检索结果-南通市图书馆

Rat adipose-derived stromal cells expressing BMP4 induce ectopic bone formation in vitro and in vivo

Acta Pharmacologica Sinica 2006年第12期27卷 1608-1615页

作者： lin lin~2 xin {3.~2 xin zhang~2 lian-xu chen~2 ji-ying zhang~2 chang-{13. yu~(2,4)kang-tao ma~3.chun-yan zhou~(3.4)2 institute of sports {23.,peking university third hospital,Beijing 1.0083.china 3.Department of Biochemistry and Molecular Biology,peking university School of Basic Medical Science,Beijing 1.0083.china institute of sports medicine Peking University Third Hospital Beijing China Department of Biochemistry and Molecular Biology Peking University School of Basic Medical Science Beijing China

Aim:Bone morphogenetic protein 4(BMP4)is one of the main local contributingfactors in callus formation in the early phase of fracture ***-derivedstromal cells(ADSC)are multipotent *** present study was conducted toinvestigate the osteogenic potential of ADSC when exposed to adenovirus con-taining BMP4 cDNA(Ad-BMP4).Methods:ADSC were harvested from Sprague-Dawley *** exposure to Ad-BMP4,ADSC were assessed by alka{3.e phos-phatase activity(ALP)assay,RT-PCR and yon Kossa ***4 expressionwas assessed by RT-PCR,immunofluorescence and Western blot analysis,ADSCtransduced with Ad-BMP4 were directly injected into the hind limb muscles ofathyrnic *** Ad-EGFP(enhanced green fluorescence protein)served *** animals were examined by X-ray film and histological ***:The expression of BMP4 was confirmed at both mRNA and protein *** expression of the osteoblastic gene,ALP activity and yon Kossa stainingconfirmed that ADSC transduced with Ad-BMP4 underwent rapid and markedosteoblast differentiation,whereas ADSC transduced with Ad-EGFP and cells leftalone displayed no osteogenic differentiation.X-ray and histological examinationconfirmed new bone formation in athymic mice transplanted with ADSC trans-duced with ***:Our data demonstrated successful osteo-genic differentiation of ADSC transduced with Ad-BMP4 in vitro and in *** may be an ideal source of mesenchyme {3.eage stem cells for gene therapyand tissue engineering.

关键词： adipose-derived stromal cells BMP4 gene therapy bone formation

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中药注射剂临床应用药物警戒指南

引用

中国中药杂志 2024年第16期49卷 4279-4284页

作者：付常宽刘峘王连心邹忆怀黎明全林亚明孙维红魏戌胡聿尔谢雁鸣黎元元中国中医科学院中医临床基础医学研究所北京100700 北京中医药大学东直门医院北京100700 长春中医药大学附属第三临床医院吉林长春130117 云南省中医医院云南昆明650021 宁夏医科大学总医院宁夏银川750004 中国中医科学院望京医院北京100102

2019年,新修订的《中华人民共和国药品管理法》发布实施,明确提出我国建立药物警戒制度。中药注射剂作为中药新剂型,临床应用广泛,其药物警戒备受关注。针对这一现状,项目组召集全国多位临床、药学、循证医学专家组成专家组,严格遵循中... 详细信息

2019年,新修订的《中华人民共和国药品管理法》发布实施,明确提出我国建立药物警戒制度。中药注射剂作为中药新剂型,临床应用广泛,其药物警戒备受关注。针对这一现状,项目组召集全国多位临床、药学、循证医学专家组成专家组,严格遵循中华中医药学会团体标准的要求,制订《中药注射剂临床应用药物警戒指南》,旨在从临床应用的角度,依据我国药物警戒法规,并借鉴国外药物警戒指南,考虑中药注射剂临床应用药物警戒的关键要素,从监测与报告、信号识别、风险评估、风险控制等4个关键环节,对中药注射剂临床应用药物警戒工作提出建议。

关键词：中药注射剂药物警戒中药药物警戒团体标准指南

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clinical trial with traditional Chinese medicine intervention ''tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'' for chronic hepatitis B-associated liver failure

引用

World Journal of Gastroenterology 2014年第48期20卷 18458-18465页

作者： Han-Min Li Zhi-Hua Ye Jun zhang Xiang Gao yan-Ming chen {3. Yao jian-xun Gu Lei Zhan yang ji jian-liang xu ying-He Zeng Fan yang {13. Xiao Guo-Guang Sheng Wei {3. Qi long Qing-jing Zhu Zhao-Hong Shi lian-Guo Ruan jia-Yao yang chang-chun Li Hong-Bin Wu Sheng-Duo chen {3.-La Luo Hepatopathy institute Affiliated Hospital of Hubei University of Chinese Medicine Hubei university of Chinese medicine jingzhou hospital of Traditional Chinese {3. Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency School of Pharmaceutical Science and Technology Tianjin University

AIM:To study the clinical efficacy of traditional Chinese medicine(TCM)intervention"tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment"("TTK")for treating liver failure due to chronic hepatitis ***:We designed the study as a randomized controlled clinical *** number of Chinese Clinical Trial Registry is Chi CTR-TRC-12002961.A total of 144 patients with liver failure due to infection with chronic hepatitis B virus were enrolled in this randomized controlled clinical *** were randomly assigned to the following three groups:(1)a modern medicine control group(MMC group,3.patients);(2)a"tonifying qi and detoxification"("TQD")group(72 patients);and(3.a"tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment"("TTK")group(3.patients).Patients in the MMC group received general internal medicine treatment;patients in the"TQD"group were given a TCM formula"tonifying qi and detoxification"and general internal medicine treatment;patients in the"TTK"group were given a TCM formula of"TTK"and general internal medicine *** participants were treated for 8 wk and then followed at 48 wk following their final *** pri{13.ryefficacy end point was the patient fatality rate in each *** of various virological and biochemical indicators served as secondary *** one-way analysis of variance and the t-test were used to compare patient outcomes in the different treatment ***:At the 48-wk post-treatment time point,the patient fatality rates in the MMC,"TQD",and"TTK"groups were 51.61%,3..3.%,and 16.67%,respectively,and the differences between groups were statistically significant(P0.05).Patients in the"TTK"group had significantly higher levels of serum to

关键词： Clinical study 'Tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK') Liver regeneration Treatment with integrated traditional and Western medicine Chronic hepatitis B-associated liver failure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical evaluation of double-bundle anterior cruciate ligament reconstruction procedure using hamstring tendon grafts： a prospective, randomized and controlled study

引用

Chinese Medical Journal 2009年第6期122卷 706-711页

作者： WANG jian-quan AO ying-fang yu {3.-long LIU Ping xu yan chen lin-xin institute of sports medicine Peking University Third Hospital Beijing 100083 China

Background In clinical studies there is still a lot of controversy about the increased anterior and rotational stability between double-bundle （DB） and single-bundle （SB） anterior cruciate ligament （ACL） reconstruction. The aim of this study was to evaluate the clinical results of four-tunnel DB ACL reconstruction.Methods Sixty-four consecutive patients with ACL ruptures from may 2005 to may 2006 were randomly assigned into two groups： 3. cases for SB ACL reconstruction and 3. cases for DB ACL reconstruction. Clinical data, including KT 2000, Biodex test, Lysholm score, Tegner score and IKDC score, were prospectively collected until at least 10 months post-operative.Results The average values of KT 2000 were （1.47±1.17） mm and （1.68±1.14） mm for the SB and DB ACL reconstruction groups at 3.° of knee flexion （P 〉0.05）, and were （1.04±0.98） mm and （1.13.0.98） mm at 90° of knee flexion （P 〉0.05）. There were also no significant differences in Lysholm score, Tegner score, IKDC score and Biodex test scores between the two groups （P 〉0.05）. The operation time of DB ACL reconstruction was 20 minutes longer than the SB ACL reconstruction （P 〈0.05）Conclusion Double bundle ACL reconstructions have no obvious clinical advantages over single bundle ACL reconstructions.

关键词： anterior cruciate ligament semitendinosus tendon gracilis tendon double bundle reconstruction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Application of next generation sequencing in the screening of monogenic diseases in china,2021:a consensus among Chinese newborn screening experts

引用

World Journal of Pediatrics 2022年第4期18卷 235-242页

作者： Fan Tong jian Wang Rui Xiao Bing-Bing Wu Chao-chun Zou Ding-Wen Wu Hua Wang Hui Zou lian-Shu Han {3. yang {3. Zou Ming-yan Hei Ru-Lai yang Tian-Ming yuan Wei Wen xin-Wen Huang xue-Fan Gu yan-{3.g yang Yong-Lan Huang Yong-Jun zhang Yong-Guo yu Zheng-Feng xu Wen-Hao zhou Zheng-yan Zhao Children’s hospital Zhejiang University School of MedicineNational Clinical Research Center for Child Health3333 Binsheng RoadBinjiang DistrictHangzhou 310052China Shanghai Children’s Medical Center Shanghai Jiaotong University School of MedicineShanghaiChina National Engineering Laboratory for Key Technology of Birth Defect Control and Prevention Screening and Diagnostic R and D CenterHangzhouChina Center for Molecular medicine Children’s Hospital of Fudan University399 Wan Yuan RoadMin Xing DistrictShanghai 200000China National Health Commission Key Laboratory for Birth Defect Research and Prevention Maternal and Child Health Hospital of Hunan ProvinceChangshaChina jinan maternity and Child Care hospital Affiliated To Shandong First Medical {3. JinanChina xinhua hospital Shanghai Institute for Pediatric ResearchShanghai Jiao Tong University School of MedicineShanghaiChina Clinical Genetic Center Children’s Hospital of Fudan UniversityShanghaiChina Children’s hospital Shanghai Jiaotong UniversityShanghaiChina Neonatal Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina Affiliated Shenzhen maternity and Child Healthcare hospital Southern Medical UniversityShenzhenChina xinhua hospital School of MedicineShanghai Jiaotong UniversityShanghaiChina peking university First hospital BeijingChina Guangzhou Women and Children’s Medical Center GuangzhouChina Center of Genetic medicine Women’s Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingChina

Newborn screening(NBS)refers to a maternal and newborn healthcare technology,in which special examinations of congenital and genetic diseases that could seriously impact the health of newborns,are implemented during the neonatal period to provide early diagnosis and treatment[1].With a history of more than 60 years,NBS has advanced greatly due to technological progress resulting in significant improvement in the number of diseases covered by NBS and in screening efficiency[2-7].

关键词： diseases diagnosis congenital

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients

引用

Chinese Medical Journal 2013年第12期126卷 2276-2280页

作者： ZHENG ying CAI Guang-yan chen Xiang-mei fu Ping chen jiang-hua DING Xiao-qiang yu xue-qing lin Hong-li LIU jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU fu-you YIN Ai-ping xinG chang-ying WANG Li SHI Wei LIU jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning chen Nan SU Zhen MEI chang-lin ZHAO jiu-yang GU Yong BAI yun-kai LUO Hui-min lin Shan chen Meng-hua GONG Li yanG Yi-bin yanG Xiao-ping LI ying WAN jian-xin WANG Nian-song LI Hai-ying XI chun-sheng HAO Li xu yan FANG jing-ai LIU Bi-cheng LI Rong-shan WANG Rong zhang jing-hong WANG jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong yuAN Wei-jie SUN Shi-ren zhang ling zhou chun-hua chen Qin-kai jiA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG liang-bao Department of Nephrology State key Laboratory of Kidney Disease Chinese PLA General Hospital Beijing 100853 China Nephrology institute of the Chinese People's Liberation Army Chinese People's Liberation Army Key Laboratory of Nephrology Beijing 100853 China Department of Nephrology West China Hospital of Sichuan University Chengdu Sichuan 610041 China Department of Nephrology First Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310003 China Department of Nephrology Zhongshan Hospital Fudan University Shanghai 200032 China Department of Nephrology First Affiiated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China Department of Nephrology First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116011 China Department of Nephrology First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830054 China Department of Nephrology First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Nephrology First Afftiated Hospital of China Medical University Shenyang Liaoning 110001 China Department of Nephrology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025 China Department of Nephrology Second Xiangya Hospital Central South University Changsha Hunan 410000 China Department of Nephrology First Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an Shaanxi 710061 China Department of Nephrology First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital) Nanjing Jiangsu 210029 China Department of Nephrology Sichuan Provincial People's Hospital Chengdu Sichuan 610072 China Department of Nephrology Guangdong Provincial People's Hospital Guangzhou Guangdong 510030 China Department of Nephrology Affliated Xiehe Hospital Tongji Medical College Huazhong Science and Technology University Wuhan Hubei 430022 China Department of Nephrology Daping Hospital Third Military Medi

Background Data on the epidemiology of hypertension in Chinese non-dialysis chronic kidney disease （CKD） patients are *** aim of the present study was to investigate the prevalence,awareness,treatment,and control of hypertension in the non-dialysis CKD patients through a nationwide,multicenter study in *** The survey was performed in 61 tertiary hospitals in 3. provinces,municipalities,and autonomous regions in china （except Hong Kong,macao,and Taiwan）.Trained physicians collected demographic and c{3.ical data and measured blood pressure （BP） using a standardized *** was defned as systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg,and/or use of antihypertensive *** 〈140/90 mmHg and 〈13./80 mmHg were used as the 2 thresholds of hypertension *** multivariate logistic regression with adjustment for sex and age,we analyzed the association between CKD stages and uncontrolled hypertension in non-dialysis CKD *** The analysis included 8927 non-dialysis CKD *** prevalence,awareness,and treatment of hypertension in non-dialysis CKD patients were 67.3.,85.8%,and 81.0%,*** hypertensive CKD patients,3..1% and 14.1% had controlled BP to 〈140/90 mmHg and 〈13./80 mmHg,*** successive CKD stages,the prevalence of hypertension in non-dialysis CKD patients increased,but the control of hypertension decreased （P〈0.001）.When the threshold of BP 〈13./80 mmHg was considered,the risk of uncontrolled hypertension in CKD 2,3.,3.,4,and 5 stages increased 1.3.1.4,1.4,2.5,and 4.0 times compared with CKD 1 stage,respectively （P〈0.05）.Using the threshold of 〈140/90 mmHg,the risk of uncontrolled hypertension increased in advanced stages （P〈0.05）.Conclusions The prevalence of hypertension Chinese non-dialysis CKD patients was high,and the hypertension control was *** successive CKD stages,the risk of uncontrolled hypertension increased.

关键词： non-dialysis chronic kidney disease chronic kidney disease stages hypertension epidemiology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

mangiferin联合硼替佐米对Burkitt淋巴瘤恶性生物学行为的调控机制及对CXCR表达的影响

引用

中国实验血液学杂志 2023年第5期31卷 1394-1402页

作者：严志民刘彦权许庆林林洁刘欣朱秋平陈鑫基刘庭波连晓岚赣南医学院第一附属医院血液内科江西赣州341000 赣南医学院第一附属医院重症医学科江西赣州341000 福建医科大学附属协和医院血液病研究所福建福州350001

目的:分析芒果苷(mangiferin)联合硼替佐米对人Burkitt淋巴瘤Raji细胞增殖、侵袭、凋亡和自噬的作用及对CXC趋化因子受体家族(CXCR)表达的影响,并探究其间存在的分子机制,为Burkitt淋巴瘤基础研究与临床提供科学依据。方法:采用不同浓度... 详细信息

目的:分析芒果苷(mangiferin)联合硼替佐米对人Burkitt淋巴瘤Raji细胞增殖、侵袭、凋亡和自噬的作用及对CXC趋化因子受体家族(CXCR)表达的影响,并探究其间存在的分子机制,为Burkitt淋巴瘤基础研究与临床提供科学依据。方法:采用不同浓度mangiferin、硼替佐米单药或联合干预Raji细胞,利用CCK-8法检测细胞增殖,Transwell小室法检测细胞侵袭能力,Annexin V/PI双染流式细胞术检测细胞凋亡,Western blot检测凋亡、自噬及Akt/m TOR通路蛋白表达情况,实时荧光定量PCR检测CXCR家族的表达变化。结果:不同浓度mangiferin干预Raji细胞不同时间后,可抑制Raji细胞活力,且呈浓度及时间依赖性(r=-0.682,r=-0.83.);与单药组相比,mangiferin联合硼替佐米干预Raji细胞时,细胞增殖与侵袭能力显著下降、凋亡水平显著升高(Pmangiferin联合硼替佐米干预Raji细胞后,可上调促凋亡蛋白Bax表达并显著下调抗凋亡蛋白Bcl-2的表达,同时亦使Caspase-3.解活化,继而诱导Raji细胞发生凋亡。mangiferin联合硼替佐米干预Raji细胞后可上调LC3.蛋白的表达,且细胞中LC3./LC3.比值较单药或对照组显著上调(Pmangiferin联合硼替佐米可显著抑制Akt和m TOR的磷酸化水平,通过抑制Akt/m TOR通路来使Raji细胞增殖及侵袭受抑,并诱导细胞发生自噬与凋亡。mangiferin及硼替佐米单药干预Raji细胞后,可下调CXCR4、CXCR7 m RNA的表达,当两药联合时CXCR4、CXCR7 m RNA表达下调更为显著(Pmangiferin单药或联合硼替佐米干预Raji细胞后CXCR5 m RNA表达无显著变化(P>0.05),但两药联合时可使CXCR3.达下调(Pmangiferin联合硼替佐米能协同抑制Raji细胞增殖、侵袭,并诱导其发生自噬与凋亡,机制可能与抑制Akt/m TOR信号通路并通过下调抗凋亡蛋白Bcl-2和上调促凋亡蛋白Bax以及使CXCR家族表达受抑等有关。

关键词：芒果苷硼替佐米 Burkitt淋巴瘤恶性生物学行为调控机制 CXC趋化因子受体

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

2017年上海市细菌耐药性监测

引用

中国感染与化疗杂志 2019年第2期19卷 113-127页

作者：杨洋郭燕朱德妹胡付品汪复蒋晓飞刘云王靖王敏周军王传清王爱敏应春妹高晶方毅张景皓袁轶群王峰沈芳胡娟喻靓张菁李华茵黄声雷胡海清刘耀婷汤瑾吴琼刘庆中汤荣张泓王春孙康德虞中敏钟政荣瞿跃红潘秋辉黄卫春孙景勇韩立中李丽周敏李敏张灏旻卫颖珏杨海慧孙晴徐伟红刘瑛陈峰张莉钱敏健龚炜朱学源王蓉吴唯一魏取好唐群力林勇翁丽贞刘兴晖沈振华汪瑞忠房华范惠清邓卫平张立朱卿戴俊华康向东唐之俭曲浩刘军彭敬红吴亚洲尧荣凤李志兰别立翰胡骏胡晓波乔昀张珏陶建敏严丽张雯雁叶杨芹袁应华刘妍侯伟伟江涟李娜邢晓宇李妮娅刘淮玉赵芳饶桂华吴文娟何丽华奚卫赵新宇袁艳玲解新复旦大学附属华山医院上海长海医院东方肝胆外科医院复旦大学附属儿科医院复旦大学附属妇产科医院复旦大学附属华东医院复旦大学附属金山医院复旦大学附属上海市第五人民医院复旦大学附属肿瘤医院复旦大学附属中山医院上海长征医院上海交通大学附属第六人民医院上海交通大学附属第一人民医院上海交通大学附属儿童医院上海交通大学医学院附属第九人民医院上海交通大学医学院附属第三人民医院上海交通大学医学院附属儿童医学中心上海交通大学医学院附属瑞金医院上海交通大学医学院附属瑞金医院北院上海交通大学医学院附属仁济医院(浦东) 上海交通大学医学院附属仁济医院(浦西) 上海交通大学医学院附属同仁医院(仙霞路院区) 上海交通大学医学院附属新华医院上海市崇明区中心医院上海市第八人民医院上海市第二人民医院上海市奉贤区中心医院上海市静安区中心医院上海市浦东新区公利医院上海市浦东新区人民医院上海市浦东医院上海市普陀区人民医院上海市普陀区中心医院上海市青浦区中心医院上海市松江区中心医院上海市杨浦区中心医院上海中医药大学附属第七人民医院上海中医药大学附属龙华医院上海中医药大学附属曙光医院上海中医药大学附属岳阳中西医结合医院同济大学附属东方医院同济大学附属第十人民医院同济大学附属同济医院中国人民解放军第四五五医院上海交通大学附属第六人民医院东院上海市闵行区中心医院同济大学附属东方医院南院上海交通大学医学院附属仁济医院南院上海市第一人民医院宝山分院

目的了解2017年上海市细菌耐药性监测结果。方法采用纸片扩散法或自动化仪器法对上海市49所医院的临床分离菌进行药敏试验。包括3.所三级医院(含3.儿童医院)和19所二级医院。采用美国临床和实验室标准化协会(CLSI)2017年版标准判断结... 详细信息

目的了解2017年上海市细菌耐药性监测结果。方法采用纸片扩散法或自动化仪器法对上海市49所医院的临床分离菌进行药敏试验。包括3.所三级医院(含3.儿童医院)和19所二级医院。采用美国临床和实验室标准化协会(CLSI)2017年版标准判断结果。结果共获13.078株临床分离菌,其中革兰阳性菌40243.,占3..0%;革兰阴性菌93.3.株,占70.0%。二级医院和三级医院菌株分别占29.0%和71.0%。在二、三级医院中革兰阳性菌和革兰阴性菌各为25.4%和74.6%、3..9%和68.1%。MRSA和MRCNS在各自菌种中的检出率分别为49.1%和79.7%。二级医院、三级医院的MRSA和MRCNS检出率分别为53.2%和72.1%、47.7%和82.2%。葡萄球菌属中未发现万古霉素耐药株。1041株儿童非脑膜炎肺炎链球菌分离株中青霉素敏感(PSSP)、中介(PISP)和耐药株(PRSP)分别占84.3.、7.8%和7.9%;3.0株成人分离株PSSP、PISP和PRSP分别为89.4%、4.2%和6.4%。检出5株(0.1%)万古霉素耐药粪肠球菌、64株(1.2%)万古霉素耐药屎肠球菌,经过PCR测序确认的菌株中主要为vanA基因型。大肠埃希菌、肺炎克雷伯菌和奇异变形杆菌中ESBL的检出率分别为54.9%、3..1%和47.6%。上述产ESBL菌株在二级医院和三级医院的检出率分别为53.7%、3..5%、44.0%和55.5%、3..0%、50.0%。肠杆菌科细菌对碳青霉烯类抗生素仍高度敏感,对亚胺培南和美罗培南的总耐药率分别为11.1%和11.0%,二级医院、三级医院分别为9.0%和9.2%、12.2%和11.9%,碳青霉烯类耐药肠杆菌科细菌(CRE)的检出率为11.9%,其中73.4%是肺炎克雷伯菌。鲍曼不动杆菌、肺炎克雷伯菌、铜绿假单胞菌和大肠埃希菌中出现对大多数测试药物耐药而仅对1～2种抗菌药物敏感的广泛耐药株,二级医院和三级医院分别为64株、3.7株、7株、25株和412株、1129株、3.株、45株。结论目前主要临床分离菌对于常用抗菌药物的耐药性仍甚为严重,尤其是多重耐药的革兰阴性杆菌,对人类健康构成严重威胁,需引起高度重视并采取有效措施防治耐药菌感染。

关键词：细菌耐药性监测碳青霉烯类耐药广泛耐药菌

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：