laake Departments of Cardiology and Medical Physiology Division of Heart and Lungs University Medical Center Utrecht P.O. box 85500 3508 GA Utrecht the Netherlands Departments of Cardiology and Medical Physiology Division of Heart and Lungs University Medical Center Utrecht P.O. box 85500 3508 GA Utrecht the Netherlands Inter university Cardiology Institute of the Netherlands P.O. box 19258 2501 DG Utrecht the Netherlands Departments of Cardiology and Medical Physiology Division of Heart and Lungs University Medical Center Utrecht P.O. box 85500 3508 GA Utrecht the Netherlands Hubrecht Institute P.O box 85164 3508 AD Utrecht the Netherlands

Cardiovascular disease is a major cause of morbidity and mortality throughout the world. Most cardiovascular diseases, such as ischemic heart disease and cardiomyopathy, are associated with loss of functional cardiomyocytes. Unfortunately, the heart has a limited regenerative capacity and is not able to replace these cardiomyocytes once lost. In recent years, stem cells have been put forward as a potential source for cardiac regeneration. Pre-clinical studies that use stem cell-derived cardiac cells show promising results. The mechanisms,though, are not well understood, results have been variable, sometimes transient in the long term, and often without a mechanistic *** are still severalmajor hurdles to be taken. Stem cell-derived cardiac cells should resemble original cardiac cell types and be able to integrate in the damaged heart. Integration requires administration of stem cell-derived cardiac cells at the right time using the right mode of delivery. Once delivered, transplanted cells need vascularization, electrophysiological coupling with the injured heart, and prevention of immunological rejection. Finally, stem cell therapy needs to be safe, reproducible, and affordable. In this review, we will give an introduction to the principles of stem cell based cardiac repair.

关键词： Stem cell Regeneration Heart Cardiomyocytes

Direct GHG emissions from a pilot scale MBR-process treating municipal wastewater

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Advances in Climate Change Research 2022年第1期13卷 138-145页

作者： Christian BARESEL Jingjing YANG Niclas BORNOLD Kare TJUS linda KANDERS Klara WESTLING IVL Swedish Environmental Research Institute AB Valhallavagen 81Stockholm 10031Sweden

To evaluate direct greenhouse gas emissions from Membrane Biological Reactor(MBR),measurements of nitrous oxide(N_(2)O)and methane(CH_(4))were made at a pilot-scale MBR treating municipal wastewater Measurements were conducted during two campaigns with some changes in processes,*** a pre-aeration tank in the second measurement,different distributions of aeration in the treatment line,not the same wastewater inflow rate,two types of ultrafiltration *** was found that about 0.004% and 0.07% of the total ammonium loads were emitted as N_(2)O,CH_(4) emissions were 0.026% and 0.12% of incoming TOC(0.008% and 0.04% of incoming COD)in 2014 and *** obtained N_(2)O emission values were relatively *** study suggested that a high aeration at the beginning of the treatment line may result in significantly high emissions of both N_(2)O and CH_(4).A significant change in aeration in the membrane ultrafiltration tank did not have the same *** MBR process is known for high quality effluent but have been questioned due to its higher carbon footprint due to energy *** study gave a reference case about direct GHG emissions from MBR process and provide information for the further evaluation of MBR processes.

关键词： Greenhouse gases(GHGs) Nitrous oxide(N_(2)O) Methane(CH_(4)) Membrane biological reactor(MBR)