检索结果-南通市图书馆

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue lin Gen Wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

谷氨酸提取技术及其废液资源化清洁生产研究进展

在线全文

学校读者我要写书评

暂无评论

中国调味品 2021年第12期46卷 196-200页

作者：王睿王倩林樟楠杨鹏波丛威中国科学院过程工程研究所生化工程国家重点实验室北京100190 中国科学院大学北京100049

我国是味精生产和消费大国,味精生产过程中如何提高谷氨酸回收率、减少废液排放量和污染物浓度、提高废液资源化利用率是行业清洁生产发展长期关注的问题。目前,经过十几年的改造和发展,谷氨酸发酵清洁生产技术取得了一定的成果,但其进... 详细信息

我国是味精生产和消费大国,味精生产过程中如何提高谷氨酸回收率、减少废液排放量和污染物浓度、提高废液资源化利用率是行业清洁生产发展长期关注的问题。目前,经过十几年的改造和发展,谷氨酸发酵清洁生产技术取得了一定的成果,但其进一步发展仍是行业面临的一个巨大挑战。文章在综合文献和行业发展的基础上,简述了谷氨酸提取和发酵废液处理的现状及存在的问题;从提高谷氨酸总提取回收率和从源头上减少酸碱使用量两个角度切入,总结了谷氨酸清洁生产技术的研究进展;根据利用方式总结并分析了发酵废液资源化方法及其应用特点,包括直接资源利用和微生物培养,为其综合利用提供了参考,并对未来的发展趋势进行了展望。

关键词：谷氨酸发酵清洁生产资源化提取技术微生物培养

浅析社区卫生服务评价方法与提升社区卫生服务效率

在线全文

学校读者我要写书评

暂无评论

卫生软科学 2017年第3期31卷 26-29页

作者：赵临郭亚楠张瑶天津医科大学公共卫生学院天津300070

介绍了国内外社区卫生服务的不同运作方式及国内外学者对社区卫生服务评价方法和服务效率的研究成果,为政府部门制定社区卫生服务发展政策并优化社区卫生服务模式提供参考。

关键词：社区卫生服务技术效率服务效率

Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3273-3286页

作者： Shiming Li Jianfeng Li Guoliang Chen Tao lin Penghui zhang Kuileung Tong Ningning Chen Shaoyu Liu Shenzhen Key Laboratory of Bone Tissue Repair and Translational Research Department of Orthopedic SurgeryThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedics and Traumatology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

We previously demonstrated that inhibiting neural stem cells necroptosis enhances functional recovery after spinal cord *** exosomes are recognized as playing a pivotal role in neural stem cells exocrine function,their precise function in spinal cord injury remains *** investigate the role of exosomes generated following neural stem cells necroptosis after spinal cord injury,we conducted singlecell RNA sequencing and validated that neural stem cells originate from ependymal cells and undergo necroptosis in response to spinal cord ***,we established an in vitro necroptosis model using neural stem cells isolated from embryonic mice aged 16-17 days and extracted *** results showed that necroptosis did not significantly impact the fundamental characteristics or number of *** sequencing of exosomes in necroptosis group identified 108 differentially expressed messenger RNAs,104 long non-coding RNAs,720 circular RNAs,and 14 microRNAs compared with the control *** of a competing endogenous RNA network identified the following hub genes:tuberous sclerosis 2(Tsc2),solute carrier family 16 member 3(Slc16a3),and forkhead box protein P1(Foxp1).Notably,a significant elevation in TSC2 expression was observed in spinal cord tissues following spinal cord ***2-positive cells were localized around SRY-box transcription factor 2-positive cells within the injury ***,in vitro analysis revealed increased TSC2 expression in exosomal receptor cells compared with other *** assessment of cellular communication following spinal cord injury showed that Tsc2 was involved in ependymal cellular communication at 1 and 3 days post-injury through the epidermal growth factor and midkine signaling *** addition,Slc16a3 participated in cellular communication in ependymal cells at 7 days post-injury via the vascular endothelial growth factor and macrophage migration inhibitory factor signaling

关键词： cellular communication competing endogenous RNA exosomes Foxp1 necroptosis neural stem cells Slc16a3 spinal cord injury transcriptome sequencing Tsc2

Crosstalk-free multichannel sensor based on a dual-Sagnac interferometer interrogated by microwave photonic filter

在线全文

学校读者我要写书评

暂无评论

Optoelectronics Letters 2025年

作者： zhang Ailing WANG Bo zhang Yongfu CHANG Pengxiang WANG Minghe lin Rui Engineering Research Center of Optoelectronic Devices & Communication Technology， Ministry of Education， Tianjin Key Laboratory of Film Electronic and Communication Devices， School of Electrical and Electronic Engineering， Tianjin University of Technology

A crosstalk-free multichannel sensor based on a dual-Sagnac interferometer interrogated by microwave photonic filter (MPF) is demonstrated theoretically and experimentally in this paper. The dual-Sagnac interferometer is taken as the sensing element as well as an optical spectrum slicer to implement a dual-passband MPF. Experimental results show that the proposed multichannel sensor is crosstalk-free， and the temperature sensitivity of each channel is -0.9884 MHz/℃ and -1.9302 MHz/℃， respectively. The sensing interrogation system has good linearity and stability and it is suitable for application scenarios where multiple points of temperature are required to monitor simultaneously.

关键词：

Thermally triggered topological polymerization in diacetylene-functionalized covalent organic framework toward enhanced memristive properties

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Panke Zhou Yuxing Huang Ziyue Yu Cong zhang Qian Chen Yiping Li Chao lin Xiong Chen State Key Laboratory of Photocatalysis on Energy and Environment Key Laboratory of Advanced Carbon-Based Functional MaterialsCollege of Chemistry Fuzhou University

The development of stimuli-responsive switching memory devices and the elucidation of their switching mechanisms in specific environments are crucial for advancing the field of molecular electronics. Herein, we propose two distinct two-dimensional covalent organic frameworks (COFs), namely Py-EDA and Py-BDA, incorporating acetylene (-C≡C-) or diacetylene(-C≡C-C≡C-) moieties, respectively, targeting fabricate memory devices exhibiting stimuli-responsive switching *** findings demonstrate that the incorporation of acetylene units effectively modulates the electronic band structure and enhances the degree ofπ-conjugation, resulting in devices that exhibit typical bipolar nonvolatile memory performance. Notably,upon thermal treatment, the memory behavior of the ITO/Py-BDA/Ag device transitions to a write-once-read-many-times(WORM) mode, displaying decreased SET voltage, increased ON/OFF current ratio, and remarkable retention reliability and cycle stability. This switching behavior is attributed to the occurrence of interlayer solid-state topological polymerization at 350℃, leading to the transformation of diacetylene columnar arrays into enyne chains within Py-BDA, thereby further promoting interlayer charge transfer and separation.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

基于微观仿真的停车场出入口规划设计方法

华北理工大学学报（自然科学版） 2018年第3期40卷 73-77页

作者：冯智芸张林许亚男张敬华北理工大学建筑工程学院河北唐山063210

在汽车保有量日益增长,可利用于建设停车场的土地资源相对匮乏的背景下,提出了一种基于微观交通仿真模拟车辆运行的方法,并对所提出的不同的停车场出入口设计方案进行分析比较,通过设定平峰高峰小时的车流量分析了不同进出口方案中车辆... 详细信息

在汽车保有量日益增长,可利用于建设停车场的土地资源相对匮乏的背景下,提出了一种基于微观交通仿真模拟车辆运行的方法,并对所提出的不同的停车场出入口设计方案进行分析比较,通过设定平峰高峰小时的车流量分析了不同进出口方案中车辆运行所产生的排队长度及延误,进而通过数据处理分析得到最佳的停车场出入口设计方案。

关键词：土地资源微观仿真模拟排队长度延误停车场出入口设计

Evaluating the impacts of converting grain to vegetable fields on nitrate transport in the deep vadose zone of the North China Plain

在线全文

学校读者我要写书评

暂无评论

Journal of Geographical Sciences 2025年第1期35卷 189-212页

作者： LIU Meiying MIN Leilei WU lin zhang Yucui QI Yongqing WANG Shiqin LIU Binbin GENG Di SHEN Yanjun Hebei Key Laboratory of Water-Saving Agriculture Key Laboratory of Agricultural Water ResourcesCenter for Agricultural Resources ResearchInstitute of Genetics and Developmental BiologyCAS School of Advanced Agricultural Sciences University of Chinese Academy of Sciences

Nitrate （NO3-） accumulation and transport processes in the thick vadose zone affect the evolution of the groundwater NO3-content in intensive agricultural *** land-use change （ALUC）,typically accompanied by substantial alterations in nitrogen fertilizer application and irrigation practices,is an important influencing *** study evaluated the changes in NO3-accumulation and transport in the deep vadose zone （DVZ,below the root zone）,and the groundwater NO3-content associated with ALUC from grain to vegetable fields in the North China Plain （NCP）.The ALUC from grain to vegetable resulted in nitrate–nitrogen （NO3--N） accumulation in DVZ increased by 235.5 kg ha-1m-1（163.2%） in the piedmont plain and 224.9 kg ha-1m-1（102.7%） in the central plain,*** change accelerated downward transport velocity in the DVZ (from 0.81±0.47 to 0.89±0.55 m yr-1in the piedmont plain,and from 0.24±0.12 to 0.92±0.12 m yr-1in the central plain) and increased NO3-leaching *** transport velocity and leaching fluxes resulted in chemical N-fertilizer entering the aquifer in several areas in the piedmont *** impact of the agricultural activity intensity changes,accompanied by the ALUC,on groundwater quantity and quality should be considered in similar regions.

关键词：

Investigation of edge states variation in valley photonic crystals by modulating the refractive index of domain walls

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Optoelectronics Letters 2025年第3期21卷 160-166页

作者： zhang Run ZHONG Xingli lin Zhongxi QIU Weibin SU Hui Key Laboratory of Optoelectronic Materials Chemistry and Physics Collaborative Innovation Center for Optoelectronic Semiconductors and Efficient Devices Fujian Institute of Research on the Structure of Matter Chinese Academy of Science University of Chinese Academy of Sciences Chinese Academy of Sciences College of Information Science and Engineering Huaqiao University Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China

Realizing the valley Hall effect by breaking the spatial inversion symmetry of photonic systems has become a cutting-edge field of micro-nano-optics, since the valley degree of freedom was introduced into photonic system. Various novel devices based on the domain walls of the valley photonic crystals have also been demonstrated. In this article,we investigate the variation of edge states by the modulation of refractive index within the domain walls, and the geometric difference between the dielectric columns of the sublattices. Straight photonic crystal waveguides with three types of domain walls (bearded, zigzag, armchair) are constructed. Simulation results show that the creation of a double-edge state in the band diagram results in two windows of stable transmission in tunable bands. Our findings might have significant implications in the field of novel optical devices.

关键词：