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Corrosion and in vitro cytocompatibility investigation on the designed Mg-Zn-Ag metallic glasses for biomedical application

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Journal of Magnesium and Alloys 2024年第4期12卷 1566-1580页

作者： Jian Wang Lingzhong Meng Weixin Xie Chen Ji Ronghua Wang Pinghu Zhang liling jin Liyuan Sheng Yufeng Zheng School of Mechanical Engineering Yangzhou UniversityYangzhou225127China Department of Materials Science and Engineering Seoul National UniversitySeoulSouth Korea Huizhou Port Customs Huizhou516081China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Institute of Translational MedicineMedical CollegeYangzhou UniversityYangzhou225009China Center for Research in Computational Thermochemistry(CRCT) Department of Chemical EngineeringEcole polytechnique de MontréalMontréalQuébecH3C 3A7Canada Shenzhen Institute Peking UniversityShenzhen 518057China PKU-HKUST ShenZhen-HongKong Institution Shenzhen518057China

In the present work,seven Mg-Zn-Ag alloys with the nominal composition of Mg_(96-x)Zn_(x)Ag_(4)(x=17,20,23,26,29,32,35 in at.%)were prepared by induction melting and single-roller melt-spinning.The X-ray diffraction(XRD)analyses indicate the metallic glasses with three composition of Mg_(73)Zn_(23)Ag_(4),Mg_(70)Zn_(26)Ag_(4),and Mg_(67)Zn_(29)Ag_(4)were obtained successfully.The differential scanning calorimetry(DSC)measurement was used to obtain the characteristic temperature of Mg-Zn-Ag metallic glasses for the glass-forming ability analysis.The maximum glass transition temperature(Trg)was found to be 0.525 with a composition close to Mg_(67)Zn_(29)Ag_(4),which results in the best glass-forming ability.Moreover,the immersion test in simulated body fluid(SBF)demonstrate the relative homogeneous corrosion behavior of the Mg-Zn-Ag metallic glasses.The corrosion rate of Mg-Zn-Ag metallic glasses in SBF solution decreases with the increase of Zn content.The sample Mg_(67)Zn_(29)Ag_(4)has the lowest corrosion rate of 0.19mm/yr,which could meet the clinical application requirement well.The in vitro cell experiments show that the Madin-Darby canine kidney(MDCK)cells cultured in sample Mg_(67)Zn_(29)Ag_(4)and its extraction medium have higher activity.However,the Mg-Zn-Ag metallic glasses exhibit obvious inhibitory effect on human rhabdomyosarcoma(RD)tumor cells.The present investigations on the glass-forming ability,corrosion behavior,cytocompatibility and tumor inhibition function of the Mg-Zn-Ag based metallic glass could reveal their biomedical application possibility.

关键词： Metallic glasses Mg-Zn-Ag Corrosion behavior In vitro cytocompatibility

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Experimental measurement on the phase equilibria of the Mg-Ag-Cu ternary system at 350℃and 400℃

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Journal of Magnesium and Alloys 2022年第2期10卷 486-494页

作者： Jian Wang Zhang Zhang Yinju Zhang liling jin Liyuan Sheng College of Mechanical Engineering Yangzhou UniversityYangzhou 225127China Shenzhen Institute Peking UniversityShenzhen 518057Guangdong ProvinceChina Center for Research in Computational Thermochemistry(CRCT) Department of Chemical EngineeringEcole polytechnique de MontréalMontréal H3C 3A7QuébecCanada

The phase equilibria of the Mg–Ag–Cu ternary system at 350℃and 400℃were experimentally investigated using twenty-eight key samples.The phase equilibria and compositions in key samples were investigated using scanning electron microscopy(SEM)equipped with energydispersive spectroscopy(EDS).Powder X-ray diffraction(XRD)technique was used to analyze the crystal structure and solid solubility of compounds.Five three-phase equilibria and several two-phase equilibria have been determined at 350℃and 400℃.The solid solubility range of Cu in the compounds Mg_(3)Ag,MgAg and fcc(Ag)were examined at 350℃and 400℃.The maximum solid solubility of Ag in the compound MgCu_(2)was found to be 11.46 at.%and 11.25 at.%with a constant value of about 66 at.%Cu at 350℃and 400℃,respectively.Besides,the solid solubility limits of Ag in the compounds Mg_(2)Cu and fcc(Cu)were found to be less than 5 at.%at 350℃and 400℃.No ternary compound was observed in the present work.

关键词： Mg–Ag–Cu system Phase diagram SEM EDS XRD

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Glutamicibacter nicotianae AT6:A new strain for the efficient biodegradation of tilmicosin

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Journal of Environmental Sciences 2024年第8期142卷 182-192页

作者： Huijuan Li Hao Zhou liling Fan Long Meng Yanyun Zhao Lanmei Zhao Bo Wang College of Chemical and Biological Engineering Shandong University of Science and TechnologyQingdao 266590China College of Chemistry and Chemical Engineering Heze UniversityHeze 274015China College of Safety and Environmental Engineering Shandong University of Science and TechnologyQingdao 266590China

The degradation of tilmicosin(TLM),a semi-synthetic 16-membered macrolide antibiotic,has been receiving increasing attention.Conventionally,there are three tilmicosin degradation methods,and among them microbial degradation is considered the best due to its high efficiency,eco-friendliness,and low cost.Coincidently,we found a new strain,Glutamicibacter nicotianae sp.AT6,capable of degrading high-concentration TLM at 100 mg/L with a 97%removal efficiency.The role of tryptone was as well investigated,and the results revealed that the loading of tryptone had a significant influence on TLM removals.The toxicity assessment indicated that strain AT6 could efficiently convert TLM into less-toxic substances.Based on the identified intermediates,the degradation of TLM by AT6 processing through two distinct pathways was then proposed.

关键词： Tilmicosin Glutamicibacter nicotianae Biodegradation Degradation pathway Pharmaceutical wastewater

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Research on Regulation Method of Energy Storage System Based on Multi-Stage Robust Optimization

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Energy Engineering 2024年第3期121卷 807-820页

作者： Zaihe Yang Shuling Wang Runhang Zhu Jiao Cui Ji Su liling Chen Electrical Dispatching and Control Center Yunnan Power GridKunming650011China Kunming Power Supply Bureau Yunnan Power Grid Co.Ltd.Kunming650011China Yuxi Power Supply Bureau Yunnan Power Grid Co.Ltd.Yuxi653100China

To address the scheduling problem involving energy storage systems and uncertain energy,we propose a method based on multi-stage robust optimization.This approach aims to regulate the energy storage system by using a multi-stage robust optimal control method,which helps overcome the limitations of traditional methods in terms of time scale.The goal is to effectively utilize the energy storage power station system to address issues caused by unpredictable variations in environmental energy and fluctuating load throughout the day.To achieve this,a mathematical model is constructed to represent uncertain energy sources such as photovoltaic and wind power.The generalized Benders Decomposition method is then employed to solve the multi-stage objective optimization problem.By decomposing the problem into a series of sub-objectives,the system scale is effectively reduced,and the algorithm’s convergence ability is improved.Compared with other algorithms,the multi-stage robust optimization model has better economy and convergence ability and can be used to guide the power dispatching of uncertain energy and energy storage systems.

关键词： Multi-stage robust optimization energy storage system regulation methods output uncertainty

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Assessment of cheese sign and its association with vascular risk factors: Data from PUMCH dementia cohort

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中华医学杂志(英文版) 2024年第7期137卷 830-836页

作者： Huang Xinying Hou Bo Wang Jie Li Jie Shang Li Mao Chenhui Dong liling Liu Caiyan Feng Feng Gao jing Peng Bin Department of Neurology State Key Laboratory of Complex Severe and Rare Disease Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing 100730 China Department of Radiology Chinese Academy of Medical Sciences and Peking Union Medical College

Background: In the clinic, practitioners encounter many patients with an abnormal pattern of dense punctate magnetic resonance imaging (MRI) signal in the basal ganglia, a phenomenon known as "cheese sign". This sign is reported as common in cerebrovascular diseases, dementia, and old age. Recently, cheese sign has been speculated to consist of dense perivascular space (PVS). This study aimed to assess the lesion types of cheese sign and analyze the correlation between this sign and vascular disease risk factors.Methods: A total of 812 patients from Peking Union Medical College Hospital (PUMCH) dementia cohort were enrolled. We analyzed the relationship between cheese sign and vascular risk. For assessing cheese sign and defining its degree, the abnormal punctate signals were classified into basal ganglia hyperintensity (BGH), PVS, lacunae/infarctions and microbleeds, and counted separately. Each type of lesion was rated on a four-level scale, and then the sum was calculated; this total was defined as the cheese sign score. Fazekas and Age-Related White Matter Changes (ARWMC) scores were used to evaluate the paraventricular, deep, and subcortical gray/white matter hyperintensities.Results: A total of 118 patients (14.5%) in this dementia cohort were found to have cheese sign. Age (odds ratio [OR]: 1.090, 95% confidence interval [CI]: 1.064-1.120,P <0.001), hypertension (OR: 1.828, 95% CI: 1.123-2.983,P = 0.014), and stroke (OR: 1.901, 95% CI: 1.092-3.259,P = 0.025) were risk factors for cheese sign. There was no significant relationship between diabetes, hyperlipidemia, and cheese sign. The main components of cheese sign were BGH, PVS, and lacunae/infarction. The proportion of PVS increased with cheese sign severity.Conclusions: The risk factors for cheese sign were hypertension, age, and stroke. Cheese sign consists of BGH, PVS, and lacunae/infarction.

关键词： Dementia Cerebrovascular disease Cheese sign Dense punctate lesions Basal ganglia Risk factor White matter

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Upper extremity motor function before and after the cerebrospinal fluid tap test in patients with idiopathic normal pressure hydrocephalus: A retrospective study

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中华医学杂志(英文版) 2024年第7期137卷 877-879页

作者： Liu Caiyan Wei Junji Dong liling Mao Chenhui Li Jie Huang Xinying Hou Bo Feng Feng Cui Liying Gao jing Department of Neurology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China Department of Neurosurgery Department of Neurosurgery and Radiology

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M6PR interacts with the HA2 subunit of influenza A virus to facilitate the fusion of viral and endosomal membranes

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Science China(Life Sciences) 2024年第3期67卷 579-595页

作者： Yuzhen Hu Li Jiang Guangwen Wang Yangming Song Zhibo Shan Xuyuan Wang Guohua Deng Jianzhong Shi Guobin Tian Xianying Zeng liling Liu Hualan Chen Chengjun Li State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069China

Influenza A virus(IAV) commandeers numerous host cellular factors for successful replication. However, very few host factors have been revealed to be involved in the fusion of viral envelope and late endosomal membranes. In this study, we identified cation-dependent mannose-6-phosphate receptor(M6PR) as a crucial host factor for the replication of IAV. We found that siRNA knockdown of M6PR expression significantly reduced the growth titers of different subtypes of IAV, and that the inhibitory effect of M6PR siRNA treatment on IAV growth was overcome by the complement of exogenously expressed M6PR. When A549 cells were treated with siRNA targeting M6PR,the nuclear accumulation of viral nucleoprotein(NP) was dramatically inhibited at early timepoints post-infection, indicating that M6PR engages in the early stage of the IAV replication cycle. By investigating the role of M6PR in the individual entry and post-entry steps of IAV replication, we found that the downregulation of M6PR expression had no effect on attachment, internalization, early endosome trafficking,or late endosome acidification. However, we found that M6PR expression was critical for the fusion of viral envelope and late endosomal membranes. Of note, M6PR interacted with the hemagglutinin(HA) protein of IAV, and further studies showed that the lumenal domain of M6PR and the ectodomain of HA2 mediated the interaction and directly promoted the fusion of the viral and late endosomal membranes,thereby facilitating IAV replication. Together, our findings highlight the importance of the M6PR–HA interaction in the fusion of viral and late endosomal membranes during IAV replication.

关键词： influenza A virus M6PR HA membrane fusion late endosome

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供电电压闪变对异步电动机转子故障在线检测的影响及应对

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中国电机工程学报 2024年第11期44卷 4525-4534,I0030页

作者：许伯强孙丽玲华北电力大学电力工程系河北省保定市071003

供电电压闪变可能对异步电动机转子故障在线检测产生不利影响,导致基于定子电流信号分析(motor current signature analysis,MCSA)的转子故障在线检测方法失效。通过理论分析,揭示供电电压闪变恶化转子故障在线检测性能的机制。提出免... 详细信息

供电电压闪变可能对异步电动机转子故障在线检测产生不利影响,导致基于定子电流信号分析(motor current signature analysis,MCSA)的转子故障在线检测方法失效。通过理论分析,揭示供电电压闪变恶化转子故障在线检测性能的机制。提出免于供电电压闪变影响的异步电动机转子故障在线检测方法,首先,根据转子故障主特征频率分量预判转子健康或故障;继而,根据转子故障独有的辅助特征频率分量进一步确认转子健康或故障。仿真与实验结果证明了该方法的有效性。

关键词：异步电动机转子故障转子断条供电电压闪变在线检测

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Unveiling a novel metal-to-metal transition in LuH_(2):Critically challenging superconductivity claims in lutetium hydrides

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Matter and Radiation at Extremes 2024年第3期9卷 65-73页

作者： Dong Wang Ningning Wang Caoshun Zhang Chunsheng Xia Weicheng Guo Xia Yin Kejun Bu Takeshi Nakagawa Jianbo Zhang Federico Gorelli Philip Dalladay-Simpson Thomas Meier Xujie Lü liling Sun jinguang Cheng Qiaoshi Zeng Yang Ding Ho-kwang Mao Center for High-Pressure Science and Technology Advanced Research Beijing 100094China Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China Shanghai Key Laboratory of Material Frontiers Research in Extreme Environments(MFree) Shanghai Advanced Research in Physical Sciences(SHARPS)Shanghai 201203China

Following the recent report by Dasenbrock-Gammon et al.[Nature 615,244–250(2023)]of near-ambient superconductivity in nitrogendoped lutetium trihydride(LuH_(3-δ)N_(ε)),significant debate has emerged surrounding the composition and interpretation of the observed sharp resistance drop.Here,we meticulously revisit these claims through comprehensive characterization and investigations.We definitively identify the reported material as lutetium dihydride(LuH_(2)),resolving the ambiguity surrounding its composition.Under similar conditions(270–295 K and 1–2 GPa),we replicate the reported sharp decrease in electrical resistance with a 30%success rate,aligning with the observations by Dasenbrock-Gammon et al.However,our extensive investigations reveal this phenomenon to be a novel pressure-induced metal-to-metal transition intrinsic to LuH_(2),distinct from superconductivity.Intriguingly,nitrogen doping exerts minimal impact on this transition.Our work not only elucidates the fundamental properties of LuH_(2)andLuH_(3),but also critically challenges the notion of superconductivity in these lutetium hydride systems.These findings pave the way for future research on lutetium hydride systems,while emphasizing the crucial importance of rigorous verification in claims of ambient-temperature superconductivity.

关键词： resistance hydride superconductivity

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Self-consistent and precise measurement of time-dependent radiative albedo of gold based on specially symmetrical triple-cavity Hohlraum

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Matter and Radiation at Extremes 2024年第3期9卷 57-64页

作者： Zhiyu Zhang Yang Zhao Xiaoying Han liling Li Bo Qing Lifei Hou Yulong Li YuXue Zhang Huan Zhang Xiangming Liu Bo Deng Gang Xiong Min Lv Tuo Zhu Chengwu Huang Tianming Song Yan Zhao Yingjie Li Lu Zhang Xufei Xie Jiyan Zhang Jiamin Yang Laser Fusion Research Center China Academy of Engineering PhysicsMianyang 621900China National Key Laboratory of Plasma Physcis Mianyang 621900China Institute of Applied Physics and Computational Mathematics Beijing 100088China

A self-consistent and precise method to determine the time-dependent radiative albedo,i.e.,the ratio of the reemission flux to the incident flux,for an indirect-drive inertial confinement fusion Hohlraum wall material is proposed.A specially designed symmetrical triple-cavity gold Hohlraum is used to create approximately constant and near-equilibrium uniform radiation with a peak temperature of 160 eV.The incident flux at the secondary cavity waist is obtained from flux balance analysis and from the shock velocity of a standard sample.The results agree well owing to the symmetrical radiation in the secondary cavity.A self-consistent and precise time-dependent radiative albedo is deduced from the reliable reemission flux and the incident flux,and the result from the shock velocity is found to have a smaller uncertainty than that from the multi-angle flux balance analysis,and also to agree well with the result of a simulation using the HYADES opacity.

关键词： precise cavity radiative

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