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Fragile X Messenger Ribonucleoprotein 1(FMR1), a novel inhibitor of osteoblast/osteocyte differentiation, regulates bone formation, mass, and strength in young and aged male and female mice

引用

Bone Research 2023年第2期11卷 384-397页

作者： Padmini Deosthale Julián Balanta-Melo Amy Creecy Chongshan Liu Alejandro Marcial Laura Morales Julita Cridlin Sylvia Robertson Chiebuka Okpara David J.Sanchez Mahdi Ayoubi Joaquín N.Lugo Christopher J.Hernandez Joseph M.Wallace lilian.i.plotkin Department of Anatomy Cell Biology&PhysiologyIndiana University School of MedicineIndianapolisIN46202USA Roudebush Veterans Administration Medical Center IndianapolisIN46202USA indiana Center for Musculoskeletal Health IndianapolisIN46202USA Universidad del Valle School of Dentistry Cali 760043Colombia Department of Biomedical Engineering Indiana University-Purdue University Indianapolis46202 IndianapolisIN46202USA Sibley School of Mechanical and Aerospace Engineering Cornell UniversityIthacaNY 14853USA Department of Materials Science and Engineering Cornell UniversityIthacaNY14853USA Department of Psychology and Neuroscience Baylor UniversityWacoTX76798USA

Fragile X Messenger Ribonucleoprotein 1(FMR1)gene mutations lead to fragile X syndrome,cognitive disorders,and,in some individuals,scoliosis and craniofacial ***-month-old(mo)male mice with deletion of the FMR1 gene exhibit a mild increase in cortical and cancellous femoral bone ***,consequences of absence of FMR1 in bone of young/aged male/female mice and the cellular basis of the skeletal phenotype remain *** found that absence of FMR1 results in improved bone properties with higher bone mineral density in both sexes and in 2-and 9-mo *** cancellous bone mass is higher only in females,whereas,cortical bone mass is higher in 2-and 9-mo males,but higher in 2-and lower in 9-mo female FMR1-knockout ***,male bones show higher biomechanical properties at 2mo,and females at both *** of FMR1 increases osteoblast/mineralization/bone formation and osteocyte dendricity/gene expression in vivo/ex vivo/in vitro,without affecting osteoclasts in vivo/ex ***,FMR1 is a novel osteoblast/osteocyte differentiation inhibitor,and its absence leads to age-,site-and sex-dependent higher bone mass/strength.

关键词： female Messenger agile

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