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Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin lin zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

INTERNAL SOLITARY WAVE IN TWO-LAYER FLUID SYSTEM TOWARDS SHELF

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Journal of Hydrodynamics 1991年第4期3卷 83-90页

作者： Jin-lin, zhu Tsinghua Univ Beijing China

The propagation of an interfacial solitary wave in a two-layer fluid system with fixed upper surface to shelf is discussed. The numerical results of the Boussinesq model show the fission of the solitary wave, the reflected waves by the slope and their dependence on the shelf height and slope. It is shown that the amplitude of the first transmitted solitary wave fully developed is esscentially independent of the bottom slope.

关键词： Hydrodynamics Water Waves Fluid Dynamics Water Waves Mathematical Models

Numerical simulation study on penetration performance of depleted Uranium(DU)alloy fragments

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Defence Technology（防务技术） 2021年第1期17卷 50-55页

作者： Fu-lin zhu Yang Chen Gui-li zhu Sichuan Aerospace System Engineering Institute Chengdu610100SichuanChina

Due to its high strength,high density,high hardness and good penetration capabilities,Depleted uranium alloys have already shined in armor-piercing *** should also be a lot of room for improvement in the application of fragment killing ***,regarding the performance of the depleted uranium alloy to penetrate the target plate,further investigation is needed to analyze its advantages and disadvantages compared to tungsten *** study the difference in penetration performance between depleted uranium alloy and tungsten alloy fragments,firstly,a theoretical analysis of the adiabatic shear sensitivity of DU and tungsten alloys was given from the perspective of material constitutive ***,taking the cylindrical fragment penetration target as the research object,the penetration process and velocity characteristics of the steel target plates penetrated by DU alloy fragment and tungsten alloy fragment were compared and analyzed,by using finite element software ANSYS/LS-DYNA and Lagrange ***,the influence of different postures when impacting target and different fragment shapes on the penetration results is carried out in the *** results show that in the penetration process of the DU and tungsten alloy fragments,the self-sharpening properties of the DU alloy can make the fragment head sharper and the penetrating ability *** the same conditions,the penetration capability of cylindrical fragment impacting target in vertical posture is better than that in horizontal posture,and the penetration capability of the spherical fragment is slightly better than that of cylindrical fragment.

关键词： Depleted uranium alloy Constitutive model Adiabatic shear Penetration performance Numerical simulation

Improved clustering method based on artificial immune

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Journal of Systems Engineering and Electronics 2010年第6期21卷 1111-1115页

作者： lin zhu Bo Li School of Management Tianjin University Tianjin 300072 E R. China

An improved clustering method based on artificial immune is proposed. To obtain the better initial solution, the initial antibody network is introduced by self organizing map （SOM） method. In the process of the clustering iteration, a series of optimization and evolution strategies are designed, such as clustering satisfaction, the threshold design of scale compression, the learning rate, the clustering monitoring points and the clustering evaluations indexes. These strategies can make the clustering thresholds be quantified and reduce the operator’s subjective factors. Thus, the local optimal and the global optimal clustering simultaneously are proposed by the synthesized function of these strategies. Finally, the experiment and the comparisons demonstrate the proposed method effectiveness.

关键词： artificial immune system (AIS) clustering self organizing map (SOM).

Objective Triangle Functors in Adjoint Pairs

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Algebra Colloquium 2017年第4期24卷 639-646页

作者： Pu Zhang lin zhu School of Mathematics Shanghai Jiao Tong University Shanghai 200240 China

An additive functor F： A→B between additive categories is objective if any morphism f in A with F（f） = 0 factors through an object K with F（K） = 0. We consider when a triangle functor in an adjoint pair is objective. We show that a triangle functor is objective provided that its adjoint （whatever left adjoint or right adjoint） is full or dense. We Mso give an example to show that the adjoint of a faithful triangle functor is not necessarily objective. In particular, the adjoint of an objective triangle functor is not necessarily objective. This is in contrast to the well-known fact that the adjoint of a triangle functor is always a triangle functor. Also, for an arbitrary a^tjoint pair （F, G） between categories which are not necessarily additive, we give a sufficient and necessary condition such that F （resp., G） is full or faithful.

关键词： adjoint pair objective triangle functor unit and counit

Wear Resistance of TiN_x/CF_y Coatings Deposited by RF Magnetron Co-Sputtering

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Journal of Materials Science & Technology 2015年第12期31卷 1207-1216页

作者： lin zhu Jinwu Wang zhuang Liu College of Engineering Northeast Agricultural University School of Light Industry Harbin University of Commerce

TiN x/CF y composite coatings were prepared by RF magnetron co-sputtering using twin cylindrical tube targets with Ar and N 2 *** composition of the coatings deposited at various positions was analyzed by X-ray photoelectron spectroscopy（XPS） and Rutherford back-scattering spectrometry（RBS）.The results revealed that the composition of the deposited coatings has a wide range of TiN x and CFy contents at different deposition positions,which leads to different structures and *** hardness of the composite coatings increases from 32 to 1603 HV with increasing the TiN x *** static contact angle of water ranges from 20° to 102° and decreases upon the incorporation of more TiN x into the CF y *** presence of the CF y groups enhances the contact angle between the coating and the solutions dropped onto it,which could effectively protect the coating from corrosion and improve the wear resistance properties in high relative humidity（RH）.The brittleness of the coatings decreases due to the softness of the CF y component,which can bear most of the load and result in less probability of crack *** results demonstrate the existence of a Ti-（C N） chemical bond in the composite coatings,which improves the wear resistance of the *** is indicated that the wear resistance of the TiN x/CF y coatings is independent of the ***,these properties depend on the uniform structure and the existence of chemical bonding between the TiN x and CF y ***,a specific ratio between the soft CF y phase and the hard TiN x phase can produce coatings with good wear resistance.

关键词： TiNx/CFy composite coatings Magnetron co-sputtering Wear resistance

On the stochastic dynamics of molecular conformation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第9期8卷 1401-1407页

作者： DENG Mao-lin zhu Wei-qiu Department of Mechanics State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China

An important functioning mechanism of biological macromolecules is the transition between different conformed states due to thermal fluctuation. In the present paper, a biological macromolecule is modeled as two strands with side chains facing each other, and its stochastic dynamics including the statistics of stationary motion and the statistics of conformational transition is studied by using the stochastic averaging method for quasi Hamikonian systems. The theoretical results are confirmed with the results from Monte Carlo simulation.

关键词： Biological macromolecule Thermal fluctuation Stationary statistics Transition time Stochastic averaging method

Easily prepared and stable functionalized magnetic ordered mesoporous silica for efficient uranium extraction

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Science China Chemistry 2016年第5期59卷 629-636页

作者： Wenlu Guo Changming Nie lin Wang Zijie Li lin zhu Liuzheng zhu Zhentai zhu Weiqun Shi Liyong Yuan School of Chemistry and Chemical Engineering University of South ChinaHengyang 421001China Laboratory of Nuclear Energy Chemistry Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China State Key Laboratory of NBC Protection for Civilian Beijing 102205China

Functionalized magnetic Fe_3O_4@SiO_2 composite nanoparticles were prepared by simply embedding iron oxide nanoparticles into MCM-41 through one-step synthesis process, followed by aminopropyls grafting on the mesopore channels, aiming to efficiently and conveniently uptake U(VI) from aqueous solution. The resultant material possesses highly ordered mesoporous structure with large surface area, uniform pore size, excellent thermal stability, quick magnetic response, and desirable acids resistance, confirmed by Fourier transform infrared spectroscopy(FTIR), scanning electron microscopy(SEM), N_2 adsorption/desorption experiments, powder X-ray diffraction(PXRD), and thermogravimetric analysis(TGA). Detailed U(VI) sorption test indicated that this material is indeed an effective U(VI) sorbent with fast sorption kinetics of less than 2 h, large sorption capacity of 160 mg/g at p H 5.0±0.1, and desirable selectivity towards U(VI) ions over a range of competing metal ions. The absorbed U(VI) can be easily desorbed by 0.01 mol/L or more concentrated HNO_3 solution, and the reclaimed sorbent can be reused with no obvious decrease of sorption capacity even after 4 sorption-desorption cycles. The present results suggest the vast opportunities of this kind of magnetic composite on the solid-phase extraction of U(VI).

关键词： aminopropyls magnetic ordered mesoporous silica uranium sorption

先天性心脏病儿童156例营养不良发生现状及影响因素分析

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安徽医药 2025年第1期29卷 83-86页

作者：肖瑾朱琳陈思陕西省森林工业职工医院儿童保健科陕西西安710300

目的探讨先天性心脏病儿童营养不良发生现状及影响因素。方法选取陕西省森林工业职工医院2019年6月至2022年7月收治的156例先天性心脏病病人,采用Z评分法评估病人的营养状况。根据病人营养状况将其分为营养不良组和正常组,比较两组病人... 详细信息

目的探讨先天性心脏病儿童营养不良发生现状及影响因素。方法选取陕西省森林工业职工医院2019年6月至2022年7月收治的156例先天性心脏病病人,采用Z评分法评估病人的营养状况。根据病人营养状况将其分为营养不良组和正常组,比较两组病人一般资料,采用多因素回归分析先天性心脏病病人营养不良的影响因素。结果156例先天性心脏病病人中营养不良发生率为58.97%,其中急性营养不良发生率为26.92%,慢性营养不良发生率为32.05%;营养不良组病情复杂占比(57.61%比34.37%)、家庭经济收入低占比(45.65%比21.88%)、母亲对疾病感知度不准确占比(57.61%比35.94%)、低出生体质量儿占比(38.04%比23.44%)、心脏增大占比(21.74%比9.37%)、治疗前有症状占比(73.91%比34.38%)、确诊时间≥1年占比(68.48%比29.69%)、住院次数>4次占比(33.70%比12.50%)、感染占比(70.65%比29.69%)及来自农村占比(63.04%比40.62%)均高于营养正常组(均P<0.05);logistic回归分析发现,病情复杂程度、家庭经济收入、出生体质量、确诊时间、住院次数及感染均是先天性心脏病病人发生营养不良的独立危险因素(P<0.05)。结论病情复杂程度、出生体质量、住院次数以及家庭来源均是先天性心脏病病人营养不良的独立危险因素。

关键词：先天性心脏病儿童营养不良营养状况影响因素