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Sleep Promotion by 3-Hydroxy-4-Iminobutyric Acid in Walnut Diaphragma juglandis Fructus

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Research 2024年第2期6卷 613-627页

作者： Jian Ji Yongli Ye lina sheng Jiadi Sun Qianqian Hong Chang Liu Jun Ding Shuxiang Geng Deping Xu Yinzhi Zhang Xiulan Sun State Key Laboratory of Food Science and Technology School of Food Science and TechnologyNational Engineering Research Center for Functional FoodSynergetic Innovation Center of Food Safety and Quality ControlJiangnan UniversityLihu Avenue 1800WuxiJiangsu 214100P.R.China College of Food Science and Pharmacy Xinjang Agricultural UniversityNo.311 Nongda Dong RoadUrumqiXinjangUygur Autonomous Region 830052P.R.China Department of Chemistry Wuhan UniversityWuhanHubei 430072P.R.China Yunnan Academy of Forestry and Grassland KunmingYunnan 650201P.R.China

Insufficient sleep can produce a multitude of deleterious repercussions on various domains of human ***,the walnut(Juglans mandshurica)confers numerous salutary biological activities pertaining to ***,the sedative and hypnotic capacities of walnut's functional constituents remain *** this investigation,we analyzed the sedative and hypnotic components of the walnut Diaphragma juglandis fructus and innovatively discovered a compound,defined as 3-hydroxy-4-iminobutyric acid(HIBA),which disrupts motor activity and enhances sleep duration by regulating the neurotransmitters(GABA,DA,etc.)within the brain and serum of ***,a metabolomics approach of the serum,basal ganglia,hypothalamus,and hippocampus as well as the gut microbiota was undertaken to unravel the underlying molecular mechanisms of sleep *** data reveal that HIBA can regulate the metabolism of basal ganglia(sphingolipids,acylcarnitines,etc.),possibly in relation to HIBA's influence on the gut microbiome(Muribaculum,Bacteroides,Lactobacillus,etc.).Therefore,we introduce a novel natural product,HIBA,and explicate the modulation of sleep promotion in mice based on the microbiota-gut-brain *** study contributes fresh insights toward natural product-based sleep research.

关键词： metabolism promotion insight

Uniformity Control of Scanned Beam in 300 MeV Proton and Heavy Ion Accelerator Complex at SESRI

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原子能科学技术 2024年第4期58卷 705-713页

作者： HOU Lingxiao YUAN Youjin SHEN Guodong RUAN Shuang LIU Jie ZHU Yunpeng WANG Geng GUO Hongliang LYU Mingbang GAO Daqing XU Zhiguo sheng lina YANG Jiancheng Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

In recent years,heavy ion accelerator technology has been rapidly developing worldwide and widely applied in the fields of space radiation simulation and particle ***,a very high uniformity in the irradiation area is required for the extracted ion beams,which is crucial because it directly affects the experimental precision and therapeutic ***,ultra-large-area and high-uniformity scanning are crucial requirements for spacecraft radiation effects assessment and serve as core specification for beamline terminal *** the 300 MeV proton and heavy ion accelerator complex at the Space Environment Simulation and Research Infrastructure(SESRI),proton and heavy ion beams will be accelerated and ultimately delivered to three irradiation *** order to achieve the required large irradiation area of 320 mm×320 mm,horizontal and vertical scanning magnets are used in the extraction beam ***,considering the various requirements for beam species and energies,the tracking accuracy of power supplies(PSs),the eddy current effect of scanning magnets,and the fluctuation of ion bunch structure will reduce the irradiation *** mitigate these effects,a beam uniformity optimization method based on the measured beam distribution was proposed and applied in the accelerator complex at *** the experiment,the uniformity is successfully optimized from 75%to over 90%after five iterations of adjustment to the PS *** this paper,the method and experimental results were introduced.

关键词： heavy ion accelerator beam uniformity scanning magnet MIC

Distributed Detection Mechanism and Resilient Consensus Strategy for Secure Voltage Control of AC Microgrids

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CSEE Journal of Power and Energy Systems 2023年第3期9卷 1066-1077页

作者： lina sheng Wei Gu Ge Cao School of Cyber Science and Engineering Southeast UniversityNanjing 211189China School of Cyber Science and Engineering and the School of Electrical EngineeringSoutheast UniversityNanjing 210096China School of Electrical Engineering Southeast UniversityNanjing 210096China

Distributed secondary control,depending on the sparse communication topology,excels for its flexibility and expandability in *** communication network plays an important role in microgrid control,but it is vulnerable to *** this paper,the mathematical model for false data injection(FDI)attacks in AC microgrids is established,and the corresponding detection mechanism based on the morphological gradient is designed for the location of cyber-attacks in communication ***,we propose a median-based resilient consensus voltage control strategy to mitigate the negative effects caused by malicious cyber-attacks and ensure the safe operation of the *** the detection method and resilient consensus control,a novel eventdriven mitigation scheme is derived to improve the resilience of microgrids under ***,a tested microgrid model composed of five different distributed generation(DG)units is simulated in the MATLAB/Simulink *** feasibility and effectiveness of the presented detection mechanism and resilient consensus strategy are verified by simulation results applying different scenarios.

关键词： Detection mechanism event-driven mitigation method FDI attacks microgrid voltage control resilient consensus control

Recent advances in metal-free CDs/g-C_(3)N_(4) photocatalysts:Synthetic strategies,mechanism insight,and applications

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Journal of Materials Science & Technology 2023年第19期150卷 11-26页

作者： Xingxing Yang lina sheng Yongli Ye Jiadi Sun Zaijun Li Xiao Ning Jin Cao Xiulan Sun State Key Laboratory of Food Science and Technology School of Food Science and TechnologyCollaborative Innovation Center of Food Safety and Quality ControlJiangnan UniversityWuxi 214122China Yixing Institute of Food and Biotechnology Co. LtdYixing 214200China School of Chemical and Material Engineering Jiangnan UniversityWuxi 214122China National Institutes for Food and Drug Control Beijing 100050China

Carbon dots/graphite carbon nitride(CDs/g-C_(3)N_(4)),a novel composite photocatalyst,has shown great po-tential for applications in energy regeneration and environmental remediation owing to its following advantages:metal-free,low cost,easily tunable,and excellent photocatalytic ***,we reviewed the development of synthetic strategies,photocatalytic enhancement mechanisms,and pho-tocatalytic applications of CDs/g-C_(3)N_(4) in this ***,the three composite strategies of CDs and g-C_(3)N_(4)-self-assembly,solvothermal,and calcination polymerization are outlined,and their advantages and disadvantages are described in ***,the photocatalytic enhancement mechanism of the com-posite strategies was elucidated according to the variation trends of CDs/g-C_(3)N_(4) band structure,electronic properties,light absorption range,and interfacial charge ***,the applications of CDs/g-C_(3)N_(4) in hydrogen evolution,pollutant degradation,CO_(2) reduction,and bacterial disinfection in recent years are reviewed ***,the current obstacles and future research directions of CDs/g-C_(3)N_(4) are discussed from the perspective of preparation technology and practical applications,respectively.

关键词： Photocatalysis Graphite carbon nitride Carbon dots Synthetic strategy Photocatalytic application

食品加工过程中丝状形态食源性致病菌的形成及防控研究进展

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微生物学通报 2024年第3期51卷 701-719页

作者：邱奕娴李晟阳卢佳琪徐舒琪吉宇涵孙嘉笛孙秀兰盛利娜江南大学食品学院江苏无锡214122

食源性致病菌引起的食源性疾病已成为我国头号食品安全问题,对公众的健康产生了严重的威胁。在食品加工过程中,渗透压、温度和pH等不利环境的胁迫作用会诱导细菌的“抵抗机制”,引发细菌异常分裂、菌体丝状化伸长。丝状形态的食源性致... 详细信息

食源性致病菌引起的食源性疾病已成为我国头号食品安全问题,对公众的健康产生了严重的威胁。在食品加工过程中,渗透压、温度和pH等不利环境的胁迫作用会诱导细菌的“抵抗机制”,引发细菌异常分裂、菌体丝状化伸长。丝状形态的食源性致病菌胁迫耐受性增强且在适宜条件下会迅速恢复分裂,使得细菌数量被严重低估,进而对食品安全造成重大影响。本文通过介绍细菌的丝状化诱导机制,为进一步控制食源性致病菌丝状化提供理论指导。

关键词：食源性致病菌丝状化异常分裂食品安全

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Commentary:Mammokine directs beige adipocytes to reserve energy for milk production in breast

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1472-1476页

作者： lina Tang Jianping Ye Metabolic Disease Research Center Zhengzhou University Affiliated Zhengzhou Central HospitalZhengzhou 450007China Research Center for Basic Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhou 450052China

Beige/brown adipocytes play a crucial role in regulating the body’s overall energy *** thermogenic function is under the influence of various tissues,including the brain,muscles,and ***,the breast tissue is not in th... 详细信息

关键词： Beige Breast Epitheliail cells scRNA-seq Thermogenesis

Harnessing bacteria for tumor therapy:Current advances and challenges

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Chinese Chemical Letters 2024年第2期35卷 97-106页

作者： lina Guo Jinsong Ding Wenhu Zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Changsha Medical University Academician WorkstationChangsha 410219China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410008China

After a century of standstill,bacteria-based tumor therapy has resurged recently benefiting from the revolution of tumor immunotherapy,which provides unique solutions to tackle the obstacles of traditional tumor *** and facultative anaerobes with active tropism can selectively colonize at tumor sites and suppress tumor growth via different mechanisms,serving as attractive tools for tumor treatment either as a monotherapy or combining with other therapies for synergistic anti-tumor *** this critical review,we introduce the recent advances of bacteria-based tumor therapy from the following ***,the general properties of bacteria are reviewed emphasizing on their structural components related to tumor immunotherapy,and the main bacteria that have been used in tumor therapy are ***,the benefits of bacteria for tumor therapy are illustrated,such as tumor targetability,deep penetration,and facile genetic engineering for attenuation,enhanced efficacy,as well as ***,anti-tumor mechanisms of bacteria are summarized,which refer to intrinsic tumoricidal activities,immune activation,bacteria metabolism,and their capability to regulate gut microbiota ***,bacteria could act as carriers to deliver various types of therapeutics to achieve combination therapy with improved *** addition,several challenges for anti-tumor applications of bacteria are discussed regarding the delivery,efficacy and safety issues,and potential solutions are also ***,the possible improvements and perspectives are discussed in the end,which provide a guideline for the design of advanced bacteria-based tumor therapeutics in the future.

关键词： Bacteria Tumor targeting Immunotherapy Combination therapy Genetic engineering Surface decoration

A new multi-turn beam dump scheme design and simulation for HIAF-BRing machine protection

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Radiation Detection Technology and Methods 2022年第4期6卷 530-539页

作者： Ren Hang Yang Jiancheng Shen Guodong Wang Geng Yao Liping Ruan Shuang sheng lina Wu Junxia Zhao He Liu Jie Cai Fucheng Gao Yunzhe Chang Mingxuan Li Minxiang Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Huizhou Research Center of Ion sciences Huizhou 516003China Lanzhou University Lanzhou 730000China

Purpose To protect accelerator devices from being damaged by high-power beam,a new beam dump system is under design for *** Based on the optical characteristics,unwanted particles are safely deﬂected to a speciﬁc internal absorber through a local bump orbit generated by active-discharging magnets,which is achieved by paralleling a bleeder resistor of 600 m�to two of dipole magnet power *** Taking alignment and multipoleﬁeld errors into account,discarded beam can be dumped within 5 ms with an efﬁciency of more than 99.8%at any operation *** The proposed beam dump solution satisﬁes the machine protection requirements for BRing and can provide a new idea for similar facilities.

关键词： HIAF Beam dump Beam losses Machine protection

Research on Alliance Decision of Dual-Channel Remanufacturing Supply Chain Considering Bidirectional Free-Riding and Cost-Sharing

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2913-2956页

作者： lina Dong Yeming Dai School of Business Qingdao UniversityQingdaoChina

This study delves into the formation dynamics of alliances within a closed-loop supply chain(CLSC)that encom-passes a manufacturer,a retailer,and an e-commerce *** leverages Stackelberg game for this exploration,contrasting the equilibrium outcomes of a non-alliance model with those of three differentiated alliance *** non-alliance model acts as a crucial benchmark,enabling the evaluation of the motivations for various supply chain entities to engage in alliance *** analysis is centered on identifying the most effective alliance strategies and establishing a coordination within these *** thoroughly investigate the consequences of diverse alliance behaviors,bidirectional free-riding and cost-sharing,and the resultant effects on the optimal decision-making among supply chain *** findings underscore several pivotal insights:(1)The behavior of alliances within the supply chain exerts variable impacts on the optimal pricing and demand of its *** comparison to the non-alliance(D)model,the manufacturer-retailer(MR)and manufacturer-e-commerce platform(ME)alliances significantly lower both offline and online resale prices for new and remanufactured *** adjustment leads to an enhanced demand for products via the MR alliance’s offline outlets and the ME alliance’s online platforms,thereby augmenting the profits for those within the ***,retailer-e-commerce platform(ER)alliance tends to increase the optimal retail price and demand across both online and offline *** specific conditions,alliance behavior can also increase the profits of non-alliance members,and the profits derived through alliance channels also exceed those from non-alliance channels.(2)The prevalence of bidirectional free-riding behavior largely remains constant across different alliance *** these models,bidirectional free-riding typically elevates the equilibrium prices in offline channel while negatively affe

关键词： Dual-channel remanufacturing supply chain alliance remanufactured products bidirectional free-riding cost-sharing