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南方医科大学学报 2023年第1期43卷 153-156,F0003页

作者：郑华姜思捷林立龙南方医科大学南方医院心血管内科广东广州510515

家族性高胆固醇血症(FH)是脂蛋白代谢异常所导致的遗传性疾病,通常为常染色体显性遗传,由于长期暴露于高水平低密度脂蛋白下,FH患者发生冠状动脉疾病的风险显著升高。基因检测对FH的诊断至关重要,除此之外,低密度脂蛋白受体功能检测对F... 详细信息

家族性高胆固醇血症(FH)是脂蛋白代谢异常所导致的遗传性疾病,通常为常染色体显性遗传,由于长期暴露于高水平低密度脂蛋白下,FH患者发生冠状动脉疾病的风险显著升高。基因检测对FH的诊断至关重要,除此之外,低密度脂蛋白受体功能检测对FH的治疗也具有重要意义。本文将从FH的诊断筛查、治疗方案及低密度脂蛋白受体功能检测等方面进行综述。

关键词：家族性高胆固醇血症低密度脂蛋白受体基因检测

高镁磷尾矿作为矿物掺合料应用于混凝土性能研究

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无机盐工业 2024年第1期56卷 90-95页

作者：姜立龙李剑秋杨林张庆刚贵州大学化学与化工学院贵州贵阳550025 贵州川恒化工股份有限公司贵州福泉550500

高镁磷尾矿是磷矿反浮选过程产生的固体废弃物,主要矿物相为白云石、少量氟磷灰石和石英。将磷尾矿烘干粉磨后制成磷尾矿粉,分析了磷尾矿粉粒径分布、毒害性,参照GB/T51003—2014《矿物掺合料应用技术规范》测定了磷尾矿粉相关性能指标... 详细信息

高镁磷尾矿是磷矿反浮选过程产生的固体废弃物,主要矿物相为白云石、少量氟磷灰石和石英。将磷尾矿烘干粉磨后制成磷尾矿粉,分析了磷尾矿粉粒径分布、毒害性,参照GB/T51003—2014《矿物掺合料应用技术规范》测定了磷尾矿粉相关性能指标。以水泥、磷尾矿粉、粉煤灰为凝胶材料,制备了不同强度等级C30、C40、C50及C60混凝土,测定了混凝土工作性能、力学性能,并分析了掺磷尾矿粉水泥浆不同水化龄期的矿物组成。结果表明,经过烘干粉磨后,磷尾矿粒径D_(90)由133.1μm降至63.4μm,烧失量为39%、28d活性指数为70%、亚甲蓝值小于1.4、流动度比大于100%。当磷尾矿粉占总凝胶材料10%时配制的C60混凝土,坍落度为230mm、28d强度为64.1MPa、90 d强度为78.6 MPa;在养护龄期为90 d时,磷尾矿粉水泥硬化体中出现新矿物相水滑石,有利于混凝土后期强度增长。磷尾矿粉可作为矿物掺合料用于制备混凝土。

关键词：高镁磷尾矿矿物掺合料混凝土毒害水化产物

Reprogramming somatic cells to cells with neuronal characteristics by defined medium both in vitro and in vivo

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Cell Regeneration 2015年第1期4卷 123-131页

作者： Songwei He Yiping Guo Yixin Zhang Yuan Li Chengqian Feng Xiang Li lilong lin lin Guo Haitao Wang Chunhua Liu Yi Zheng Chuanming Luo Qiang Liu Fuhui Wang Hao Sun lining Liang lingyu Li Huanxing Su Jiekai Chen Duanqing Pei Hui Zheng CAS Key Laboratory of Regenerative Biology Guangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineGuangzhou Institutes of Biomedicine and HealthChinese Academy of Sciences#190 Kaiyuan AvenueScience CityGuangzhou 510530China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacaoChina Anhui University Hefei 230601China

Background:Currently,direct conversion from somatic cells to neurons requires virus-mediated delivery of at least one transcriptional factor or a combination of several small-molecule *** of transcriptional factors may affect genome stability,while small-molecule compounds may require more evaluations when applied in ***,a defined medium with only conventional growth factors or additives for cell culture is desirable for inducing neuronal ***:Here,we report that a defined medium(5C)consisting of basic fibroblast growth factor(bFGF),N2 supplement,leukemia inhibitory factor,vitamin C(Vc),andβ-mercaptoethanol(βMe)induces the direct conversion of somatic cells to cells with neuronal *** of 5C medium converted mouse embryonic fibroblasts(MEFs)into TuJ+neuronal-like cells,which were capable of survival after being transplanted into the mouse *** same 5C medium could convert primary rat astrocytes into neuronal-like cells with mature electrophysiology characteristics in vitro and facilitated the recovery of brain injury,possibly by inducing similar conversions,when infused into the mouse brain in ***,5C medium could also induce neuronal characteristics in several human cell ***:In summary,this 5C medium not only provides a means to derive cells with neuronal characteristics without viral transfection in vitro but might also be useful to produce neurons in vivo for neurodegenerative disease treatment.

关键词： Neurons Somatic cells Astrocytes Trans-differentiation Defined medium

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节段预制混凝土斜拉桥索导管角度定位方法

铁道建筑技术 2021年第10期 109-112,117页

作者：林李龙中国铁路广州局集团有限公司广州广东511470

斜拉索导管精准定位是斜拉桥设计的重要内容,同时也是施工精度的重要保证。本文分析导管安装角度的影响因素,包括拉索垂度效应、梁段预拱度、桥塔变形、梁轴向角度及导管固定支架变形;推导各因素所对应角度修正公式,提出索导管安装角度... 详细信息

斜拉索导管精准定位是斜拉桥设计的重要内容,同时也是施工精度的重要保证。本文分析导管安装角度的影响因素,包括拉索垂度效应、梁段预拱度、桥塔变形、梁轴向角度及导管固定支架变形;推导各因素所对应角度修正公式,提出索导管安装角度计算方法,并结合工程实例,对索导管安装角度修正结果进行探讨。结果表明:拉索垂度效应产生的角度修正值最大,梁段预拱度和轴向角度次之,桥塔变形和支架变形最小;拉索长度越长,其对应的角度修正值越大;对于中跨索,梁段预拱度产生的修正值较大,而边跨索对应值较小。

关键词：节段预制混凝土斜拉桥索导管角度定位

不同施肥措施对河套灌区盐化潮土氨挥发及氧化亚氮排放的影响

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土壤 2017年第4期49卷 745-752页

作者：武岩红梅林立龙美丽张建强内蒙古农业大学/内蒙古自治区土壤质量与养分资源重点实验室呼和浩特010010 内蒙古土壤肥料工作站呼和浩特010011 杭锦后旗农业推广中心内蒙古巴彦淖尔015000

本研究以河套灌区农田盐化潮土为研究对象,通过静态暗箱-气相色谱法和田间土壤氨挥发原位测定法(通气法),研究了4种不同施肥措施(农民习惯施肥、膨润土+农民习惯施肥、生物炭+农民习惯施肥、腐殖酸+农民习惯施肥,分别标记为CK、B、C、HA... 详细信息

本研究以河套灌区农田盐化潮土为研究对象,通过静态暗箱-气相色谱法和田间土壤氨挥发原位测定法(通气法),研究了4种不同施肥措施(农民习惯施肥、膨润土+农民习惯施肥、生物炭+农民习惯施肥、腐殖酸+农民习惯施肥,分别标记为CK、B、C、HA)对土壤氨(NH_3)挥发及氧化亚氮(N_2O)排放的影响。结果表明:B处理可以显著降低土壤N_2O的排放,其N_2O累计排放量较CK降低30.9%,氮肥损失率较CK降低31.5%;其他处理N_2O累计排放量与CK无显著差异。各处理NH_3挥发速率于施肥灌水后3~5 d达到峰值,之后逐渐降低趋于平稳。B、C、HA处理可以显著降低土壤NH_3挥发,NH_3累计挥发量较CK降低56.0%、41.2%、49.0%,氮肥损失率较CK降低56.0%、41.2%、52.1%。相关性分析表明,土壤温度和空气温度与土壤N_2O的排放呈显著正相关;生育期土壤含水量处于151.2~203.3 g/kg,在这一范围内,土壤含水量与土壤N_2O的排放呈正相关关系。B处理可显著降低土壤NH3挥发及N_2O排放,且比CK增产11.1%,是较为合理的施肥措施。

关键词：施肥措施 NH3 N2O 河套灌区

急性冠脉综合征患者斑块侵蚀诊断的影像学进展

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分子影像学杂志 2022年第1期45卷 134-139页

作者：吕萍潘杭雨胡可欣林立龙郭志刚南方医科大学南方医院心血管内科广东广州510515

斑块侵蚀是急性冠脉综合征的重要发病机制之一。针对斑块侵蚀的急性冠脉综合征患者,抗栓治疗而非支架治疗是其更为安全有效的治疗选择,因此临床上斑块侵蚀的准确识别至关重要。技术的发展极大地推进了斑块侵蚀的诊断进展,本文从人体尸... 详细信息

斑块侵蚀是急性冠脉综合征的重要发病机制之一。针对斑块侵蚀的急性冠脉综合征患者,抗栓治疗而非支架治疗是其更为安全有效的治疗选择,因此临床上斑块侵蚀的准确识别至关重要。技术的发展极大地推进了斑块侵蚀的诊断进展,本文从人体尸检研究的重要发现、光学相干断层扫描、血管内超声、近红外光谱、冠状动脉计算机断层扫描血管造影、生物标志物几个方面展开,就上述诊断手段进行回顾与总结。

关键词：动脉粥样硬化斑块侵蚀斑块破裂光学相干断层扫描血管内超声近红外光谱冠状动脉计算机断层扫描血管造影

GraphCWGAN-GP:A Novel Data Augmenting Approach for Imbalanced Encrypted Traffic Classification

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Computer Modeling in Engineering & Sciences 2023年第8期136卷 2069-2092页

作者： Jiangtao Zhai Peng lin Yongfu Cui lilong Xu Ming Liu School of Electronics and Information Engineering Nanjing University of Information Science and TechnologyNanjing210044China School of Tourism and Geography Science Qingdao UniversityQingdao266071China

Encrypted traffic classification has become a hot issue in network security *** class imbalance problem of traffic samples often causes the deterioration of Machine Learning based classifier *** the Generative Adversarial Network(GAN)method can generate new samples by learning the feature distribution of the original samples,it is confronted with the problems of unstable training andmode *** this end,a novel data augmenting approach called Graph CWGAN-GP is proposed in this *** traffic data is first converted into grayscale images as the input for the proposed ***,the minority class data is augmented with our proposed model,which is built by introducing conditional constraints and a new distance metric in typical ***,the classical deep learning model is adopted as a classifier to classify datasets augmented by the Condition GAN(CGAN),Wasserstein GAN-Gradient Penalty(WGAN-GP)and Graph CWGAN-GP,*** with the state-of-the-art GAN methods,the Graph CWGAN-GP cannot only control the modes of the data to be generated,but also overcome the problem of unstable training and generate more realistic and diverse *** experimental results show that the classification precision,recall and F1-Score of theminority class in the balanced dataset augmented in this paper have improved by more than 2.37%,3.39% and 4.57%,respectively.

关键词： Generative Adversarial Network imbalanced traffic data data augmenting encrypted traffic classification

Facile Synthesis and High-Value Utilization of Ammonia

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Chinese Journal of Chemistry 2022年第8期40卷 953-964页

作者： Yu Luo Shijing Liang Xiuyun Wang Bingyu lin Chongqi Chen lilong Jiang National Engineering Research Center of Chemical Fertilizer Catalyst Fuzhou UniversityFuzhouFujian 350002China Qingyuan Innovation Laboratory QuanzhouFujian 362801China

Ammonia is a key component in fertilizer and the carbon-free hydrogen *** ammonia synthesis and utilization have played a central role in the development of chemical *** industrial production of ammonia remains dependent on the energy-and carbon-intensive Haber-Bosch process.A major effort has been devoted to developing robust and efficient catalysts,as well as alternative benign ***,we detail our endeavors that develop the ammonia synthesis and decomposition catalysts,and utilize the ammonia *** firstly discuss the catalysts for ammonia synthesis via dissociative and associative process,and the regulation of catalysts'***,we review the burgeoning electrocata-lytic nitrogen reduction process,focusing on the enhanced catalytic performances by the regulation of the catalysts and the ***,we provide a novel high-value utilization of ammonia to achieve the"zero-carbon"circular *** promising catalysts,reactors,and ammonia energy systems have been discussed in *** end this Account that offers future research directions and prospects of ammonia.

关键词： Nitrogen fixation Ammonia-to-hydrogen Carbon-free Heterogeneous catalysis Supported catalysts

Highly efficient subnanometer Ru-based catalyst for ammonia synthesis via an associative mechanism

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Chinese Journal of Chemical Engineering 2022年第3期35卷 177-184页

作者： Yanliang Zhou Qianjin Sai Zhenni Tan Congying Wang Xiuyun Wang Bingyu lin Jun Ni Jianxin lin lilong Jiang National Engineering Research Center of Chemical Fertilizer Catalyst Fuzhou UniversityFuzhou 350002China

The industrial manufacture of ammonia(NH_(3))using Fe-based catalyst works under rigorous *** the goal of carbon-neutrality,it is highly desired to develop advanced catalyst for NH_(3)synthesis at mild conditions to reduce energy consumption and CO_(2)***,the main challenge of NH_(3)synthesis at mild conditions lies in the dissociation of steady N≡N triple *** this work,we report the design of subnanometer Ru clusters(0.8 nm)anchored on the hollow N-doped carbon spheres catalyst(Ru-SNCs),which effectively promotes the NH_(3)synthesis at mild conditions via an associative *** NH_(3)synthesis rate over Ru-SNCs(0.49%(mass)Ru)reaches up to 11.7 mmol NH_(3)·(g cat)^(-1)·h^(-1) at 400℃ and 3 MPa,which is superior to that of 8.3 mmol NH_(3)·(g cat)^(-1)·h^(-1) over Ru nanoparticle catalyst(1.20%(mass)Ru).Various characterizations show that the N_(2)H_(4)species are the main intermediates for NH_(3)synthesis on Ru-SNCs *** demonstrates that Ru-SNCs catalyst can follow an associative route for N_(2)activation,which circumvents the direct dissociation of N_(2)and results in highly efficient NH_(3)synthesis at mild conditions.

关键词： Ammonia synthesis Sustainability Subnanometer Ru clusters Associative route Catalysis