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Association of sleep quality with myopia based on different genetic risk levels

International Journal of Ophthalmology(English edition) 2022年第10期15卷 1657-1664页

作者： Juan He Yao-Yao lin jie Chen Bing Sun Yan-Hui Wang Dan-Dan Jiang lin-jie liu Shu-Dan lin Yan-Yan Chen School of Optometry and Ophthalmology Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina The Eye Hospital Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM: To analyse the association of sleep quality with myopia under different genetic risk(GR) ***: A cross-sectional survey of students aged 9-14 y in Wenzhou, China, was conducted. Refraction without cycloplegia and ocular parameters were measured. Sleep quality was assessed with the Pittsburgh Sleep Quality Index(PSQI). Seventeen single nucleotide polymorphisms(SNPs) were replicated by association analysis and used to compute the GR score(GRS). Possible confounders were assessed by a questionnaire that collected information about the children and their parents. Generalized linear models were used to analyse the sleep quality, the GR, and their interaction effects on the risk of ***: Out of 1354 children included in this study, 353(26.07%) had sleep disturbances. The GRS ranged from 4.49 to 12.89 with a mean of 7.74±1.23, and the participants were divided into a low GR group, a moderate GR group and a high GR group according to the GRS quartile. In the generalized linear model, the children with sleep disturbances and high GR had a higher risk of myopia than those without sleep disturbances and with low GR(OR=1.59, 95%CI: 1.12-2.25;OR=1.88, 95%CI: 1.23-2.88, respectively). Compared to those with low GR and SDs, children with high GR with or without SDs had a higher risk of myopia(OR=4.88, 95%CI: 2.03-11.71;OR=1.70, 95%CI: 1.06-2.72, respectively).CONCLUSION: The prevalence of sleep disturbances in elementary school students in Wenzhou was 26.07%. There is a significant interaction between sleep disturbances and a high GR of myopia, suggesting that a high GR of myopia may increase children’s sensitivity to sleep disturbances. This study indicates that children with a high GR of myopia need to achieve adequate sleep duration and excellent sleep quality.

关键词： sleep quality genetic risk score myopia children

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Monte Carlo simulation on kinetic behavior of one-pot hyperbranched polymerization based on AA*+CB_2

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Science China Chemistry 2010年第12期53卷 2481-2489页

作者： ZHAN jie,lin Ying,liu XiaoHui & LI YueSheng State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China 1. State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China

Monte Carlo simulation was applied to investigate the kinetic behavior of AA*+CB2 *** algorithm consisted of two procedures to simulate the in-situ synthesis of AB2-like intermediate and the subsequent polymerization,*** order to improve the accuracy of the prediction,the mobility distinction between different scale molecules in polymerization was taken into account by relating the reaction rate constants to the collision possibility of each pair of *** feed ratio of initial monomers and the activity difference between the two functional groups within AA* were studied systematically to catch the essential features of the *** results have revealed that the achievable maximum conversion primarily depends on the extent of the reactivity difference between A and A*-groups,and it is suggested that A*-group should be at least 10 times more active than A-group to achieve high number-average degree of polymerization.

关键词： Monte Carlo hyperbranched kinetic AA+CB2

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Two different autorefractors for vision screening in children and adolescents

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 331-338页

作者： Xiao-Jun Chen lin-jie liu Bing Sun Dan-Dan Jiang Shu-Shu Zuo Yan-Hui Wang Chun-Hua Zhang Yan-Yan Chen School of Optometry and Ophthalmology Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To compare the consistency of two autorefractors(Tianle RM-9000 and Topcon KR-800)for school-age myopia children,and to provide a basis for largescale data analysis and ***:The refractive error in 909 subjects(age 4–18y)were measured using both autorefractors without *** data were analyzed using Fourier decomposition and the correlation coefficients,intraclass correlation coefficients(ICC),and Bland-Altman limits of agreement(LoA)for each parameter were ***:There was a strong correlation between the spherical equivalent(SE),sphere diopter(DS),and cylinder diopter(DC)readings of the Tianle RM-9000 and those of the Topcon KR-800,with correlation coefficient values of 0.98,0.98 and 0.83 and ICC values of 0.99,0.99 and 0.93,***,the correlation coefficients and ICC values of J0 and J45 were unreliable(R=-0.004,-0.034;both ICClinically acceptable *** J0 and J45,the mean differences were close to zero(P=0.43,0.84);however,the 95%LoA were relatively wide(J0 SD:0.53;95%CI:-1.00,1.10;J45 SD:0.52;95%CI:-1.00,1.00).CONCLUSION:The two autorefractors are consistent with each other,as the differences in SE,DS,and DC were within the clinically acceptable *** can compare the data measured by either device in different studies and use the two devices in the same study to generate a dataset that can be analyzed ***,the J0 and J45 vectors are unreliable and should not be used to assess astigmatism.

关键词： refractive error autorefractors school-age myopia children

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Proliferating cell nuclear antigen involved in the repair process of ouabain-induced brain damage independent of hypertension in rats

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Chinese Medical Journal 2014年第11期127卷 2111-2116页

作者： You Beian Shen lin Qiu jie liu Xiangju Zhao Shaohua Ji Xiang Wang Yan Gao Haiqing Department of Geriatrics Qilu Hospital of Shandong University Shandong Provincial Key Laboratory of Cardiovascular Proteomics Jinan Shandong 250012 China

Background Ouabain is a mammalian adrenocortical hormone that is involved in the pathogenesis of hypertension by inhibiting Na-K ATPase *** also participates in a variety of kinase-mediated signaling pathways associated with Na-K *** studies have shown that ouabain can cause cardiac remodeling independent of elevated blood pressure and that proliferating cell nuclear antigen （PCNA） plays a coordinating role for numerous proteins involved in multiple processes associated with DNA ***,we hypothesized that ouabain might play a role in the cerebral cortex through signaling pathways independent of *** PCNA might be involved in this *** Male Sprague-Dawley rats were treated with ouabain or with 0.9% nitric sodium as the control *** blood pressure was recorded *** four weeks of treatment,morphological changes in the cerebral cortex were analyzed using light and transmission electron *** expression of PCNA in the cerebral cortex was evaluated by immunohistochemistry,real time quantitative PCR,and Western *** After 4-week treatment,there was no significant difference in systolic blood pressure compared with the control group,but both structural deterioration and up-regulated expression of PCNA in the brain was induced by ouabain *** These results suggest that ouabain induces alterations in the brain structure,and this effect is independent of blood *** might be involved in the repair process of ouabain-induced brain damage.

关键词： ouabain proliferating cell nuclear antigen hypertension brain Na-K ATPase

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G-protein beta 3 subunit polymorphisms and essential hypertension： a case-control association study in northern Han Chinese

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Journal of Geriatric Cardiology 2015年第2期12卷 127-134页

作者： Mei LI Bei ZHANG Chuang LI jie-lin liu Li-Juan WANG Ya liu Zuo-Guang WANG Shao-Jun WEN Department of Hypertension Research Beijing Anzhen Hospital Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel DiseasesBeijing 100029 China

Objective To explore the association between the three polymorphisms [ C825T, C1429T and G（-350）A] of the gene encoding the G protein beta 3 subunit （GNB3） and hypertension by performing a case-control study in the northern Han Chinese population. Methods We recnaited 731 hypertensive patients and 673 control subjects （the calculated power value was 〉 0.8）. Genotyping was performed to identify C825T, C1429T and G（-350）A polymorphisms using the TaqMan assay. Comparisons of allelic and genotypic frequencies between cases and controls were made by using the chi-square test. Logistic regression analyses were performed to investigate the relationships between the three polymorphisms of GNB3 gene under different genetic models （additive, dominant and recessive models）. Results The genotype dis- tribution and allele frequencies of C825T, C1429T and G（-350）A polymorphisms did not differ significantly between hypertensive patients and control subjects, either when the full sample was assessed, or when the sample was stratified by gender. No significant association was observed between C825T, C 1429T and G（-350）A polymorphisms and the risk of essential hypertension in any genetic model. linkage dis- equilibrium was only detected between C825T and C 1429T polymorphisms. Haplotype analyses observed that none of the three estimated haplotypes significantly increased the risk of hypertension. Conclusions Our study suggested that the GNB3 gene polymorphisms [C825T, C 1429T and G（-350）A] were not significantly associated with essential hypertension in northern Han Chinese population.

关键词： G protein beta 3 subunit gene Haplotype Hypertension Polymorphism

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Interplay between creeping fat and gut microbiota: A brand-new perspective on fecal microbiota transplantation in Crohn's disease

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World Journal of Gastroenterology 2025年第2期31卷 138-143页

作者： Ying Wang jie liu Department of Life Sciences and Medicine South District of Endoscopic CenterThe First Affiliated Hospital of University of Science and Technology of ChinaUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Gastroenterology The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001Anhui ProvinceChina

Inflammatory bowel disease,particularly Crohn's disease(CD),has been linked to modifications in mesenteric adipose tissue(MAT)and the phenomenon known as"creeping fat"(CrF).The presence of CrF is believed to serve as a predictor for early clinical recurrence following surgical intervention in patients with ***,the incorporation of the mesentery during ileocolic resection for CD has been correlated with a decrease in surgical recurrence,indicating the significant role of MAT in the pathogenesis of *** numerous studies have indicated that dysbiosis of the gut microbiota is a critical factor in the development of CD,the functional implications of translocated microbiota within the MAT of CD patients remain *** manuscript commentary discusses a recent basic research conducted by Wu et *** their study,intestinal bacteria from individuals were transplanted into CD model mice,revealing that fecal microbiota trans-plantation(FMT)from healthy donors alleviated CD symptoms,whereas FMT from CD patients exacerbated these ***,FMT was found to affect intestinal permeability,barrier function,and the levels of proinflammatory factors and ***,these findings suggest that targeting MAT and CrF may hold therapeutic potential for patients with ***,the study did not evaluate the composition of the intestinal microbiota of the donors or the subsequent alterations in the gut ***,the gut microbiota plays a crucial role in the histopathology of CD,and thus,targeting MAT and CrF may represent a promising avenue for treatment in this patient population.

关键词： Crohn's disease Mesenteric adipose tissue Creeping fat Fecal microbiota transplantation Gut microbiota

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Alterations of ATPase activity and erythrocyte oxygen consumption in patients with liver-blood deficiency syndrome

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World Journal of Gastroenterology 1997年第3期3卷 52-53页

作者： SHI lin jie 1, liu Jun Fan 2, ZHANG Zi Qiang 1, LU Yi Qin 2, SHU Yi Gang 3, CHEN Guo lin 1, XIN Zhi Hua 1 and XU Jin Yao 2

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ＡｌｔｅｒａｔｉｏｎｓｏｆＡＴＰａｓｅａｃｔｉｖｉｔｙａｎｄｅｒｙｔｈｒｏｃｙｔｅｏｘｙｇｅｎｃｏｎｓｕｍｐｔｉｏｎｉｎｐａｔｉｅｎｔｓｗｉｔｈｌｉｖｅｒｂｌｏｏｄｄｅｆｉｃｉｅｎｃｙｓｙｎｄｒｏｍｅＳＨＩＬｉｎＪｉｅ１，ＬＩＵＪｕｎＦａｎ２...

关键词： erythrocytes cell membrane oxygen consumption adenosinetriphosphatase liver blood deficiency syndrome anemia,iron deficiency anemia, aplastic

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HIRFL-CSR Control System Progress

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2002年第1期 87-91页

作者： Qiao Weimin, Jing Lan, Ma Yunhai, Gou Shizhe, lin jie, Liang Yihai, liu Ning, Zhang Chunxia Wang Dan, Zhang Shuocheng, Meng Jian, liu Junke and Zhang Changshuan

The control system architecture is divided into several parts and three levels. Level I: CPCI architecture for special control *** II: Industrial computer, (PC and SUN SPARC). PCI Modules for general control processing. Level III: Micro-gateway + 31 application modules. The Gateway connects Ethernet to RS-485 and CANBUS or other field-Level II System Progress bus. Run real-time linUX (NUT) for general control processing.

关键词： HIRFL-CSR控制系统专门处理控制常规处理控制实时运行常规控制照相控制器数据结构设计

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Sulfolane‑Based Flame‑Retardant Electrolyte for High‑Voltage Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 498-516页

作者： Xuanlong He jie Peng Qingyun lin Meng Li Weibin Chen Pei liu Tao Huang Zhencheng Huang Yuying liu Jiaojiao Deng Shenghua Ye Xuming Yang Xiangzhong Ren Xiaoping Ouyang Jianhong liu Biwei Xiao Jiangtao Hu Qianling Zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1H,1H,5H-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte High voltage Layered oxide cathode Flame retardant

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急性脑卒中患者溶栓治疗后发生早期神经功能恶化的危险因素研究

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中国急救医学 2018年第3期38卷 224-228页

作者：董琳琳姜丽杰刘莹刘铁红大连大学附属中山医院干部病房辽宁大连116001 大连大学附属中山医院神经内科辽宁大连116001

目的评价急性脑卒中患者溶栓治疗24 h后，患者发生早期神经功能恶化（END）的危险因素。方法收集在我院接受溶栓治疗的678例急性缺血性脑卒中患者的临床资料进行回顾性分析。根据患者溶栓治疗24 h后是否发生END，将患者分为END组与非... 详细信息

目的评价急性脑卒中患者溶栓治疗24 h后，患者发生早期神经功能恶化（END）的危险因素。方法收集在我院接受溶栓治疗的678例急性缺血性脑卒中患者的临床资料进行回顾性分析。根据患者溶栓治疗24 h后是否发生END，将患者分为END组与非END组，比较两组患者临床资料与预后，评价患者发生END的致病机制，采用多变量Logistic回归分析评价患者发生END的相关因素。结果 678例患者中有142（20.9%）例患者在溶栓后24 h发生END。单因素分析显示，影响患者发生END的因素包括：高血压（χ2=5.483，P=0.019）、糖尿病（χ2=5.353，P=0.021）、吸烟（χ211.302，P＜0.001）、大动脉粥样硬化（χ221.168，P＜0.001）、心源性脑卒中（χ2=28.129，P＜0.001）和入院NIHSS评分（χ2=5.623，P=0.025）。END组患者预后明显变差。大动脉粥样硬化（OR=5.549，95% CI=1.124～2.388，P=0.037）、糖尿病（OR=2.678，95% CI=1.258～5.539，=P=0.015）、高血压（OR=1.642，95% CI=1.178～2.263，P=0.005）与急性脑卒中患者溶栓治疗24 h发生END显著相关。END的致病机制包括：缺血进展（42/142，=29.6%）、卒中复发（35/142，=24.6%）、梗死后出血转化（33/142，23.2%）与脑水肿（32/142，=22.6%）。结论缺血进展、卒中复发是溶栓治疗后患者发生END的重要原因，大动脉粥样硬化、糖尿病与高血压是溶栓治疗后24 h内发生END的独立预测因素。

关键词：急性脑卒中早期神经功能恶化(END) 致病机制

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