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Acupuncture-movement therapy for acute lumbar sprain: a randomized controlled clinical trial

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Journal of Traditional Chinese Medicine 2016年第1期36卷 19-25页

作者： lin ruizhu Zhu Ning Liu Jian Li Xinjian Wang Yue Zhang Jie Xi Chaolei Department of Rehabilitation Medicine General Hospital of Ningxia Medical University Medical School of Acupuncture Fujian University of Traditional Chinese Medicine

OBJECTIVE： Several studies have reported that acupuncture is effective for treatment of acute lumbar sprain, but they neglected to consider that acupuncture cannot remarkably improve lumbar activity. We performed a randomized controlled trial to evaluate the effect of acupuncture-movement therapy versus conventional acupuncture in the trea ment of acute lumbar sprain. METHODS： Sixty patients were randomized into four groups： the acupuncture-movement （AM） group, sham acupuncture-movement （SAM） group, conventional acupuncture （CA） group, and physical therapy （PT） group. Patients in the AM group were treated with acupuncture at Yintang （EX-HN 3） and exercise of the lumbar region during acupuncture. Patients in the SAM group were treated with sham acupuncture at Yintang （EX-HN 3） and exercise of the lumbar region during sham acupuncture. Con- ventional acupuncture was performed in the CA group, and physical therapy was applied in the PT group. Each treatment lasted for 20 min. Patients were assessed before and after treatment using a visual analogue scale （VAS） and the Roland Morris Questionnaire （RMQ）. RESULTS： The VAS and RMQ scores in the AM group were significantly lower after than before treatment （P 〈 0.01）. The AM group reported lower RMQ scores in after-treatment and 24 h after treatment and lower VAS score in 24 h after treatment in comparison with those of the CA, SAM, and PT groups （P 〈 0.05）. CONCULSlON： Acupuncture-movement therapy is effective for treating acute lumbar sprain with a persistent pain-relief and remarkable improvement of lumbar activity. Movement, that is, lumbar exercise during acupuncture, enhances the effect of acupuncture.

关键词： Acupuncture Movement Exercise Lumbar sprain Randomized controlled trial

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内热针疗法治疗膝骨关节炎的Meta分析

中医药导报 2024年第1期30卷 131-136,151页

作者：田富宝马良辰陈坤徐玉娟连佳伟陈梦莹许建峰林瑞珠宁夏医科大学总医院宁夏银川750004

目的:分析内热针疗法治疗膝骨关节炎(KOA)的临床疗效。方法:检索内热针干预膝骨关节炎的(单独应用或联合其他治疗方法)的临床随机对照试验(RCT),检索时间限制在数据库建立至2022年11月30日,对符合条件的研究实施质量评价。借助Review Ma... 详细信息

目的:分析内热针疗法治疗膝骨关节炎(KOA)的临床疗效。方法:检索内热针干预膝骨关节炎的(单独应用或联合其他治疗方法)的临床随机对照试验(RCT),检索时间限制在数据库建立至2022年11月30日,对符合条件的研究实施质量评价。借助Review Manager 5.4.1软件,根据总有效率、疼痛评分、西安大略和麦克马斯特大学骨关节炎指数(WOMAC)评分、Lysholms评分等结局指标进行Meta分析。结果:最终纳入11项研究,均为RCT,共涉及病例951例,治疗组和对照组分别475例、476例。Meta分析结果显示,治疗组总有效率高于对照组[RR=1.19,95%CI(1.13,1.25),P<0.00001],WOMAC评分低于对照组[MD=-9.05,95%CI(-9.98,-8.12),P<0.00001],疼痛评分低于对照组[SMD=-4.18,95%CI(-5.82,-2.54),P<0.00001],Lysholms评分高于对照组[MD=16.51,95%CI(4.42,28.60),P<0.00001]。结论:内热针无论是单独治疗还是联合其他方法治疗,均对膝骨关节炎患者产生良好疗效。但鉴于本研究的异质性和样本量的限制,未来需要更大的多中心和高质量的RCT来验证内热针治疗膝骨关节炎的疗效。

关键词：膝骨关节炎内热针 Meta分析随机对照试验

Effect of acupuncture anesthesia on acne vulgaris of pricking-blood-letting cupping: a single-blind randomized clinical trail

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Journal of Traditional Chinese Medicine 2013年第6期33卷 752-756页

作者： Jianfeng Xu ruizhu lin Jing Wang Yongli Wu Yingxu Wang Yuequan Zhang Chaolei Xi Qiang Wu Medical School of Acupuncture Fujian University of Chinese Medicine Department of Orthopedics and Traumatology General Hospital of Ningxia Medical University

OBJECTIVE: To evaluate the effect on acne vulgaris of pricking-bloodletting cupping at Dazhui(GV 14) under acupuncture anesthesia, and establish whether providing anesthesia to the treatment area by manipulating Hegu(LI 4) and Quchi(LI 11) might have an additional therapeutic benefit. METHODS: Thirty-eight patients were recruited and randomized into a control group and an intervention group with a single-blind(observer-blind) method. The control group was treated by pricking-bloodletting cupping at Dazhui(GV 14) and the studied group by pricking-bloodletting cupping at Dazhui(GV 14) under acupuncture anesthesia at Hegu(LI 4) and Quchi(LI 11). Both groups were treated twice weekly for 6 weeks. The analgesic and therapeutic effects of acupuncture were evaluated on a visual analog scale(VAS) and global acne grading system(GAGS), ***: There were differences in the VAS scores of pain on pricking and in the pricked area, and the duration of pain between the groups. After 12 treatments, there was a significant reduction in GAGS scores from baseline in both groups, but there was no significant difference between the groups. CONCLUSION: Acupuncture anesthesia at Hegu(LI 4) and Quchi(LI 11) is an effective means of alleviating the pain of pricking-bloodletting cupping and reducing the duration of pain in the treatment area. Pricking-bloodletting cupping at Dazhui(GV 14) improves the skin lesions of patients with moderate acne vulgaris, but acupuncture anesthesia does not appear to have an additional therapeutic effect.

关键词： Acupuncture anesthesia Bloodlettingtherapy Acne vulgaris Single-blind method Ran-domized controlled trial Point Dazhui (GV 14) Point Hegu (LI 4) Point Quchi (LI 11 )

Effect of stimulating acupoint Guanyuan(CV 4) on lower back pain by burning moxa heat for different time lengths: a randomized controlled clinical trial

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Journal of Traditional Chinese Medicine 2015年第1期35卷 36-40页

作者： Xu Jianfeng lin ruizhu Wu Yongli Wang Yingxu Liu Jian Zhang Yanling Zhang Yuequan Xi Chaolei Wu Qiang Li Xinjian Medical School of Acupuncture Fujian University of Traditional Chinese Medicine Department of Orthopedics and Traumatology General Hospital of Ningxia Medical University

OBJECTIVE: To investigate the effect of different heat-stimulating time lengths on lower back ***: Forty participants were randomly assigned to four groups of various heating time lengths. The short heating time length group(SL),moderate heating time length group(ML), and long heating time length group(LL) respectively received 15, 30, and 60 min of moxibustion therapy stimulating the acupoint Guanyuan(CV 4). The conventional acupuncture group(CA) received needle acupuncture treatment as a control group. The participants were treated continuously over a 2-week treatment period for a total of 10 sessions, with five sessions given per week. Participants were assessed weekly by blinded assessors, using the visual analogue scale(VAS) and Roland Morris Questionnaire(RMQ).RESULTS: The VAS and RMQ scores reduced in all four groups during treatment. There were significant differences in VAS scores(P < 0.01) and RMQ scores(P < 0.01) between before treatment and after 2 weeks of treatment in the LL group. After treatment, the LL group reported significantly lower VAS scores compared with the CA group, ML group,and SL group(P < 0.05).CONCLUSION: The long and moderate lengths of heat-stimulating time of 30 and 60 min may be more effective for relieving lower back pain than that of short stimulating time lengths.

关键词： Moxibustion Burning moxa Heatingtime length Acupuncture Lower back pain Guanyuan (CV 4) Randomized controlled trials

非限域条件下单体天冬酰胺分子的手性转变机制

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吉林大学学报（理学版） 2016年第4期54卷 902-908页

作者：祝颖林芮竹孙佰顺吉林医药学院生物医学工程学院吉林吉林132013 吉林大学原子与分子物理研究所长春130012

基于密度泛函理论B3LYP/6-311+G(2df)水平,研究非限域条件下单体天冬酰胺分子的手性转变过程.通过寻找过渡态和中间体反应过程的各极值点结构,绘制天冬酰胺分子的手性转变路径反应势能面,并分析各极值点的几何及电子结构特性.结果表明:... 详细信息

基于密度泛函理论B3LYP/6-311+G(2df)水平,研究非限域条件下单体天冬酰胺分子的手性转变过程.通过寻找过渡态和中间体反应过程的各极值点结构,绘制天冬酰胺分子的手性转变路径反应势能面,并分析各极值点的几何及电子结构特性.结果表明:S型天冬酰胺分子手性碳上的氢原子以羧基上的氧原子为桥梁,转移至手性碳原子的另一侧,实现了从S型到R型天冬酰胺分子的手性转变;该路径有4个中间体和5个过渡态,最大的反应能垒为316.372 8kJ/mol,来源于第4个过渡态TS_2-R-Asn.

关键词：手性天冬酰胺过渡态转变过程势能面

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限域1F-分子筛Asn分子的手性转变机制

吉林大学学报（理学版） 2018年第3期56卷 718-723页

作者：祝颖林芮竹陈洪斌吉林医药学院生物医学工程学院吉林吉林132013

基于密度泛函理论,在ONIOM(CAM-B3LYP/6-31G(d,p):UFF)基组水平上,研究1F-分子筛限域条件下的天冬酰胺(Asn)分子手性转变过程,寻找天冬酰胺分子手性反应过程中各过渡态与中间体的极值点结构,绘制1F-分子筛限域条件下完整的天冬酰胺分子... 详细信息

基于密度泛函理论,在ONIOM(CAM-B3LYP/6-31G(d,p):UFF)基组水平上,研究1F-分子筛限域条件下的天冬酰胺(Asn)分子手性转变过程,寻找天冬酰胺分子手性反应过程中各过渡态与中间体的极值点结构,绘制1F-分子筛限域条件下完整的天冬酰胺分子手性转变路径反应势能面,并分析各极值点的几何和电子结构特性.结果表明:1F-分子筛限域条件下S型天冬酰胺分子手性C上的H原子以羧基上的O原子为桥梁,转移至手性C原子的另一侧,实现从S型到R型天冬酰胺分子的手性转变;最大的反应能垒为321.361 2kJ/mol,来源于第二个过渡态TS_1-S-Asn@1F-MOL.

关键词：手性天冬酰胺过渡态手性转变

Phenotype and molecular characteristics in 45 Chinese children with 5 α-reductase Type 2 deficiency from South China

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Phenotype and molecular characteristics in 45 Chinese childr...

第十四次全国医学遗传学学术会议

作者： Jing Cheng ruizhu lin Wen Zhang Guochang Liu Huiying Sheng Xiuzhen Li Zhihong Zhou Xiaojian Mao Li Liu Department of Genetics and Endocrinology Guangzhou Women and Children' s Medical Center Department of Pediatric Surgery Guangzhou Women and Children' s Medical Center

Background:Affected by steroid 5α-reductase type 2 deficiency(5α-RD2),46,XY individuals present divergent phenotypes characterized by under-virilization of male external *** identify the disorder,mutational analysis of 5α-reductase type 2 gene(SRD5A2)is a reliable ***,the genotype-phenotype relationship has not been ***:In order to improve the diagnosis and expand the knowledge of the disease,we collected and analyzed relevant data of clinical diagnosis,biological investigation,and molecular determination in 45 childrenwith the SRD5A2 gene mutations from South China in our *** and Methods:45 patients from 45 unrelated families were *** clinical information were collected and *** analysis of the SRD5A2 gene was performed in each ***:Isolated micropenis(35.6%)and microphallus associated with various degree of hypospadias(55.6%)were frequent *** external genitalia with clitoromegaly(8.9%)was *** hCG stimulation test was performed in 18 of 45patients.16 of 18(88.9%)had hCG-stimulated T/DHT ratio above *** 45 patients,we identified 15 different *** have never been described:***90ThrfsX31,***21Arg,***149Asp,***145Leu,*** ***227Gln mutation was detected in 41(91.1%)*** ***89Val polymorphism was found in 38(84.4%)*** mutations were presented in 16(35.6%)patients,compound heterozygous mutations in 20(44.4%)patients,compound heterozygous mutations alone with the ***89Val polymorphism in 9(20.0%)*** 1 and 4 were most affected,and the number of mutant alleles per exon was 78.1%and 12.2%respectively..Conclusions The study demonstrated a wide spectrum of phenotypes,biological profiles and genotypes in the children with 5 a-RD2 from South *** heterozygous mutation ***227Gln is presumably a hot spot mutation and suggests a founder effect in the population of South China that may explain a

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非限域单体异亮氨酸分子的手性转变机制

吉林大学学报（理学版） 2016年第5期54卷 1152-1160页

作者：祝颖王健林芮竹孙佰顺吉林医药学院生物医学工程学院吉林吉林132013 吉林大学原子与分子物理研究所长春130012 吉林大学学报编辑部长春130012

基于密度泛函理论的B3LYP方法,在6-311+G(2df)基组水平上考察非限域条件下单体异亮氨酸分子的手性转变过程.通过寻找包括过渡态和中间体的反应过程各极值点结构,绘制非限域条件下完整的异亮氨酸分子手性转变路径反应势能面,并分析各极... 详细信息

基于密度泛函理论的B3LYP方法,在6-311+G(2df)基组水平上考察非限域条件下单体异亮氨酸分子的手性转变过程.通过寻找包括过渡态和中间体的反应过程各极值点结构,绘制非限域条件下完整的异亮氨酸分子手性转变路径反应势能面,并分析各极值点的几何及电子结构特性.结果表明:非限域条件下,S型异亮氨酸分子手性C上的H原子以羧基上的O原子为桥梁,转移至手性C原子的另一侧,实现了从S型到R型异亮氨酸分子的手性转变;非限域条件下,该路径有4个中间体和5个过渡态,最大反应能垒为325.824 6kJ/mol,来源于第二个过渡态TS2-S-Ile.

关键词：手性异亮氨酸过渡态非限域

A fast forward computational method for nuclear measurement using volumetric detection constraints

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Nuclear Science and Techniques 2024年第2期35卷 47-63页

作者： Qiong Zhang lin-Lv lin University of Electronic Science and Technology of China Chengdu 610000China

Owing to the complex lithology of unconventional reservoirs,field interpreters usually need to provide a basis for interpretation using logging simulation *** the various detection tools that use nuclear sources,the detector response can reflect various types of information of the *** Monte Carlo method is one of the primary methods used to obtain nuclear detection responses in complex ***,this requires a computational process with extensive random sampling,consumes considerable resources,and does not provide real-time response ***,a novel fast forward computational method(FFCM)for nuclear measurement that uses volumetric detection constraints to rapidly calculate the detector response in various complex environments is ***,the data library required for the FFCM is built by collecting the detection volume,detector counts,and flux sensitivity functions through a Monte Carlo ***,based on perturbation theory and the Rytov approximation,a model for the detector response is derived using the flux sensitivity function method and a one-group diffusion *** environmental perturbation is constrained to optimize the model according to the tool structure and the impact of the formation and borehole within the effective detection ***,the method is applied to a neutron porosity tool for *** various complex simulation environments,the maximum relative error between the calculated porosity results of Monte Carlo and FFCM was 6.80%,with a rootmean-square error of 0.62 *** field well applications,the formation porosity model obtained using FFCM was in good agreement with the model obtained by interpreters,which demonstrates the validity and accuracy of the proposed method.

关键词： Nuclear measurement Fast forward computation Volumetric constraints