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The Functional Motif of SARS-CoV S Protein Involved in the Interaction with ACE2

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中国病毒学 2007年第1期22卷 1-7页

作者： Yi ZHANG Wei WANG Jin-rong GAO Li ye Xiao-nan FANG Ying-chun ZENG Zheng-hui WU Ying-long SHE lin-bai ye State Key Laboratory of Virology College of Life Science Wuhan University Wuhan 430072 China

SARS-CoV 是一最新引起严重尖锐呼吸问题的发现病原体。在这病原体的 S 蛋白质由和 ACE2 受体的相互作用在 SARS-CoV 的吸附和穿入玩一条重要规则进宿主细胞，这被建立了。到 S 蛋白质的功能的主题涉及和 ACE2 的相互作用的决定因素，从... 详细信息

SARS-CoV 是一最新引起严重尖锐呼吸问题的发现病原体。在这病原体的 S 蛋白质由和 ACE2 受体的相互作用在 SARS-CoV 的吸附和穿入玩一条重要规则进宿主细胞，这被建立了。到 S 蛋白质的功能的主题涉及和 ACE2 的相互作用的决定因素，从 N 或 C 终端删除的七截断的 S 蛋白质被一个 *** 表达式系统获得并且由列层析净化了到同质。每截断的 S 蛋白质被修理在上到 ELISA 的井，板和一个相互作用与 ACE2 蛋白质被开始。吸附被 ELISA 确定，并且结果显示从 388 ～ 496 S 蛋白质的氨基酸为和 ACE2 受体的相互作用负责，并且相互作用能被对这些氨基酸特定的抗体完全破坏。邻近这个领域的删除不看起来在和 ACE2 的相互作用上有重要影响，建议 SARS-CoV 的 S 蛋白质能作为阻止 SARS-CoV 的传播的一支疫苗被开发。关键词 SARS-CoV - S 蛋白质 - ACE2 - 相互作用 CLC 数字

关键词： SARS-CoV S protein ACE2 Interaction

Restraining growth of Zn dendrites by poly dimethyl diallyl ammonium cations in aqueous electrolytes

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Rare Metals 2024年第8期43卷 3735-3747页

作者： Xiang-Xin Zhang Yuan-Qiang Chen Chang-Xin lin Yuan-Sheng lin Guo-lin Hu Yong-Chuan Liu Xi-Lai Xue Su-Jing Chen Zhan-lin Yang bai-Sheng Sa Yi-Ning Zhang Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Helmholtz Institute Ulm(HIU) 89081 UlmGermany Karlsruhe Institute of Technology(KIT) 76021 KarlsruheGermany College of Materials Science and Engineering Fuzhou UniversityFuzhou350108China

Metallic zinc is an excellent anode material for Zn-ion batteries,but the growth of Zn dendrite severely hinders its practical ***,an efficient and economical cationic additive,poly dimethyl diallyl ammonium(PDDA) was reported,used in aqueous Zn-ion batteries electrolyte for stabilizing Zn *** growth of zinc dendrites can be significantly restrained by benefiting from the pronounced electrostatic shielding effect from PDDA on the Zn metal ***,the PDDA is preferentially absorbed on Zn(002) plane,thus preventing unwanted side reactions on Zn *** to the introduction of a certain amount of PDDA additive into the common ZnSO_(4)-based electrolyte,the cycle life of assembled Zn‖Zn cells(1 mA·cm^(-2) and 1 mAh·cm^(-2)) is prolonged to more than 1100 *** response to the perforation issue of Zn electrodes caused by PDDA additives,the problem can be solved by combining foamy copper with zinc *** real application,Zn-ion hybrid supercapacitors and MnO_(2)‖Zn cells were assembled,which exhibited excellent cycling stability with PDDA *** work provides a new solution and perspective to cope with the dendrite growth problem of Zn anode.

关键词： PDDA Electrostatic shielding effect Zn anode Zn dendrites

The Relationships between Executive Function and Problem Behavior of Preschool Children:Contextual Specificity and Gender Differences

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Frontiers of Education in China 2024年第2期19卷 119-137页

作者： bai Rong YAN Rong WANG Qian LI ye XING Shufen Beijing Key Laboratory of Learning and Cognition School of PsychologyCapital Normal UniversityBeijing 100048China Institute of Leadership and Education Advanced Development Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China

This study utilized a longitudinal design to examine the relationships between the specific components of executive function(EF)and the internalizing and externalizing behavior across different genders and contexts in Chinese cultural ***,cognitive flexibility,and working memory of EF based on 101 preschool children’s(48 boys and 53 girls)(M_(T1)=4.25,SD=0.76)performances were measured when completing tasks in NIH *** months later,boys’and girls’internalizing and externalizing behavior in home-and school-settings was assessed through mother’s feedback on the Strengths and Difficulties Questionnaire and teachers’reports of the Child Behavior Rating *** results show that boys’inhibition,cognitive flexibility,and working memory negatively predict their externalizing behavior in the home context,while their cognitive flexibility negatively predicts externalizing behavior in the school ***,boys’inhibition positively predicts their internalizing behavior only in the school *** girls,their cognitive flexibility positively predicts externalizing behavior only in the school *** significant relationship is found among the girls between EF and problem behavior in the home *** findings suggest that gender differences and a shift in contexts could alternate the relationship between EF and children’s problem *** study sheds light on targeted preventions and interventions based on contexts and gender.

关键词： executive function(EF) problem behavior contextual specificity gender differences preschool children

Responses of growth performance,antioxidant function,small intestinal morphology and mRNA expression of jejunal tight junction protein to dietary iron in yellow-feathered broilers

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Journal of Integrative Agriculture 2024年第4期23卷 1329-1337页

作者： Kaiwen Lei Hao Wu Jerry W Spears Xi lin Xi Wang Xue bai Yanling Huang Key Laboratory of Animal Science of State Ethnic Affairs Commission Southwest Minzu UniversityChengdu 610041China Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization Southwest Minzu UniversityChengdu 610041China Department of Animal Science North Carolina State UniversityRaleighNC 27695-7621USA

This study aimed to investigate the dose-effect of iron on growth performance,antioxidant *** morphology,and mRNA expression of jejunal tight junction protein in 1-to21-d-old yellow-feathered broilers.A total of 7201-d-old yellow-feathered maleb roilers were allocated to 9 treatments with 8 replicate cages of 10 birds per *** dietary treatments were consisted of a basal diet(contained 79.6 mg Fe kg^(-1))supplemented with 0,20,40,60,80,160,320,640,and 1,280 mg Fe kg^(-1)in the form of FeSO_(4)·7H_(2)*** with the birds in the control group,birds supplemented with 20mg Fe kg^(-1)had higher average daily gain(ADG)(Plinearly(Plinearly(Plinearly(P?0.05)as dietary *** dietary Fe increased,the jejunal relative mRNA abundance of claudin-1 decreased linearly(P=0.001),but the jejunal relative mRNA abundance of zona occludens-1(ZO-1)and occludin decreased linearly(P?0.05)or quadratically(P?0.05).Compared with the supplementation of 20 mg Fe kg^(-1),the supplementation of640 mg Fe kg^(-1)or higher increased(P?0.05)MDA concentrations in plasma,duodenum,and jejunum,decreased VH in the duodenum and jejunum,and the addition of 1,280 mg Fe kg^(-1)reduced(P?0.05)the jejunal tight junction protein(claudin-1,ZO-1,occludin)mRNA *** summary,640 mg of supplemental Fe kg^(-1)or greater was associated with decreased growth performance,increased oxidative stress,disrupted intestinal morphology,and reduced mRNA expression of jejunal tight junction protein.

关键词： iron yellow-feathered broiler antioxidant function intestinal morphology tight junction protein

Normal sperm head morphometric reference values in fertile Asian males

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Asian Journal of Andrology 2024年第3期26卷 315-320页

作者： ye-lin Jia Ying-Bi Wu lin Yu Yan Zheng Ting-Ting Yang Yan-Yun Wang Bin Zhou lin Zhang Fu-Ping Li Laboratory of Andrology West China Second University Hospital Human Sperm BankChengdu 610000China Laboratory of Molecular Translational Medicine Center for Translational MedicineChengdu 610061China Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengdu 610061China NHC Key Laboratory of Chronobiology West China Second University HospitalSichuan UniversityChengdu 610000China

Sperm head morphology is crucial for male factor infertility diagnosis and assessment of male reproductive *** are available to analyze sperm head morphology,but they are limited by poor methodology comparability and *** study aimed to explore comprehensive and new normal morphometric reference values for spermatozoa heads infertile Asian *** automated sperm morphology analysis system captured 23152 stained spermatozoa from confirmed *** these samples,1856 sperm head images were annotated by three experienced laboratory technicians as“normal”.Weemployed 14 novel morphometric features to describe sperm head size(head length,head width,length/width ratio,and girth),shape(ellipse intersection over union,girth intersection over union,short-axis symmetry,and long-axis symmetry),area(head,acrosome,postacrosomal areas,and acrosome area ratio),and degrees of acrosome and nuclear *** straight-forwardmethod for the morphometric analysis of sperm by accurate visual measurements is clinically *** measured parameterspresent valuable information to establish morphometric reference intervals for normal sperm heads in fertile Asian *** detailed measurement data will be valuable for interlaboratory comparisons and technician *** vitro fertilizationand andrology laboratory technicians can use these parameters to perform objective morphology evaluation when assessing malefertilization potential.

关键词： fertile Asian males head morphometric reference value normal spermatozoa

Genome editing toward biofortified soybean with minimal trade-off between low phytic acid and yield

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aBIOTECH 2024年第2期5卷 196-201页

作者： Wenxin lin Mengyan bai Chunyan Peng Huaqin Kuang Fanjiang Kong Yuefeng Guan Sanya Institute of China Agricultural University Sanya 572000China College of Agronomy China Agricultural UniversityBeijing 100193China Guangdong Provincial Key Laboratory of Plant Adaptation and Molecular Design Innovative Center of Molecular Genetics and EvolutionSchool of Life SciencesGuangzhou UniversityGuangzhou 510006China College of Life Sciences Fujian Agriculture and Forestry UniversityFuzhou 350002China

Phytic acid(PA)in grain seeds reduces the bioavailability of nutrient elements in monogastric animals,and an important objective for crop seed biofortification is to decrease the seed PA ***,we employed CRISPR/Cas9 to generate a PA mutant population targeting PA biosynthesis and transport genes,including two multi-drug-resistant protein 5(MRP5)and three inositol pentose-phosphate kinases(IPK1).We characterized a variety of lines containing mutations on multiple IPK and MRP5 *** seed PA was more significantly decreased in higher-order mutant lines with multiplex ***,such mutants also exhibited poor agronomic *** the population,we identified two lines carrying single mutations in ipk1b and ipk1c,*** mutants exhibited moderately reduced PA content,and regular agronomic performance compared to the wild *** study indicates that moderately decreasing PA by targeting single GmIPK1 genes,rather than multiplex mutagenesis toward ultra-low PA,is an optimal strategy for low-PA soybean with a minimal trade-off in yield performance.

关键词： Genome editing Phytic acid Soybean Agronomic traits CRISPR/Cas9

Reducing children’s exposure to di(2-ethylhexyl)phthalate in homes and kindergartens in China:Impact on lifetime cancer risks and burden of disease

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Building Simulation 2024年第3期17卷 431-440页

作者： Dongsheng Tao Wen Sun Donghui Mo Yonghui lin Wei Lv Daniel Mmereki Yousheng Xu Yanghui ye Yuanjun Tang Chao ye Cong Dong Zhongming Bu Zhejiang Ecowell Energy Management Technology Co. LtdHangzhouChina Department of Energy and Environmental System Engineering Zhejiang University of Science and TechnologyHangzhouChina Faculty of Health Sciences School of Clinical MedicineUniversity of the WitwatersrandParktown2193JohannesburgSouth Africa

Exposure to di(2-ethylhexyl)phthalate(DEHP)in the indoor environment has been linked with significant health risks for Chinese ***-phase DEHP concentrations in Chinese residences and kindergartens were estimated using a mass balance model based on the current baseline condition and control strategies(i.e.,increasing ventilation rate,reducing area of sources,using mechanical ventilation systems,and using portable air cleaners).The health benefits of each control strategy were quantified as the reduction in lifetime cancer risks(LCR)and burden of disease(BoD).In the current situation,the mean LCR and disability-adjusted life years(DALY)number attributable to indoor DEHP exposure for Chinese children were around 6.0×10^(−6) and 155 thousand,*** mean LCR and DALY might be reduced by 25%-54%and 16%-40%,respectively,by increasing air exchange rates by 100%,reducing the use of source materials by two-thirds or deploying commercial air cleaners in naturally ventilated ***,avoidable DALYs could result in a reduction of mean economic losses of 2.2-5.3 billion *** ventilation systems with filtration units may not be helpful for reducing children’s health ***-specific and tailor-made control measures are critical in lowering indoor exposure to DEHP to promote sustainable buildings and children’s health in China.

关键词： indoor air di(2-ethylhexyl)phthalate children exposure control strategies health benefits

Preparation and Rheological Characterization of Long Chain Branching Polyglycolide

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Chinese Journal of Polymer Science 2024年第8期42卷 1177-1184页

作者： Wei-lin Liu Ming-Fu Lyu Heng-Yuan Zhang Jian-ye Liu Shi-Jun Zhang Beijing University of Chemical Technology Beijing 100029China SINOPEC(Beijing)Research Institute of Chemical Industry Co. Ltd.Beijing 100013China

The long chain branching(LCB)polyglycolide(PGA)was successfully prepared by the successive reactions of the terminal hydroxyl groups of PGA with triglycidyl isocyanurate(TGIC)and pyromellitic dianhydride(PMDA).The influence of LCB produced by functional group reaction on rheological and crystallization behavior was studied and discussed through linear rheology,uniaxial elongation and DSC(differential scanning calorimetry).The much higher viscosity and the more notable strain hardening behavior of modified PGA indicates the LCB with high degree of entanglements are *** melt strength of PGA is finally improved greatly and can make su re that the supercritical CO_(2)foaming can be carried out successfully.

关键词： Polyglycolide(PGA) Long chain branching(LCB) Rheology

Fabrication of Silane and Desulfurization Ash Composite Modified Polyurethane and Its Interfacial Binding Mechanism

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Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 288-297页

作者：吴旺华 CHEN Shuichang ye Haodong 李世迁 lin Yuanzhi 陈庆华 XIAO Liren College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350117China College of Materials and Package Engineering Fujian Provincial Key Lab of Coastal Basin EnvironmentFujian Polytechnic Normal UniversityFuqing 350300China College of Agriculture Guangxi UniversityGuangxi 530004China

Polyurethane/desulfurization ash(PU/DA)composites were synthesized using"one-pot method",with the incorporation of a silane coupling agent(KH550)as a"molecular bridge"to facilitate the integration of DA as hard segments into the PU molecular *** effects of DA content(φ)on the mechanical properties,thermal stability,and hydrophobicity of PU,both before and after the addition of KH550,were thoroughly *** results of microscopic mechanism analysis confirmed that KH550 chemically modified the surface of DA,facilitating its incorporation into the polyurethane molecular chain,thereby significantly enhancing the compatibility and dispersion of DA within the PU *** the mass fraction of modified DA(MDA)reached 12%,the mechanical properties,thermal stability,and hydrophobicity of the composites were substantially improved,with the tensile strength reaching 14.9 MPa,and the contact angle measuring 100.6°.

关键词： polyurethane silane coupling agent desulfurization ash modification mechanical property hydrophobicity thermal stability