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Genome wide association analysis identifies candidate genes for fruit quality and yield in Actinidia eriantha

Journal of Integrative Agriculture 2024年第6期23卷 1929-1939页

作者： Yingzhen Wang Ying Wu Xinlei Wang Wangmei Ren Qinyao Chen Sijia Zhang Feng Zhang yunzhi lin Junyang Yue Yongsheng Liu School of Horticulture Anhui Agricultural UniversityHefei 230036China School of Forestry Science and Technology Lishui Vocational and Technical CollegeLishui 323000China College of Life Science Sichuan UniversityChengdu 610064China

Quality and yield are the primary concerns in kiwifruit breeding,but research on the genetic mechanisms of fruit size,shape,and ascorbic acid(ASA)content is currently very limited,which restricts the development of kiwifruit molecular *** this study,we obtained a total of 8.88 million highly reliable single nucleotide polymorphism(SNP)markers from 140 individuals from the natural hybrid offspring of Actinidia eriantha cv.‘White’using whole genome resequencing technology.A genome-wide association study was conducted on eight key agronomic traits,including single fruit weight,fruit shape,ASA content,and the number of inflorescences per branch.A total of 59 genetic loci containing potential functional genes were located,and candidate genes related to single fruit weight,fruit length,ASA content,number of inflorescences per branch and other traits were identified within the candidate interval,such as AeWUSCHEL,AeCDK1(cell cycle dependent kinase),AeAO1(ascorbic oxidase)and AeCO1(CONSTANS-like 4).After constructing an RNAi vector for AeAO1 and injecting it into the fruit of cv.‘Midao 31’to interfere with the expression of the AeAO1 gene,the results showed that the activity of ascorbic oxidase in the fruit of‘Midao 31’significantly decreased,while the content of ASA significantly *** study provides valuable insights into the genetic basis of variation in *** fruit traits,which may benefit molecular marker-assisted breeding efforts.

关键词： Actinidia eriantha GWAS SNP QTLs fruit quality

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Prevalence and risk evaluation of cardiovascular disease in the newly diagnosed prostate cancer population in China:A nationwide,multi-center,population-based cross-sectional study

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Chinese Medical Journal 2024年第11期137卷 1324-1331页

作者： Weiyu Zhang Huixin Liu Ming Liu Shi Ying Renbin Yuan Hao Zeng Zhenting Zhang Sujun Han Zhannan Si Bin Hu Simeng Wen Pengcheng Xu Weimin Yu Hui Chen Liang Wang Zhitao lin Tao Dai yunzhi lin Tao Xu Department of Urology Peking University People’s HospitalBeijing 100044China Department of Clinical Epidemiology and Biostatistics Peking University People’s HospitalBeijing 100044China Department of Urology Beijing HospitalNational Center of GerontologyBeijing 100005China Institute of Geriatric Medicine Chinese Academy of Medical SciencesBeijing 100005China Department of Urology Wuhan Union HospitalHuazhong University of Science&TechnologyWuhanHubei 430022China Department of Urology The Third People’s Hospital of ChengduChengduSichuan 610014China Department of Urology West China Hospital of Sichuan UniversityChengduSichuan 610041China Department of Urologic Oncology Tianjin Medical University Cancer Institute&HospitalTianjin 300060China Department of Urology Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China National Cancer Center Beijing 100021China National Clinical Research Center for Cancer Beijing 100021China Department of Urology Liaoning Cancer HospitalShenyangLiaoning 110801China Department of Urology The Second Hospital of Tianjin Medical UniversityTianjin 300141China Tianjin Institute of Urology Tianjin Medical UniversityTianjin 300141China Department of Urology Lu’an Affiliated Hospital of Anhui Medical UniversityLu’anAnhui 237322China Department of Urology Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Department of Urology Harbin Medical University Affiliated Cancer HospitalHarbinHeilongjiang 150081China Department of Urology The Second Hospital of Dalian Medical UniversityDalianLiaoning 116023China Department of Urology Surgery Fujian Cancer HospitalFuzhouFujian 350014China Department of Urology Surgery Hunan Cancer HospitalChangshaHunan 410031China Department of Urology Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350004China

Background:Cardiovascular disease(CVD)has emerged as the leading cause of death from prostate cancer(PCa)in recent decades,bringing a great disease burden *** with preexisting CVD have an increased risk for major adverse cardiovascular events when treated with androgen deprivation therapy(ADT).The present study aimed to explore the prevalence and risk evaluation of CVD among people with newly diagnosed PCa in ***:Clinical data of newly diagnosed PCa patients were retrospectively collected from 34 centers in China from 2010 to 2022 through convenience *** was defined as myocardial infarction,arrhythmia,heart failure,stroke,ischemic heart disease,and *** risk was estimated by calculating Framingham risk scores(FRS).Patients were accordingly divided into low-,medium-,and high-risk groups.χ2 or Fisher’s exact test was used for comparison of categorical ***:A total of 4253 patients were enrolled in the present study.A total of 27.0%(1147/4253)of patients had comorbid PCa and CVD,and 7.2%(307/4253)had two or more *** enrolled population was distributed in six regions of China,and approximately 71.0%(3019/4253)of patients lived in urban *** imaging and pathological evaluation,most PCa patients were diagnosed at an advanced stage,with 20.5%(871/4253)locally progressing and 20.5%(871/4253)showing *** of them initiated prostatectomy(46.6%,1983/4253)or regimens involving ADT therapy(45.7%,1944/4253)for prostate *** the present PCa cohort,43.1%(1832/4253)of patients had hypertension,and half of them had poorly controlled blood *** FRS stratification,as expected,a higher risk of CVD was related to aging and metabolic ***,we also found that patients with treatment involving ADT presented an originally higher risk of CVD than those without *** was in accordance with clinical practice,i.e.,aged patients or patients at advanced oncological stages were inclined to accept sys

关键词： Prostate cancer Castration Cardiovascular disease Prevalence Cardiovascular risk

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基于PSO算法的轨道交通WPT系统规划研究

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铁道工程学报 2024年第3期41卷 100-105页

作者：林云志赖一雄中铁电气化局集团有限公司北京100036

研究目的:面向轨道交通的无线电能传输技术正处于快速发展中,在大规模工程应用之前,对线路的“电源”如何配置、充电的策略等问题缺乏系统性研究,特别是系统的配电规划是一个系统性的非线性问题,具有多维度、多目标、多约束、多变量等特... 详细信息

研究目的:面向轨道交通的无线电能传输技术正处于快速发展中,在大规模工程应用之前,对线路的“电源”如何配置、充电的策略等问题缺乏系统性研究,特别是系统的配电规划是一个系统性的非线性问题,具有多维度、多目标、多约束、多变量等特点,为提高整个工程的经济性,实现建设成本与运营成本的最优,需要一种最优的规划算法。研究结论:(1)从静动态电源配合、动态导轨长度、装置容量选择等多要素进行规划和考虑,基于粒子群优化算法(PSO)对优化求解算法进行运算;(2)首先搭建非线性数学模型,并给出了约束条件、配电系统的规划以及方案的选择标准;最后通过实例仿真验证了其可行性;(3)本文算法在轨道交通WPT系统规划中具有优越的全局寻优性能。

关键词：粒子群优化算法无线电能传输配电方案

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湖南省自然灾害风险可接受程度研究

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西北地质 2024年第1期57卷 55-63页

作者：刘健康刘丙秋匡文龙肖拥军林云志卢正新中化地质矿山总局湖南地质勘查院湖南长沙410018 湖南科技大学地球科学与空间信息工程学院湖南湘潭411201

自然灾害是湖南省面临的主要灾害之一,确定自然灾害风险可接受程度对该省的可持续发展意义重大。通过分析湖南省2010~2020年因灾死亡人数与经济损失、总人口、GDP等数据,参照国内外相关研究,开展自然灾害风险可接受水平研究。取意愿系数... 详细信息

自然灾害是湖南省面临的主要灾害之一,确定自然灾害风险可接受程度对该省的可持续发展意义重大。通过分析湖南省2010~2020年因灾死亡人数与经济损失、总人口、GDP等数据,参照国内外相关研究,开展自然灾害风险可接受水平研究。取意愿系数β=0.01,确定个人生命可接受风险标准;使用人均GDP这一指标,量化个人可接受经济风险;根据最低合理可行准则,分别构建社会生命与经济风险可接受准则模型。结果表明:个人可接受和可容忍生命风险分别为10^(-6)/a和10^(-5)/a;个人可接受经济风险指数为0.01,即个人经济风险的可接受风险范围不超过人均GDP的1%;因灾死亡100人的概率大于10^(-9)、经济损失10亿元的概率大于10^(-2)都属于不可接受风险。研究结果可用于辅助湖南省自然灾害风险的评估、决策与管理,也为其他地区相关研究提供参考。

关键词：自然灾害风险可接受程度 F-N曲线 F-D曲线湖南省

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Photo-enhanced thermal catalytic CO_(2) methanation activity and stability over oxygen-deficient Ru/TiO_(2) with exposed TiO_(2){001}facets:Adjusting photogenerated electron behaviors by metal-support interactions

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Chinese Journal of Catalysis 2022年第2期43卷 391-402页

作者： Ke Wang Shihui He yunzhi lin Xun Chen Wenxin Dai Xianzhi Fu Research Institute of Photocatalysis State Key Laboratory of Photocatalysis on Energy and EnvironmentFuzhou UniversityFuzhou 350108FujianChina Key Laboratory of Eco-Materials Advanced Technology Fuzhou UniversityFuzhou 350108FujianChina

In this study,two Ru/TiO_(2)samples with different TiO_(2)facets were prepared to investigate their photo-thermal catalytic CO_(2)+H_(2)reaction *** UV irradiation,the Ru/TiO_(2)with 67%{001}facet(3 RT)displayed improved thermal catalytic activity for CO_(2)methanation than that of Ru/TiO_(2)with 30%{001}facet(0 RT).After H_(2)pretreatment,both samples exhibited enhanced thermal catalytic activities,but the H_(2)-treated 3 RT(3 RT-H)exhibited superior activity to that of the H_(2)-treated 0 RT(0 RT-H).Under UV irradiation,3 RT-H exhibited apparent photo-promoted thermal catalytic activity and stability,but the enhanced catalytic activity was lower than that of 0 *** on the characterization results,it is proposed that both the surface oxygen vacancies(Vos)(activating CO_(2))and the metallic Ru nanoparticles(activating H_(2))were mainly responsible for CO_(2)*** 0 RT,H_(2)pretreatment and subsequent UV irradiation did not promote the formation of Vos,resulting in low catalytic *** 3 RT,on the one hand,H_(2)pretreatment promoted the formation of Vos,which were regenerated under UV irradiation;on the other hand,the photogenerated electrons from TiO_(2)transferred to Ru to maintain the metallic Ru *** behaviors promoted the activation of CO_(2)and H_(2)and enhanced CO_(2)***,the photogenerated holes favored the dissociated H at Ru migrating to TiO_(2),also promoting CO_(2)*** behaviors occurring on 3 RT-H may be attributed to the suitable metal-support interaction between the Ru nanoparticles and TiO_(2){001},resulting in the easy activation of lattice oxygen in TiO_(2)to *** reference to the analysis of intermediates,a photo-thermal reaction mechanism is proposed for the Ru/TiO_(2){001}facet sample.

关键词： Photo-thermal CO_(2)reduction Oxygen vacancy Ru/TiO_(2) Metal-support interaction

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基于刻意练习理念的辨证教学模式培养中医临床思维能力探究

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中国中医药现代远程教育 2024年第16期22卷 56-58,65页

作者：颜靖文陆瑞峰林云志杜文婷顾耘上海市浦东新区周浦医院中医科上海201318 上海中医药大学附属龙华医院老年科上海200032

以培养学生中医临床思维能力为导向,探索刻意练习理念在中医辨证教学中的运用,以符合刻意练习理念,有明确的目标、清晰的内容、有效的过程、及时的反馈、反复练习的循环的教学设计,帮助学生形成自动心理表征。文章在辨证理论教学中尝试... 详细信息

以培养学生中医临床思维能力为导向,探索刻意练习理念在中医辨证教学中的运用,以符合刻意练习理念,有明确的目标、清晰的内容、有效的过程、及时的反馈、反复练习的循环的教学设计,帮助学生形成自动心理表征。文章在辨证理论教学中尝试多种方法,在辨证实践教学中尝试分阶段教学(情境案例教学、临床实践教学、病案书写教学),将西方教学理论与中医传统教学相融合,提升中医辨证教学质量,以期为中医辨证教学提供新思路、新方法。

关键词：刻意练习中医临床思维中医辨证教学教学改革

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Telomere‑to‑telomere and haplotype‑resolved genome of the kiwifruit Actinidia eriantha

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Molecular Horticulture 2023年第1期3卷 361-371页

作者： Yingzhen Wang Minhui Dong Ying Wu Feng Zhang Wangmei Ren yunzhi lin Qinyao Chen Sijia Zhang Junyang Yue Yongsheng Liu School of Horticulture Anhui Agricultural UniversityHefei 230036China School of Forestry Science and Technology Lishui Vocational and Technical CollegeLishui 323000China Ministry of Education Key Laboratory for Bio‑Resource and Eco‑Environment College of Life ScienceState Key Laboratory of Hydraulics and Mountain River EngineeringSichuan UniversityChengdu 610064China

Actinidia eriantha is a characteristic fruit tree featuring with great potential for its abundant vitamin C and strong disease *** has been used in a wide range of breeding programs and functional genomics *** published genome assemblies of *** are quite fragmented and not highly *** multiple sequencing strategies,we get the haplotype-resolved and gap-free genomes of an elite breeding line“Midao 31”(MD),termed MDHAPA and *** new assemblies anchored to 29 pseudochromosome pairs with a length of 619.3 Mb and 611.7 Mb,as well as resolved 27 and 28 gap-close chromosomes in a telomere-to-telomere(T2T)*** on the haplotype-resolved genome,we found that most alleles experienced purifying selection and coordinately *** to the high continuity of assemblies,we defined the centromeric regions of ***,and identified the major repeating monomer,which is designated as *** resource lays a solid foundation for further functional genomics study and horticultural traits improvement in kiwifruit.

关键词： Kiwifruit Actinidia eriantha Genome Telomere-to-telomere Haplotype Centromeric

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篆刻艺术与幼儿园美育的融合

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学前教育研究 2020年第5期 93-96页

作者：林云芝福州市晋安区教师进修学校附属幼儿园福州350001

幼儿园美育通过构建富有感染力的审美环境来培养幼儿的美感,塑造幼儿的人格,提升幼儿的审美感知能力和欣赏能力,是促进幼儿个性全面发展的重要途径。篆刻是一门书法和镌刻相结合、以印章为表现载体的艺术形式。通过篆刻艺术开展美育,要... 详细信息

幼儿园美育通过构建富有感染力的审美环境来培养幼儿的美感,塑造幼儿的人格,提升幼儿的审美感知能力和欣赏能力,是促进幼儿个性全面发展的重要途径。篆刻是一门书法和镌刻相结合、以印章为表现载体的艺术形式。通过篆刻艺术开展美育,要求幼儿园秉持大美育观来审视并开发篆刻艺术所蕴含的审美要素,构建立体丰富的幼儿园美育场域以促进幼儿园美育实践。为促进幼儿认识美、欣赏美与创造美,幼儿园应重构融合篆刻之美的美育课程体系,创设渗透篆刻之美的美育园所环境,并切实开展能让幼儿体验篆刻之美的美育活动。

关键词：幼儿园美育篆刻艺术美育活动

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Telomere-to-telomere and gap-free reference genome assembly of the kiwifruit Actinidia chinensis

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Horticulture Research 2023年第2期10卷 134-146页

作者： Junyang Yue Qinyao Chen Yingzhen Wang Lei Zhang Chen Ye Xu Wang Shuo Cao yunzhi lin Wei Huang He Xian Hongyan Qin Yanli Wang Sijia Zhang Ying Wu Songhu Wang Yi Yue Yongsheng Liu School of Horticulture Anhui Agricultural UniversityHefeiAnhui 230036China Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural SciencesShenzhenGuangdong 518124China Institute of Fruit and Tea Hubei Academy of Agricultural SciencesWuhanHubei 430064China School of Information and Computer Anhui Agricultural UniversityHefeiAnhui 230036China Ministry of Education Key Laboratory for Bio-resource and Eco-environment College of Life ScienceState Key Laboratory of Hydraulic and Mountain River EngineeringSichuan UniversityChengduSichuan 610064China Department of Bioinformatics Anhui Double Helix Gene Technology CorporationHefeiAnhui 230022China Comprehensive Testing Ground Xinjiang Academy of Agricultural SciencesUrumqiXinjiang 830012China Institute of Special Animal and Plant Sciences Chinese Academy of Agricultural SciencesChangchunJilin 130112China

Kiwifruit is an economically and nutritionally important fruit crop with extremely high contents of vitamin ***,the previously released versions of kiwifruit genomes all have a mass of unanchored or missing ***,we report a highly continuous and completely gap-free reference genome of Actinidia chinensis cv.‘Hongyang’,named Hongyang v4.0,which is the first to achieve two de novo haploid-resolved haplotypes,HY4P and ***4P and HY4A have a total length of 606.1 and 599.6 Mb,respectively,with almost the entire telomeres and centromeres assembled in each *** comparison with Hongyang v3.0,the integrity and contiguity of Hongyang v4.0 is markedly improved by filling all unclosed gaps and correcting some misoriented regions,resulting in∼38.6–39.5 Mb extra sequences,which might affect 4263 and 4244 protein-coding genes in HY4P and HY4A,***,our gap-free genome assembly provides the first clue for inspecting the structure and function of ***,centromeric regions are characterized by higher-order repeats that mainly consist of a 153-bp conserved centromere-specific monomer(Ach-CEN153)with different copy numbers among *** enrichment analysis of the genes located within centromeric regions demonstrates that chromosome centromeres may not only play physical roles for linking a pair of sister chromatids,but also have genetic features for participation in the regulation of cell *** availability of the telomere-to-telomere and gap-free Hongyang v4.0 reference genome lays a solid foundation not only for illustrating genome structure and functional genomics studies but also for facilitating kiwifruit breeding and improvement.

关键词： breeding linking assembly

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中国生猪养殖业规模化动力、路径及影响研究

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农村经济 2020年第8期 126-135页

作者：郭利京林云志安徽财经大学经济学院安徽蚌埠233030

生猪养殖规模化生产效率高、疫病防控能力强,是稳定生猪生产、保证猪肉供给的重要手段。本文在分析中国生猪养殖业规模化现状及趋势的基础上,着重分析了生猪生产规模化的动力、路径及影响,并得出几点结论。一是养殖用工机会成本持续上... 详细信息

生猪养殖规模化生产效率高、疫病防控能力强,是稳定生猪生产、保证猪肉供给的重要手段。本文在分析中国生猪养殖业规模化现状及趋势的基础上,着重分析了生猪生产规模化的动力、路径及影响,并得出几点结论。一是养殖用工机会成本持续上升、环保政策趋紧、疫病防控压力导致散养户加速退出,生猪规模化快速发展,中国生猪生产结构从金字塔型、纺锤型向哑铃型转变。二是规模化推动生猪养殖业转型升级,使生猪生产从劳动密集型行业向资本、技术密集型转变,从穷人养猪向富人养猪转变。三是"公司+家庭农场户"模式符合环境可持续发展原则、规模化轻资产扩张需求及以政府政策引导方向,长期来看该模式将成为中国生猪养殖业规模化的主要路径。四是生猪规模化养殖需要大规模固定资产投资,沉没成本高,规模养殖场融资能力强、达产周期长,因此,规模化将拉长生猪价格波动周期,当前大规模养殖集团的高额净资产收益率源于工业化、专业化生产模式对农户小规模、散养模式的替代,随着规模化的普及,市场竞争将迫使生猪养殖者提高生产效率、降低生产成本。

关键词：生猪养殖业规模化生产效率机会成本疫病防控

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