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Characterization of spatial relationships between three remotely sensed indirect indicators of biodiversity and climate:a 21years’data series review across the Canadian boreal forest

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International Journal of Digital Earth 2016年第7期9卷 676-696页

作者： liliana Perez Trisalyn Nelson Nicholas C.Coops Fabio Fontana C.Ronnie Drever Laboratory of Environmental Geosimulation(LEDGE) Department of GeographyUniversity of MontrealMontrealQCCanada Spatial Pattern Analysis&Research(SPAR)Lab Department of GeographyUniversity of VictoriaVictoriaBCCanada Department of Forest Resources Management University of British ColumbiaVancouverBCCanada The Nature Conservancy OttawaONCanada

Climate drives ecosystem processes and impacts *** patterns over large areas,such as Canada’s boreal,can be monitored using indirect indicators derived from remotely sensed *** this paper,we characterized the historical space–time relationships between climate and a suite of indirect indicators of biodiversity,known as the Dynamic Habitat Index(DHI)to identify where climate variability is co-occurring with changes in biodiversity *** represented biodiversity using three indirect indicators generated from 1987 to 2007 National Oceanic and Atmospheric Administration Advanced Very High Resolution Radiometer *** quantifying and clustering temporal variability in climate data,we defined eight homogeneous climate variability zones,where we then analyzed the *** identified unique areas of change in climate,such as the Hudson Plains,that explain significant variations in *** variability in temperatures and growing season index had a strong influence on observed vegetation productivity and seasonality changes throughout Canada’s *** in precipitation,for most of the area,was not associated with DHI *** methodology presented here enables assessment of spatial–temporal relationships between biodiversity and climate variability and characterizes distinctive zones of variation that may be used for prioritization and planning to ensure long-term biodiversity conservation in Canada.

关键词： Climate change biodiversity boreal forest spatial–temporal analysis fPAR DHI

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Insight into the antifungal mechanism of Neosartorya fischeri antifungal protein

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Protein & Cell 2015年第7期6卷 518-528页

作者： Mate Viragh Annamaria Marton Csaba Vizier liliana Toth Csaba Vagvolgyi Florentine Marx Laszlo Galgoczy Department of Microbiology Faculty of Science and Informatics University of Szeged Szeged Hungary Institute of Biochemistry Biological Research Centre Hungarian Academy of Sciences Szeged Hungary Division of Molecular Biology Biocenter Innsbruck Medical University Innsbruck Austria

Small, cysteine-rich, highly stable antifungal proteins secreted by filamentous Ascomycetes have great po- tential for the development of novel antifungal strate- gies. However, their practical application is still limited due to their not fully clarified mode of action. The aim of this work was to provide a deep insight into the anti-fungal mechanism of Neosartorya fischeri antifungal protein （NFAP）, a novel representative of this protein group. Within a short exposure time to NFAP, reduced cellular metabolism, apoptosis induction, changes in the actin distribution and chitin deposition at the hyphal tip were observed in NFAP-sensitive Aspergillus nidulans. NFAP did show neither a direct membrane disrupting- effect nor uptake by endocytosis. Investigation of A. nidulans signalling mutants revealed that NFAP acti- vates the cAMP/protein kinase A pathway via G-protein signalling which leads to apoptosis and inhibition of polar growth. In contrast, NFAP does not have any in- fluence on the cell wall integrity pathway, but an un- known cell wall integrity pathway-independent mitogen activated protein kinase A-activated target is assumed to be involved in the cell death induction. Taken to- gether, it was concluded that NFAP shows similarities, but also differences in its mode of antifungal action compared to two most investigated NFAP-related pro-teins from Aspergillus giganteus and Penicillium chrysogenum.

关键词： Neosartorya fischeri antifungal protein,Aspergillus nidulans cAMP/Pka signalling Pkc/Mpksignalling antifungal mechanism

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零起点葡萄牙语

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作者：颜巧容 (葡)liliana Goncalves

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Problematic Internet use in drug addicts under treatment in public rehab centers

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World Journal of Psychiatry 2019年第3期9卷 55-64页

作者： Stefano Baroni Donatella Marazziti Federico Mucci Elisa Diadema liliana Dell’Osso Dipartimento di Medicina Clinica e Sperimentale Section of Psychiatry University of Pisa

BACKGROUND Problematic Internet use(PIU)or Internet addiction has been recognized to be a behavioral addiction characterized by excessive or poorly controlled preoccupations,urges,or behaviors regarding computer use and Internet access that leads to impairment or distress resembling substance *** To investigate the prevalence and characteristics of Internet use and abuse in a group of drug addicts from Southern Italy,by means of a specific questionnaire[“Questionario sull’Utilizzo delle Nuove Tecnologie”(QUNT)].METHODS All subjects(183)were heavy smokers,almost 50%of them used heroin and/or opioid compounds,30%alcohol,10%cannabis,8%cocaine,and 5%were polydrug *** 10%of the individuals were also suffering from gambling *** The time spent online was more than 4 hours a day in the total sample,with a slight prevalence in male *** and cannabis users spent more than 6 hours online,significantly more than opioid and alcohol *** of the QUNT factors was not different in both *** users showed higher scores at the“loss of control”,“pornography addiction”,and“addiction to social networks”factors,for the stimulant effect of this ***,15 out of the total 17 cocaine users were pathological *** and statistically significant relationships were observed between some QUNT factors and body mass *** These findings indicate that PIU is less severe in subjects taking sedative substances,such as heroin/opioids and alcohol,than in subjects taking ***,it may be used as a“stimulant”trigger in cocaine and cannabis *** effect of abuse drugs was noted on possible sex-related differences in QUNT *** observed a sort of“protective”effect of a love relationship and/or living together with a partner,as those engaged subjects showed lower scores on different items than single subjects or those living *** relationship between time spent online(and re

关键词： Internet Problematic Internet use Behavioral addictions Drug abuse Rehab centers

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社会隔离量表葡萄牙语版在社区老年人群中的验证研究（英文）

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International Journal of Nursing Sciences 2023年第2期 151-157页

作者： Jo?o Tavares Ana Faria Delphine Gon?alves Diana Mendes Sofia Silva liliana Sousa Health School University of Aveiro Center for Health Technology and Services Research (CINTESISRISE) Health Sciences Research Unit: Nursing (UICISA: E) Department of Education and Psychology University of Aveiro The Polytechnic Institute of Coimbra Coimbra Education School

目的分析社会隔离量表(Social Isolation Scale,SIS)在葡萄牙社区老年人中应用的信度和效度。方法选取250名社区老年人(≥65岁)进行横向描述性调查研究。调查工具包括社会人口学问卷、SIS、老年抑郁量表-4 (Geriatric Depression Scal... 详细信息

目的分析社会隔离量表(Social Isolation Scale,SIS)在葡萄牙社区老年人中应用的信度和效度。方法选取250名社区老年人(≥65岁)进行横向描述性调查研究。调查工具包括社会人口学问卷、SIS、老年抑郁量表-4 (Geriatric Depression Scale-4,GDS-4)、6项卢本社会网络量表(6-item Lubben Social Network Scale,LSNS-6)、孤独自我评估问题和生活满意度量表(Satisfaction with Life Scale,SWLS)。分析结构效度(验证性因素分析)和收敛效度,评估ISI内部信度(综合信度)、外部信度(重测、组内相关系数)和评分者间信度(Cohen's kappa系数)。结果验证性因素分析显示双因素模型具有良好的拟合指数。SIS得分与LSNS-6(r=0.47)、SWLS(r=0.26)、孤独自我评估(r=0.35)和GDS-4(r=-0.16)得分相关。SIS组合信度良好(0.708)。组内相关系数0.84～0.98。Cohen's kappa系数为0.936～1。结论 SIS可作为评估葡萄牙社区老年人社会隔离的有效和可靠工具。医疗保健专业人员,特别是在社区工作的护士,可使用SIS评估老年人的社会隔离状况,以设计、实施和评估干预措施。

关键词：老年人孤独心理测量学社会隔离问卷调查

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Neurocysticercosis causing sudden death:a case report

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Asian Pacific Journal of Tropical Medicine 2010年第8期3卷 669-670页

作者： Martinez Fernanda Seley Celeste Marchesi liliana Fontanarossa Victoria Rodriguez Dominique Troncoso Alcides Department of Microbiology Parasitology and Infectious DiseasesSchool of MedicineBuenos Aires University

We report an acute case of a native man from Bolivia suffered from cephalalgia which rapidly worsened and ended in his sudden and unexpected *** resonance imaging(MRI) of the brain was *** demonstrated on brain MRI scan were consistent with a diagnosis of neurocysticercosis(NCC).An autopsy showed the presence of intraventricular Taenia solium(***) cysts which caused blockage of cerebrospinal fluid and secondary *** to the increasing travel movements of people neurocysticercosis must be considered as a cause of unexplained sudden death.

关键词： Neurocysticercosis Taenia solium Sudden death

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Effects of chlorpyrifos on enzymatic systems of Cydia pomonella （Lepidoptera： Tortricidae） adults

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Insect Science 2017年第3期24卷 455-466页

作者： Laura Beatriz Parra Morales Raul Adolfo Alzogaray liliana Cichon Silvina Garrido Jimena Soleno Cristina Monica Montagna Laboratorio de Investigaciones Bioquimicas Quimicas y de Medio Ambiente Facultad de Ingenieria Universidad Nacional del ComahueBuenos Aires 1400 (Q83001BX) Neuquen Facultad de Ciencias del Ambiente y la Salud Universidad Nacional del Comahue Buenos Aires 1400 Neuquen Centro de Investigaciones de Plagas e Insecticidas (CIPEIN-UNIDEFICONICET) Villa Martelli Buenos Aires Instituto de Investigacion e Ingenieria Ambiental (3iA-UNSAM) San Martin Provincia de Buenos Aires Instituto Nacional de Tecnologia Agropecuaria Estacion Experimental Alto Valle General Roca Argentina

The control program of codling moth （Cydia pomonella L.） in the Rio Negro and Neuqu6n Valley is intended to neonate larvae. However, adults may be subjected to sublethal pesticide concentrations generating stress which might enhance both mutation rates and activity of the detoxification system. This study assessed the exposure effects of chlorpyrifos on target enzyme and, both detoxifying and antioxidant systems of surviving adults from both a laboratory susceptible strain （LSS） and a field population （FP）. The results showed that the FP was as susceptible to chlorpyrifos as the LSS and, both exhibited a similar chlorpyrifos-inhibitory concentration 50 （IC50） of acetylcholinesterase （ACHE）. The FP displayed higher carboxylesterase （CarE） and 7-ethoxycoumarine O-deethylase （ECOD） activities than LSS. Both LSS and FP showed an increase on CarE activity after the exposure to low-chlorpyrifos concentrations, followed by enzyme inhibition at higher concentrations. There were no significant differences neither in the activities of glutathione S-transferases （GST）, catalase （CAT） and superoxide dismutase （SOD） nor in the reduced glutathione （GSH） content between LSS and FP. Moreover, these enzymes were unaffected by chlorpyrifos. In conclusion, control adults from the FP exhibited higher CarE and ECOD activities than control adults from the LSS. AChE and CarE activities were the most affected by chlorpyrifos. Control strategies used for C. pomonella, such as rotations of insecticides with different modes of action, will probably delay the evolution of insecticide resistance in FPs from the study area.

关键词： acetylcholinesterase antioxidant system chlorpyrifos codling moth detoxification enzymes

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Bridging the lesion—engineering a permissive substrate for nerve regeneration 5th China-Europe Symposium on Biomaterials in Regenerative Medicine(CESB 2015)Hangzhou,China April 7–10,2015

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Regenerative Biomaterials 2015年第3期2卷 203-214页

作者： liliana R.Pires Ana P.Peˆgo INEB—Instituto de Engenharia Biome´dica Universidade do PortoRua do Campo Alegre 8234150-180 PortoPortugal Instituto de Investigac¸a˜o e Inovac¸a˜o em Sau´de Universidade do PortoPortugal Faculdade de Engenharia—Universidade do Porto(FEUP) PortoPortugal Instituto de Cieˆncias Biome´dicas Abel Salazar(ICBAS) Universidade do PortoPortoPortugal

Biomaterial-based strategies to restore connectivity after lesion at the spinal cord are focused on bridging the lesion and providing an favourable substrate and a path for axonal *** spinal cord injury(SCI)a hostile environment for neuronal cell growth is established by the activation of multiple inhibitory mechanisms that hamper regeneration to *** scaffolds can provide mechanical support and physical guidance for axon re-growth and,at the same time,contribute to alleviate the hostile environment by the in situ delivery of therapeutic molecules and/or relevant *** research on SCI has been contributing with the description of inhibitory mechanisms for regeneration as well as identifying drugs/molecules that can target *** knowledge is the background for the development of combined strategies with ***,scaffold design is significantly *** the early simple hollow conduits,scaffolds with complex architectures that can modulate cell fate are currently being tested.A number of promising pre-clinical studies combining scaffolds,cells,drugs and/or nucleic acids are reported in the open ***,it is considered that to address the multi-factorial inhibitory environment of a SCI,a multifaceted therapeutic approach is *** progress in the identification of molecules that target inhibition after SCI and its combination with scaffolds and/or cells are described and discussed in this review.

关键词： Spinal cord nerve regeneration scaffolds biomaterials drug delivery

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General Evaluation of the Potential of the Cultural-Historical Heritage Built in the Republic of Moldova

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Open Journal of Applied Sciences 2021年第6期11卷 633-646页

作者： liliana Jitari Department Engineering Law and Real Estate Valuation Technical University of Moldova Chisinau The Republic of Moldova

This article analyzes the efficiency of the administration, as well as the way of financing the cultural heritage of the Republic of Moldova through the prism of the legal, institutional and cultural policy framework. Following the research, it was found that in the last 30 years the efficient and transparent management of the material cultural heritage of the Republic of Moldova has not been ensured, which endangers the national cultural heritage. If the current management and financing model does not change significantly in the near future, there is a risk that the cultural heritage of the Republic of Moldova will reach an unrecoverable condition.

关键词： Cultural Heritage Historical Monument Cultural Value

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Risk of venous thromboembolic disease in postmenopausal women taking oral or transdermal hormone replacement therapy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第1期12卷 12-17页

作者： Barbara RUSZKOWSKA GraZyna GADOMSKA liliana BIELIS Marzena GRUSZKA Barbara GóRALCZYK Danuta RO GraZyna ODROWAZ-SYPNIEWSKA Department of Pathophysiology Collegium Medicum in BydgoszczNicolaus Copernicus University in Toruń Department of Laboratory Medicine Collegium Medicum in BydgoszczNicolaus Copernicus University in Toruń Department of Laboratory Medicine Collegium Medicum in BydgoszczNicolaus Copernicus University in Toruń

Objective: The influence of hormone replacement therapy (HRT) on hemostasis processes depends on the type of hormone,the combination of doses,the time of taking HRT,and the route of administration (oral,transdermal,implanted).The aim of the current study was to assess some parameters of coagulation,especially tissue factor pathway inhibitor (TFPI) and tissue factor (TF) in postmenopausal women using oral or transdermal ***: The study was conducted on 76 healthy women,including 46 women aged 44–58 years who were taking oral (26) or transdermal (20) HRT,and 30 women aged 44–54 years who did not take HRT as the control *** concentrations of TF,TFPI,thrombin-antithrombin complex (TAT),and D-dimer were performed by enzyme-linked immunosorbent assay (ELISA).Moreover,the concentration of fibrinogen and activity of protein C were measured by chromogenic and chronometric ***: We observed a significantly higher concentration of TF and a significantly lower concentration of TFPI in women taking oral and transdermal HRT in comparison with the control *** also found a significantly lower concentration of fibrinogen in women taking oral HRT *** control ***,no statistically significant changes in concentrations of TAT and D-dimer,or activity of protein C were ***: In this study,the occurrence of an increased TF concentration simultaneously with a decreased concentration of TFPI in women taking HRT indicates *** significant modification of TAT or D-dimer occurred,and thus there may not be increased risk of thrombosis.

关键词： Menopause Coagulation Hormone replacement therapy

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