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Flood Duration Estimation Based on Multisensor,Multitemporal Remote Sensing:The Sardoba Reservoir Flood

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Journal of Earth Science 2023年第3期34卷 868-878页

作者： limei wang Guowang Jin Xin Xiong Institute of Geospatial Information Information Engineering UniversityZhengzhou 450001China

Single-sensor monitoring of flood events at high spatial and temporal resolutions is difficult because of the lack of data owing to instrument defects,cloud contamination,imaging ***,combining multisensor data provides an impressive solution to this *** this study,11 synthetic aperture radar(SAR)images and 13 optical images were collected from the Google Earth Engine(GEE)platform during the Sardoba Reservoir flood event to constitute a time series ***-based and indices-based methods were used for SAR and optical data,respectively,to extract the water *** final sequential flood water maps were obtained by fusing the results from multisensor time series *** show that,when compare with the Global Surface Water Dynamic(GSWD)dataset,the overall accuracy and Kappa coefficient of the water body extent extracted by our methods range from 98.8%to 99.1%and 0.839 to 0.900,*** flooded extent and area increased sharply to a maximum between May 1 and May 4,and then experienced a sustained decline over *** flood lasted for more than a month in the lowland areas in the north,indicating that the northern region is severely *** cover changes could be detected using the temporal spectrum analysis,which indicated that detailed temporal information benefiting from the multisensor data is highly important for time series analyses.

关键词： multitemporal flood monitoring SAR-optical data integration flood area assessment remote sensing flood control

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PTA clad (Cr,Fe)_7C_3/γ-Fe in situ ceramal composite coating

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Journal of University of Science and Technology Beijing 2006年第6期13卷 538-541页

作者： Junbo Liu limei wang Jihua Huang School of Mechanical and Electronic Engineering Weifang University Shandong Weifang 261061 China School of Information and Control Engineering Weifang University Shandong Weifang 261061 China School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

A wear-resistant （Cr, Fe）7C3/γ-Fe in situ ceramal composite coating was fabricated on the substrate of 0.45wt%C carbon steel by a plasma-transferred arc cladding process using the Fe-Cr-C elemental powder blends. The microstructure, microhardness, and dry-sliding wear resistance of the coating were evaluated. The results indicate that the microstructure of the coating, which was composed of （Cr, Fe）7C3 primary phase uniformly distributed in the γ-Fe, and the （Cr, Fe）7C3 eutectic matrix was metallurgically bonded to the 0.45wt%C carbon steel substrate. From substrate to coating, the microstructure of the coating exhibited an evident epitaxial growth character. The coating, indehiscent and tack-free, had high hardness and appropriate gradient. It had excellent wear resistance under the dry sliding wear test condition.

关键词： plasma-transferred arc cladding (Cr, Fe)7C3/γ-Fe coating microstructure wear-resistance

Highlights for the 6th International Ion Channel Conference:ion channel structure,function,disease and therapeutics

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Acta Pharmaceutica Sinica B 2017年第6期7卷 665-669页

作者： limei wang Kewei wang Department of Pharmacology Qingdao University School of PharmacyQingdao 266021China

To foster communication and interactions amongst international scholars and scientists in the field of ion channel research, the 6 th International Ion Channel Conference(IICC-2017) was held between June 23–27, 2017 in the eastern coastal city of Qingdao, China. The meeting consisted of 450 attendees and 130 speakers and poster presenters. The program consisted of research progress, new findings and ongoing studies that were focused on(1) Ion channel structure and function;(2) Ion channel physiology and human diseases;(3) Ion channels as targets for drug discovery;(4) Technological advances in ion channel research. An insightful overview was presented on the structure and function of the mechanotransduction channel Drosophila NOMPC(No mechanoreceptor potential C), a member of the transient receptor potential(TRP) channel family. Recent studies on Transmembrane protein 16 or Anoctamin-1(TMEM16A, a member of the calcium-activated chloride channel [CaCC] family) were summarized as well. In addition, topics for ion channel regulation, homeostatic feedback and brain disorders were thoroughly discussed. The presentations at the IICC-2017 offer new insights into our understanding of ion channel structures and functions, and ion channels as targets for drug discovery.

关键词： Ion channel Structure Function Channelopathy Drug target Mechanotransduction Voltage-gated Ca2+ channel Anoctamin-1 Calcium activated chloride channel M-type potassium channel GIRK channel Voltage-gated sodium channel

Chlamydomonas WDR92 in association with R2TP-like complex and multiple DNAAFs to regulate ciliary dynein preassembly

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Journal of Molecular Cell Biology 2019年第9期11卷 770-780页

作者： Guang Liu limei wang Junmin Pan MOE Key Laboratory of Protein Sciences Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266200China

The motility of cilia or eukaryotic flagella is powered by the axonemal dyneins,which are preassembled in the cytoplasm by proteins termed dynein arm assembly factors(DNAAFs)before being transported to and assembled on the ciliary ***,we characterize the function of WDR92 in *** of WDR92,a cytoplasmic protein,in a mutant wdr92 generated by DNA insertional mutagenesis resulted in aflagellate cells or cells with stumpy or short flagella,disappearance of axonemal dynein arms,and diminishment of dynein arm heavy chains in the cytoplasm,suggesting that WDR92 is a *** of WDR92 followed by mass spectrometry identified inner dynein arm heavy chains and multiple DNAAFs including RuvBLl,RPAP3,MOT48,ODA7,and *** PIH1 domain-containing protein MOT48 formed a R2TP-like complex with RuvBLl/2 and RPAP3,while PF13,another PIH1 domain-containing protein with function in dynein preassembly,did ***,the third PIH1 domain-containing protein TWI1 was not related to flagellar ***92 physically interacted with the R2TP-like complex and the other identified *** data suggest that WDR92 functions in association with the HSP90 co-chaperone R2TP-like complex as well as linking other DNAAFs in dynein preassembly.

关键词： cilia motility dynein arm assembly factors R2TP complex WDR92 Chlamydomonas

Multi-axial Fatigue of 2024-T4 Aluminum Alloy

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Chinese Journal of Mechanical Engineering 2011年第2期24卷 195-201页

作者： wang Xiaogui GAO Zengliang QIU Baoxiang wang limei JIANG Yanyao College of Mechanical Engineering Zhejiang University of Technology Hangzhou 310032 China Department of Mechanical Engineering University of Nevada Reno NV89557 USA

Only the fatigue initiation is considered by the safe-life design approach,while fatigue crack propagation is paid more attention by the damage tolerance *** reasonable fatigue design method and durability assessment standard should give these two phases equivalent *** develop a unified model of fatigue initiation and crack propagation,a great deal of baseline fatigue properties of a material should be obtained by fatigue ***,there is lack of thorough and comprehensive experiment study on the fatigue properties of 2024-T4 aluminum alloy,which is widely used as load-bearing components in aircraft *** this paper,strain-controlled uniaxial,torsion,and combined axial-torsion fatigue experiments are conducted on 2024-T4 aluminum alloy in ambient *** reversed uniaxial and pure torsion experiments employ solid cylindrical *** experiments under the fully reversed shear loading with a static axial stress,proportional axial-torsion loading,and 90°out-of-phase axial-torsion nonproportional loading are conducted by using thin-walled tubular *** experimental results show that the mean stress has a significant influence on the fatigue strength of the material.A tensile mean stress decreases the fatigue life dramatically,while a compressive mean stress increases the fatigue *** strain-life fatigue results obtained from the fully reversed uniaxial fatigue experiments can be represented by one smooth curve of a three-parameter ***,two fitting curves are needed for characterizing the results of the fully reversed pure torsion fatigue tests because of the existence of an obvious *** baseline fatigue properties of 2024-T4 aluminum alloy obtained from the fatigue experiments have applications for the fatigue design and safe assessment of engineering components.

关键词： 2024-T4 aluminum alloy fatigue life loading path multiaxial fatigue SWT fatigue parameter

State of Charge Estimation for Lithium-Ion Battery Based on Improved Cubature Kalman Filter Algorithm

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Automotive Innovation 2021年第2期4卷 189-200页

作者： Guochun Li Chang Liu Enlong wang limei wang Automotive Engineering Research Institute Jiangsu UniversityZhenjiang 212013China Institute for Energy Research Jiangsu UniversityZhenjiang 212013China

An improved cubature Kalman filter(CKF)algorithm for estimating the state of charge of lithium-ion batteries is *** improved algorithm implements the diagonalization decomposition of the covariance matrix and a strong tracking ***,a first-order RC equivalent circuit model is first established and verified,whose voltage estimation error is within 1.5%;this confirms that the model can be used to describe the characteristics of a *** the calculation processes of the traditional and proposed CKF algorithms are ***,the improved CKF algorithm is applied to the state of charge estimation under the constant-current discharge and dynamic stress test *** average errors for these two conditions are 0.76%and 1.2%,respectively,and the maximum absolute error is only 3.25%.The results indicate that the proposed method has higher filter stability and estimation accuracy than the extended Kalman filter(EKF),unscented Kalman filter(UKF)and traditional CKF ***,the convergence rates of the above four algorithms are compared,among which the proposed algorithm track the referenced values at the highest speed.

关键词： Lithium-ion battery State of charge Cubature Kalman filter Strong tracking filter Covariance matrix diagonalization decomposition

Discovery of Novel Tricyclic 5H-Pyridazino[4,5-b]indoles as Potent Antitumor Agents： Design, Synthesis and Biological Evaluation

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Chemical Research in Chinese Universities 2015年第3期31卷 372-380页

作者： ZHAI Xin wang limei SHI Jiyue GONG Ping Key Laboratory of Structure-based Drug Design and Discovery Ministry of EducationShenyang Pharmaceutical University Shenyang 110016 P.R.China

A novel series of 5H-pyridazino[4,5-b]indoles（L-01-L-32） was synthesized and characterized by means of 1H NMR, MS and elemental analysis. The cytotoxicity of the target compounds against Bel-7402 and HT-1080 cell lines were evaluated by 3-（4,5-dimethylthiazol-2-y1）-2,5-diphenyltetrazolium bromide（MTT） assay. Most of them exhibited moderate to excellent cytotoxicity, and six compounds（L-04, L-06, L-18, L-20, L-21 and L-23） possessed dramatically increased cytotoxicity superior to Gefitinib. Of these initial hits, compound L-21 displayed remarkable cytotoxicity against the tested cell lines with half maximal inhibitory concentration（IC50） values of 4.6 and 2.1 μmol/L, respectively, which was 13.9- to 25.6-fold more potent than positive control.

关键词： 1-Anilino-5H-pyridazino[4,5-b]indole EGFR inhibitor Cytotoxicity

Research of Direct-drive XY Table Contouring Control Based on NURBS Interpolator

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Research of Direct-drive XY Table Contouring Control Based o...

Metabolic programming in dendritic cells tailors immune responses and homeostasis

第25届中国控制与决策会议

作者： limei wang Rui Liu School of Electrical Engineering Shenyang University of Technology

ISBN: (纸本)9781467355322

Feedrate fluctuation, chord errors, machining time, machine characteristics, and unreasonable planning may affect machining quality from some extent. Compared with conventional interpolation methods, parametric interpolation method perform better on reducing feedrate fluctuations, chord errors and it can save interpolation time simultaneously. Reasonable feedrate planning and dynamic motion control are also significant for precision improving. In this paper, NURBS interpolation is employed and feedrate is planned on basis of curve geometry and machine dynamic characters. Further more, a model-based disturbance attention control method is adopted in each single axis to reduce the disturbance and friction, besides, CCC combined with PEC control algorithm is applied in biaxial coordination control to improve the contour accuracy. Simulation results demonstrate that the proposed approach can significantly reduce the machining error of XY table.

关键词： XY Table Contour Control NURBS Disturbance Attenuation CCC PEC

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Cellular & Molecular Immunology 2022年第3期19卷 370-383页

作者： Sofie Hedlund Møller limei wang Ping-Chih Ho Department of Fundamental Oncology University of LausanneLausanneSwitzerland Ludwig Institute for Cancer Research University of LausanneEpalingesSwitzerland

It is being increasingly acknowledged that immune cells depend on certain metabolic traits to perform their functions and that the extracellular environment can influence cell metabolism and vice *** cell(DC)subsets traffic through highly diverse environments from the bone marrow,where they develop,to the various peripheral tissues,where they differentiate and capture antigens,before they migrate to the lymph node to present antigens and prime T *** is plausible that DC subsets modulate their stimulatory abilities in response to unique metabolic *** metabolic requirements of DCs are just recently being discovered,and subset-and context-specific metabolic phenotypes in DCs are highly intertwined with DC *** this review,we present the current knowledge on the intrinsic and extrinsic determinants of DC metabolism,how they regulate DC function with examples from tumor biology and in interaction with the microbiota,and discuss how this can be applied therapeutically.

关键词： Dendritic cells Immunometabolism Homeostasis Tumor immunity Microbiota