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慢性子宫内膜炎对子宫内膜异位症相关性不孕妊娠结局的影响

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山东大学学报（医学版） 2021年第3期59卷 55-60页

作者：梁炎春叶海花陆丽美戴郁菁程谦益蔡婉玲曾涵秋陈杏欢王兴韦雅婧杨如玉中山大学附属第一医院妇产科广东广州510080 南宁市武鸣区妇幼保健院妇产科广西南宁530100 中山大学中山医学院广东广州510080

目的探讨慢性子宫内膜炎(CE)在子宫内膜异位症相关性不孕(EAI)患者中发生的高危因素及对患者妊娠预后的影响。方法选择2018年6月1日至2019年6月1日因不孕进行宫腹腔镜联合诊治术的患者122例作为研究对象,所有患者经腹腔镜手术和术后病... 详细信息

目的探讨慢性子宫内膜炎(CE)在子宫内膜异位症相关性不孕(EAI)患者中发生的高危因素及对患者妊娠预后的影响。方法选择2018年6月1日至2019年6月1日因不孕进行宫腹腔镜联合诊治术的患者122例作为研究对象,所有患者经腹腔镜手术和术后病理证实为子宫内膜异位症(EMs)。根据CE的两种诊断标准,将研究对象分为慢性子宫内膜炎组和非慢性子宫内膜炎组,统计分析CE发生的高危因素,并追踪和比较两组患者术后不同时间段的累积妊娠率。结果按高倍镜下1个或以上浆细胞为诊断标准,EAI患者中合并CE的比例是82.79%(101/122),输卵管粘连(P=0.008)是其发生的高危因素。按高倍镜下5个或以上浆细胞为诊断标准,EAI患者中合并CE的比例是54.1%(66/122),合并的其他妇科疾病(包括子宫肌瘤、多囊卵巢综合征等)是其发生的高危因素。无论采用何种诊断标准,EAI同时合并CE的患者在经过规范的抗生素疗程治疗之后,其术后的6、9、12个月的累积妊娠率与无合并CE的EAI患者之间差异无统计学意义(P>0.05)。结论CE在EAI患者中发生率高;输卵管粘连或同时合并多囊卵巢综合征、子宫肌瘤等基础妇科疾病,可能是EAI同时合并CE的高危因素。规范的抗生素治疗可以改善EAI合并CE患者的妊娠预后。

关键词：慢性子宫内膜炎子宫内膜异位症不孕 CD138

Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jiang Zhenjie lu Yanwen Ding Shujun Liu Zhijie Qi Tian Tang Yunfan Zhang Zhiyuan Ma Jingwen Sun Liang Xue Wenyao Zhang Pan Xiong Xin Wang Junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Ductility

Efficient large-area flexible organic photovoltaic modules on transparent thin silver electrodes

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Science China Chemistry 2025年

作者： Cong Xie Zedong Xiong Xinlu Liu Wen Wang Yang Liu Xueshi Jiang Xin lu lulu Sun Yinhua Zhou Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Kunming Institute of Physics

Large-area flexible organic photovoltaic（OPV） modules are challenging to achieve high power conversion efficiency（PCE）.Electrical shunts or shortages generally occur in large-area OPV modules due to the ultrathin（100–200 nm） and soft active layers. Improving the surface smoothness of bottom transparent electrode will be able to suppress the shunts and shortages. In this work, we report a method to fabricate smooth and flexible transparent electrodes based on thin silver film, and further to fabricate efficient large-area flexible OPV modules. The fabricated thin silver transparent electrodes simultaneously have high conductivity, high optical transmittance, good mechanical flexibility and low surface roughness. Humidity exposure（h.e.）treatment on MoO3effectively facilitates the continuous growth of the thin transparent silver electrode. 6 nm silver film on MoO3（h.e.） on plastic substrate shows a transmittance up to 89%, a sheet resistance of 15 Ω/sq, and a low surface roughness with a rootmean-square value of 0.276 nm. Furthermore, 52-cm2flexible organic solar modules（15 subcells） showed a certified PCE of12.66%. Furthermore, a 1350 cm2flexible component assembled by 25 pieces of 52–55 cm2modules showed certified PCE of12.10% with an open-circuit voltage of 62.85 V.

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Sequential gastrodin release PU/n-HA composite scaffolds reprogram macrophages for improved osteogenesis and angiogenesis

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Bioactive Materials 2023年第1期19卷 24-37页

作者： limei Li Qing Li Li Gui Yi Deng lu Wang Jianlin Jiao Yingrui Hu Xiaoqian Lan Jianhong Hou Yao Li Di lu Yunnan Key Laboratory of Stem Cell and Regenerative Medicine Science and Technology Achievement Incubation CenterKunming Medical UniversityKunming650500China Department of Endocrinology The Third People’s Hospital of Yunnan ProvinceKunming650011China School of Chemical Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu610065China Department of Neurology The First Affiliated HospitalKunming Medical UniversityKunming650000China Department of Orthopaedics The Third People’s Hospital of Yunnan ProvinceKunming650011China Department of Stomatology The First People’s Hospital of Yunnan ProvinceKunming650032China

Wound healing is a highly orchestrated process involving a variety of cells,including immune *** immunomodulatory biomaterials for regenerative engineering applications,such as bone regeneration,is an appealing ***,inspired by the immunomodulatory effects of gastrodin(a bioactive component in traditional Chinese herbal medicine),a series of new immunomodulatory gastrodin-comprising biodegradable polyurethane(gastrodin-PU)and nano-hydroxyapatite(n-HA)(gastrodin-PU/n-HA)composites were *** 264.7 macrophages,rat bone marrow mesenchymal stem cells(rBMSCs),and human umbilical vein endothelial cells(HUVECs)were cultured with gastrodin-PU/n-HA containing different concentrations of gastrodin(0.5%,1%,and 2%)to decipher their immunomodulatory effects on osteogenesis and angiogenesis in *** demonstrated that,compared with PU/n-HA,gastrodin-PU/n-HA induced macrophage polarization toward the M2 phenotype,as evidenced by the higher expression level of pro-regenerative cytokines(CD206,Arg-1)and the lower expression of pro-inflammatory cytokines(iNOS).The expression levels of osteogenesis-related factors(BMP-2 and ALP)in the rBMSCs and angiogenesis-related factors(VEGF and BFGF)in the HUVECs were significantly up-regulated in gastrodin-PU/n-HA/macrophage-conditioned *** immunomodulatory effects of gastrodin-PU/n-HA to reprogram macrophages from a pro-inflammatory(M1)phenotype to an anti-inflammatory and pro-healing(M2)phenotype were validated in a rat subcutaneous implantation *** the 2%gastrodin-PU/n-HA significantly decreased fibrous capsule formation and enhanced ***,2%gastrodin-PU/n-HA scaffolds implanted in the rat femoral condyle defect model showed accelerated osteogenesis and ***,the novel gastrodin-PU/n-HA scaffold may represent a new and promising immunomodulatory biomaterial for bone repair and regeneration.

关键词： Gastrodin-delivery Immune/inflammatory response Osteogenesis Angiogenesis Tissue repair

Carbon dots self-assembly enables near-infrared emission

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Science China Chemistry 2025年

作者： Shurong Ding Shasha Liu Yuzhuo Yang Linlin Shi Yongqiang Zhang Jingkun Yu Haoqiang Song Yingge Shi Siyu lu College of Chemistry Pingyuan Laboratory Zhengzhou University Henan Institute of Advanced Technology Zhengzhou University

In the fields of biomedicine, detection, and anti-counterfeiting, there is a widespread demand for cost-effective, easily synthesized, and environmentally friendly near-infrared(NIR) materials. Carbon dots(CDs), a cheap and non-toxic zero-dimensional carbon nanomaterial exhibiting exceptional photoluminescence(PL) properties and facile structural modification, have emerged as a promising candidate for the development of novel NIR materials. This study presents the synthesis of CDs capable of emitting a wide range of wavelengths from blue to NIR(456–836 nm) as their concentrations increase. The incorporation of oxygen and nitrogen co-doped atoms facilitates the optimization of non-coplanar angles, thereby promoting favorable π-πstacking interactions. This leads to the formation of metal-free rigid clusters through interconnecting adjacent nanoparticles in a gear-like meshing pattern through self-assembly. Consequently, intramolecular motion is constrained, vibration coupling is mitigated, non-radiative transition losses are minimized, and efficient NIR emission from CD clusters in high concentrations is ensured. Furthermore, NIR light-emitting diode(NIR LED) based on the CD clusters was successfully fabricated and employed for various applications including information encryption, anti-counterfeiting, and penetration detection in the field of NIR imaging.

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A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng Jingai Zhang Boxin Liu Yu Shi Haoxue Wang Lijie Huang Su Zhang Ruixin Zhang Song Wang Guangxu lu Peifu Tang Zhongyang Liu Kai Wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

Dietary carbohydrate intake and risk of type 2 diabetes:a 16-year prospective cohort study

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Science China Life Sciences 2025年

作者： lu Gan Yi Yang Bin Zhao Kai Yu Kehua Guo Fang Fang Zhiguang Zhou Demetrius Albanes Jiaqi Huang Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University CSU-Sinocare Research Center for Nutrition and Metabolic Health Xiangya School of Public Health Central South UniversityFurong Laboratory Division of Cancer Epidemiology and Genetics National Cancer Institute NIH Department of Health and Human Services School of Computer Science and Engineering Central South University Institute of Environmental Medicine Karolinska Institute National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University

Despite considerable research underscoring the importance of carbohydrate intake in relation to the risk of type 2 diabetes(T2D), a comprehensive assessment of this relationship is currently lacking. We aimed to examine the associations of various types and food sources of dietary carbohydrate intake with the risk of T2D, to evaluate potential effect modification by other factors, including genetic susceptibility,and to explore the potential mediators for such associations. The present study included 161,872 participants of the UK Biobank who were free of prevalent cancer, cardiovascular disease, or diabetes, and had at least one validated 24-h dietary recall assessment. Multivariableadjusted age-stratified Cox proportional hazard regression models were applied to estimate hazard ratios(HRs) and 95% confidence intervals(CI) for the associations of various types and food sources of dietary carbohydrate intake with risk of T2D. During a median follow-up of13.6 years, 4,176 incident cases of T2D were identified. In the multivariable-adjusted models, a greater intake of fiber, carbohydrates from whole grains, and carbohydrates from non-starchy vegetables was significantly associated with a lower risk of T2D(highest vs. lowest quantile, HR [95% CI]=0.70 [0.62–0.79], 0.74 [0.67–0.82], and 0.83 [0.75–0.92], respectively, all P for trend lues luding individuals with different genetic susceptibility to T2D. Mediation analyses of the inverse association between T

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Genome-wide identification and analysis of cytokinin dehydrogenase/oxidase(CKX) family genes in Brassica oleracea *** their involvement in response to Plasmodiophora brassicae infections

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Horticultural Plant Journal 2022年第1期8卷 68-80页

作者： Mingzhao Zhu Yong Wang Shujin lu limei Yang Mu Zhuang Yangyong Zhang Honghao Lv Zhiyuan Fang Xilin Hou State Key Laboratory of Crop Genetics and Germplasm Enhancement College of HorticultureNanjing Agricultural UniversityNanjing 210095China Key Laboratory of Biology and Genetic Improvement of Horticultural Crops Ministry of AgricultureInstitute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing 100081China

Cytokinins are a class of phytohormones that promote cell division and differentiation and are thought to affect plant immunity to multiple ***,a comprehensive analysis of cytokinin dehydrogenase/oxidase(CKX)family genes in cabbage has not been *** this study,a total of 36 CKX genes were identified using a genome-wide search *** analysis classified these genes into three *** were distributed unevenly across nine chromosomes in ***,and 15 of them did not contain any *** results of colinearity analysis showed that 36 CKX gene in Arabidopsis was present in several copies in the Brassica oleracea *** analysis of cisacting elements indicated that all genes possessed at least one stress or hormone responsive cis-acting element.A heatmap of CKX gene expression showed the patterns of expression of these genes in various tissues and *** genes(Bol028363,Bol031036 and Bol018140)were relatively highly expressed in all of the investigated tissues under normal conditions,showing the expression profile of housekeeping ***,the expression patterns of CKX genes in Jingfeng 1 and Xiangan 336 were quite different under the same ***,three genes(Bol020547,Bol028392 and Bol045724)were significantly down-regulated and up-regulated in the susceptible and resistant material,respectively,after inoculation,which may indicate their crucial roles in resistance to clubroot *** results provide insights for better understanding the roles of CKX genes in the ***–*** interaction.

关键词： Brassica oleracea Genome-wide Cytokinin dehydrogenase/oxidase(CKX)genes Clubroot

Gastrodin modified polyurethane conduit promotes nerve repair via optimizing Schwann cells function

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Bioactive Materials 2022年第2期7卷 355-367页

作者： Hongcai Yang Qing Li limei Li Shaochun Chen Yu Zhao Yingrui Hu lu wang Xiaoqian Lan Lianmei Zhong Di lu Yunnan Key Laboratory of Stem Cell and Regenerative Medicine Department of NeurologyThe First Affiliated HospitalKunming Medical UniversityKunming650500China Yunnan Key Laboratory of Stem Cell and Regenerative Medicine Science and Technology Achievement Incubation CenterKunming Medical UniversityKunming650500China The School of Rehabilitation Kunming Medical UniversityKunming650500China

Peripheral nerve regeneration and functional recovery remain a major clinical *** guidance conduit(NGC)that can regulate biological behavior of Schwann cells(SCs)and facilitate axonal regeneration through microenvironmental remodeling is beneficial for nerve regeneration and functional ***,a main constituent of a Chinese traditional herbal medicine,has been known to display several biological and pharmacological properties,especially antioxidative,anti-inflammatory and nerve ***,polyurethane(PU)NGCs modified by different weight ratio of Gastrodin(0,1 and 5 wt%)were designed for sequential and sustainable drug release,that created a favorable microenvironment for nerve *** scaffold showed suitable pore structure and biocompatibility in vitro,and evidently promoted morphological and functional recovery of regenerated sciatic nerves in *** to the PU and 1% Gastrodin/PU scaffolds,the 5% Gastrodin/PU significantly enhanced the proliferation,migration and myelination of SCs and up-regulated expression of neurotrophic factors,as well as induction of the differentiation of PC12 ***,the obvious anti-inflammatory response was observed in 5% Gastrodin/PU by reduced expression of TNF-α and iNOS,which also evidenced by the few fibrous capsule formation in the subcutaneous *** a construct presented a similarity to autograft in vivo repairing a 10 mm sciatic nerve *** was able to not only boost the regenerated area of nerve and microvascular network,but also facilitate functional axons growth and remyelination,leading to highly improved functional *** findings demonstrate that the 5% Gastrodin/PU NGC efficiently promotes nerve regeneration,indicating their potential for use in peripheral nerve regeneration applications.

关键词： Gastrodin/PU SCs biological behavior Anti-inflammatory Peripheral nerve regeneration