Clinical trial with traditional Chinese medicine intervention ''tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'' for chronic hepatitis B-associated liver failure
Clinical trial with traditional Chinese medicine intervention ''tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'' for chronic hepatitis B-associated liver failure作者机构：Hepatopathy Institute Affiliated Hospital of Hubei University of Chinese Medicine Hubei University of Chinese Medicine Jingzhou Hospital of Traditional Chinese Medicine Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency School of Pharmaceutical Science and Technology Tianjin University
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2014年第20卷第48期
页 面：18458-18465页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100401[医学-流行病与卫生统计学] 10[医学]
基 金：Supported by National Science and Technology Key Projects on"Major Infectious Diseases such as HIV/AIDS,Viral Hepatitis Prevention and Treatment",No.2008ZX10005-007 Research Projects of Key Disease of National Traditional Chinese Medicine(Hepatopathy)Clinical Research Center(Hubei Province),No.JDZX2012054 National Natural Science Foundation of China,No.81373513,No.90709041,No.30672590,No.30271562,No.30371787,No.81102531 and No.81274147 Key Projects of Natural Science Foundation of Hubei Province,No.2011CDB463 Specialized Research Fund for the Doctoral Programs in Institution of Higher Education,No.20124230110001 Key Subjects of Department of Science and Technology of Wuhan City,No.201260523199
主 题：Clinical study 'Tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK') Liver regeneration Treatment with integrated traditional and Western medicine Chronic hepatitis B-associated liver failure
摘 要：AIM:To study the clinical efficacy of traditional Chinese medicine(TCM)interventiontonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment(TTK)for treating liver failure due to chronic hepatitis ***:We designed the study as a randomized controlled clinical *** number of Chinese Clinical Trial Registry is Chi CTR-TRC-12002961.A total of 144 patients with liver failure due to infection with chronic hepatitis B virus were enrolled in this randomized controlled clinical *** were randomly assigned to the following three groups:(1)a modern medicine control group(MMC group,36patients);(2)atonifying qi and detoxification(TQD)group(72 patients);and(3)atonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment(TTK)group(36patients).Patients in the MMC group received general internal medicine treatment;patients in theTQDgroup were given a TCM formulatonifying qi and detoxificationand general internal medicine treatment;patients in theTTKgroup were given a TCM formula ofTTKand general internal medicine *** participants were treated for 8 wk and then followed at 48 wk following their final *** primaryefficacy end point was the patient fatality rate in each *** of various virological and biochemical indicators served as secondary *** one-way analysis of variance and the t-test were used to compare patient outcomes in the different treatment ***:At the 48-wk post-treatment time point,the patient fatality rates in the MMC,TQD,andTTKgroups were 51.61%,35.38%,and 16.67%,respectively,and the differences between groups were statistically significant(P0.05).Patients in theTTKgroup had significantly higher levels of serum to
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