Hepatitis C virus-related mixed cryoglobulinemia: Is genetics to blame?

作     者：Laura Gragnani Elisa Fognani Alessia Piluso Anna Linda Zignego 

作者机构：Center for Systemic Manifestations of Hepatitis VirusesDepartment of Experimental and Clinical MedicineUniversity of Florence50134 FlorenceItaly 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第47期

页      面：8910-8915页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Supported by Grants from the"Associazione Italiana per la Ricerca sul Cancro"Investigator Grant,No.1461 ‘‘Istituto Toscano Tumori’’ "Fondazione Istituto di Ricerche Virologiche Oretta Bartolomei Corsi" "Ente Cassa di Risparmio di Firenze" 

主　　题：Hepatitis C virus Mixed cryoglobulinemia Genetics Viral pathogenetic factors Host pathogenetic factors 

摘      要：Mixed cryoglobulinemia(MC)is the extrahepatic manifestation most strictly correlated with hepatitis C virus(HCV)infection;it is a benign autoimmune and lymphoproliferative disorder that evolves to lymphoma in5%-10%of *** is reputed to be a multistep and multifactorial process whose pathogenicity is still poorly *** is still unknown why only some chronically infected HCV patients develop MC and only some of these exhibit systemic symptoms(MC syndrome).Several studies have investigated the pathogenetic basis of MC and the most recent ones suggest that the virus is able to trigger such a disorder only in the presence of genetic factors that are still ***,we try to clarify the complex relationship between HCVrelated MC and the host’s genetic *** data that we report are heterogeneous and sometimes even ***,large,multicenter studies are clearly *** identification of a characteristic genetic signature of cryoglobulinemic patients would be an important step toward a personalized approach in their clinical *** new wide-ranging genomics technologies will hopefully help to resolve these complex issues.