检索结果-南通市图书馆

Genome-wide CRISPR screening identifies critical role of phosphatase and tensin homologous (PTEN) in sensitivity of acute myeloid leukemia to chemotherapy

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第8期25卷 700-710页

作者： Liming lin Jingjing TAO Ying MENG Yichao GAN xin HE Shu LI Jiawei ZHANG Feiqiong GAO Dijia xin Luyao WANG Yili FAN Boxiao CHEN Zhimin LU Yang xu Department of Hematology the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Zhejiang Provincial Key Laboratory of Pancreatic Disease the First Affiliated Hospital and Institute of Translational MedicineCancer CenterZhejiang University School of MedicineHangzhou 310029China Institute of Genetics Zhejiang UniversityHangzhou 310058China Division of Hematopoietic Stem Cell&Leukemia Research Beckman Research Institute of City of HopeDuarteCA 91010USA Department of Hematology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Although significant progress has been made in the development of novel targeted drugs for the treatment of acute myeloid leukemia(AML)in recent years,chemotherapy still remains the mainstay of treatment and the overall survival is poor in most ***,we demonstrated the antileukemia activity of a novel small molecular compound NL101,which is formed through the modification on bendamustine with a suberanilohydroxamic acid(SAHA)***101 suppresses the proliferation of myeloid malignancy cells and primary AML *** induces DNA damage and caspase 3-mediated apoptosis.A genome-wide clustered regularly interspaced short palindromic repeats(CRISPR)library screen revealed that phosphatase and tensin homologous(PTEN)gene is critical for the regulation of cell survival upon NL101 *** knockout or inhibition of PTEN significantly reduced NL101-induced apoptosis in AML and myelodysplastic syndrome(MDS)cells,accompanied by the activation of protein kinase B(AKT)signaling *** inhibition of mammalian target of rapamycin(mTOR)by rapamycin enhanced the sensitivity of AML cells to NL101-induced cell *** findings uncover PTEN protein expression as a major determinant of chemosensitivity to NL101 and provide a novel strategy to treat AML with the combination of NL101 and rapamycin.

关键词： Genome-wide clustered regularly interspaced short palindromic repeats(CRISPR)library Phosphatase and tensin homologous(PTEN) Rapamycin Acute myeloid leukemia(AML) Chemotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Boosting MA-based two-dimensional Ruddlesden-Popper perovskite solar cells by incorporating a binary spacer

引用

Journal of Energy Chemistry 2024年第8期95卷 348-356,I0008页

作者： xue Dong Yinhao Tang Yiqun Li xin Li Yuzhen Zhao Wenqi Song Fangmin Wang Shudong xu Yipeng Zhou Chenxin Ran Zongcheng Miao lin Song Zhongbin Wu Xi’an Key Laboratory of Advanced Photo-Electronics Materials and Energy Conversion Device Technological Institute of Materials&Energy Science(TIMES)Xijing UniversityXi’an 710123ShaanxiChina Frontiers Science Center for Flexible Electronics Xi’an Institute of Flexible Electronics(IFE)Northwestern Polytechnical UniversityXi'an 710072ShaanxiChina School of Artificial Intelligence Optics and Electronics(iOPEN) Northwestern Polytechnical UniversityXi'an 710072ShaanxiChina

Two-dimensional Ruddlesden-Popper(2DRP)perovskite exhibits excellent stability in perovskite solar cells(PSCs)due to introducing hydrophobic long-chain organic ***,the poor charge transporting property of bulky organic cation spacers limits the performance of 2DRP *** by the Asite cation alloying strategy in 3D perovskites,2DRP perovskites with a binary spacer can promote charge transporting compared to the unary spacer ***,the superior MA-based 2DRP perovskite films with a binary spacer,including 3-guanidinopropanoic acid(GPA)and 4-fluorophenethylamine(FPEA)are *** films(GPA_(0.85)FPEA_(0.15))_(2)MA_(4)Pb_5I_(16)show good morphology,large grain size,decreased trap state density,and preferential orientation of the as-prepared ***,the present 2DRP-based PSC with the binary spacer achieves a remarkable efficiency of 18.37%with a V_(OC)of1.15 V,a J_(SC)of 20.13 mA cm^(-2),and an FF of 79.23%.To our knowledge,the PCE value should be the highest for binary spacer MA-based 2DRP(n≤5)PSCs to ***,owing to the hydrophobic fluorine group of FPEA and the enhanced interlayer interaction by FPEA,the unencapsulated 2DRP PSCs based on binary spacers exhibit much excellent humidity stability and thermal stability than the unary spacer counterparts.

关键词： Perovskite solar cells Two-dimensional Ruddlesden-Popper perovskite Binary spacers Stability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

RNase P:Beyond Precursor tRNA Processing

引用

Genomics, Proteomics & Bioinformatics 2024年第1期22卷 19-28页

作者： Peipei Wang Juntao lin Xiangyang Zheng xingzhi xu Guangdong Key Laboratory for Genome Stability&Disease Prevention and Marshall Laboratory of Biomedical Engineering Shenzhen University Medical SchoolShenzhen UniversityShenzhen 518060China Department of Urology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000China Shenzhen University General Hospital-Dehua Hospital Joint Research Center on Precision Medicine Dehua HospitalDehua 362500China

Ribonuclease P(RNase P)was first described in the 1970’s as an endoribonuclease acting in the maturation of precursor transfer RNAs(tRNAs).More recent studies,however,have uncovered non-canonical roles for RNase P and its ***,we review the recent progress of its involvement in chromatin assembly,DNA damage response,and maintenance of genome stability with implications in *** possibility of RNase P as a therapeutic target in cancer is also discussed.

关键词： RNase P Chromatin assembly DNA damage response Genome stability Tumorigenesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Machine learning-based performance predictions for steels considering manufacturing process parameters:a review

引用

Journal of Iron and Steel Research International 2024年第7期31卷 1555-1581页

作者： Wei Fang Jia-xin Huang Tie-xu Peng Yang Long Fu-xing Yin Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology School of Materials Science and EngineeringHebei University of TechnologyTianjin 300132China Institute of New Materials Guangdong Academy of ScienceGuangzhou 510651GuangdongChina

Steels are widely used as structural materials,making them essential for supporting our lives and ***,further improving the comprehensive properties of steel through traditional trial-and-error methods becomes challenging due to the continuous development and numerous processing parameters involved in steel *** address this challenge,the application of machine learning methods becomes crucial in establishing complex relationships between manufacturing processes and steel *** review begins with a general overview of machine learning methods and subsequently introduces various performance predictions in steel *** classification of performance pre-diction was used to assess the current application of machine learning model-assisted *** important issues,such as data source and characteristics,intermediate features,algorithm optimization,key feature analysis,and the role of environmental factors,were summarized and *** insights will be beneficial and enlightening to future research endeavors in this field.

关键词： Steel Manufacturing process Machine learning Performance prediction Algorithm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hot-exciton effects on exciton diffusion and circular polarization dynamics in a single PbI_(2)nanoflake

引用

Science China(Technological Sciences) 2024年第1期67卷 83-90页

作者： xu ChenYu WANG Lei CUI lin GAO BingRong WANG HaiYu State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012China

As one of the emerging two-dimensional lead halide materials,lead iodide(PbI_(2))nanosheets have proven to possess strong application potential in the fields of high-energy radiation detection and highly efficient perovskite solar ***,the underlying photophysical properties such as hot-exciton-related carrier dynamics remain unclear for PbI_(2)***,we report the exciton dynamics of a single PbI_(2)nanoflake prepared by an aqueous solution *** a three-dimensional(3D)diffusion model,we obtain the exciton annihilation radius and diffusion coefficient of a single PbI_(2)nanoflake under nonresonant and resonant excitation conditions of band-edge exciton *** initial exciton densities increase,we find the carrier recombination mechanism for a single PbI_(2)nanoflake gradually changes from exciton-exciton annihilation to free-carrier ***,we reveal the room-temperature circular polarization of a single PbI_(2)nanoflake is due to free-carrier recombination with a band-edge exciton dissociation time of~120 fs under the resonant excitation condition.

关键词： single PbI_(2)nanoflake exciton diffusion room-temperature circular polarization ultrafast spectroscopy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

System Strength Assessment Based on Multi-task Learning

引用

CSEE Journal of Power and Energy Systems 2024年第1期10卷 41-50页

作者： Baoluo Li Shiyun xu Huadong Sun Zonghan Li lin Yu Key Laboratory of Power System Intelligent Dispatch and Control of Ministry of Education Shandong UniversityJinan 250014China China Electric Power Research Institute Beijing 100192China

Increase in permeability of renewable energy sources(RESs)leads to the prominent problem of voltage stability in power system,so it is urgent to have a system strength evaluation method with both accuracy and practicability to control its access scale within a reasonable ***,a hybrid intelligence enhancement method is proposed by combining the advantages of mechanism method and data driven ***,calculation of critical short circuit ratio(CSCR)is set as the direction of intelligent enhancement by taking the multiple renewable energy station short circuit ratio as the quantitative ***,the construction process of CSCR dataset is proposed,and a batch simulation program of samples is developed accordingly,which provides a data basis for subsequent ***,a multi-task learning model based on progressive layered extraction is used to simultaneously predict CSCR of each RESs connection point,which significantly reduces evaluation error caused by weak *** performance and anti-noise performance of the proposed method are verified on the CEPRI-FS-102 bus system,which provides strong technical support for real-time monitoring of system strength.

关键词： Critical short circuit ratio hybrid intelligence enhancement multi-task learning system strength

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The principle and amelioration of lithium plating in fast-charging lithium-ion batteries

引用

Journal of Energy Chemistry 2024年第10期97卷 453-459,I0009页

作者： Yi Yang Xia-lin Zhong Lei xu Zhuo-lin Yang Chong Yan Jia-Qi Huang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Yangtze River Delta Graduate School of Beijing Institute of Technology Jiaxing 314003ZhejiangChina

Fast charging is restricted primarily by the risk of lithium(Li)plating,a side reaction that can lead to the rapid capacity decay and dendrite-induced thermal runaway of lithium-ion batteries(LIBs).Investigation on the intrinsic mechanism and the position of Li plating is crucial to improving the fast rechargeability and safety of ***,we investigate the Li plating behavior in porous electrodes under the restricted transport of Li^(+).Based on the theoretical model,it can be concluded that the Li plating on the anodeseparator interface(ASI)is thermodynamically feasible and kinetically ***,the prior deposition of metal Li on the ASI rather than the anode-current collector interface(ACI)is verified *** order to facilitate the transfer of Li^(+)among the electrode and improve the utilization of active materials without Li plating,a bilayer asymmetric anode composed of graphite and hard carbon(GH)is *** and simulation results suggest that the GH hybrid electrode homogenizes the lithiated-rate throughout the electrode and outperforms the pure graphite electrode in terms of the rate performance and inhibition of Li *** work provides new insights into the behavior of Li plating and the rational design of electrode structure.

关键词： Graphite Hard carbon Fast charging Lithium plating Lithium-ion batteries

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Glioma-derived ANXA1 suppresses the immune response to TLR3 ligands by promoting an anti-inflammatory tumor microenvironment

引用

Cellular & Molecular Immunology 2024年第1期21卷 47-59页

作者： Yu Zheng Haihui Jiang Naixue Yang Shaoping Shen Daosheng Huang Lemei Jia Jing ling Longchen xu Mingxiao Li Kefu Yu Xiaohui Ren Yong Cui xun Lan Song lin xin lin Institute for Immunology and School of Medicine Tsinghua UniversityBeijing100084China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityChina.National Clinical Research Center for Neurological DiseasesCenter of Brain TumorBeijing Institute for Brain Disorders and Beijing Key Laboratory of Brain TumorBeijing100070China Department of Neurosurgery Peking University Third HospitalPeking UniversityBeijing100191China Tsinghua-Peking Center for Life Sciences Beijing100084China

A highly immunosuppressive tumor microenvironment(TME)and the presence of the blood‒brain barrier are the two major obstacles to eliciting an effective immune response in patients with high-grade glioma(HGG).Here,we tried to enhance the local innate immune response in relapsed HGG by intracranially injecting poly(I:C)to establish a robust antitumor immune response in this registered clinical trial(NCT03392545).During the follow-up,12/27(44.4%)patients who achieved tumor control concomitant with survival benefit were regarded as responders in our *** found that the T-cell receptor(TCR)repertoire in the TME was reshaped after poly(I:C)*** on the RNA-seq analysis of tumor samples,the expression of annexin A1(ANXA1)was significantly upregulated in the tumor cells of nonresponders,which was further validated at the protein *** vitro and in vivo experiments showed that ANXA1 could induce the production of M2-like macrophages and microglia via its surface receptor formyl peptide receptor 1(FPR1)to establish a Treg cell-driven immunosuppressive TME and suppress the antitumor immune response facilitated by poly(I:C).The ANXA1/FPR1 signaling axis can inhibit the innate immune response of glioma patients by promoting an anti-inflammatory and Treg-driven ***,ANXA1 could serve as a reliable predictor of response to poly(I:C),with a notable predictive accuracy rate of 92.3%.In light of these notable findings,this study unveils a new perspective of immunotherapy for gliomas.

关键词： glioma ANXA1 TLR3 poly(I:C) immunotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Real-time Prediction System for Molecular-level Information of Heavy Oil Based on Machine Learning

引用

China Petroleum Processing & Petrochemical Technology 2024年第2期26卷 121-134页

作者： Yuan Zhuang Wang Yuan Zhang Zhibo Yuan Yibo Yang Zhe xu Wei lin Yang Yan Hao Zhou xin Zhao Hui Yang Chaohe State Key Laboratory of Chemical Safety SINOPEC Research Institute of Safety Engineering Co.LtdQingdaoShandong 266000People’s Republic of China State Key Laboratory of Heavy Oil Processing China University of PetroleumQingdaoShandong 266580People’s Republic of China College of Chemistry and Chemical Engineering Ocean University of ChinaQingdaoShandong 266100People’s Republic of China

Acquiring accurate molecular-level information about petroleum is crucial for refining and chemical enterprises to implement the“selection of the optimal processing route”*** the development of data prediction systems represented by machine learning,it has become possible for real-time prediction systems of petroleum fraction molecular information to replace analyses such as gas chromatography and mass ***,the biggest difficulty lies in acquiring the data required for training the neural *** address these issues,this work proposes an innovative method that utilizes the Aspen HYSYS and full two-dimensional gas chromatography-time-of-flight mass spectrometry to establish a comprehensive training ***,a deep neural network prediction model is developed for heavy distillate oil to predict its composition in terms of molecular *** training,the model accurately predicts the molecular composition of catalytically cracked raw oil in a *** validation and test sets exhibit R2 values of 0.99769 and 0.99807,respectively,and the average relative error of molecular composition prediction for raw materials of the catalytic cracking unit is less than 7%.Finally,the SHAP(SHapley Additive ExPlanation)interpretation method is used to disclose the relationship among different variables by performing global and local weight comparisons and correlation analyses.

关键词： heavy distillate oil molecular composition deep learning SHAP interpretation method

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Heat Treatment on Microstructure and Mechanical Properties of Multiscale SiC_p Hybrid Reinforced 6061 Aluminum Matrix Composites

引用

Journal of Wuhan University of Technology(Materials Science) 2024年第1期39卷 174-181页

作者：吴健铭许晓静 ZHANG xu LUO Yuntian LI Shuaidi HUANG lin Institute for Advanced Manufacturing and Modern Equipment Technology Jiangsu UniversityZhenjiang 212013China

The performance of solid solution aging treatment on aluminum matrix composites prepared by powder metallurgy and reinforced with 6061 aluminum alloy powder as matrix;meanwhile, nano silicon carbide particles(nm Si Cp), submicron silicon carbide particles(1 μm Si Cp) and Ti particles were studied. The Al/Si Cp composite powder was prepared by high-energy ball milling, and then cold-pressed, sintered, hotextruded, and then heat-treated with different solution temperatures and aging times for the extruded composites. Optical microscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy(EDS), X-ray diffractometer(XRD) and extrusion testing were used to analyze and test the microstructure and mechanical properties of aluminum matrix composites. The results show that after the multi-stage solid solution at 530 ℃×2 h+535 ℃×2 h+540 ℃×2 h, the particles are mainly equiaxed grains and uniformly distributed. There is no reinforcement agglomeration, and the surface is dense and the insoluble phase is basically dissolved. In the matrix, the strengthening effect is good, and the hardness and compressive strength are 179.43 HV and 680.42 MPa, respectively. Under this solution process, when the aluminum matrix composites are aged at 170 ℃ for 10 h, the hardness and compressive strength can reach their peaks and increase to 195.82 HV and 721.48 MPa, respectively.

关键词： aluminum matrix composites Si C particles multiscale hybrid enhancement heat treatment mechanical properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：