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Rat adipose-derived stromal cells expressing BMP4 induce ectopic bone formation in vitro and in vivo

Acta Pharmacologica Sinica 2006年第12期27卷 1608-1615页

作者： lin lin~2 xin fu~2 xin zhang~2 lian-xu chen~2 ji-ying zhang~2 chang-long yu~(2,4)kang-tao ma~3 chun-yan zhou~(3,4)2 institute of sports medicine,peking university third hospital,beijing 100083,china 3 Department of Biochemistry and Molecular Biology,peking university School of Basic Medical Science,beijing 100083,china institute of sports medicine Peking University Third Hospital Beijing China Department of Biochemistry and Molecular Biology Peking University School of Basic Medical Science Beijing China

Aim:Bone morphogenetic protein 4(BMP4)is one of the main local contributingfactors in callus formation in the early phase of fracture ***-derivedstromal cells(ADSC)are multipotent *** present study was conducted toinvestigate the osteogenic potential of ADSC when exposed to adenovirus con-taining BMP4 cDNA(Ad-BMP4).Methods:ADSC were harvested from Sprague-Dawley *** exposure to Ad-BMP4,ADSC were assessed by alkaline phos-phatase activity(ALP)assay,RT-PCR and yon Kossa ***4 expressionwas assessed by RT-PCR,immunofluorescence and Western blot analysis,ADSCtransduced with Ad-BMP4 were directly injected into the hind limb muscles ofathyrnic *** Ad-EGFP(enhanced green fluorescence protein)served *** animals were examined by X-ray film and histological ***:The expression of BMP4 was confirmed at both mRNA and protein *** expression of the osteoblastic gene,ALP activity and yon Kossa stainingconfirmed that ADSC transduced with Ad-BMP4 underwent rapid and markedosteoblast differentiation,whereas ADSC transduced with Ad-EGFP and cells leftalone displayed no osteogenic differentiation.X-ray and histological examinationconfirmed new bone formation in athymic mice transplanted with ADSC trans-duced with ***:Our data demonstrated successful osteo-genic differentiation of ADSC transduced with Ad-BMP4 in vitro and in *** may be an ideal source of mesenchyme lineage stem cells for gene therapyand tissue engineering.

关键词： adipose-derived stromal cells BMP4 gene therapy bone formation

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert maarten Boonekamp marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao jianshe Cao Antoine Chance xuejun chang yue chang Zhe chang xinyuan chang Wei Chao Auttakit Chatrabhuti Yimin Che yuzhi Che Bin chen Danping chen fuqing chen fusan chen Gang chen Guoming chen Hua-xing chen Huirun chen jinhui chen ji-yuan chen Kai chen mali chen Mingjun chen Mingshui chen Ning chen Shanhong chen Shanzhen chen Shao-long chen Shaomin chen Shiqiang chen Tianlu chen Wei chen Xiang chen Xiaoyu chen xin chen xun chen xurong chen Ye chen ying chen yukai chen Zelin chen Zilin chen Gang chen Boping chen chunhui chen Hok Chuen cheng Huajie cheng Shan cheng Tongguang cheng yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-yun Dai xinchen Dai xuwen Dai Antonio De maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing beijing Computational Science Research Center Beijing beijing Conveyi LTD Beijing beijing Glass Research institute Co. LtdBeijing beijing institute of Technology Beijing beijing Normal university Beijing Brown university ProvidenceRI Budker institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china institute of Atomic Energy Beijing china jiliang university HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china university of Geosciences Beijing china university of Geosciences WuhanHubei china university of Mining and Technology XuzhouJiangsu china West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint institute for Nuclear Research(DLNP jiNR) Dubna East china university Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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Clinical trial with traditional Chinese medicine intervention ''tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'' for chronic hepatitis B-associated liver failure

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World Journal of Gastroenterology 2014年第48期20卷 18458-18465页

作者： Han-Min Li Zhi-Hua Ye Jun zhang Xiang Gao yan-Ming chen xin Yao jian-xun Gu Lei Zhan yang ji jian-liang xu ying-He Zeng Fan yang lin Xiao Guo-Guang Sheng Wei xin Qi long Qing-jing Zhu Zhao-Hong Shi lian-Guo Ruan jia-Yao yang chang-chun Li Hong-Bin Wu Sheng-Duo chen xin-La Luo Hepatopathy institute Affiliated Hospital of Hubei University of Chinese Medicine Hubei university of Chinese medicine jingzhou hospital of Traditional Chinese medicine Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency School of Pharmaceutical Science and Technology Tianjin University

AIM:To study the clinical efficacy of traditional Chinese medicine(TCM)intervention"tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment"("TTK")for treating liver failure due to chronic hepatitis ***:We designed the study as a randomized controlled clinical *** number of Chinese Clinical Trial Registry is Chi CTR-TRC-12002961.A total of 144 patients with liver failure due to infection with chronic hepatitis B virus were enrolled in this randomized controlled clinical *** were randomly assigned to the following three groups:(1)a modern medicine control group(MMC group,36patients);(2)a"tonifying qi and detoxification"("TQD")group(72 patients);and(3)a"tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment"("TTK")group(36patients).Patients in the MMC group received general internal medicine treatment;patients in the"TQD"group were given a TCM formula"tonifying qi and detoxification"and general internal medicine treatment;patients in the"TTK"group were given a TCM formula of"TTK"and general internal medicine *** participants were treated for 8 wk and then followed at 48 wk following their final *** primaryefficacy end point was the patient fatality rate in each *** of various virological and biochemical indicators served as secondary *** one-way analysis of variance and the t-test were used to compare patient outcomes in the different treatment ***:At the 48-wk post-treatment time point,the patient fatality rates in the MMC,"TQD",and"TTK"groups were 51.61%,35.38%,and 16.67%,respectively,and the differences between groups were statistically significant(P0.05).Patients in the"TTK"group had significantly higher levels of serum to

关键词： Clinical study 'Tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK') Liver regeneration Treatment with integrated traditional and Western medicine Chronic hepatitis B-associated liver failure

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Divergence in flowering time is a major component contributing to reproductive isolation between two wild rice species(Oryza rufipogon and O. nivara)

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Science china(Life Sciences) 2020年第11期63卷 1714-1724页

作者： xun xu Qing-lin Meng Mu-Fan Geng Ning-Ning Ren lian zhou yu-Su Du Zhe Cai Mei-Xia Wang xin Wang Xiu-Hua Wang jing-Dan Han Shuai jiang chun-yan jing Rong Liu Xiao-Ming Zheng Qing-Wen yang fu-Min zhang Song Ge State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesBeijing 100093China university of Chinese Academy of Sciences Beijing 100049China National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

It is of critical importance for our understanding of speciation process to determine the forms of reproductive isolation and their relative importance in species divergence. Oryza nivara and O. rufipogon are direct ancestors of Asian cultivated rice and a progenitor-daughter species pair. Investigating the reproductive isolation between them provides insights into plant speciation and helps understanding of the rice domestication. Here, we quantitatively measured the major components of reproductive isolation between the two species based on common garden and crossing experiments for three pairs of sympatric populations in Nepal, Cambodia and *** revealed significant differences in the flowering times between species pairs, with O. nivara flowering much earlier than O. rufipogon. A very weak reduction in seed set but no reduction in F1 viability and fertility were detected for the crosses between species relative to those within species. Moreover, we detected asymmetrical compatibility between species and found that emasculation significantly decreased pollination success in O. nivara but not in O. *** study demonstrates that the divergence between O. nivara and O. rufipogon is maintained almost entirely by the difference in flowering times and suggests that differential flowering times contribute to both habitat preferences and reproductive isolation between species.

关键词： reproductive isolation flowering time speciation adaptation Oryza species

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Application of next generation sequencing in the screening of monogenic diseases in china,2021:a consensus among Chinese newborn screening experts

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World Journal of Pediatrics 2022年第4期18卷 235-242页

作者： Fan Tong jian Wang Rui Xiao Bing-Bing Wu Chao-chun Zou Ding-Wen Wu Hua Wang Hui Zou lian-Shu Han lin yang lin Zou Ming-yan Hei Ru-Lai yang Tian-Ming yuan Wei Wen xin-Wen Huang xue-Fan Gu yan-ling yang Yong-Lan Huang Yong-Jun zhang Yong-Guo yu Zheng-Feng xu Wen-Hao zhou Zheng-yan Zhao Children’s hospital Zhejiang University School of MedicineNational Clinical Research Center for Child Health3333 Binsheng RoadBinjiang DistrictHangzhou 310052China Shanghai Children’s Medical Center Shanghai Jiaotong University School of MedicineShanghaiChina National Engineering Laboratory for Key Technology of Birth Defect Control and Prevention Screening and Diagnostic R and D CenterHangzhouChina Center for Molecular medicine Children’s Hospital of Fudan University399 Wan Yuan RoadMin Xing DistrictShanghai 200000China National Health Commission Key Laboratory for Birth Defect Research and Prevention Maternal and Child Health Hospital of Hunan ProvinceChangshaChina jinan maternity and Child Care hospital Affiliated To Shandong First Medical university JinanChina xinhua hospital Shanghai Institute for Pediatric ResearchShanghai Jiao Tong University School of MedicineShanghaiChina Clinical Genetic Center Children’s Hospital of Fudan UniversityShanghaiChina Children’s hospital Shanghai Jiaotong UniversityShanghaiChina Neonatal Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina Affiliated Shenzhen maternity and Child Healthcare hospital Southern Medical UniversityShenzhenChina xinhua hospital School of MedicineShanghai Jiaotong UniversityShanghaiChina peking university First hospital BeijingChina Guangzhou Women and Children’s Medical Center GuangzhouChina Center of Genetic medicine Women’s Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingChina

Newborn screening(NBS)refers to a maternal and newborn healthcare technology,in which special examinations of congenital and genetic diseases that could seriously impact the health of newborns,are implemented during the neonatal period to provide early diagnosis and treatment[1].With a history of more than 60 years,NBS has advanced greatly due to technological progress resulting in significant improvement in the number of diseases covered by NBS and in screening efficiency[2-7].

关键词： diseases diagnosis congenital

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Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-xin Liu yue Huang Guang-cheng Xiao Qing-Cui Bu jin-Lu Qu Shu zhang Shuang-Nan zhang Shu-Mei jia Fang-Jun Lu Xiang ma lian tao Wei zhang Li chen Li-Ming Song Ti-Pei Li yu-Peng xu xue-Lei Cao Yong chen Cong-Zhan Liu Ce Cai Zhi chang Gang chen Tian-Xiang chen Yi-Bao chen yu-Peng chen Wei Cui Wei-Wei Cui jing-kang Deng Yong-Wei Dong yuan-yuan Du Min-xue fu Guan-Hua Gao He Gao Min Gao Ming-yu Ge yu-Dong Gu Ju Guan cheng-cheng Guo Da-Wei Han jia Huo Lu-Hua jiang Wei-chun jiang jing jin Yong-jie jin ling-Da Kong Bing Li cheng-Kui Li Gang Li mao-Shun Li Wei Li Xian Li Xiao-Bo Li xu-Fang Li yang-Guo Li Zheng-Wei Li Xiao-Hua liang jing-yuan Liao Bai-Sheng Liu Guo-Qing Liu Hong-Wei Liu Xiao-jing Liu Yi-Nong Liu Bo Lu xue-Feng Lu Qi Luo tao Luo Bin Meng Yi Nang jian-Yin Nie Ge Ou Na Sai Ren-cheng Shang xin-ying Song liang Sun ying Tan You-Li Tuo chen Wang Guo-Feng Wang Juan Wang ling-Jun Wang Weng-Shuai Wang yu-Sa Wang Xiang-yang Wen Bai-yang Wu Bo-Bing Wu Mei Wu Shuo Xiao Shao-lin Xiong He xu jia-Wei yang Sheng yang yan-ji yang Yi-Jung yang Qi-Bin Yi Qian-Qing Yin yuan You Ai-Mei zhang cheng-Mo zhang Fan zhang Hong-Mei zhang Juan zhang Tong zhang Wan-chang zhang Wen-Zhao zhang Yi zhang Yi-Fei zhang Yong-jie zhang yuan-Hang zhang yue zhang Zhao zhang Zhi zhang Zi-liang zhang Hai-Sheng Zhao Xiao-Fan Zhao Shi-jie Zheng Yao-Guang Zheng Deng-Ke zhou jian-Feng zhou yu-xuan Zhu Ren-lin Zhuang yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

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Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients

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Chinese Medical Journal 2013年第12期126卷 2276-2280页

作者： ZHENG ying CAI Guang-yan chen Xiang-mei fu Ping chen jiang-hua DING Xiao-qiang yu xue-qing lin Hong-li LIU jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU fu-you YIN Ai-ping xinG chang-ying WANG Li SHI Wei LIU jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning chen Nan SU Zhen MEI chang-lin ZHAO jiu-yang GU Yong BAI yun-kai LUO Hui-min lin Shan chen Meng-hua GONG Li yanG Yi-bin yanG Xiao-ping LI ying WAN jian-xin WANG Nian-song LI Hai-ying XI chun-sheng HAO Li xu yan FANG jing-ai LIU Bi-cheng LI Rong-shan WANG Rong zhang jing-hong WANG jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong yuAN Wei-jie SUN Shi-ren zhang ling zhou chun-hua chen Qin-kai jiA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG liang-bao Department of Nephrology State key Laboratory of Kidney Disease Chinese PLA General Hospital Beijing 100853 China Nephrology institute of the Chinese People's Liberation Army Chinese People's Liberation Army Key Laboratory of Nephrology Beijing 100853 China Department of Nephrology West China Hospital of Sichuan University Chengdu Sichuan 610041 China Department of Nephrology First Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310003 China Department of Nephrology Zhongshan Hospital Fudan University Shanghai 200032 China Department of Nephrology First Affiiated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China Department of Nephrology First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116011 China Department of Nephrology First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830054 China Department of Nephrology First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Nephrology First Afftiated Hospital of China Medical University Shenyang Liaoning 110001 China Department of Nephrology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025 China Department of Nephrology Second Xiangya Hospital Central South University Changsha Hunan 410000 China Department of Nephrology First Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an Shaanxi 710061 China Department of Nephrology First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital) Nanjing Jiangsu 210029 China Department of Nephrology Sichuan Provincial People's Hospital Chengdu Sichuan 610072 China Department of Nephrology Guangdong Provincial People's Hospital Guangzhou Guangdong 510030 China Department of Nephrology Affliated Xiehe Hospital Tongji Medical College Huazhong Science and Technology University Wuhan Hubei 430022 China Department of Nephrology Daping Hospital Third Military Medi

Background Data on the epidemiology of hypertension in Chinese non-dialysis chronic kidney disease （CKD） patients are *** aim of the present study was to investigate the prevalence,awareness,treatment,and control of hypertension in the non-dialysis CKD patients through a nationwide,multicenter study in *** The survey was performed in 61 tertiary hospitals in 31 provinces,municipalities,and autonomous regions in china （except Hong Kong,macao,and Taiwan）.Trained physicians collected demographic and clinical data and measured blood pressure （BP） using a standardized *** was defned as systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg,and/or use of antihypertensive *** 〈140/90 mmHg and 〈130/80 mmHg were used as the 2 thresholds of hypertension *** multivariate logistic regression with adjustment for sex and age,we analyzed the association between CKD stages and uncontrolled hypertension in non-dialysis CKD *** The analysis included 8927 non-dialysis CKD *** prevalence,awareness,and treatment of hypertension in non-dialysis CKD patients were 67.3%,85.8%,and 81.0%,*** hypertensive CKD patients,33.1% and 14.1% had controlled BP to 〈140/90 mmHg and 〈130/80 mmHg,*** successive CKD stages,the prevalence of hypertension in non-dialysis CKD patients increased,but the control of hypertension decreased （P〈0.001）.When the threshold of BP 〈130/80 mmHg was considered,the risk of uncontrolled hypertension in CKD 2,3a,3b,4,and 5 stages increased 1.3,1.4,1.4,2.5,and 4.0 times compared with CKD 1 stage,respectively （P〈0.05）.Using the threshold of 〈140/90 mmHg,the risk of uncontrolled hypertension increased in advanced stages （P〈0.05）.Conclusions The prevalence of hypertension Chinese non-dialysis CKD patients was high,and the hypertension control was *** successive CKD stages,the risk of uncontrolled hypertension increased.

关键词： non-dialysis chronic kidney disease chronic kidney disease stages hypertension epidemiology

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猪伪狂犬病病毒和猪圆环病毒2型混合感染猪场伪狂犬病净化方案研究

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动物医学进展 2019年第1期40卷 121-124页

作者：宋春莲李鑫张雪谢相悦刘永波吴常月凌万旭张桂生兰春林王艳芬李鲜舒相华云南农业大学动物医学院云南昆明650201 昆明伟牧得生物科技有限公司云南昆明650201 云南曲靖市陆良滇陆猪研究所云南曲靖655815 云南省保山市昌宁县畜牧局云南昌宁678100 云南省红河州蒙自动物疫病预防控制中心云南蒙自661100 永德县动物卫生监督所云南临沧677600

为研究伪狂犬病病毒(PRV)和猪圆环病毒2型(PCV2)混合感染猪场伪狂犬病的净化,采用PCR和ELISA进行病毒核酸与抗体检测,采用不同的净化方法,选取云南省3个自繁自养种猪场,A场同时净化PRV和PCV2,免疫接种PRV疫苗;B场净化PRV,免疫接种PRV疫... 详细信息

为研究伪狂犬病病毒(PRV)和猪圆环病毒2型(PCV2)混合感染猪场伪狂犬病的净化,采用PCR和ELISA进行病毒核酸与抗体检测,采用不同的净化方法,选取云南省3个自繁自养种猪场,A场同时净化PRV和PCV2,免疫接种PRV疫苗;B场净化PRV,免疫接种PRV疫苗;C场同时净化PRV和PCV2,免疫接种PRV和PCV2疫苗。结果表明,C场实施猪伪狂犬病净化前gE阳性率为15.94%,gB阳性率为86.96%,实施猪伪狂犬病净化3年后gE阳性率为1.43%,gB阳性率100%。结果提示,C场在同时净化PRV和PCV2,同时接种猪伪狂犬病和圆环病毒2型疫苗的模式下,净化效果最优,为地区种猪场提供疾病净化思路。

关键词：伪狂犬病病毒猪圆环病毒2型混合感染净化种猪

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2012年—2016年云南省部分地区规模猪场4种常见病毒感染情况的调查

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动物医学进展 2018年第1期39卷 117-120页

作者：宋春莲曾敬元陶杨张雪谢相悦刘永波吴常月李鑫凌万旭何锦张桂生兰春林王艳芬李鲜舒相华云南农业大学云南昆明650201 昆明伟牧得生物科技有限公司云南昆明650201 云南曲靖市陆良滇陆猪研究所云南曲靖655815 云南省保山市昌宁县畜牧局云南昌宁678100 云南省红河州蒙自动物疫病预防控制中心云南蒙自661100 永德县动物卫生监督所云南临沧677600

为了解云南省部分地区4种常见病毒感染情况,2012年-2016年在云南省部分地区共采集1 632份样品,用PCR、RT-PCR进行了猪瘟病毒(CSFV)、猪繁殖与呼吸综合征病毒(PRRSV)、猪伪狂犬病病毒(PRV)、猪圆环病毒2型(PCV2)的抗原检测。检测结果显示... 详细信息

为了解云南省部分地区4种常见病毒感染情况,2012年-2016年在云南省部分地区共采集1 632份样品,用PCR、RT-PCR进行了猪瘟病毒(CSFV)、猪繁殖与呼吸综合征病毒(PRRSV)、猪伪狂犬病病毒(PRV)、猪圆环病毒2型(PCV2)的抗原检测。检测结果显示,CSFV的阳性率在2012年—2016年分别为16.27%、9.09%、9.09%、4.11%和7.14%,PRRSV的阳性率分别为13.16%、10.48%、29.93%、16.87%和29.58%,PRV的阳性率分别为2.38%、0.00%、2.65%、13.33%和1.37%,PVC2的阳性率分别为43.75%、37.25%、28.38%、53.06%和47.83%;有二重感染,其中PRRSV+PCV2最多,为6.32%,CSFV+PRV最少,为0.62%;三重感染CSFV+PRV+PCV2与PRRV+PRV+PCV2分别为0.71%和0.68%;无四重感染。CSFV、PRRSV、PRV、PCV2在滇中的阳性率分别为5.31%、28.33%、4.44%和48.62%,在滇南的阳性率分别为12.12%、20.37%、3.70%和29.03%,在滇西的阳性率分别为6.38%、20.41%、7.69%和47.37%,在滇东的阳性率分别为15.57%、7.58%、0.90%和27.27%。说明云南省规模猪场以上4种病毒感染比较严重,应加强监督和防控工作。

关键词：猪瘟病毒猪繁殖与呼吸综合征病毒猪伪狂犬病病毒猪圆环病毒2型感染

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2005年中国城市CO2排放数据集

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中国人口·资源与环境 2018年第4期28卷 1-7页

作者：蔡博峰刘晓曼陆军王金南刘红光陈洋陈占明丛建辉崔志鹏代春艳董会娟方恺冯彤郭杰李芬孟凡鑫唐伟王庚哲谢运生张建军阿依吐尔逊·沙木西布买日也木·买买提蔡伟光曾胜常盼陈前利陈振国单钰理丁冠乔独威范敏冯相昭干晓宇高壮飞谷雨何凌昊何姚胡鸣明黄丽珍黄桥贾小平菊春燕蓝菁李爽李松李耀光李照令刘合林刘婧文刘庆燕刘竹逯飞马贤磊欧金沛潘栋沈杨税月孙露谭效时唐敏唐袆祺王柯王思亓王香爱王晓培吴家杰吴雪萍肖连香邢文婷徐丽笑叶瑞克袁子坤张飞云张袆张明张琦峰张曦文张宇赵晶赵胜男郑思伟周来友朱天琦曹丽斌冯乐李栋李一静龙瀛孙瑞红环境保护部环境规划院北京100012 中国科学院大气物理研究所北京100029 南京农业大学公共管理学院江苏南京210095 上海财经大学城市与区域科学学院上海200433 中国人民大学经济学院北京100872 山西大学经济与管理学院山西太原030006 E20环境平台咨询部北京100195 重庆工商大学长江上游经济研究中心重庆400067 上海交通大学环境科学与工程学院上海200240 浙江大学公共管理学院浙江杭州310058 天津大学管理与经济学部天津300072 南京农业大学土地管理学院江苏南京210095 深圳市建筑科学研究院股份有限公司北京研创中心广东深圳518049 华南理工大学环境与能源学院广东广州510006 杭州市环境保护科学研究院环境政策研究中心浙江杭州310014 埃因霍芬理工大学建筑学院荷兰埃因霍芬5616SC 江西省科学院能源研究所江西南昌330000 中国地质大学(北京)土地科学技术学院北京100083 新疆农业大学管理学院新疆乌鲁木齐830052 重庆大学建设管理与房地产学院重庆400044 重庆工商大学财政金融学院重庆400067 东安格利亚大学国际发展学院英国诺维奇NR47TJ 环境保护部环境发展中心北京100029 环境保护部环境与经济政策研究中心北京100029 四川大学建筑与环境学院四川成都610065 浙江工业大学政治与公共管理学院浙江杭州310023 美国绿色建筑委员会城市与社区部北京100085 挪威科技大学工程学院挪威约尔维克2815 北京师范大学统计学院北京100875 青岛科技大学环境学院山东青岛266000 北京大学遥感与地理信息系统研究所北京100871 北京师范大学环境学院北京100875 筑波大学日本筑波305-0005 华中科技大学建筑与城市规划学院湖北武汉430074 美国东北大学工学院美国波士顿02115 河北省环境科学研究院规划所河北石家庄050037 中山大学地理科学与规划学院广东广州北京林业大学环境科学与工程学院北京宁波职业技术学院商贸外语学院浙江宁波重庆工商大学土地管理学院重庆日本国立环境研究所社会环境系统研究中心日本筑波中国船舶重工集团公司第七一四研究所北京重庆工商大学管理学院重庆渭南师范学院化学与材料学院陕西渭南福州大学经济与管理学院福建福州扬州大学环境科学与工程学院江苏扬州中国矿业大学管理学院江苏徐州北京大学城市与环境学院北京内蒙古大学公共管理学院内蒙古呼和浩特江苏大学财经学院江苏镇江赤峰学院资源与环境科学学院内蒙古赤峰新余学院经济管理学院江西新余北京市环境保护科学研究院生态与城市环境研究所北京北京清华同衡规划设计研究院有限公司技术创新中心北京100085 北京大学汇丰商学院英国校区华威大学交叉学科研究方法中心英国牛津100871 清华大学建筑学院北京100062 上海工程技术大学管理学院上海021620

2005年是中国承诺碳减排目标的基准年份,因而也是中国城市碳减排战略制定和近中期低碳转型的基准年份和对照年份。中国城市2005年CO_2排放数据的一致性、全面性和精准性对于中国所有城市和每个具体城市的目标考核和评估都有重要意义。... 详细信息

2005年是中国承诺碳减排目标的基准年份,因而也是中国城市碳减排战略制定和近中期低碳转型的基准年份和对照年份。中国城市2005年CO_2排放数据的一致性、全面性和精准性对于中国所有城市和每个具体城市的目标考核和评估都有重要意义。基于中国高空间分辨率网格数据(CHRED 2.0)、城市层面统计数据以及大量现场调研和走访,建立2005年中国城市CO_2排放数据集,包括工业能源排放、工业过程排放、农业排放、服务业排放、城镇生活排放、农村生活排放、交通排放7个部门的直接排放数据和间接排放数据。该数据集的建立汇总了86名研究人员的工作成果,在企业、城市不同行业与部门、城市工业和城市总化石能源等不同层面进行了大量的交叉验证和数据分析,有效保障了数据的精确性和准确性。结果显示,2005年中国城市碳排放呈现出较大的体量差异和空间格局差异。排放前10的城市几乎比排放后10的城市的排放量高出两个数量级。高排放城市基本都是城市群的核心城市。东部城市直接排放占全国直接排放比例最高,达到44.59%,其次是西部城市21.76%,中部城市22.70%,东北城市10.95%。

关键词：城市 CO 2排放数据集中国高空间分辨率网格

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