Fragile X Messenger Ribonucleoprotein 1(FMR1), a novel inhibitor of osteoblast/osteocyte differentiation, regulates bone formation, mass, and strength in young and aged male and female mice

作     者：Padmini Deosthale Julián Balanta-Melo Amy Creecy Chongshan Liu Alejandro Marcial Laura Morales Julita Cridlin Sylvia Robertson Chiebuka Okpara David J.Sanchez Mahdi Ayoubi Joaquín N.Lugo Christopher J.Hernandez Joseph M.Wallace Lilian I.Plotkin Padmini Deosthale;Julián Balanta-Melo;Amy Creecy;Chongshan Liu;Alejandro Marcial;Laura Morales;Julita Cridlin;Sylvia Robertson;Chiebuka Okpara;David J.Sanchez;Mahdi Ayoubi;Joaquín N.Lugo;Christopher J.Hernandez;Joseph M.Wallace;Lilian I.Plotkin

作者机构：Department of AnatomyCell Biology&PhysiologyIndiana University School of MedicineIndianapolisIN46202USA Roudebush Veterans Administration Medical CenterIndianapolisIN46202USA Indiana Center for Musculoskeletal HealthIndianapolisIN46202USA Universidad del Valle School of DentistryCali 760043Colombia Department of Biomedical EngineeringIndiana University-Purdue University Indianapolis46202 IndianapolisIN46202USA Sibley School of Mechanical and Aerospace EngineeringCornell UniversityIthacaNY 14853USA Department of Materials Science and EngineeringCornell UniversityIthacaNY14853USA Department of Psychology and NeuroscienceBaylor UniversityWacoTX76798USA 

出 版 物：《Bone Research》 (骨研究（英文版）)

年 卷 期：2023年第11卷第2期

页      面：384-397页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by the National Institutes of Health R01-AR053643 Veterans Research Administration Merit Award I01BX00515 a Research Support Funds Grant(RSFG),Indiana University Purdue University Indianapolis-Office of the Vice Chancellor for Research,Indianapolis to LIP supported by ASBMR Fund for Research and Education Research and Collaborative Grant Program supported by the National Institutes of Health R01AG067997 to CJH supported by the IUPUI Diversity Scholars Research Program(DSRP) Diversity Summer Undergraduate Research Opportunity Program(DS-UROP) Indiana CTSI Student Summer Research Program IUPUI work study program supported by the Life Health Science Internship(LHSI) 

主　　题：female Messenger agile 

摘      要：Fragile X Messenger Ribonucleoprotein 1(FMR1)gene mutations lead to fragile X syndrome,cognitive disorders,and,in some individuals,scoliosis and craniofacial ***-month-old(mo)male mice with deletion of the FMR1 gene exhibit a mild increase in cortical and cancellous femoral bone ***,consequences of absence of FMR1 in bone of young/aged male/female mice and the cellular basis of the skeletal phenotype remain *** found that absence of FMR1 results in improved bone properties with higher bone mineral density in both sexes and in 2-and 9-mo *** cancellous bone mass is higher only in females,whereas,cortical bone mass is higher in 2-and 9-mo males,but higher in 2-and lower in 9-mo female FMR1-knockout ***,male bones show higher biomechanical properties at 2mo,and females at both *** of FMR1 increases osteoblast/mineralization/bone formation and osteocyte dendricity/gene expression in vivo/ex vivo/in vitro,without affecting osteoclasts in vivo/ex ***,FMR1 is a novel osteoblast/osteocyte differentiation inhibitor,and its absence leads to age-,site-and sex-dependent higher bone mass/strength.