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Synthesis and Characterization of Novel Orange-emitting Iridium(III) Complexes with Diphenylquinoline Ligands Containing Fluorinated Substituent

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Chinese Chemical Letters 2006年第3期17卷 411-414页

作者： Xiao Wei ZHANG Chu Luo YANG Zhong An LI lin na zhu Jin Gui QIN Jia GAO Dong Ge MA Department of Chemistry Key Lab on Organic and Polymeric Opto-electronic Materials Wuhan University Wuhan 430072 State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022

Three new cyclometalated iridium（m） complexes based on ligands of diphenylquinoline with fluorinated subsfituents were prepared, and characterized by elemental analysis （EA）, ^1H NMR, and mass spectroscopy （MS）.... 详细信息

关键词： Iridium complexes phenylquinoline photoluminescence electrophosphorescence

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao Yu-Gui Peng Peng Wu Zong-lin Li Xue-Feng zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

Non-coding Rnas in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin lin zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding Rnas(ncRnas)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRnas in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRnas can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRnas in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRnas in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRnas(microRnas,long ncRnas,and circular Rnas)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRnas to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRnas in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular Rnas excitatory toxicity long non-coding Rnas microRnas neuroinflammation non-coding Rnas oxidative stress

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智能用车APP用户体验量化模型构建

包装工程 2017年第20期38卷 120-125页

作者：方浩张丹丹张言林朱娜东南大学艺术学院南京210018 中国地质大学艺术与传媒学院武汉430074

目的构建智能用车APP用户体验量化模型,提出智能用车APP用户体验设计策略。方法首先,进行深度访谈得到智能用车APP用户需求和体验要素;然后,将其与用户体验蜂窝模型和服务质量模型融合,确定用户体验量化模型维度,在所得维度下采用文献... 详细信息

目的构建智能用车APP用户体验量化模型,提出智能用车APP用户体验设计策略。方法首先,进行深度访谈得到智能用车APP用户需求和体验要素;然后,将其与用户体验蜂窝模型和服务质量模型融合,确定用户体验量化模型维度,在所得维度下采用文献分析和专家访谈方法确定影响因子,设计调查问卷;最后,使用主成分分析法分析问卷数据确定智能用车APP用户体验量化模型权重。结论确定了智能用车APP用户体验量化模型7个维度与26个影响因子及权重,提出了信息与对象明确、合理优惠与简洁操作等用户体验设计策略。

关键词：智能用车用户体验量化模型影响因子

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

Novel adaptive laser scanning sensor for reverse engineering measurement

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仪器仪表学报 2007年第7期28卷 1164-1169页

作者： Zhao Ji MaZi lin na zhu Quanmin Automation Research Center Dalian Maritime University Liaoning 116026 China Faculty of Computing Engineering and Mathematical Science University of the West of England Frenchey Campus Coldharbour Lane Bristol BS161Q Y UK

In this paper,a series of new techniques are used to optimize typical laser scanning *** integrated prototype is compared with traditional approach to demonstrate the much improved *** the research and development,camera calibration is achieved by extracting characteristic points of the laser plane,so that the calibra- tion efficiency is improved *** feedback control of its intensity,the laser is automatically adjusted for different material.A modified algorithm is presented to improve the accuracy of laser stripe *** fusion of data extracted from left and right camera is completed with re-sampling *** scanner is integrated with a robot arm and some other machinery for on-line measurement and inspection,which provides a flexible measurement tool for reverse engineering.

关键词：逆向工程激光扫描传感器激光强度控制照相机校准

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule zhu Yumin Wu Xiaowu lin Yiming Qian Jiashu Lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

Pollen Morphology of Eight Genera of the Subtribe Mutisiinae Less. sensu Bremer （Compositae） from Asia

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Journal of Integrative Plant Biology 2005年第9期47卷 1036-1046页

作者： na-na lin Hong WANG De-zhu LI Stephen BLACKMORE Laboratory of Biodiversity and Plant Biogeography Kunming Institute of Botany the Chinese Academy of Sciences Kunming 650204 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China Royal Botanic Garden Edinburgh Edinburgh EH3 5LR Scotland UK

The pollen morphology of 28 species and one variety representing eight genera of the subtribe Mutisiinae Less. sensu Bremer （Compositae） was investigated by scanning electron microscopy （SEM） and light microscopy. The pollen grains are usually radically symmetrical, isopolar, and tricolporate. The shape varies from spheroidal to subprolate in equatorial view and is three-lobed circular in polar view. Based on exine sculpturing observed under SEM, the pollen grains can be divided into three types：（i） type Ⅰ, with macrogranulate sculpture; （ii） type Ⅱ, with a finely granulate sculpture; and （iii） type Ⅲ with spiny sculpture. The palynological data showed that the Macroclinidium Maxim. was remarkably distinguished from those of the other seven genera. The variation of pollen characteristics within the Mutisiinae in Asia is little at species level, but it proves some useful information for studying the relationships among genera and it has an important significance in further understanding the evolutionary history of Mutisiinae.

关键词： Asia Compositae Mutisiinae pollen morphology.

职前教师学科教学知识的认知:困境、原因与改进策略

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教师教育学报 2025年第1期12卷 20-27页

作者：郭学君林林李娜宁波大学教师教育学院浙江宁波315211 上海财经大学国际文化交流学院上海200433 华中师范大学数学与统计学学院湖北武汉430079

职前教师学科教学知识的认知包括学科知识认知与教学实践两个层面。研究基于9位职前教师的27次反思报告,运用质性研究方法,通过分析职前教师对学科知识的诠释、重组、呈现,探究职前教师学科知识认知与教学实践之间的关系,并阐释职前教... 详细信息

职前教师学科教学知识的认知包括学科知识认知与教学实践两个层面。研究基于9位职前教师的27次反思报告,运用质性研究方法,通过分析职前教师对学科知识的诠释、重组、呈现,探究职前教师学科知识认知与教学实践之间的关系,并阐释职前教师学科教学知识的认知困境与原因。研究发现,如果职前教师未能意识到学科知识的独立性和专业性,则很难恰当地将学科知识融入教学实践,以致教学实践中存在学科知识欠缺的现象。故教师培养者应补充相关的学科知识,以帮助职前教师形成合理、整体、全面的学科教学知识;职前教师应深化、重组学科知识认知,调整审视教学内容的视角并在教学实践中恰当地呈现学科知识。

关键词：职前教师学科教学知识学科知识认知教学实践反思报告