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Frontiers of Computer Science 2019年第2期13卷 231-246页

作者： Min GAO Bin LING linda YANG Junhao WEN Qingyu XIONG Shun LI Key Laboratory of Dependable Service Computing in Cyber Physical Society (Chongqing University) Ministry of Education Chongqing 400044 China School of Software Engineering Chongqing University Chongqing 400044 China School of Engineering University of Portsmouth Portsmouth PO1 3 AH UK

Collaborative filtering (CF) is a technique commonly used for personalized recommendation and Web service quality-of-service (QoS) prediction. However, CF is vulnerable to shilling attackers who inject fake user profiles into the system. In this paper, we first present the shilling attack problem on CF-based QoS recommender systems for Web services. Then, a robust CF recommendation approach is proposed from a user similarity perspective to enhance the resistance of the recommender systems to the shilling attack. In the approach, the generally used similarity measures are analyzed, and the DegSim (the degree of similarities with top k neighbors) with those measures is selected for grouping and weighting the users. Then, the weights are used to calculate the service similarities/differences and predictions. We analyzed and evaluated our algorithms using WS-DREAM and Movielens datasets. The experimental results demonstrate that shilling attacks influence the prediction of QoS values, and our proposed features and algorithms achieve a higher degree of robustness against shilling attacks than the typical CF algorithms.

关键词： collaborative filtering service recommendation system robustness shilling attack

Photosynthetic and Respiratory Acclimation to Experimental Warming for Four SpeCies in a Tallgrass Prairie Ecosystem

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Journal of Integrative Plant Biology 2007年第3期49卷 270-281页

作者： Xuhui Zhou Xiaozhong Liu linda L. Wallace Yiqi Luo Department of Botany and Microbiology University of Oklahoma Norman Oklahoma 73019 USA

Global temperature has been Increased by 0.6 ℃ over the past century and is predicted to Increase by 1.4-5.8 ℃ by the end of this century. It is unclear what impacts global warming will have on tallgrass species. In the present study, we examined leaf net photosynthetic rate （P.） and leaf respiration rate in darkness （Rd） of Aster erlcoldes （L.） Nesom, Ambrosia psllostachya DC., Helianthus mollis Lam., and Sorghastrum nutans （L.） Nash In response to experimental warming in a tallgrass prairie ecosystem of the Great Plains, USA, in the autumn （fall） of 2000 and through 2001. Warming has been Implemented with infrared heaters since 21 November 1999. The P. increased significantly In spring, decreased in early fall, and did not change in summer and late fall in the four species under warming compared with control. The Rd of the four species increased significantly until mid-summer and then did not change under warming. Measured temperature-response curves of P. showed that warming Increased the optimum temperature of P. （Topt） by 2.32 and 4.59 ℃ for H. mollis and S. nutans, respectively, in August, whereas there were no changes in May and September, and A. ericoldes and A. psllostachya also showed no changes in any of the 3 months. However, P. at optimum temperature （Popt） showed downregulation in September and no regulation in May and August for all four species. The temperature-response curves of Rd Illustrate that the temperature sensitivity of Rd, Q10, was lower in the warmed plots compared with the control plots, except for A. ericoides in August, whereas there were no changes In May and September for all four species. The results of the present study indicate that photosynthetic and respiratory acclimation varies with species and among seasons, occurring In the mid-growing season and not in the early and late growing seasons.

关键词： acclimation Ambrosia psilostachya climatic warming photosynthesis respiration Sorghastrum nutans tallgrass prairie temperature

Perfluoroalkyl acid transformation and mitigation by nNiFe-activated carbon nanocomposites in steady-state flow column studies

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Journal of Environmental Sciences 2023年第5期127卷 678-687页

作者： Mahsa Modiri-Gharehveran Younjeong Choi Jenny E.Zenobio linda S.Lee Department of Agronomy Purdue UniversityWest LafayetteIN 47907USA Interdisciplinary Ecological Sciences&Engineering Purdue UniversityWest LafayetteIN 47907USA

The ongoing contamination of groundwater with per-and polyfluoroalkyl substances(PFAS)has resulted in a global and rapidly growing interest in PFAS groundwater *** technologies that lead to PFAS destruction are often limited by not addressing all PFAS,being energy-intensive or not being suited for in-situ *** developed nNiFeactivated carbon(AC)nanocomposites and demonstrated varying degrees of PFAS reduction and fluoride generation with these nanocomposites in batch reactors for several *** we explore nNiFe-AC’s effectiveness to transform perfluoroalkyl acid acids(PFAAs)under steady-state flow(0.0044 to 0.15 mL/min)in nNiFe-AC:sand packed *** experiments included,two perfluorooctane sulfonate(PFOS)in deionized water and two PFAA mixtures in deionized water or bicarbonate buffer containing five perfluoroalkyl carboxylates(PFCAs,C5-C9)and three perfluoroalkyl sulfonates(PFSAs,C4,C6 and C8)at temperatures of 50 or 60℃ were *** transformation was similar in PFOS-only and PFAA mixture column ***,%PFAA transformation under flow conditions exceeded what we observed previously in batch reactors with up to 53%transformation of a PFAA mixture with∼8%*** chain PFAS dominated the PFAAs transformed and a bicarbonate matrix appeared to reduce overall *** breakthrough was slower than predicted from only sorption due to transformation;some longer chain PFAS like PFOS did not ***,nNiFe-AC technology with both in-situ and ex-situ potential application was shown to be a plausible part of a treatment train needed to address the ongoing challenge for cleaning up PFAS-contaminated waters.

关键词： PFAAs PFAS Zero valent iron Nanoparticles Remediation Groundwater

A primer on stochastic epidemic models:Formulation,numerical simulation,and analysis

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Infectious Disease Modelling 2017年第2期2卷 128-142页

作者： linda J.S.Allen Department of Mathematics and Statistics Texas Tech UniversityLubbockTX 79409-1042USA

Some mathematical methods for formulation and numerical simulation of stochastic epidemic models are ***,models are formulated for continuous-time Markov chains and stochastic differential *** well-known examples are used for illustration such as an SIR epidemic model and a host-vector malaria *** methods for approximating the probability of a disease outbreak are also discussed.

关键词： Branching process Continuous-time Markov chain Minor outbreak Stochastic differential equation

Active surveillance in low-and intermediate-risk prostate cancer

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Asian Journal of Andrology 2024年第6期26卷 582-583页

作者： linda Cerbone Giovanni Regine Fabio Calabrò Department of Medical Oncology San Camillo Forlanini HospitalRome 00152Italy Radiology Department San Camillo Forlanini HospitalRome 00152Italy Oncology Department IRCCS National Cancer Center Regina ElenaRome 00144Italy

Based on the GLOBOCAN statistics 2023, prostate cancer is the first and most commonly diagnosed cancer and the second cause of cancer death in men, with estimated 288 300 new cancer cases and 34 700 deaths.1 Interestingly, the incidence rate of prostate cancer decreased around 40% from 2007 to 2014. This reflects the recommendation of the United States Preventive Services Task Force (USPSTF) to avoid prostate-specific antigen (PSA) testing screening for ≥75 years old men in 2008 and for all men in 2012.1 In the 1990s, PSA testing for screening purpose was widely adopted. In a few years, considering how common prostate cancer is, many issues related to overdiagnosis and overtreatment of early detected localized prostate cancer raised in scientific community.2 Several studies showed that patients with early moderately and highly differentiated prostate cancer who did not undergo local treatment have a low death rate. Considering that curative treatment options such as surgery or radiotherapy are at risk of significant side effects, definition of deferred treatment approach for those patients started to become a medical need. Two different conservative approaches with different goals and inclusion criteria are considered with the aim to reduce overtreatment: active surveillance (AS) and watchful waiting (WW), as shown in Table 1. In this opinion, we will focus on AS.3,4.

关键词： testing Active raised

Do we really need a standardized approach to spontaneously ruptured hepatocellular carcinoma?

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 191-193页

作者： Tomoki Sempokuya linda L.Wong Division of Gastroenterology and Hepatology Department of MedicineJohn A.Burns School of MedicineUniversity of Hawaii at ManoaHonoluluHIUSA Department of Surgery John A.Burns School of MedicineUniversity of Hawaii at ManoaHonoluluHIUSA

Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-related death in Asian and African countries due to a high prevalence of chronic hepatitis B infections(1,2).The vast majority of current studies focus on the treatment of HCC itself rather than complications from HCC.A potentially life-threatening complication of HCC is spontaneous rupture,and its prevalence has been reportedly to be 5-15%of all HCC cases(1).This is the third leading cause of HCC-related death after tumor progression and liver failure,and there is a high mortality associated with rupture(3,4).

关键词： Hepatocellular carcinoma(HCC) spontaneous rupture liver resection trans-arterial embolization(TAE)

Ten-year survival and recurrence of hepatocellular cancer

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Hepatoma Research 2019年第10期5卷 32-41页

作者： Tomoki Sempokuya linda L.Wong Department of Medicine John A.Burns School of MedicineUniversity of Hawaii at ManoaHonoluluHawaiiHI 96813USA Division of Gastroenterology and Hepatology University of Nebraska Medical CenterOmahaNebraskaNE 68198USA Department of Surgery John A.Burns School of MedicineUniversity of Hawaii at ManoaHonoluluHawaiiHI 96813USA.

Aim:Long-term survival after hepatocellular cancer(HCC)is difficult to achieve likely related to *** study aimed to identify factors that were predictive of 10-year survival after the diagnosis of ***:In a prospectively collected database of 1374 HCC cases(1993-2019),we identified 70 patients who survived over 10 years regardless of *** then identified 164 patients in the entire cohort who either had liver resection or transplant,and died before 10 ***,tumor characteristics,treatment,recurrence and treatment of recurrence were ***:Of the 10-year survivors,36 underwent transplant,27 had liver resection and 7 patients had only locoregional *** to the non-survivors,the 10-year survivors were younger and had fewer comorbidities or recurrence,smaller tumor size,lower AST,ALT,AFP,platelets,neutrophil-to-lymphocyte *** analysis showed only age and diabetes to be negative *** occurred in 24 survivors(34.3%)with mean time to recurrence with standard deviation 57.1±42.6 months compared to 80 non-survivors(48.7%)with mean time to recurrence of 15.3±14.8 *** hepatic resection,10-year survivors had longer time to recurrence compared to non-survivors(median:31.3 months).Conclusion:Long-term survivors mostly occur after resection or transplant,but 10%of our cohort survived 10 years with only locoregional *** health status maybe an important predictor of 10-year survival for ;patients receiving liver *** of HCC occurs in both 10-year survivors and non-survivors,but later recurrence with aggressive treatment of the recurrence may allow for 10-year survival.

关键词： Hepatocellular cancer 10-year survival liver transplantation hepatic resection

Hepatitis C virus-related mixed cryoglobulinemia: Is genetics to blame?

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World Journal of Gastroenterology 2013年第47期19卷 8910-8915页

作者： Laura Gragnani Elisa Fognani Alessia Piluso Anna linda Zignego Center for Systemic Manifestations of Hepatitis Viruses Department of Experimental and Clinical MedicineUniversity of Florence50134 FlorenceItaly

Mixed cryoglobulinemia(MC)is the extrahepatic manifestation most strictly correlated with hepatitis C virus(HCV)infection;it is a benign autoimmune and lymphoproliferative disorder that evolves to lymphoma in5%-10%of *** is reputed to be a multistep and multifactorial process whose pathogenicity is still poorly *** is still unknown why only some chronically infected HCV patients develop MC and only some of these exhibit systemic symptoms(MC syndrome).Several studies have investigated the pathogenetic basis of MC and the most recent ones suggest that the virus is able to trigger such a disorder only in the presence of genetic factors that are still ***,we try to clarify the complex relationship between HCVrelated MC and the host’s genetic *** data that we report are heterogeneous and sometimes even ***,large,multicenter studies are clearly *** identification of a characteristic genetic signature of cryoglobulinemic patients would be an important step toward a personalized approach in their clinical *** new wide-ranging genomics technologies will hopefully help to resolve these complex issues.

关键词： Hepatitis C virus Mixed cryoglobulinemia Genetics Viral pathogenetic factors Host pathogenetic factors

Noninvasive genetic assessment of the population trend and sex ratio of the Shennongjia population of Sichuan snub-nosed monkeys(Rhinopithecus roxellana)

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Chinese Science Bulletin 2012年第10期57卷 1135-1141页

作者： CHANG ZongFei LIU ZhiJin YANG JingYuan LIMing VIGILANT linda Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China Department of Primatology Max Planck Institute for Evolutionary Anthropology Leipzig 04103 Germany Graduate University of the Chinese Academy of Sciences Beijing 100039 China Hubei Province Key Laboratory of Conservation Biology of Shennongjia Golden Monkey Muyu 44241l China

Effective population management relies on assessments of population size and sex ***,these estimates are difficult to obtain for elusive and rare ***,noninvasive genetic census methods have been developed as an alternative to tradi-tional capture-mark-recapture *** this study,we estimated the size of the Sichuan snub-nosed monkey(Rhinopithecus roxellana) population in the Shennongjia Nature Reserve(SNR) using a noninvasive sampling method based on 16 microsatellite *** also used a PCR-based genetic method to sex the sampled individuals and infer the population sex *** population size of *** in the SNR was estimated to be 1044 individuals(95% CITIRM:613-1409) .The estimated population sex ratio is more female-biased than expected,which we attribute to the sampling biased towards one male units and limited sampling of bachelor male ***,there is no suggestion that the heavy traffic road through the reserve might block movement of *** results of this study indicate genetic assessments based on a noninvasive sampling method can provide useful in-formation regarding populations of elusive primates.

关键词：神农架自然保护区人口规模川金丝猴性别比例遗传评估侵入性信噪比估计抽样方法