Chemical constituents and antibacterial activities of Aspidistra typica

作     者：LIANG Xiao-Xia KONG Lin-Xi FEI Wen-Bo HE Min 

作者机构：Natural Medicine Research Center College of Veterinary Medicine Sichuan Agricultural University 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2018年第16卷第6期

页      面：465-470页

核心收录：

学科分类：0710[理学-生物学] 1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 0703[理学-化学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the Research Platform for the project of the application basic plan in Sichuan Province(No.2014JY0113) the project of Department of Science in Sichuan Province,China(No.14ZA0003) 

主　　题：Aspidistra typica Benzene substituted coumarin Organic phosphonic compounds Xanthone Antibacterial activity 

摘      要：In the present investigation, we carried a phytochemical study of an ethanol-soluble extract from the root barks of Aspidistra typica Baill., a traditional food and herb medicine, leading to the isolation of four different kinds of compounds, including one benzene substituted coumarin, two organic phosphonic compounds, and one xanthone. The novel benzene substituted coumarin typicacoumarin A(1) was a new type of coumarin, and the two new organic phosphonic compounds, typicalphosphine A(2) and typicalphosphine B(3) were isolated for the first time, and their structures were elucidated by spectral techniques, viz.1 D, 2 D NMR spectra and HR-ESI-MS. The xanthone compound typicaxanthone A(4) was discovered from nature for the first time. The two new organic phosphonic chlorides(2, 3) showed stronger antibacterial activities, which were comparable to berberine hydrochloride. And typicaxanthone A(4) showed much stronger antibacterial activity against Escherichia coli ATCC-25922 bacterial strain, while typicacoumarin A(1) showed moderate antibacterial activities, weaker than berberine hydrochloride.