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锂电铜箔表面防氧化工艺研究

有色金属工程 2024年第8期14卷 31-38页

作者：马秀玲陈明彪潘美君他得保袁世祺李永贞彭丽军青海交通职业技术学院西宁810000 青海电子材料产业发展有限公司西宁810000 有研工程技术研究院有限公司北京101407

锂电铜箔在生产、储存、运输和使用时,很容易使铜箔表面发生氧化变色,会直接影响锂电池的产品良率、可靠性、使用寿命、粘接性等,要求铜箔有良好的防氧化性能。采用SEM、EDAX等表征手段,研究了不同浸泡工艺和微量电镀工艺条件下铜箔表... 详细信息

锂电铜箔在生产、储存、运输和使用时,很容易使铜箔表面发生氧化变色,会直接影响锂电池的产品良率、可靠性、使用寿命、粘接性等,要求铜箔有良好的防氧化性能。采用SEM、EDAX等表征手段,研究了不同浸泡工艺和微量电镀工艺条件下铜箔表面形貌和氧含量的变化,得到浸泡工艺和微量电镀工艺对铜箔表面防氧化性能的影响。结果表明:在电流密度为5 A/dm^(2),电镀时间为10 s,铬酐浓度为0.5 g/L,葡萄糖浓度为1.5 g/L时,铜箔经高温烘烤后表面无变色,防氧化性能较优。

关键词：锂电铜箔浸泡微量电镀防氧化性能

拮抗剂方案中HCG扳机日直径16~18 mm卵泡比例对PCOS患者IVF-ET结局的影响

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中国临床新医学 2024年第5期17卷 517-522页

作者：彭丽君谢奇君杨烨王鑫宇胡晴云凌秀凤南京医科大学附属妇产医院(南京市妇幼保健院) 江苏210004

目的探讨拮抗剂方案中人绒毛膜促性腺激素(HCG)扳机日直径16~18 mm卵泡比例对接受拮抗剂方案的多囊卵巢综合征(PCOS)患者体外受精-胚胎移植(IVF-ET)结局的影响。方法回顾性分析2016年1月至2021年12月于南京医科大学附属妇产医院行IVF-E... 详细信息

目的探讨拮抗剂方案中人绒毛膜促性腺激素(HCG)扳机日直径16~18 mm卵泡比例对接受拮抗剂方案的多囊卵巢综合征(PCOS)患者体外受精-胚胎移植(IVF-ET)结局的影响。方法回顾性分析2016年1月至2021年12月于南京医科大学附属妇产医院行IVF-ET助孕的PCOS患者的临床资料。根据HCG扳机日双侧卵巢直径16~18 mm卵泡比例以三分位法将患者分为三组,该比例0.05)。三组胚胎着床率、生化妊娠率、临床妊娠率、流产率、活产率、妊娠期糖尿病发生率及妊娠期高血压发生率等比较差异无统计学意义(P>0.05)。结论在拮抗剂方案中,HCG扳机日直径16~18 mm卵泡比例可反映卵母细胞发育潜能,当该比例≥0.56时可获得较好的获卵数、2PN数、卵裂数、囊胚形成数以及可移植胚胎数,在一定程度上可作为PCOS患者HCG扳机时机的参考指标,但该比例并不影响后续首次FET的妊娠结局。

关键词：多囊卵巢综合征体外受精-胚胎移植卵泡直径 HCG扳机时机拮抗剂方案

Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific antibodies against B-cell acute lymphoblastic leukemia:targeted immunotherapy for acute lymphoblastic leukemia

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Frontiers of Medicine 2022年第1期16卷 139-149页

作者： Sisi Wang lijun peng Wenqian Xu Yuebo Zhou Ziyan Zhu Yushan Kong Stewart Leung Jin Wang Xiaoqiang Yan Jian-Qing Mi Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Pôle Franco-Chinois de Recherche en Sciences du Vivant et Genomique Shanghai 200025China Shanghai Blood Center Shanghai 200051China Generon Biomed Shanghai 201210China

The CD19-targeting bispecific T-cell engager blinatumomab has shown remarkable efficacy in patients with relapsed/refractory B-cell precursor acute lymphoblastic ***,several studies showed that blinatumomab has a short plasma half-life due to its low molecular weight,and thus its clinical use is ***,multiple trials have shown that approximately 30%of blinatumomab-relapsed cases are characterized by CD19 negative leukemic ***,we design and characterize two novel antibodies,A-319 and *** and A-319 are CD3/CD19 bispecific antibodies with different molecular sizes and structures,and A-2019 is a novel CD3/CD19/CD20 trispecific antibody with an additional anti-CD20 *** in vitro,ex vivo,and in vivo experiments demonstrated that A-319 and A-2019 are potent antitumor agents and capable of recruiting CD3 positive T cells,enhancing T-cell function,mediating B-cell depletion,and eventually inhibiting tumor growth in Raji xenograft *** two molecules are complementary in terms of efficacy and specificity *** activity of A-319 demonstrated superior to that of A-2019,whereas A-2019 has an additional capability to target CD20 in cells missing CD19,suggesting its potential function against CD19 weak or negative CD20 positive leukemic cells.

关键词： B-cell acute lymphoblastic leukemia bispecific antibody trispecific antibody CD19 CD20

肺结核患者合并感染非发酵菌的检出情况及药敏结果分析

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温州医科大学学报 2024年第3期54卷 228-232页

作者：孙海琼彭利君蔡龙方婷婷戴玲珊魏慧杭州市红十字会医院临床医学检验实验中心浙江杭州310003

目的:分析肺结核患者合并感染非发酵菌的检出情况及药敏结果,为临床用药提供依据。方法:选取2018年1月至2022年12月杭州市红十字会医院收治的肺结核合并感染非发酵菌的394例住院患者为研究对象,参照美国临床和实验室标准化协会标准,对... 详细信息

目的:分析肺结核患者合并感染非发酵菌的检出情况及药敏结果,为临床用药提供依据。方法:选取2018年1月至2022年12月杭州市红十字会医院收治的肺结核合并感染非发酵菌的394例住院患者为研究对象,参照美国临床和实验室标准化协会标准,对分离的非发酵菌的检出情况和药敏结果进行统计分析。结果:394例肺结核合并感染非发酵菌的患者共分离出401株非发酵菌,2018至2022年结核科非发酵菌检出率为30%左右,结核科非发酵菌/全院非发酵菌比例逐年增长。药敏结果显示:铜绿假单胞菌对亚胺培南和美罗培南的耐药率分别为14.6%和12.7%;鲍曼不动杆菌对亚胺培南和美罗培南的耐药率分别为51.3%和60.0%;嗜麦芽窄食单胞菌对米诺环素和替卡西林/克拉维酸的耐药率<10%;洋葱伯克霍尔德菌对美罗培南、头孢他啶、米诺环素和甲氧苄啶-磺胺甲唑的耐药率范围为0~15.4%。结论:结核科非发酵菌/全院非发酵菌比例逐年增长,临床应重视肺结核患者合并非发酵菌的感染和耐药性监测,根据药敏试验结果并结合临床合理使用抗生素。

关键词：非发酵菌肺结核感染耐药

Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

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Frontiers of Medicine 2022年第3期16卷 442-458页

作者： Mengping Xi Shanshan Guo Caicike Bayin lijun peng Florent Chuffart Ekaterina Bourova-Flin Sophie Rousseaux Saadi Khochbin Jian-Qing Mi Jin Wang Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Pôle de Recherches Sino-Français en Science du Vivant et Génomique Shanghai 200025China CNRS UMR 5309/INSERM U1209/UniversitéGrenoble Alpes/Institute for Advanced Biosciences 38706 La TroncheFrance

T-cell acute lymphoblastic leukemia(T-ALL)is one of the most dangerous hematological malignancies,with high tumor heterogeneity and poor *** than 60%of T-ALL patients carry NOTCH1 gene mutations,leading to abnormal expression of downstream target genes and aberrant activation of various signaling *** found that chidamide,an HDAC inhibitor,exerts an antitumor effect on T-ALL cell lines and primary cells including an anti-NOTCH1 *** particular,chidamide inhibits the NOTCH1-MYC signaling axis by down-regulating the level of the intracellular form of NOTCH1(NICD1)as well as MYC,partly through their ubiquitination and degradation by the proteasome *** also report here the preliminary results of our clinical trial supporting that a treatment by chidamide reduces minimal residual disease(MRD)in patients and is well *** results highlight the effectiveness and safety of chidamide in the treatment of T-ALL patients,including those with NOTCH1 mutations and open the way to a new therapeutic strategy for these patients.

关键词： T-cell acute lymphoblastic leukemia HDAC inhibitor chidamide NOTCH1 MYC ubiquitination

胸腔积液游离DNA检测在结核性胸膜炎中的诊断价值

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浙江中西医结合杂志 2024年第9期34卷 829-832页

作者：朱明智彭利君方婷婷戴玲珊孙海琼邵燕琴徐金田杭州市红十字会医院临床医学检验实验中心杭州310003 杭州市红十字会医院结核病诊疗中心杭州310003

结核性胸膜炎(tuberculous pleurisy,TP)是肺部胸膜下结核性干酪样病灶破裂导致结核分枝杆菌(Mycobacterium tuberculosis,MTB)及其裂解后的蛋白质进入胸膜腔引起过敏反应,进而产生的胸膜炎症^([1])。结核性胸腔积液是TP最常见的表现形... 详细信息

结核性胸膜炎(tuberculous pleurisy,TP)是肺部胸膜下结核性干酪样病灶破裂导致结核分枝杆菌(Mycobacterium tuberculosis,MTB)及其裂解后的蛋白质进入胸膜腔引起过敏反应,进而产生的胸膜炎症^([1])。结核性胸腔积液是TP最常见的表现形式^([2])。TP可导致严重的并发症,包括胸膜增厚、胸膜结核瘤、脓胸、钙化和长期肺功能障碍^([3]),但由于胸腔积液中含菌量不高,目前常用的病原学方法检出效果均不理想,结核分枝杆菌/利福平耐药实时荧光定量核酸扩增检测技术(Xpert)分枝杆菌培养的阳性检出率仅为20%~30%左右^([4]),涂片的阳性检出率不到6%^([5])。

关键词：结核性胸膜炎胸腔积液游离DNA 诊断

RNA ac^(4)C modification in cancer biology:from regulatory mechanisms to clinical applications

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Science China(Life Sciences) 2024年第4期67卷 832-835页

作者： lijun Tao Yunqing Lu Zhuojia Chen Lichen Ge Junming He Jianxin peng Hongsheng Wang School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Department of Hepatobiliary Surgery Guangdong Province Traditional Chinese Medical HospitalGuangzhou 510120China

RNA modifications are increasingly recognized for their significance in diverse physiological and pathological processes,with over 170 types of chemical modifications having been discovered since *** these modifications,N4-acetylcytidine(ac^(4)C)is the first acetylated modification identified on eukaryotic RNAs,previously reported in transfer RNA(t RNA)and ribosomal RNA(rRNA)。

关键词： clinical (4) modification

Spermine increases bactericidal activity of silver-nanoparticles against clinical methicillin-resistant Staphylococcus aureus

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Chinese Chemical Letters 2018年第12期29卷 1824-1828页

作者： Chang Liu Han Shen Su Wang Xiaoli Cao Hongpan Xu Yanyan Xia Tingting Bai Yufeng Liu lijun peng Chuchu Li Zhirui Guo Zhiyang Li Department of Clinical Laboratory The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Geriatrics The Second Affiliated HospitalKey Laboratory for Aging&DiseaseNanjing Medical UniversityNanjing 210011China College of Life Science Yangtze UniversityJingzhou 434025China Department of Technical Services Jiangsu Provincial Center for Disease Prevention and ControlNanjing 210009China

Methicillin-resistant Staphylococcus aureus(MRSA) has emerged worldwide as a major multidrugresistant pathogen that causes notable morbidity and mortality. Fast emerging of MRSA prevalence requires special attention for strengthening the inventory of antimicrobial compounds. Silver nanoparticles(AgNPs) have been widely used to treat multi-drug resistant pathogens due to the unique antibacterial properties, meanwhile spermine has been proven to exert outstanding inhibition effect to *** with not yet fully understood mechanisms. The aim of this study was to investigate the synergistic effect of AgNPs and spermine as well as to determine the antibacterial activity of their combination against MRSA strains. Several clinical MRSA isolates and ATCC BAA-1026 were used to determine minimum inhibitory concentration(MIC) and fractional inhibitory concentration indices(FICI) of AgNPs and spermine, and a synergistic effect was observed. This phenomenon was further confirmed by growth curve and time-killing assays, showed that spermine could be used as an adjuvant for AgNPs in the treatment of MRSA infections.

关键词： Spermine Silver nanoparticles Staphylococcus aureus Synagistic effect Antimicrobial

Why the Belt and Road Initiative Is Anything but a Debt Trap

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China Today 2019年第5期68卷 10-11页

作者： ZHU SHAOBIN GAO ZHU peng lijun 不详

ALMOST six years after Chinese President Xi Jinping proposed the Belt and Road Initiative (BRI), the grand vision for promoting common development through better connectivity among countries and regions has been morphing into a solution for speeding up global cooperation for greater prosperity. But as global enthusiasm for and confidence in the BRI grow, some noises ensue, often with ill intentions to discourage its wide adoption and send misleading messages to nations who seek to benefit from BRI participation. One such message claims that the BRI pushes some countries into a “debt trap.”

关键词： Belt and Road Initiative Debt Trap