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Chinese Journal of Chemistry 2015年第10期33卷 1178-1188页

作者： lijuan lu Chaoguo Yan College of Chemistry & Chemical Engineering Yangzhou University Yangzhou Jiangsu 225002 China

The base mediated cycloaddition reactions of 4-dimethylamino-l-phenacylpyridinium bromides with two mo- lecular 3-phenaeylideneoxindoles in methylene dichloride afforded functionalized dispirocyclopentyl-3,3＇-bisoxin- doles in good yields and with high diastereoselectivity. The similar cycloaddition reactions of 1-（N,N-dialkylcarba- moylmethyl） and 1-cyanomethyl 4-dimethylamino-pyridinium bromide in refluxing ethanol in the presence of triethylamine a/so resulted in dispirocyclopentyl-3,3＇-bisoxindoles with high diastereoselectivity. The stereochemis- try of dispirocyclopentyl-3,3＇-bisoxindoles was elucidated on the basis of ^1H NMR data and single crystal struc- tures.

关键词： domino reaction cycloaddition reaction pyridinium N-ylide spirooxindole diastereoselectivity

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思政课把道理讲深、讲透、讲活的三个发力点

科教文汇 2025年第1期 43-46页

作者：林勇灵陆礼娟广西工商职业技术学院马克思主义学院广西南宁530008

习近平总书记对讲好思政课提出了讲深、讲透、讲活的明确要求。思政课教师要切实把习近平总书记的要求落到实处,需要从以下三个方面发力:重研学,夯实理论功底,着力把思政课“讲深”;重实践,把握社会现实,着力把思政课“讲透”;重技能,... 详细信息

习近平总书记对讲好思政课提出了讲深、讲透、讲活的明确要求。思政课教师要切实把习近平总书记的要求落到实处,需要从以下三个方面发力:重研学,夯实理论功底,着力把思政课“讲深”;重实践,把握社会现实,着力把思政课“讲透”;重技能,创新教学方法,着力把思政课“讲活”。把重研学、重实践、重技能有机统一起来,着力把思政课的道理讲深、讲透、讲活。

关键词：思政课理论功底社会现实教学方式

Improved hydrogen oxidation reaction under alkaline conditions by Au–Pt alloy nanoparticles

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Journal of Energy Chemistry 2020年第1期29卷 52-56,I0003页

作者： lijuan lu Lishan Peng Li Li Jing Li Xun Huang Zidong Wei College of Chemistry and Chemical Engineering Chongqing University

This work demonstrates the outstanding performance of alloyed Au1 Pt1 nanoparticles on hydrogen oxidation reaction(HOR)in alkaline *** to the weakened hydrogen binding energy caused by uniform incorporation of Au,the alloyed Au1Pt1/C nanoparticles exhibit superior HOR activity than commercial PtRu/*** the contrary,the catalytic performance of the phase-segregated Au2Pt1/C and Au1Pt1/C bimetallic nanoparticles in HOR is significantly ***,Au1Pt1/C shows a remarkable durability with activity dropping only 4% after 3000 CV cycles,while performance attenuation of commercial PtRu/C is high up to 15% under the same *** results indicate that the alloyed Au1Pt1/C is a promising candidate to substitute commercial PtRu/C for hydrogen oxidation reaction in alkaline electrolyte.

关键词： Hydrogen oxidation reaction Pt-Au alloy Nanoparticles Alkaline electrolyte

AMPK activation by peri-sciatic nerve administration of ozone attenuates CCl-induced neuropathic pain in rats

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Journal of Molecular Cell Biology 2017年第2期9卷 132-143页

作者： lijuan lu Cailong Pan lu Chen Liang Hu Chaoyu Wang Yuan Han Yanjing Yang Zhixiang Cheng Wen-Tao Liu Department of Pain Affiliated Drum Tower Hospital of Medical School of Nanjing University Nanjing 210008 China Jiangsu Key Laboratory of Neurodegeneration Department of Pharmacology Nanjing Medical University Nanjing 210029 China State Key Laboratory of Natural Medicines China Pharmaceutical University Nanjing 210009 China Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing 210029 China Department of Pain Management & Cancer Biotherapy Center The Second Affiliated Hospital of Nanjing Medicat University Nanjing 210029 China

Neuropathic pain is a debilitating clinical condition with few efficacious treatments, warranting development of novel therapeu- tics. Ozone is widely used as an alternative therapy for many different pain conditions, with exact mechanisms still elusive. In this study, we found that a single peri-sciatic nerve injection of ozone decreased mechanical aUodynia and thermal hyperalgesia, and normalized the phosphorylation of protein kinase C y, N-methyI-D-aspartate receptor, and extracellular signal-regulated kinase in a chronic constriction injury （CCI） model in rat sciatic nerve. Meanwhile, ozone significantly suppressed CCI-induced activation of spinal microgUa. More importantly, the anti-nociceptive effect of ozone depended on the activation of 5＇-adenosine monophosphate （AMP）-activated protein kinase （AMPK）, which was proved by the fact that the phosphorylated AMPK level increased during the ozone therapy and AMPK antagonist abolished the effect of ozone in vivo and in vitro. In addition, direct injection of AMPK agonist could replicate the anti-nociceptive effect of ozone in CCI rats. In conclusion, our observations indicate that peri-sciatic nerve injection of ozone activates AMPK to attenuate CCI-induced neuropathic pain.

关键词： AMPK ozone therapy neuropathic pain

Recent developments of nanoparticle-based enrichment methods for mass spectrometric analysis in proteomics

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Science China Chemistry 2010年第4期53卷 695-703页

作者： ZHANG lijuan, lu HaoJie & YANG PengYuan Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China Department of Chemistry and Institutes of Biomedical Sciences Fudan University Shanghai China

In proteome research, rapid and effective separation strategies are essential for successful protein identification due to the broad dynamic range of proteins in biological samples. Some important proteins are often expressed in ultra low abundance, thus making the pre-concentration procedure before mass spectrometric analysis prerequisite. The main purpose of enrichment is to isolate target molecules from complex mixtures to reduce sample complexity and facilitate the subsequent analyzing steps. The introduction of nanoparticles into this field has accelerated the development of enrichment methods. In this review, we mainly focus on recent developments of using different nanomaterials for pre-concentration of low-abundance peptides/ proteins, including those containing post-translational modifications, such as phosphorylation and glycosylation, prior to mass spectrometric analysis.

关键词： enrichment nanoparticles mass spectrometry proteomics phosphorylation glycosylation

Changing predominance of norovirus strains in children with acute gastroenteritis in Shanghai,2018–2021

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Virologica Sinica 2023年第5期38卷 671-679页

作者： lijuan lu Yuanyun Ao Ran Jia Huaqing Zhong Pengcheng Liu Menghua Xu Liyun Su Lingfeng Cao Jin Xu Department of Clinical Laboratory Children's Hospital of Fudan UniversityNational Children's Medical CenterShanghai201100China Shanghai Institute of Infectious Disease and Biosecurity Fudan UniversityShanghai201100China

Norovirus(NoV)is a major pathogen that causes acute gastroenteritis(AGE)in people of all ages,especially in *** this study,we investigated the molecular epidemiological characteristics of NoV in children with AGE in Shanghai from 2018 to *** overall detection rate of NoV was 11.9%(181/1545),with annual detection rates of 9.4%(36/381),13.6%(29/213),5.8%(13/226)and 14.2%(103/725),*** note,the prevalence of NoV in 2020 was significantly lower than that in 2018-2019(10.9%,65/594)(P=0.023)and 2021(14.2%,103/725)(P=0.000).The 181 NoV strains identified in this study were classified into the GI group(1.1%,2/181),GII group(98.3%,178/181)and GIX group(0.6%,1/181)according to the VP1 *** most common NoV VP1 genotype was GII.4 Sydney_2012(63.5%,115/181),followed by GII.3(19.9%,36/181)and GII.2(9.4%,17/181).For P genotypes,174 strains were sequenced successfully according to the RdRp gene,and the predominant genotype was GII.P16(44.8%,78/174),followed by GII.P31(25.9%,45/174)and GII.P12(21.3%,37/174).Among the 174 cases,GII.4 Sydney_2012[P16](36.8%,64/174)was the dominant genotype,followed by GII.4 Sydney_2012[P31](25.3%,44/174),GII.3[P12](20.1%,35/174)and GII.2[P16](8.0%,14/174).In particular,the dominant genotypes in Shanghai changed from GII.4 Sydney_2012[P31]in 2018-2019 to GII.4 Sydney_2012[P16]in *** is the first report to describe the epidemiological changes in NoV infection before and during the COVID-19 pandemic in *** data highlight the importance of continuous surveillance for NoV in children with AGE in Shanghai.

关键词： Norovirus(NoV) Acute gastroenteritis Children Genotype Recombination

The Correlation between Corporate Social Responsibility(CSR)and Chinese Family Enterprises in China

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电子商务学刊（中英文版） 2024年第1期10卷 1-7页

作者： lijuan lu Sengteck Tan Beijing Institute of Technology ZhuhaiChina INTI International University NilaiMalaysia

It is imperative to aggressively advocate for and transmit the ideas of corporate social responsibility as Chinese family enterprises transition into the phase of corporate *** study conducts a thorough examination of existing literature to elucidate the concept and model of western corporate social *** also analyses the current state of Chinese corporate social responsibility and highlights the fulfilment of corporate social responsibility by private ***,it specifically investigates the significance of family enterprises in promoting and preserving the culture of corporate ***,it delves into the correlation between corporate social responsibility and family *** study presents the process of transmission and inheritance of Chinese family firms,focusing on the influence of Chinese traditional culture,the original purpose of enterprise development,and enterprise image.

关键词： Corporate Social Responsibility(CSR) Family-Owned Businesses Inheritance and Transmission

The aggregation characteristics and formation mechanism of nanoparticles in ductile shear zone

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Acta Geologica Sinica(English Edition) 2017年第S1期91卷 263-264页

作者： CAI Zhourong HUANG Qiangtai LI Jianfeng XIANG Junyang lu lijuan School of Marine Sciences Sun Yat-sen UniversityGuangzhou 510006China Guangdong Key Laboratory of Offshore Oil Exploration and Development Guangzhou 510006China Guangzhou Institute of Geochemistry Chinese Academy of SciencesGuangzhou 510640China

1 Introduction Nanoparticles are widely found in the ductile shear zone and it is considered to have a close relation with *** sizes of these nanoparticles are generallyless than 100 *** have a variety of morphologies... 详细信息

关键词： The aggregation characteristics and formation mechanism of nanoparticles in ductile shear zone

Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke Cai Youluan lu Fanpeng Cheng lijuan Shi Qun Yi Yao Liu Yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Oxygen evolution reaction

Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

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Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu Zhang Yuqi Liu Fangxia Xu Chengcheng Zhou Kaimei lu Bin Fang lijuan Wang Lina Huang Zifeng Xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons