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Optical identification of interlayer coupling of graphene/MoS_(2) van der Waals heterostructures

Nano Research 2021年第7期14卷 2241-2246页

作者： Mingming Yang Longlong Wang Guofeng Hu Xue Chen Peng Lai gong Xin Cong Yi Liu Yuanbo Yang Xiaoli Li Xiaohui Zhao Xuelu Liu National-Local Joint Engineering Laboratory of New Energy Photoelectric Devices&Hebei Key laboratory of Optic-electronic Information and Materials College of Physics Science and TechnologyHebei UniversityBaoding 071002China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Department of Physics Southern University of Science and TechnologyShenzhen 518055China

The interlayer coupling in van der Waals(vdW)heterostructures(vdWHs)is at the frontier of the fundamental research,underlying many optical *** graphene/MoS_(2) vdWHs provide an ideal platform to reveal the good interfacial coupling between graphene and MoS_(2) ***,three groups of graphene/MoS_(2) vdWHs were prepared by transferring 1–3 layers of graphene onto monolayer MoS_(2).The interlayer coupling within graphene/MoS_(2) vdWHs were characterized and analyzed by Raman spectroscopy,photoluminescence(PL)spectroscopy and optical contrast(OC)*** upshift of the A_(1g) peak of MoS_(2) and the upshift of the D and 2D peaks of SLG show that the electrons move from MoS_(2) to graphene accompanied by the dielectric shielding effect on *** weakened PL intensities and the slight red shift of A peak prove that the electrons move from MoS_(2) to graphene meanwhile the recombination of hole and electron pairs is blocked in *** results deepen the understanding of the interlayer coupling of graphene/MoS_(2) vdWHs and therefore provide guidelines for the practical design and application of optoelectronic devices based on graphene/MoS_(2) vdWHs.

关键词： graphene/MoS_(2)vdWHs Raman spectroscopy PL spectroscopy OC spectroscopy dielectric shielding effect interlayer coupling

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The contribution of different polyphenol compositions from chokeberry produced in China to cellular antioxidant and antiproliferative activities

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Food Science and Human Wellness 2023年第5期12卷 1590-1600页

作者： Ningxuan Gao Xu Si Wenzhong Han Ersheng gong Chi Shu Jinlong Tian Yuehua Wang Jiyue Zhang Binxu Li Bin Li Department of Food Science College of FoodShenyang Agricultural UniversityShenyang 110161China National R&D Professional Center For Berry Processing Shenyang 110161China Agriculture and Forest Institute in Arid of Liaoning Chaoyang 122000China

Abundant polyphenols make chokeberry have beneficial antioxidant and antiproliferative activity. In order to explore the contribution of different polyphenols in chokeberry to these activities, this study was conducted to determine polyphenol composition from 7 chokeberry varieties produced in China. Totally, 11 kinds of main polyphenol monomers were identified and quantified by UPLC-Q-TOF-MS and UPLC-PDA. HepG2 cells were used to evaluate their cellular antioxidant and antiproliferative activities. Partial least squares method was utilized to analyze multivariate correlations between proportion of different composition and monomers in total polyphenols with these activities. The results showed that the highest proportion in chokeberry polyphenols was proanthocyanidins. In comparing the bioactivities of 7 varieties of chokeberry, ‘Viking' and purple chokeberry had the strongest antioxidant activity, while 'Fukangyuan 1#' had the strongest antiproliferative activity. In terms of the contribution sources of these bioactivities, the total antioxidant activity of chokeberry mainly depended on the contribution of free polyphenols. As the main source of cellular antioxidant activity, anthocyanins and neochlorogenic acid can provide more contribution. The antiproliferative activity mainly depended on the proportion of free polyphenols and proanthocyanidins in total polyphenols. The results may provide some new possibilities for the comprehensive utilization of polyphenols from chokeberry.

关键词： Chokeberry Anthocyanins Proanthocyanidins Antioxidant Antiproliferation

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Advances in the design and development of SARS-CoV-2 vaccines

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Military Medical Research 2022年第4期9卷 484-513页

作者： Xue-Liang Peng Ji-Si-Yu Cheng Hai-Lun gong Meng-Di Yuan Xiao-Hong Zhao Zibiao Li Dai-Xu Wei Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi'an 710069China Institute of Materials Research and Engineering A*STAR(Agency for ScienceTechnology and Research)2 Fusionopolis WayInnovis#08-03Singapore 138634Singapore.

Since the end of 2019,coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has spread *** RNA genome of SARS-CoV-2,which is highly infectious and prone to rapid mutation,encodes both structural and non-structural *** is currently the only effective method to prevent COVID-19,and structural proteins are critical targets for vaccine ***,many vaccines are in clinical trials or are already on the *** review highlights ongoing advances in the design of prophylactic or therapeutic vaccines against COVID-19,including viral vector vaccines,DNA vaccines,RNA vaccines,live-attenuated vaccines,inactivated virus vaccines,recombinant protein vaccines and bionic nanoparticle *** addition to traditional inactivated virus vaccines,some novel vaccines based on viral vectors,nanoscience and synthetic biology also play important roles in combating ***,many challenges persist in ongoing clinical trials.

关键词： Severe acute respiratory syndrome coronavirus 2 Coronavirus disease 2019 Vaccine Synthetic biology Nanoscience

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Sensitivity of SARS-CoV-2 to different temperatures

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Animal Models and Experimental Medicine 2020年第4期3卷 316-318页

作者： Qi Lv Mingya Liu Feifei Qi Shuran gong Shasha Zhou Shisheng Zhan Linlin Bao Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of HealthBeijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijingChina

This study was designed to investigate the sensitivity of SARS-CoV-2 to different temperatures,to provide basic data and a scientific basis for the control of COVID-19 *** virus was dispersed in 1 mL basal DMEM medium at a final concentration of 103.2 TCID 50/mL and then incubated at 4,22,30,35,37,38,39 and 40°C for up to 5 *** infectivity of residual virus was titrated using the Vero E6 cell *** results showed that the virus remained viable for 5 days at 4°C,and for 1 day only at 22 and 30°*** found that the infectivity of the virus was completely lost after less than 12 hours at 37,38 and 39°C,while at 40°C,the inactivation time of the virus was rapidly reduced to 6 *** show that SARS-CoV-2 is sensitive to heat,is more stable at lower temperatures than higher temperature,remains viable for longer at lower temperatures,and loses viability rapidly at higher temperatures.

关键词： SARS-CoV-2 sensitivity temperature viability

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Identifying a competency improvement strategy for infection prevention and control professionals:A rapid systematic review and cluster analysis

Health Care Science

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Health Care Science 2024年第1期3卷 53-66页

作者： Nuo Chen Shunning Li Zhengling Kuang Ting gong Weilong Zhou Ying Wang School of Public Health and Management Hubei University of MedicineShiyanChina Tianjin Key Laboratory of Retinal Functions and Diseases Tianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjinChina State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesHaihe Laboratory of Cell EcosystemInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin Institutes of Health ScienceTianjinChina Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital and Institutes of Biomedical SciencesFudan UniversityShanghaiChina Department of Infection Control and Prevention West China Second University HospitalSichuan UniversityChengduChina Department of Infection Prevention and Control Management Zhongnan Hospital of Wuhan UniversityWuhanChina Hubei Engineering Center for Infectious Disease Prevention Control and TreatmentWuhanChina

Remarkable progress has been made in infection prevention and control(IPC)in many countries,but some gaps emerged in the context of the coronavirus disease 2019(COVID-19)*** capabilities such as standard clinical precautions and tracing the source of infection were the focus of IPC in medical institutions during the ***,the core competences of IPC professionals during the pandemic,and how these contributed to successful prevention and control of the epidemic,should be *** investigate,using a systematic review and cluster analysis,fundamental improvements in the competences of infection control and prevention professionals that may be emphasized in light of the COVID-19 *** searched the PubMed,Embase,Cochrane Library,Web of Science,CNKI,WanFang Data,and CBM databases for original articles exploring core competencies of IPC professionals during the COVID-19 pandemic(from January 1,2020 to February 7,2023).Weiciyun software was used for data extraction and the Donohue formula was followed to distinguish high-frequency technical *** analysis was performed using the within-group linkage method and squared Euclidean distance as the metric to determine the priority competencies for *** identified 46 studies with 29 high-frequency technical *** most common term was“infection prevention and control training”(184 times,17.3%),followed by“hand hygiene”(172 times,16.2%).“Infection prevention and control in clinical practice”was the most-reported core competency(367 times,34.5%),followed by“microbiology and surveillance”(292 times,27.5%).Cluster analysis showed two key areas of competence:Category 1(program management and leadership,patient safety and occupational health,education and microbiology and surveillance)and Category 2(IPC in clinical practice).During the COVID-19 pandemic,IPC program management and leadership,microbiology and surveillance,education,patient safety,and occupational health were the most i

关键词： infection prevention and control professionals competency improvement cluster analysis COVID-19 review

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New insights into the mechanism of surfactant enhanced oil recovery:Micellar solubilization and in-situ emulsification

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Petroleum Science 2022年第2期19卷 870-881页

作者： Xue-Zhi Zhao Guang-Zhi Liao Ling-Yan gong Huo-Xin Luan Quan-Sheng Chen Wei-Dong Liu Dong Liu Yu-Jun Feng Polymer Research Institute State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu610065People's Republic of China PetroChina Exploration&Production Company Beijing100007People's Republic of China Research Institute of Experiment and Detection Xinjiang Oilfield Branch CompanyPetroChinaKaramay834000People's Republic of China Research Institute of Petroleum Exploration&Development PetroChina Company LimitedBeijing100083People's Republic of China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang621000People's Republic of China

Reducing the oil-water interfacial tension(IFT)to ultra-low is believed the primary mechanism for surfactant-based enhanced oil recovery(EOR)***,field trials have shown that low concentration surfactant flooding can also improve oil recovery without ultra-low *** clarify the mechanism behind,the currently-used surfactant,naphthenic arylsulfonate(NAS),was used to unravel its function during surfactant flooding from the horizon of micron-and *** solubilization capacity of NAS micelle to petroleum fractions was evaluated through light absorbance strategy,smallangle neutron scattering,dynamic light scattering and transmission electron *** was found that micellar solubilization plays a significant role during the surfactant ***-situ emulsification was visualized in microfluidics with three types of microchips,respectively.A series of displacement tests were carried out with NAS solution pumping into oil-saturated *** results show that in-situ emulsification improve oil recovery mainly through blocking and entrainment *** from this work aid in understanding the interaction between surfactant solution and petroleum fractions at low surfactant concentration,which is helpful for design surfactant-based displacing system for EOR process.

关键词： Enhanced oil recovery Surfactant flooding Micellar solubilization Microfluidics In-situ emulsification

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Deciphering the Origin and Formation of Aminopyrrole Moiety in Kosinostatin Biosynthesis

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Chinese Journal of Chemistry 2021年第12期39卷 3329-3333页

作者： Yu Hu Qiang Zhou Zhuan Zhang Hai-Xue Pan Yulia Ilina Mikko Metsa-Ketela Yasuhiro Igarashi gong-Li Tang State Key Laboratory of Bio-organic and Natural Products Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of Sciences(CAS)CASShanghai 200032China The Research Center of Chiral Drugs Innovation Research Institute of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai 201203China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences1 Sub-lane XiangshanHangzhouZhejiang 310024China Department of Biochemistry University of TurkuVatselankatu 2FIN-20014Finland Biotechnology Research Center Toyama Prefectural University 5180 KurokawaImizuToyama 939-0398Japan

Kosinostatin(KST)contains an uncommon aminopyrrole moiety,whose biosynthesis has remained ***,aminopyrrolinic acid,which was generated by an L-ectoine synthase-like enzyme KstB3 via cyclization of L-glutamine,was identified to be the real substrate of adenylation enzyme ***,a FAD-dependent dehydrogenase KstB4 along with a transglutaminase-like enzyme KstB6 were also involved in formation of *** results provided an unusual pathway for 2-aminopyrrole formation in KST biosynthesis.

关键词： Biosynthesis Aminopyrrole Kosihbstatin Cyclization Hydrolysis

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Cocktail hepatocarcinoma therapy by a super-assembled nano-pill targeting XPO1 and ATR synergistically

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Journal of Pharmaceutical Analysis 2023年第6期13卷 603-615页

作者： Liuyun gong Yinliang Lu Jing Wang Xinyue Li Jing Zhao Yuetong Chen Rongze Ma Jinlu Ma Tianya Liu Suxia Han Department of Radiation Oncology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710061China National&Local Joint Engineering Research Center of Biodiagnosis and Biotherapy The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710004China Department of Radiotherapy The First Affiliated Hospital Soochow UniversitySuzhouJiangsu215000China

Intensive cancer treatment with drug combination is widely exploited in the clinic but suffers from inconsistent pharmacokinetics among different therapeutic *** overcome it,the emerging nanomedicine offers an unparalleled opportunity for encapsulating multiple drugs in a ***,a two-step super-assembled strategy was performed to unify the pharmacokinetics of a peptide and a small molecular *** this proof-of-concept study,the bioinformatics analysis firstly revealed the potential synergies towards hepatoma therapy for the associative inhibition of exportin 1(XPO1)and ataxia telangiectasia mutated-Rad3-related(ATR),and then a super-assembled nano-pill(gold nano drug carrier loaded AZD6738 and 97110 amino acids of apoptin(AP)(AA@G))was constructed through camouflaging AZD6738(ATR small-molecule inhibitor)-binding human serum albumin onto the AP-Au supramolecular *** expected,both in vitro and in vivo experiment results verified that the AA@G possessed extraordinary biocompatibility and enhanced therapeutic effect through inducing cell cycle arrest,promoting DNA damage and inhibiting DNA repair of hepatoma *** work not only provides a co-delivery strategy for intensive liver cancer treatment with the clinical translational potential,but develops a common approach to unify the pharmacokinetics of peptide and small-molecular compounds,thereby extending the scope of drugs for developing the advanced combination therapy.

关键词： Liver cancer Drug combination Cancer therapy ATR inhibitor XPO1 inhibitor

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Adult-repopulating lymphoid potential of yolk sac blood vessels is not confined to arterial endothelial cells

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Science China(Life Sciences) 2021年第12期64卷 2073-2087页

作者： Chaojie Wang Yandong gong Anbang Wei Tao Huang Siyuan Hou Junjie Du Zongcheng Li Junliang Wang Bing Liu Yu Lan Key Laboratory for Regenerative Medicine of Ministry of Education Institute of HematologySchool of MedicineJinan UniversityGuangzhou 510632China State Key Laboratory of Experimental Hematology Institute of HematologyFifth Medical Center of Chinese PLA General HospitalBeijing 100071China State Key Laboratory of Proteomics Academy of Military Medical SciencesAcademy of Military SciencesBeijing 100850China Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan UniversityGuangzhou 510632China Department of radiotherapy Fifth Medical Center of Chinese PLA General HospitalBeijing 100071China

During embryogenesis,hematopoietic stem progenitor cells(HSPCs)are believed to be derived from hemogenic endothelial cells(HECs).Moreover,arterial feature is proposed to be a prerequisite for HECs to generate HSPCs with lymphoid *** the molecular basis of hematopoietic stem cell-competent HECs has been delicately elucidated within the embryo proper,the functional and molecular characteristics of HECs in the extraembryonic yolk sac(YS)remain largely *** this study,we initially identified six molecularly different endothelial populations in the midgestational YS through integrated analysis of several single-cell RNA sequencing(scRNA-seq)datasets and validated the arterial vasculature distribution of Gja5+ECs using a Gja5-EGFP reporter mouse ***,we explored the hemogenic potential of different EC populations based on their Gja5-EGFP and CD44 expression *** hemogenic potential was ubiquitously detected in spatiotemporally different vascular beds on embryonic days(E)8.5–E9.5 and gradually concentrated in CD44-positive ECs from ***,B-lymphoid potential was detected in the YS ECs as early as E8.5 regardless of their arterial ***,the capacity for generating hematopoietic progenitors with in vivo lymphoid potential was found in nonarterial as well as arterial YS ECs on E10.0–***,the distinct identities of E10.0–E10.5 HECs between YS and intraembryonic caudal region were revealed by further scRNA-seq ***,these findings extend our knowledge regarding the hemogenic potential of ECs from anatomically and molecularly different vascular beds,providing a theoretical basis for better understanding the sources of HSPCs during mammalian development.

关键词： yolk sac hematopoietic stem progenitor cell hemogenic endothelial cell single-cell RNA sequencing arterial endothelial cells lymphoid potential

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Probing higher-order band topology via spin texture measurements:quantum simulation

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Science Bulletin 2021年第18期66卷 1817-1818页

作者： Linhu Lia Jiangbin gong Guangdong Provincial Key Laboratory of Quantum Metrology and Sensing School of Physics and AstronomySun Yat-sen University Zhuhai CampusZhuhai 519082China Department of Physics National University of SingaporeSingapore 117551Singapore

The long-term goal of quantum simulation is to assemble at will many-body quantum systems of vast complexity,to discover emerging new physics or obtain important results beyond the computational capability of classical *** this ambitious and game-changing journey,one milestone is to achieve flexible and high-fidelity quantum simulations with a few ***,qubits based on superconducting Josephson junction.

关键词： quantum Josephson 量子模拟

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