Enriched environment for offspring improves learning and memory impairments induced by sevoflurane exposure during the second trimester of pregnancy

作     者：Shao-Wei Yin Yi-Lin Meng Chuang Li Yuan Wang Shao-Wei Yin;Yi-Lin Meng;Chuang Li;Yuan Wang

作者机构：Department of ObstetricsShengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of AnesthesiologyShengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第6期

页      面：1293-1298页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 1010[医学-医学技术（可授医学、理学学位）] 100215[医学-康复医学与理疗学] 100204[医学-神经病学] 10[医学] 

主　　题：apoptosis fetal learning memory neurogenesis offspring proliferation sevoflurane signal pathway 

摘      要：Studies in animals indicate that sevoflurane exposure in the second trimester of pregnancy has harmful effects on the learning and memory of *** an enriched environment can reverse the damage of sevoflurane exposure in the second trimester of pregnancy on the learning and memory of rat offspring remains *** this study,rats at 14 days of pregnancy were exposed to 3.5%sevoflurane for 2 hours and their offspring were treated with an enriched environment for 20 successive *** found that the enriched environment for offspring increased nestin and Ki67 levels in hippocampal tissue,increased hippocampal neurogenesis,inhibited glycogen synthase kinase 3βactivity,and increased the expression of cell proliferation-relatedβ-catenin and apoptosis-related Bcl-2,indicating that an enriched environment reduces sevoflurane-induced damage by increasing the proliferation of stem cells in the *** findings suggest that an enriched environment can reverse the effects of sevoflurane inhaled by rats during the second trimester of pregnancy on learning and memory of *** study was approved by the Animal Ethics Committee of Shengjing Hospital of China Medical University(approval No.2018PS07K)on January 2,2018.