Metabolic programming in dendritic cells tailors immune responses and homeostasis
作者机构：Department of Fundamental OncologyUniversity of LausanneLausanneSwitzerland Ludwig Institute for Cancer ResearchUniversity of LausanneEpalingesSwitzerland
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2022年第19卷第3期
页 面：370-383页
核心收录：
学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学]
基 金：P-CH was supported in part by SNSF project grants(31003A_182470) the European Research Council Staring Grant(802773-MitoGuide),the Swiss Cancer League(KFS-3949-08-2016),the Cancer Research Institute(Lloyd J.Old Star award and CLIP Investigator award),the Melanoma Research Alliance Established Investigator Award,and EMBO Young Investigator award
主 题：Dendritic cells Immunometabolism Homeostasis Tumor immunity Microbiota
摘 要：It is being increasingly acknowledged that immune cells depend on certain metabolic traits to perform their functions and that the extracellular environment can influence cell metabolism and vice *** cell(DC)subsets traffic through highly diverse environments from the bone marrow,where they develop,to the various peripheral tissues,where they differentiate and capture antigens,before they migrate to the lymph node to present antigens and prime T *** is plausible that DC subsets modulate their stimulatory abilities in response to unique metabolic *** metabolic requirements of DCs are just recently being discovered,and subset-and context-specific metabolic phenotypes in DCs are highly intertwined with DC *** this review,we present the current knowledge on the intrinsic and extrinsic determinants of DC metabolism,how they regulate DC function with examples from tumor biology and in interaction with the microbiota,and discuss how this can be applied therapeutically.
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