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Topological Wannier Cycles for the Bulk and Edges

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Chinese Physics Letters 2022年第8期39卷 39-46页

作者： Ze-lin kong Zhi-Kang lin Jian-Hua Jiang School of Physical Science and Technology and Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhou 215006China Key Lab of Advanced Optical Manufacturing Technologies of Jiangsu Province and Key Lab of Modern Optical Technologies of Ministry of EducationSoochow UniversitySuzhou 215006China

Topological materials are often characterized by unique edge states which are in turn used to detect different topological phases in ***,with the discovery of various higher-order topological insulators,such spectral topological characteristics are extended from edge states to corner ***,the chiral symmetry protecting the corner states is often broken in genuine materials,leading to vulnerable corner states even when the higher-order topological numbers remain quantized and ***,we show that a local artificial gauge flux can serve as a robust probe of the Wannier type higher-order topological insulators,which is effective even when the chiral symmetry is *** resultant observable signature is the emergence of the cyclic spectral flows traversing one or multiple band *** spectral flows are associated with the local modes bound to the artificial gauge *** phenomenon is essentially due to the cyclic transformation of the Wannier orbitals when the local gauge flux acts on *** extend topological Wannier cycles to systems with C_(2)and C_(3)symmetries and show that they can probe both the bulk and the edge Wannier centers,yielding rich topological phenomena.

关键词： topological gauge Wannier

Steroids from the Roots of Asparagus officinalis and Their Cytotoxic Activity

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Journal of Integrative Plant Biology 2008年第6期50卷 717-722页

作者： Xue-Feng Huang Yu-Ying lin ling-Yi kong Department of Natural Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China

One new （Sarsasapogenin O） and seven known steroids were isolated from the roots of Asparagus offlcinalis L. Their structures were elucidated on the basis of spectroscopic analysis, including various 2D-NMR techniques, hydrolysis, and by comparison of spectral data of known compounds. These compounds together with nine steroids which were previously isolated from this plant, were tested for cytotoxic activity. Among them, eight compounds displayed significant cytotoxiciUes against human A2780, HO-8910, Eca-109, MGC-803, CNE, LTEP-a-2, KB and mouse L1210 tumor cells.

关键词： Asparagus officinalis cytotoxic activity Sarsasapogenin O steroid

New Polypeptides from Chinese Mistletoe, Viscum coloratum (Kom.) Nakai

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Chinese Chemical Letters 2006年第1期17卷 41-44页

作者： Shi Lei LIU Xiu Bao DU Jing lin kong Research Institute of Chemical Defense Beijing 102205

Three viscotoxins have been isolated from Chinese mistletoe, Viscum coloratura （Kom.） Nakai. The primary structures were determined unambiguously by the combination of Edman degradation, endoproteinase Elu-c digestion, and Q-TOF mass spectrometry. One was identified as viscotoxin C1, which was for the first time isolated from Chinese mistletoe. The other two were new polypeptides, named as viscotoxin B5 and viscotoxin B8. Pharmacological studies showed that the polypeptides exhibit distinct cytotoxicity to human cancer cells.

关键词： Viscum coloratura mistletoe isolation primary structure viscotoxin.

Chemical constituents and antibacterial activities of Aspidistra typica

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Chinese Journal of Natural Medicines 2018年第6期16卷 465-470页

作者： LIANG Xiao-Xia kong lin-Xi FEI Wen-Bo HE Min Natural Medicine Research Center College of Veterinary Medicine Sichuan Agricultural University

In the present investigation, we carried a phytochemical study of an ethanol-soluble extract from the root barks of Aspidistra typica Baill., a traditional food and herb medicine, leading to the isolation of four different kinds of compounds, including one benzene substituted coumarin, two organic phosphonic compounds, and one xanthone. The novel benzene substituted coumarin typicacoumarin A(1) was a new type of coumarin, and the two new organic phosphonic compounds, typicalphosphine A(2) and typicalphosphine B(3) were isolated for the first time, and their structures were elucidated by spectral techniques, viz.1 D, 2 D NMR spectra and HR-ESI-MS. The xanthone compound typicaxanthone A(4) was discovered from nature for the first time. The two new organic phosphonic chlorides(2, 3) showed stronger antibacterial activities, which were comparable to berberine hydrochloride. And typicaxanthone A(4) showed much stronger antibacterial activity against Escherichia coli ATCC-25922 bacterial strain, while typicacoumarin A(1) showed moderate antibacterial activities, weaker than berberine hydrochloride.

关键词： Aspidistra typica Benzene substituted coumarin Organic phosphonic compounds Xanthone Antibacterial activity

Surface engineering of synthetic nanopores by atomic layer deposition and their applications

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Frontiers of Materials Science 2013年第4期7卷 335-349页

作者： Ce-Ming WANG De-lin kong Qiang CHEN Jian-Ming XUE State Key Laboratory of Nuclear Physics and Technology Peking University Beijing 100871 China Laboratory of Plasma Physics and Materials Beijing Institute of Graphic Communication Beijing 102600 China

In the past decade, nanopores have been developed extensively for various potential applications, and their performance greatly depends on the surface properties of the nanopores. Atomic layer deposition （ALD） is a new technology for depositing thin films, which has been rapidly developed from a niche technology to an established method. ALD films can cover the surface in confined regions even in nanoscale conformally, thus it is proved to be a powerful tool to modify the surface of the synthetic nanopores and also to fabricate complex nanopores. This review gives a brief introduction on nanopore synthesis and ALD fundamental knowledge, and then focuses on the various aspects of synthetic nanopores processing by ALD and their applications, including single-molecule sensing, nanofiuidic devices, nanostructure fabrication and other applications.

关键词： synthetic nanopore atomic layer deposition (ALD) surface engineering

Continual learning fault diagnosis:A dual-branch adaptive aggregation residual network for fault diagnosis with machine increments

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Chinese Journal of Aeronautics 2023年第6期36卷 361-377页

作者： Bojian CHEN Changqing SHEN Juanjuan SHI lin kong Luyang TAN Dong WANG Zhongkui ZHU School of Rail Transportation Soochow UniversitySuzhou 215131China China Chang Guang Satellite Technology CO.LTD Changchun 130102China Department of Industrial Engineering and Management and in the State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200030China

As a data-driven approach, Deep Learning(DL)-based fault diagnosis methods need to collect the relatively comprehensive data on machine fault types to achieve satisfactory performance. A mechanical system may include multiple submachines in the real-world. During condition monitoring of a mechanical system, fault data are distributed in a continuous flow of constantly generated information and new faults will inevitably occur in unconsidered submachines, which are also called machine increments. Therefore, adequately collecting fault data in advance is difficult. Limited by the characteristics of DL, training existing models directly with new fault data of new submachines leads to catastrophic forgetting of old tasks, while the cost of collecting all known data to retrain the models is excessively high. DL-based fault diagnosis methods cannot learn continually and adaptively in dynamic environments. A new Continual Learning Fault Diagnosis method(CLFD) is proposed in this paper to solve a series of fault diagnosis tasks with machine increments. The stability–plasticity dilemma is an intrinsic issue in continual learning. The core of CLFD is the proposed Dual-branch Adaptive Aggregation Residual Network(DAARN).Two types of residual blocks are created in each block layer of DAARN: steady and dynamic blocks. The stability–plasticity dilemma is solved by assigning them with adaptive aggregation weights to balance stability and plasticity, and a bi-level optimization program is used to optimize adaptive aggregation weights and model parameters. In addition, a feature-level knowledge distillation loss function is proposed to further overcome catastrophic forgetting. CLFD is then applied to the fault diagnosis case with machine increments. Results demonstrate that CLFD outperforms other continual learning methods and has satisfactory robustness.

关键词： Catastrophic forgetting Continual learning Fault diagnosis Knowledge distillation Machine increments Stability-plasticity dilemma

A novel plant defensin from Chinese mistletoe,Viscum coloratum (Kom.) Nakai

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Chinese Chemical Letters 2007年第1期18卷 55-58页

作者： Shi Lei Liu Xiu Bao Du Jing lin kong Hui Jiang Research Institute of Chemical Defense Beijing 102205 China

A novel polypeptide named as defensin CM was isolated from Chinese mistletoe, Viscum coloratura （Kom.） Nakai. The amino acid sequence was determined by the combination of Edman degradation, endoproteinase Lys-C digestion, and MALDI-TOF mass spectrometry. The primary structure was ATCSAPSGRF KGACFSSNTC SNICKTLEGL KDGHCTGLAC YCSRNC.

关键词： Viscum coloratura Mistletoe Primary structure Plant defensin Polypeptide

A midgut-specific lytic polysaccharide monooxygenase of Locusta migratoria is indispensable for the deconstruction of the peritrophic matrix

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Insect Science 2022年第5期29卷 1287-1298页

作者： Ming-Bo Qu Xiao-Xi Guo lin kong ling-Jie Hou Qing Yang School of Bioengineering Dalian University of TechnologyDalianLiaoning ProvinceChina State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijingChina Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong ProvinceChina

Lytic polysaccharide monooxygenases(LPMOs)are important enzymes that boost the hydrolysis of recalcitrant polysaccharides,such as *** are found extensively in different insect species and are classified as auxiliary activities family 15(AA15)LPMOs(LPMO15).Some of them were identified from the insect midgut and proven to act on ***,knowledge about their physiological roles during insect growth and development remains ***,we found that midgut-specific LPMO15s are widely distributed in different insect orders,such as the orthopteran Locusta migratoria and the lepidopteran Bombyx *** *** as a model insect,the function of midgut-specific LmLPMO15-3 during development was ***-stranded RNA-mediated downregulation of LmLPMO15-3 expression at the 4th or 5th instar nymph stage severely decreased the survival rate and resulted in lethal *** and eosin staining results indicated that the deficient individuals exhibited incompletely digested peritrophic matrix(PM),which suggested that LmLPMO15-3 is essential for the deconstruction of the PM during *** study provides direct evidence of the physiological importance of a midgut-specific LPMO15 during insect *** *** is one of the most destructive agricultural pests,LmLPMO15-3 is a potential target for pest management.

关键词： chitin Locusta migratoria lytic polysaccharide monooxygenase midgut peritrophic matrix RNAi

Photo-induced Bacillus subtilis-spore transformation for bowel disease therapy and therapeutic outcome visualization

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Aggregate

Aggregate 2024年第5期5卷 413-422页

作者： lin kong Wei He Junyi Gong Zijie Qiu Zheng Zhao Ben Zhong Tang School of Chemistry and Chemical Engineering Anhui UniversityHefeiChina Clinical Translational Research Center of Aggregation-Induced Emission The Second Afﬁliated HospitalSchool of Science and EngineeringShenzhen Key Laboratory of Functional Aggregate MaterialsThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)GuangdongChina Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina HKUST-Shenzhen Research Institute No.9 Yuexing 1st RDSouth AreaHi-tech Park NanshanShenzhenChina

Efﬁcient strategies for transforming Bacillus subtilis vegetative cells into spores(BtS transformation)are still limited,although they show promise for the treatment of inﬂammatory bowel disease(IBD).A novel,simple,and rapid photo-induced BtS transformation mechanism is now presented that utilizes a novel aggregation-induced emission luminogen(AIEgen)photosensitizer,triphenylamine-benzothiadiazole-pyridine-p-tolylboronic acid bromine salt(TBPBB),that generates reactive oxygen species(ROS)when exposed to *** ROS selectively target and damage the membranes of Bacillus subtilis and trigger their transformation into *** spores demonstrate considerable promise for the effective treatment of IBD in a mouse disease ***,theﬂuorescence signal generated by TBPBB can be used to directly visualize the recovery of damaged intestinal *** is a valuable tool for monitoring the healing process and gaining insights into therapeutic efﬁ*** study highlights the remarkable practical value of AIEgen-induced BtS transformation for identifying,localizing,and visualizing the therapeutic outcomes of IBD treatments.

关键词： AIE photosensitizer BtS transformation inﬂammatory bowel disease reactive oxygen species therapeutic outcome visualization