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Photo-manipulated polyunsaturated fatty acid-doped liposomal hydrogel for flexible photoimmunotherapy

Chinese Chemical Letters 2024年第4期35卷 268-274页

作者： Xinyue Lan Junguang Liang Churan Wen Xiaolong Quan Huimin lin Qinqin Xu Peixian Chen Guangyu Yao Dan Zhou Meng Yu Breast Center Department of General SurgeryNanfang HospitalSouthern Medical UniversityGuangzhou 510515China NMPA Key Laboratory for Research and evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Breast Surgery The First People's Hospital of FoshanFoshan 528100China Zhujiang Hospital Southern Medical UniversityGuangzhou 510282China

Despite the synergy of immune checkpoint blockade(iCB) therapy and photodynamic therapy(PDT) holds great promise as countermeasures against breast cancer, exploring long-term or flexible short-time therapeutic strategies in “cold” tumors remains a great challenge. Here, we present a polyunsaturated fatty acid-doped liposomal hydrogel Lp(DHA)@CP Gel loaded with photosensitizer chlorin e6(Ce6) and programmed death-ligand 1 antibody(αPD-L1) for flexible local photoimmunotherapy with merely singledosed administration. The presence of polyunsaturated fatty acid(docosahexaenoic acid, DHA) doped in particle membrane endows liposomes with flexibly reactive oxygen species(ROS)-responsive release capability, which was attributed to the presence of abundant unsaturated groups. The αPD-L1 was repeatedly induced to in situ release in response to the PDT under photo-exposure. The immunogenic cell death(iCD) effect of PDT evoked “cold” breast tumor to “hot” one, and then assisted the cascade releasedαPD-L1 to synergistically boost the immunotherapy. After a single dose of peritumoral administration of Lp(DHA)@CP Gel, the on-demand treatment can maximize patient compliance and safety by adjusting therapeutic behaviors via a photo on-off switch. This work presents a flexible medication platform,showing promise in improving the objective response rate of iCB therapy and minimizing its systemic toxicity.

关键词： Photodynamic therapy immunotherapy Responsive release immunogenic cell death Liposomal hydrogel

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Geophysical prediction of organic matter abundance in source rocks based on geochemical analysis:A case study of southwestern Bozhong Sag,Bohai Sea,China

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Petroleum Science 2024年第1期21卷 31-53页

作者： Xiang Wang Guang-Di Liu Xiao-lin Wang Jin-Feng Ma Zhen-Liang Wang Fei-Long Wang Ze-Zhang Song Chang-Yu Fan State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China State Key Laboratory of Continental Dynamics Northwest UniversityXi'an710069ShaanxiChina Department of Geology Northwest UniversityXi'an710069ShaanxiChina CNOOC Tianjin Branch Company Tianjin300459China

The Bozhong Sag is the largest petroliferous sag in the Bohai Bay Basin,and the source rocks of Paleogene Dongying and Shahejie Formations were buried *** of the drillings were located at the structural high,and there were few wells that met good quality source rocks,so it is difficult to evaluate the source rocks in the study area precisely by geochemical analysis *** on the Rock-eval pyrolysis,total organic carbon(TOC)testing,the organic matter(OM)abundance of Paleogene source rocks in the southwestern Bozhong Sag were evaluated,including the lower of second member of Dongying Formation(e_(3)d2L),the third member of Dongying Formation(e_(3)d_(3)),the first and second members of Shahejie Formation(e_(2)s_(1+2)),the third member of Shahejie Formation(e_(2)s_(3)).The results indicate that the e_(2)s_(1+2)and e_(2)s_(3)have better hydrocarbon generative potentials with the highest OM abundance,the e_(3)d_(3)are of the second good quality,and the e_(3)d2L have poor to fair hydrocarbon generative ***,the well logs were applied to predict TOC and residual hydrocarbon generation potential(S_(2))based on the sedimentary facies classification,usingΔlogR,generalizedΔlogR,logging multiple linear regression and BP neural network *** various methods were compared,and the BP neural network method have relatively better prediction *** on the pre-stack simultaneous inversion(P-wave impedance,P-wave velocity and density inversion results)and the post-stack seismic attributes,the three-dimensional(3D)seismic prediction of TOC and S_(2)was carried *** results show that the seismic near well prediction results of TOC and S_(2)based on seismic multi-attributes analysis correspond well with the results of well logging methods,and the plane prediction results are identical with the sedimentary facies map in the study *** TOC and S_(2)values of e_(2)s_(1+2)and e_(2)s_(3)are higher than those in e_(3)d_(3)and e_(3)d_(2)L,basicall

关键词： Total organic carbon(TOC) Residual hydrocarbon generation potential(S_(2)) Geophysical prediction Seismic attribute Bozhong Sag Bohai Bay Basin

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A novel responsive stabilizing Janus nanosilica as a nanoplugging agent in water-based drilling fluids for exploiting hostile shale environments

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Petroleum Science 2024年第2期21卷 1190-1210页

作者： Alain Pierre Tchameni Lv-Yan Zhuo Lesly Dasilva Wandji Djouonkep Robert Dery Nagre Lu-Xin Chen lin Zhao Chao Ma Bin-Qiang Xie College of Petroleum engineering Yangtze UniversityWuhan430100HubeiChina Key Laboratory of Drilling and Production engineering for Oil and Gas HubeiChina Lost Circulation Control Laboratory National Engineering Laboratory for Petroleum Drilling EngineeringYangtze UniversityWuhan430100HubeiChina College of Petroleum engineering Shandong Institute of Petroleum and Chemical TechnologyDongying257061ShandongChina Petroleum engineer Research institute of Petrochina Dagang Oilfield Tianjin300280China Department of Chemical engineering Kumasi Technical UniversityP.O.Box 854KumasiGhana

Thermo-responsive nanocomposites have recently emerged as potential nanoplugging agents for shale stabilization in high-temperature water-based drilling fluids(WBDFs). However, their inhibitory properties have not been very effective in high-temperature drilling operations. Thermo-responsive Janus nanocomposites are expected to strongly interact with clay particles from the inward hemisphere of nanomaterials, which drive the establishment of a tighter hydrophobic membrane over the shale surface at the outward hemisphere under geothermal conditions for shale stabilization. This work combines the synergistic benefits of thermo-responsive and zwitterionic nanomaterials to synchronously enhance the chemical inhibitions and plugging performances in shale under harsh conditions. A novel thermoresponsive Janus nanosilica(TRJS) exhibiting zwitterionic character was synthesized, characterized,and assessed as shale stabilizer for WBDFs at high temperatures. Compared to pristine nanosilica(Si NP)and symmetrical thermo-responsive nanosilica(TRS), TRJS exhibited anti-polyelectrolyte behaviour, in which electrolyte ions screened the electrostatic attraction between the charged particles, potentially stabilizing nanomaterial in hostile shaly environments(i.e., up to saturated brine or APi brine). Macroscopically, TRJS exhibited higher chemical inhibition than Si NP and TRS in brine, prompting a better capability to control pressure penetration. TRJS adsorbed onto the clay surface via chemisorption and hydrogen bonding, and the interactions became substantial in brine, according to the results of electrophoretic mobility, surface wettability, and X-ray diffraction. Thus, contributing to the firm trapping of TRJS into the nanopore structure of the shale, triggering the formation of a tight hydrophobic membrane over the shale surface from the outward hemisphere. The addition of TRJS into WBDF had no deleterious effect on fluid properties after hot-treatment at 190℃, implying that TRJ

关键词： Janus nanosilica Thermo-responsive copolymer Anti-polyelectrolyte effect Shale stabilizer inhibition Plugging Drilling fluid

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不确定环境下的航空发动机装配线适应性调度方法

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控制与决策 2024年第5期39卷 1629-1635页

作者：王怡琳刘鹃乔非张家谔同济大学电子与信息工程学院上海201800 中国航空制造技术研究院北京100020

航空发动机装配是航空发动机制造过程的关键环节,其工序多,流程复杂,生产过程中扰动频发,如装配时间波动、不合格返工等.针对不确定环境下的航空发动机装配线的调度问题,提出一种基于门控循环神经网络(GRU)的适应性调度方法.该调度方法... 详细信息

航空发动机装配是航空发动机制造过程的关键环节,其工序多,流程复杂,生产过程中扰动频发,如装配时间波动、不合格返工等.针对不确定环境下的航空发动机装配线的调度问题,提出一种基于门控循环神经网络(GRU)的适应性调度方法.该调度方法包含扰动识别和调度规则调整两个部分:扰动识别模块以滑动时间窗口为周期,利用GRU神经网络进行渐近型扰动的识别;调度规则调整模块以扰动识别的结果为触发,通过构建基于GRU神经网络的调度规则决策模型,输出适配当前生产状态的新的调度规则,用以指导生成更新的调度方案.最后,以某航空发动机装配线为研究案例,对所提出适应性调度方法进行验证分析.对比实验结果表明,所提出方法能够有效提升装配线的设备利用率、日均生产率等性能.

关键词：适应性调度扰动识别深度学习门控循环神经网络航空发动机装配调度规则

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Vonoprazan-amoxicillin dual therapy for Helicobacter pylori eradication in Chinese population:A prospective,multicenter,randomized,two-stage study

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World Journal of Gastroenterology 2024年第27期30卷 3304-3313页

作者： Xue-Ping Huang Zhi-Hui lin Yi-Juan Liu Shao-Wei lin Yan-Feng Shao Feng Qiu Qing-Wu Qiu Zhang-Kun Xu Jin-Xian Chen Liang-Huo Chen Zhen-Qun lin Wen-Hua Dai Ming-Qing Zhang Qi Jiang Zhong-Qin Xiao Xian-Xing Cheng Xiang-Fei Zhang Wen-Bin You Wei Chen Long-Qin Li Wei-Xing lin Yong-Fu Wang Fu-Jin Lai Long-Qun Chen Zhong-Hua Huang Wen-Qi Zheng Jin-Qi Wei Department of Gastroenterology Shengli Clinical Medical College of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina School of Public Health Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The Third People’s Hospital of Fujian ProvinceFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Fujian Provincial Hospital North Brance Fujian Provincial Geriatric HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Xiaoao HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The General Hospital of Fujian Energy GroupFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The Second Hospital of ZhangzhouZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology Anxi Country HospitalQuanzhou 362000Fujian ProvinceChina Department of Gastroenterology Zhangzhou Municipal Hospital of TCMZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology Zhangpu HospitalZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology The Affiliated Dongnan Hospital of Xiamen UniversityZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology First Hospital of Nanping CityNanping 353000Fujian ProvinceChina Department of Gastroenterology Fujian Nanping Second HospitalNanping 353000Fujian ProvinceChina Department of Gastroenterology Wuyishan Municipal HospitalNanping 353000Fujian ProvinceChina Department of Gastroenterology Fuzhou Changle District HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Changle City Second HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Jinjiang Municipal HospitalQuanzhou 362000Fujian ProvinceChina Department of Gastroenterology Fuding Hospital Affiliated to Fuj

BACKGROUND The efficacy of Vonoprazan-amoxicillin dual therapy(VAT)in the treatment of Helicobacter pylori(***)is *** To evaluate the efficacy of VAT in the Chinese *** This prospective,multicenter,randomized,open-label,and two-stage study was conducted at 23 centers in Fujian,China(May 2021-April 2022).***-infected patients were randomized to bismuth quadruple therapy(BQT),BQT-Vonoprazan(BQT-V),seven-day VAT(VAT-7),ten-day VAT(VAT-10),and fourteen-day VAT(VAT-14)*** primary endpoint was the *** eradication *** secondary endpoint was the frequency of adverse *** study was registered with the Chinese Clinical Trial Registry,*** in the first stage,VAT-7 and BQT-V groups were selected for early termination because less than 23 among 28 cases were *** the second stage,the eradication rates for BQT,VAT-10,and VA-14 were 80.2%[95%confidence interval(95%Ci):71.4%-86.8%],93.2%(86.6%-96.7%),92.2%(85.3%-96.0%)in the intention-to-treat(iTT)analysis,and 80.9%(95%Ci:71.7%-87.5%),94.0%(87.5%-97.2%),and 93.9%(87.4%-97.2%)in the per-protocol *** iTT analysis showed a higher eradication rate in the VAT-10 and VAT-14 groups than in the BQT group(P=0.022 and P=0.046,respectively).The incidence of adverse events in the VAT-10 and VAT-14 groups was lower than in the BQT group(25.27%and 13.73%vs 37.62%,respectively;PiON VAT with a duration of 10 or 14 days achieves a higher eradication rate than the BQT,with a more tolerable safety profile in ***-infected patients in *** XP et *** for *** eradication.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Bismuth quadruple therapy

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Soft multifunctional neurological electronic skin through intrinsically stretchable synaptic transistor

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Nano Research 2024年第7期17卷 6550-6559页

作者： Pengcheng Zhu Shuairong Mu Wenhao Huang Zeye Sun Yuyang lin Ke Chen Zhifeng Pan Mohsen Golbon Haghighi Roya Sedghi Junlei Wang Yanchao Mao Key Laboratory of Materials Physics of Ministry of education School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450001China School of Mechanical and Power engineering Zhengzhou UniversityZhengzhou 450001China Department of Chemistry Shahid Beheshti UniversityTehran ***Iran

Neurological electronic skin(e-skin)can process and transmit information in a distributed manner that achieves effective stimuli perception,holding great promise in neuroprosthetics and soft *** e-skin with multifunctional perception abilities can enable robots to precisely interact with the complex surrounding ***,current neurological e-skins that possess tactile,thermal,and visual perception abilities are usually prepared with rigid materials,bringing difficulties in realizing biologically synapse-like ***,we report a soft multifunctional neurological e-skin(SMNe)comprised of a poly(3-hexylthiophene)(P3HT)nanofiber polymer semiconductor-based stretchable synaptic transistor and multiple soft artificial sensory receptors,which is capable of effectively perceiving force,thermal,and light *** stretchable synaptic transistor can convert electrical signals into transient channel currents analogous to the biological excitatory postsynaptic *** it also possesses both short-term and long-term synaptic plasticity that mimics the human memory *** integrating a stretchable triboelectric nanogenerator,a soft thermoelectric device,and an elastic photodetector as artificial receptors,we further developed an SMNe that enables the robot to make precise actions in response to various surrounding *** with traditional neurological e-skin,our SMNe can maintain the softness and adaptability of biological synapses while perceiving multiple stimuli including force,temperature,and *** SMNe could promote the advancement of e-skins for intelligent robot applications.

关键词： electronic skin soft stretchable polymer semiconductor synaptic transistor multifunctional

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Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1147-1164页

作者： Yan Guo Pan Xiang Xiaojiao Sun Wei Liu Jiafeng Zhou Bin Yin lin Hou Boqin Qiang Huiliang Li Pengcheng Shu Xiaozhong Peng Department of Molecular Biology and Biochemistry Institute of Basic Medical SciencesMedical Primate Research CenterNeuroscience CenterChinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijingChina State Key Laboratory of Common Mechanism Research for Major Diseases Beijing 100005China Wolfson institute for Biomedical Research University College LondonGower StreetLondon WC1E 6BTUK Chinese institute for Brain Research Beijing 102206China State Key Laboratory of Respiratory Health and Multimorbidity Beijing 100005China institute of Laboratory Animal Science Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China

The appropriate and specific response of nerve cells to various external cues is essential for the establishment and maintenance of neural circuits,and this process requires the proper recruitment of adaptor molecules to selectively activate downstream ***,we identified that DOK6,a member of the Dok(downstream of tyrosine kinases)family,is required for the maintenance of peripheral axons,and that loss of Dok6 can cause typical peripheral neuropathy symptoms in mice,manifested as impaired sensory,abnormal posture,paw deformities,blocked nerve conduction,and ***,Dok6 is highly expressed in peripheral neurons but not in Schwann cells,and genetic deletion of Dok6 in peripheral neurons led to typical peripheral myelin outfolding,axon destruction,and hindered retrograde axonal ***,DOK6 acts as an adaptor protein for selectivitymediated neurotrophic signal transduction and retrograde transport for TrkC and Ret but not for TrkA and ***6 interacts with certain proteins in the trafficking machinery and controls their phosphorylation,including MAP1B,Tau and Dynein for axonal transport,and specifically activates the downstream eRK1/2 kinase pathway to maintain axonal survival and *** finding provides new clues to potential insights into the pathogenesis and treatment of hereditary peripheral neuropathies and other degenerative diseases.

关键词： impaired restrain peripheral

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Spatiotemporal Variability and environmental Controls of Temperature Sensitivity of ecosystem Respiration across the Tibetan Plateau

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Advances in Atmospheric Sciences 2024年第9期41卷 1821-1842页

作者： Danrui SHeNG Xianhong MeNG Shaoying WANG Zhaoguo Li Lunyu SHANG Hao CHeN lin ZHAO Mingshan DeNG Hanlin NiU Pengfei XU Xiaohu WeN Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Zoige Plateau Wetlands ecosystem Research Station Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China Key Laboratory of ecological Safety and Sustainable Development in Arid Lands Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

Warming-induced carbon loss via ecosystem respiration(R_(e))is probably intensifying in the alpine grassland ecosystem of the Tibetan Plateau owing to more accelerated warming and the higher temperature sensitivity of R_(e)(Q_(10)).However,little is known about the patterns and controlling factors of Q_(10)on the plateau,impeding the comprehension of the intensity of terrestrial carbon-climate feedbacks for these sensitive and vulnerable ***,we synthesized and analyzed multiyear observations from 14 sites to systematically compare the spatiotemporal variations of Q_(10)values in diverse climate zones and ecosystems,and further explore the relationships between Q_(10)and environmental ***,structural equation modeling was utilized to identify the direct and indirect factors predicting Q_(10)values during the annual,growing,and non-growing *** results indicated that the estimated Q_(10)values were strongly dependent on temperature,generally,with the average Q_(10)during different time periods increasing with air temperature and soil temperature at different measurement depths(5 cm,10 cm,20 cm).The Q_(10)values differentiated among ecosystems and climatic zones,with warming-induced Q_(10)declines being stronger in colder regions than elsewhere based on spatial *** was the most cardinal factor in predicting annual Q_(10)values,significantly and positively correlated with Q_(10).Soil temperature(Ts)was identified as the other powerful predictor for Q_(10),and the negative Q_(10)-Ts relationship demonstrates a larger terrestrial carbon loss potentiality in colder than in warmer regions in response to global *** that the interpretations of the effect of soil moisture on Q_(10)were complicated,reflected in a significant positive relationship between Q_(10)and soil moisture during the growing season and a strong quadratic correlation between the two during the annual and non-growing *** findings are conducive to imp

关键词： carbon cycle eddy covariance measurements ecosystem respiration Q_(10)value Tibetan Plateau climate change

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Using Copula functions to predict climatic change impacts on floods in river source regions

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Advances in Climate Change Research 2024年第3期15卷 406-418页

作者： Ting-Xing CHeN Hai-Shen LYU Robert HORTON Yong-Hua ZHU Ren-Sheng CHeN Ming-Yue SUN Ming-Wen LiU Yu lin The National Key Laboratory of Water Disaster Prevention College of Hydrology and Water ResourcesHohai UniversityNanjing 2098China College of Hydrology and Water Resources Hohai UniversityNanjing 210098China Departmentof Agronomy lowa State UniversityAmes IA5oollUSA Qilian Alpine eology and Hydrology Research Station Northwest Instiuteof Eco-Environmentand ReourcesChinese Academy of SciencesLanzhou0000 China

Flood frequency in river source regions is significantly affected by rainfall and snowmelt as part of climatic changes.A traditional univariate flood frequency analysis cannot reflect the complexity of floods,and when used in isolation,it can only underestimate flood *** effective flood prevention and mitigation,it is essential to consider the combined effects of precipitation and *** functions can effectively quantify the joint distribution relationship between floods and their associated variables without restrictions on their distribution *** study uses copula functions to consider a multivariate probability distribution model of flood peak flow(Q)with cumulative snowmelt(CSm)and cumulative precipitation(CPr)for the Hutubi River basin located in northern Xinjiang,*** joint frequencies of rainfall and snowmelt floods are predicted using copula models based on the Coupled Model intercomparison Project Phase 6 *** results show that Q has a significant positive correlation with 24-d CSm(r=0.559,p=0.002)and 23-d CPr(r=0.965,pequency will increase in the future,and mid-(2050e2074)and long-term(2075e2099)floods will be more severe than those in the near-term(2025e2049).The probability of flood occurrence is higher under the SSP2-4.5 and SSP1-2.6 scenarios than under *** during the historical period(1990e2014)led to extreme floods,and increasing future precipitation trends are found to be *** increases with rising temperatures and occurs earlier than estimated,leading to an earlier flood period in the basin and more frequent snowmelt *** Q under the joint return period is larger than that during the same univariate return *** difference indicates that neglecting the interaction between precipitation and snowmelt for floods leads to an underestimation of the flood risk(with underestimations ranging from 0.3%to 22%).The underestimations decrease with an increase

关键词： Climate change Flood frequency Copula CMiP6 River source regions

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Reducing children’s exposure to di(2-ethylhexyl)phthalate in homes and kindergartens in China:impact on lifetime cancer risks and burden of disease

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Building Simulation 2024年第3期17卷 431-440页

作者： Dongsheng Tao Wen Sun Donghui Mo Yonghui lin Wei Lv Daniel Mmereki Yousheng Xu Yanghui Ye Yuanjun Tang Chao Ye Cong Dong Zhongming Bu Zhejiang ecowell energy Management Technology Co. LtdHangzhouChina Department of energy and environmental System engineering Zhejiang University of Science and TechnologyHangzhouChina Faculty of Health Sciences School of Clinical MedicineUniversity of the WitwatersrandParktown2193JohannesburgSouth Africa

exposure to di(2-ethylhexyl)phthalate(DeHP)in the indoor environment has been linked with significant health risks for Chinese ***-phase DeHP concentrations in Chinese residences and kindergartens were estimated using a mass balance model based on the current baseline condition and control strategies(i.e.,increasing ventilation rate,reducing area of sources,using mechanical ventilation systems,and using portable air cleaners).The health benefits of each control strategy were quantified as the reduction in lifetime cancer risks(LCR)and burden of disease(BoD).in the current situation,the mean LCR and disability-adjusted life years(DALY)number attributable to indoor DeHP exposure for Chinese children were around 6.0×10^(−6) and 155 thousand,*** mean LCR and DALY might be reduced by 25%-54%and 16%-40%,respectively,by increasing air exchange rates by 100%,reducing the use of source materials by two-thirds or deploying commercial air cleaners in naturally ventilated ***,avoidable DALYs could result in a reduction of mean economic losses of 2.2-5.3 billion *** ventilation systems with filtration units may not be helpful for reducing children’s health ***-specific and tailor-made control measures are critical in lowering indoor exposure to DeHP to promote sustainable buildings and children’s health in China.

关键词： indoor air di(2-ethylhexyl)phthalate children exposure control strategies health benefits

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