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A novel Ireland-Claisen rearrangement/Diels-Alder tandem reaction of propargylic acrylates with acyclic dienophiles

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Chinese Chemical Letters 2013年第2期24卷 137-139页

作者： Yun-Xia Li yi-lin Sheng Bi-Song Zhang College of Pharmaceutics and Material Engineering Jinhua College of Profession and Technology

Received 18 October 2012 Received in revised form 14 December 2012 Accepted 21 December 2012 Available online 29 January 2013

关键词： lreland-Claisen rearrangementDiels-Alder reactionTandem reactionPropargylic acrylates

De Winter syndrome and ST-segment elevation myocardial infarction can evolve into one another: Report of two cases

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World Journal of Clinical Cases 2019年第20期7卷 3296-3302页

作者： Yang-yi lin Yu-Dan Wen Guo-lin Wu Xiang-Dong Xu Department of Cardiology Jiading District Central Hospital Affiliated Shanghai University of Medical and Health SciencesShanghai 201800China Department of Electrocardiology the Third Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325200Zhejiang ProvinceChina

BACKGROUND The de Winter electrocardiography(ECG)pattern is a sign that implies proximal left anterior descending coronary artery occlusion in patients with chest *** previous view was that the de Winter ECG pattern is *** SUMMARY A 65-year-old man presented with sudden chest pain at rest associated with diaphoresis for 55 *** first ECG showed only T-wave inversion in III and aVF *** ECG was performed at the 100th minute,showing upsloping ST segments depressed with tall and symmetrical T waves in the precordial leads;the J point was raised by 0.1 mV at the aVR *** patient was referred to our catheterization laboratory.A third ECG showed ST segment elevation by 0.2 mV in the I and aVL *** patient underwent emergency coronary angiography,which revealed complete proximal left anterior descending coronary(LAD)*** second patient presented with a 1-h history of sudden-onset,severe,substernal crushing chest *** first ECG showed STsegment elevation(0.1–1.7 mV)in I,aVL,and precordial *** patient was referred to the catheterization *** arrival,his symptoms alleviated,and ECG showed that the ST-segments had significantly fallen *** third ECG showed a typical de Winter *** angiography revealed 99%stenosis of the middle *** The de Winter ECG pattern is transient and dynamic,and it reflects proximal or mid-LAD subtotal occlusion rather than total occlusion.

关键词： De Winter syndrome ST-segment upsloping depression Dynamic Case report

An alternative aqueous synthetic route to preparing CdTe quantum dots with tunable photoluminescence

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Chinese Chemical Letters 2012年第3期23卷 359-362页

作者： yi lin Wang Sheng Yan Liu Li Ya Zhou School of Chemistry and Chemical Engineering Guangxi UniversityNanning 530004China

An aqueous synthetic route has been developed for the preparation of mercaptosuccinic acid（MSA）-capped CdTe quantum dots （QDs） using TeO_2 as tellurium source and sodium borohydride as *** size and the emission color of CdTe QDs can be tuned by varying the reflux *** obtained QDs were characterized by photoluminescence（PL） spectroscopy,X-ray powder diffraction（XRD） and high-resolution transmission electron microscopy（HRTEM）.The results show that the CdTe QDs were of zinc-blende crystal structure in a sphere-like shape.

关键词： Cadmium telluride Quantum dots Synthesis Photoluminescence

Identification of necroptosis-related lncRNAs for prognosis prediction and screening of potential drugs in patients with colorectal cancer

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World Journal of Gastrointestinal Oncology 2023年第11期15卷 1951-1973页

作者： Zhi-Hua Chen yi-lin lin Shao-Qin Chen Xiao-Yu Yang Department of Gastrointestinal Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Gastrointestinal Surgery National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhou 350212Fujian ProvinceChina Peking University People’s Hospital Beijing 100044China School of Basic Medicine Sciences Fujian Medical UniversityFuzhou 350122Fujian ProvinceChina

BACKGROUND Tumor recurrence and metastasis lead to a poor prognosis in colorectal cancer(CRC).Necroptosis is closely related to the tumor microenvironment(TME)and affects tumor recurrence and *** aimed to stratify CRC patients according to necroptosis-related long noncoding RNAs(lncRNAs),which can be used to not only evaluate prognosis and improve precision medicine in clinical practice but also screen potential immunotherapy *** To stratify CRC patients according to necroptosis-related lncRNAs(NRLs),which can be used to not only evaluate prognosis and improve precision medicine in clinical practice but also screen potential immunotherapy *** LncRNA expression profiles were collected from The Cancer Genome *** were identified by coexpression *** regression analysis identified a NRL ***,the value of this signature was comprehensively and multidimensionally evaluated,and its reliability for CRC prognosis prediction was assessed with clinical CRC data and compared with that of six other lncRNA were also performed according to the risk score(RS)of the *** An 8-lncRNA signature significantly associated with overall survival(OS)was constructed,and its reliability was validated with clinical CRC *** of the areas under the receiver operating characteristic curves(AUCs)values for 1-,3-and 5-year OS for this signature were higher than those for the other six lncRNA ***,disease-specific survival and the progression-free interval were all significantly poorer in the high-risk *** RS of the signature showed good concordance with the predicted prognosis,with AUCs for 1-,3-and 5-year OS of 0.79,0.81 and 0.77,***,the calibration plots for this signature combined with clinical factors showed that this combination could effectively improve the ability to predict *** RS was correlated with tumor stage,lymph node metastasis and distant *** of the enriched Kyoto

关键词： Long noncoding RNA Necroptosis Immunotherapy Prognosis Colorectal cancer

A multiple template approach for robust tracking of fast motion target

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Applied Mathematics(A Journal of Chinese Universities) 2016年第2期31卷 177-197页

作者： SUN Jun HE Fa-zhi CHEN yi-lin CHEN Xiao State Key Laboratory of Software Engineering School of Computer Science Wuhan UniversityWuhan 430072 China Huanggang Polytechnic College Huanggang 438002 China

Target tracking is very important in computer vision and related areas. It is usually difficult to accurately track fast motion target with appearance variations. Sometimes the tracking algorithms fail for heavy appearance variations. A multiple template method to track fast motion target with appearance changes is presented under the framework of appearance model with Kalman filter. Firstly, we construct a multiple template appearance model, which includes both the original template and templates affinely transformed from original one. Generally speaking, appearance variations of fast motion target can be covered by affine transformation. Therefore, the affine tr templates match the target of appearance variations better than conventional models. Secondly, we present an improved Kalman filter for approx- imate estimating the motion trail of the target and a modified similarity evaluation function for exact matching. The estimation approach can reduce time complexity of the algorithm and keep accuracy in the meantime. Thirdly, we propose an adaptive scheme for updating template set to alleviate the drift problem. The scheme considers the following differences： the weight differences in two successive frames; different types of affine transformation applied to templates. Finally, experiments demonstrate that the proposed algorithm is robust to appearance varia- tion of fast motion target and achieves real-time performance on middle/low-range computing platform.

关键词： Target tracking Fast motion target Multiple template match Kalman filter forecast.

Asymmetrical Bell state analysis for photon-atoms hybrid system

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Science China(Physics,Mechanics & Astronomy) 2019年第12期62卷 10-18页

作者： yi-lin Liu Miao-Wei Wang Chun-Yu Bai Tie-Jun Wang School of Science Beijing University of Posts and TelecommunicationsBeijing 100876China State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China

Bell-state analysis(BSA) has great application in the quantum communication. To our best knowledge, the current works are devoted to the physical realization of symmetrical 2×2-dimensional or 2^N× 2^N-dimensional 2-qudit BSA, and there is no work focused on the physical realization of the asymmetrical high-dimensional(for example 3×4-dimensional 2-qudit) Bell-states complete analysis. In this paper, by using the nonlinear interaction between the atoms and photons, we propose a scheme to completely distinguish the asymmetrical 3×4-dimensional 2-qudit Bell states of a hybrid system. We use the quantum information splitting, which is exploited to resolve the degree-mismatch issue in the quantum state sharing schemes, as an example to show the application of the asymmetrical BSA. Finally, we discuss its possible realization with current experimental techniques. Our asymmetrical high-dimensional BSA protocol may pave a new way for high-capacity long-distance quantum communication.

关键词： quantum optics quantum information processing quantum cryptography

Enriched environment for offspring improves learning and memory impairments induced by sevoflurane exposure during the second trimester of pregnancy

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Neural Regeneration Research 2022年第6期17卷 1293-1298页

作者： Shao-Wei yin yi-lin Meng Chuang Li Yuan Wang Department of Obstetrics Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Anesthesiology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Studies in animals indicate that sevoflurane exposure in the second trimester of pregnancy has harmful effects on the learning and memory of *** an enriched environment can reverse the damage of sevoflurane exposure in the second trimester of pregnancy on the learning and memory of rat offspring remains *** this study,rats at 14 days of pregnancy were exposed to 3.5%sevoflurane for 2 hours and their offspring were treated with an enriched environment for 20 successive *** found that the enriched environment for offspring increased nestin and Ki67 levels in hippocampal tissue,increased hippocampal neurogenesis,inhibited glycogen synthase kinase 3βactivity,and increased the expression of cell proliferation-relatedβ-catenin and apoptosis-related Bcl-2,indicating that an enriched environment reduces sevoflurane-induced damage by increasing the proliferation of stem cells in the *** findings suggest that an enriched environment can reverse the effects of sevoflurane inhaled by rats during the second trimester of pregnancy on learning and memory of *** study was approved by the Animal Ethics Committee of Shengjing Hospital of China Medical University(approval No.2018PS07K)on January 2,2018.

关键词： apoptosis fetal learning memory neurogenesis offspring proliferation sevoflurane signal pathway

Epithelial-mesenchymal transition effect of fine particulate matter from the Yangtze River Delta region in China on human bronchial epithelial cells

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Journal of Environmental Sciences 2018年第4期30卷 155-164页

作者： Yulang Chi Qiansheng Huang yi lin Guozhu Ye Huimin Zhu Sijun Dong Center for Excellence in Urban Atmospheric Environment Institute of Urban Environment Chinese Academy of Sciences Key Lab of Urban Environment and Health Institute of Urban Environment Chinese Academy of Sciences College of Resources and Environment University of Chinese Academy of Sciences

Epidemiological studies have demonstrated that fine particulate matter（PM（2.5）） exposure causes airway inflammation, which may lead to lung cancer. The activation of epithelial–mesenchymal transition（EMT） is assumed to be a crucial step in lung tumor metastasis and development. We assessed the EMT effect of low concentrations（0, 0.1, 1.0, and 5.0 μg/m L）of PM（2.5） organic extract on a human bronchial epithelial cell line（BEAS-2 B）. PM（2.5） samples were collected from three cities（Shanghai, Ningbo, and Nanjing） in the Yangtze River Delta（YRD） region in autumn 2014. BEAS-2 B cells were exposed to the PM（2.5） extract to assess cell viability, invasion ability as well as the relative m RNA and protein expressions of EMT markers. Our findings revealed that BEAS-2 B cells changed from the epithelial to mesenchymal phenotype after exposure. In all groups, PM（2.5） exposure dose-dependently decreased the expression of E-cadherin and increased the expression of Vimentin. The key transcription factors, including ZEB1 and Slug, were significantly up-regulated upon exposure. These results indicated that the PM（2.5） organic extract induced different degrees of EMT progression in BEAS-2 B cells. The cell invasion ability increased in a concentration-dependent manner after 48 hr of treatment with the extract. This study offers a novel insight into the effects of PM（2.5） on EMT and the potential health risks associated with PM（2.5） in the YRD region.

关键词： PM2.5 BEAS-2B Epithelial–mesenchymal transition Cell invasion

Cluster DetectionMethod of Endogenous Security Abnormal Attack Behavior in Air Traffic Control Network

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Computers, Materials & Continua 2024年第5期79卷 2523-2546页

作者： Ruchun Jia Jianwei Zhang yi lin Yunxiang Han Feike Yang College of Computer Science Sichuan UniversityChengdu610065China Equipment Management and Unmanned Aerial Vehicle College of Air Force Engineering University Air Force Engineering UniversityXi’an710051China

In order to enhance the accuracy of Air Traffic Control(ATC)cybersecurity attack detection,in this paper,a new clustering detection method is designed for air traffic control network security *** feature set for ATC cybersecurity attacks is constructed by setting the feature states,adding recursive features,and determining the feature *** expected information gain and entropy of the feature data are computed to determine the information gain of the feature data and reduce the interference of similar feature *** autoencoder is introduced into the AI(artificial intelligence)algorithm to encode and decode the characteristics of ATC network security attack behavior to reduce the dimensionality of the ATC network security attack behavior *** on the above processing,an unsupervised learning algorithm for clustering detection of ATC network security attacks is ***,determine the distance between the clustering clusters of ATC network security attack behavior characteristics,calculate the clustering threshold,and construct the initial clustering ***,the new average value of all feature objects in each cluster is recalculated as the new cluster ***,it traverses all objects in a cluster of ATC network security attack behavior feature ***,the cluster detection of ATC network security attack behavior is completed by the computation of objective *** experiment took three groups of experimental attack behavior data sets as the test object,and took the detection rate,false detection rate and recall rate as the test indicators,and selected three similar methods for comparative *** experimental results show that the detection rate of this method is about 98%,the false positive rate is below 1%,and the recall rate is above 97%.Research shows that this method can improve the detection performance of security attacks in air traffic control network.

关键词： Air traffic control network security attack behavior cluster detection behavioral characteristics information gain cluster threshold automatic encoder