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Toxicity of methamphetamine and the protection of tatinol

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中国药理学与毒理学杂志 2002年第6期16卷 418-418页

作者： lij WangX InstituteofMentalHealth WestChinaHospitalofSichuanUniversityChengdu610041China

To investigate the neurotoxicity of methamphetamine and the neuroprotection of tatinol,an acute toxic dosing model in rat was established by intraperitoneal injection of methamphetamine,and being treated with *** and silver staining,observed with light microscope;apoptosis was detected by *** results showed that methamphetamine may damage brain and induce apoptosis,tatinol could protect against apoptosis.

关键词：甲苯丙胺毒性保护 tatinol

Isolation and identifi cation of antimicrobial metabolites from sea anemone-derived fungus emericella ***01

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Journal of Oceanology and Limnology 2021年第3期39卷 1010-1019页

作者： yang YUe Huahua YU Rongfeng LI Linfeng HU Song LIU Rong’e XING Pengcheng LI Key Laboratory of experimental Marine Biology Center for Ocean Mega-ScienceInstitute of OceanologyChinese Academy of SciencesQingdao 266071China Laboratory for Marine Drugs and Bioproducts Pilot Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China School of Chemistry and Chemical engineering Henan Institute of Science and TechnologyXinxiang 453003China

Marine symbiotic fungi represent an intriguing source of discovery of novel secondary metabolites with various biological *** anemones are benthic marine invertebrates,however,the cultivable symbiotic fungi residing in the sea anemones are paid few attentions compared to those derived from their cnidarian *** we show the identification of antimicrobial secondary metabolites from the sea anemone-derived symbiotic *** offive isolated fungal strains,only the strain SMA01 showed strong antimicrobial activities,which was assigned into the genus emericella based on the morphological characteristics and the ITS *** swift from liquid fermentation to solid rice medium presented little influence on its antibacterial activity.A chemical investigation of the ethyl acetate extract of the emericella ***01 led to discovery of the primary antibiotic metabolite phenazine-1-carboxylic *** IC_(50) values of the phenazine-1-carboxylic acid against Phytophthora capsici,Gibberella zeae,and Verticillium dahliae were determined to be 23.26-53.89μg/*** the best of our knowledge,this was the first report of emericella *** sea *** current study may benefit understanding of the defensive chemical interactions between the symbiotic fungi and their host sea anemones.

关键词： sea anemone symbiotic fungi phenazine-1-carboxylic acid antimicrobial activity

The intrinsic nonlinear multiscale interactions among the mean flow, low frequency variability and mesoscale eddies in the Kuroshio region

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Science China earth Sciences 2019年第3期62卷 595-608页

作者： yang yang X.San LIANG School of Marine Sciences Nanjing University of Information Science and Technology School of Atmospheric Sciences Nanjing University of Information Science and Technology

Using a new functional analysis tool, multiscale window transform(MWT), and the MWT-based localized multiscale energetics analysis and canonical transfer theory, this study reconstructs the Kuroshio system on three scale windows, namely,the mean flow window, the interannual-scale(low-frequency) window, and the transient eddy window, and investigates the climatological characteristics of the intricate nonlinear interactions among these windows. Significant upscale energy transfer is observed east of Taiwan, where the mean Kuroshio current extracts kinetic energy from both the interannual and eddy *** is found that the canonical transfer from the interannual variability is an intrinsic source that drives the eddy activities in this region. The multiscale variabilities of the Kuroshio in the east China Sea(eCS) are mainly controlled by the interaction between the mean flow and the *** mean flow undergoes mixed instabilities(i.e., both barotropic and baroclinic instabilities) in the southern eCS, while it is barotropically stable but baroclinically unstable to the north. The multiscale interactions are found to be most intense south of Japan, where strong mixed instabilities occur; both the canonical transfers from the mean flow and the interannual scale are important mechanisms to fuel the eddies. It is also found that the interannual-scale energy mainly comes from the barotropically unstable jet, rather than the upscale energy transfer from the high frequency eddies.

关键词： Kuroshio Multiscale window transform Canonical transfer Multiscale energetics analysis Multiscale interaction Barotropic instability Baroclinic instability

Differential generation of hydrogen peroxide upon exposure to zinc and cadmium in the hyperaccumulating plant specie(Sedum alfredii Hance)

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第3期9卷 243-249页

作者： Yue-en CHAO Min ZHANG Sheng-ke TIAN Ling-li LU Xiao-e yang MOe Key Laboratory of environmental Remediation and ecosystem Health College of Environmental and Resource Sciences Zhejiang University Hangzhou 310029 China

Sedum alfredii Hance has been identified as zinc(Zn) and cadmium(Cd) *** this paper the relationships of Zn or Cd hyperaccumulation to the generation and the role of H2O2 in Sedum alfredii *** *** results show that Zn and Cd contents in the shoots of Sedum alfredii *** with 1000 μmol/L Zn2+ and/or 200 μmol/L Cd2+ increased linearly within 15 *** of total S,glutathione(GSH) and H2O2 in shoots also increased within 15 d,and then *** S and GSH contents in shoots were higher under Cd2+ treatment than under Zn2+ ***,reverse trends of H2O2 content in shoots were obtained,in which much higher H2O2 content was observed in Zn2+-treated shoots than in Cd2+-treated ***,the microscopic imaging of H2O2 accumulation in leaves using H2O2 probe technique showed that much higher H2O2 accumulation was observed in the Zn2+-treated leaf than in the Cd2+-treated *** results suggest that there are different responses in the generation of H2O2 upon exposure to Zn2+ and Cd2+ for the hyperaccumulator Sedum alfredii *** this is the first report that the generation of H2O2 may play an important role in Zn hyperaccumulation in the *** results also imply that GSH may play an important role in the detoxification of dissociated Zn/Cd and the generation of H2O2.

关键词： Hydrogen peroxide (H2O2) Glutathione (GSH) Sedum alfredii Hance Zinc (Zn) Cadmium (Cd) Hyperaccumulator

Computational fluid dynamics simulation of hydrodynamics in the riser of an external loop airlift reactor

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Particuology 2016年第4期14卷 95-101页

作者： Xuedong Jiang Ning yang Bolun yang Department of Chemical engineering State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong University Xi'an 710049 China Center for Mesoscience and State Key Laboratory of Multiphase Complex Systems Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China

Local hydrodynamics in the riser of an external loop airlift reactor （eL-ALR） are identified and the performances of three drag models are evaluated in computational fluid dynamics simulation. The simulation results show that the Schiller-Naumann drag model underestimated the local gas holdup at lower superficial gas velocity whereas the Tomiyama drag model overestimated that at higher superficial gas velocity. By contrast, the dual-bubble-size （DBS）-local drag model gave more reasonable radial and axial distri-butions of gas holdup in all cases. The reason is that the DBS-local drag model gave correct values of the lumped parameter, i,e., the ratio of the drag coefficient to bubble diameter, for varying operating conditions and radial positions. This ratio is reasonably expected to decrease with increasing superficial gas velocity and be smaller in the center and larger near the wall. Only the DBS-local drag model correctly reproduced these trends. The radial profiles of the axial velocity of the liquid and gas predicted by the DBS-local model also agreed well with experimental data.

关键词： Computational fluid dynamics external loop airlift reactor Drag model Gas holdup Mnltiscale Mesoscale

extensional collapse of the Gondwana orogen: evidence from Cambrian mafic magmatism in the Trivandrum Block, southern India

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Geoscience Frontiers 2019年第1期10卷 263-284页

作者： Qiong-Yan yang Sohini Ganguly e.Shaji Yunpeng Dong V.Nanda-Kumar School of earth Science and Resources China University of Geosciences Department of earth Science Goa University Department of Geology University of Kerala State Key Laboratory of Continental Dynamics Department of Geology Northwest University National Center for earth Science Studies Akkulam Trivandrum India

The assembly of Late Neoproterozoice Cambrian supercontinent Gondwana involved prolonged subduction and accretion generating arc magmatic and accretionary complexes, culminating in collision and formation of high grade metamorphic orogens. Here we report evidence for mafic magmatism associated with post-collisional extension from a suite of gabbroic rocks in the Trivandrum Block of southern Indian Gondwana fragment. Our petrological and geochemical data on these gabbroic suite show that they are analogous to high Fe tholeiitic basalts with evolution of the parental melts dominantly controlled by fractional crystallization. They display enrichment of LILe and LRee and depletion of HFSe with negative anomalies at Zre Hf and Ti corresponding to subduction zone magmatic regime. The tectonic affinity of the gabbros coupled with their geochemical features endorse a heterogeneous mantle source with collective melt contributions from sub-slab asthenospheric mantle upwelling through slab break-off and arc-related metasomatized mantle wedge, with magma emplacement in subduction to post-collisional intraplate settings. The high Nb contents and positive Nbe Ta anomalies of the rocks are attributed to inflow of asthenospheric melts containing ancient recycled subducted slab components and/or fusion of subducted slab materials owing to upwelling of hot asthenosphere. Zircon grains from the gabbros show magmatic crystallization texture with low U and Pb content. The LA-ICPMS analyses show ^(206) Pb/^(238) U mean ages in the range of 507-494 Ma suggesting Cambrian mafic magmatism. The post-collisional mafic magmatism identified in our study provides new insights into mantle dynamics during the waning stage of the birth of a supercontinent.

关键词： Mafic dykes Geochemistry Zircon Ue Pb geochronology Post-collisional extension Gondwana supercontinent

Detecting broiler chickens on litter floor with the YOLOv5-CBAM deep learning model

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Artificial Intelligence in Agriculture 2023年第3期9卷 36-45页

作者： yangyang Guo Samuel e.Aggrey Xiao yang Adelumola Oladeinde Yongliang Qiao Lilong Chai School of Internet Anhui UniversityHefeiAnhui 230039China Department of Poultry Science University of GeorgiaAthensGA 30602USA U.S.National Poultry Research Center USDA-ARSAthensGA 30605USA Australian Centre for Field Robotics(ACFR) Faculty of EngineeringThe University of SydneyNSW 2006Australia

For commercial broiler production,about 20,000–30,000 birds are raised in each confined house,which has caused growing public concerns on animal ***,daily evaluation of broiler wellbeing and growth is conducted manually,which is labor-intensive and subjectively subject to human ***,there is a need for an automatic tool to detect and analyze the behaviors of chickens and predict their welfare *** this study,we developed a YOLOv5-CBAM-broiler model and tested its performance for detecting broilers on litter *** proposed model consisted of two parts:(1)basic YOLOv5 model for bird or broiler feature extraction and object detection;and(2)the convolutional block attention module(CBAM)to improve the feature extraction capability of the network and the problem of missed detection of occluded targets and small targets.A complex dataset of broiler chicken images at different ages,multiple pens and scenes(fresh litter versus reused litter)was constructed to evaluate the effectiveness of the new *** addition,the model was compared to the Faster R-CNN,SSD,YOLOv3,efficientDet and YOLOv5 *** results demonstrate that the precision,recall,F1 score and an mAP@0.5 of the proposed method were 97.3%,92.3%,94.7%,and 96.5%,which were superior to the comparison *** addition,comparing the detection effects in different scenes,the YOLOv5-CBAM model was still better than the comparison ***,the proposed YOLOv5-CBAM-broiler model can achieve real-time accurate and fast target detection and provide technical support for the management and monitoring of birds in commercial broiler houses.

关键词： Poultry production Deep learning YOLOv5 Attention mechanism

New Second-Level-Discrete Zeroing Neural Network for Solving Dynamic Linear System

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Ieee/CAA Journal of Automatica Sinica 2024年第6期11卷 1521-1523页

作者： Min yang School of Robotics Hunan UniversityChangsha 410082China

Dear editor,This letter deals with a new second-level-discretization method with higher precision than the traditional first-level-discretization ***,the traditional discretization method utilizes the first-order time derivative information,and it is termed first-level-discretization *** contrast,the new discretization method not only utilizes the first-order time derivative information,but also makes use of the second-order derivative *** combining the new second-level-discretization method with zeroing neural network(ZNN),the second-level-discrete ZNN(SLDZNN)model is proposed to solve dynamic(i.e.,time-variant or time-dependent)linear *** experiments and application to angle-of-arrival(AoA)localization show the effectiveness and superiority of the SLDZNN model.

关键词： method derivative utilize

Myeloid adrenerglc signaling via CaMKII forms a feedforward loop of catecholarnine biosynthesis

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Journal of Molecular Cell Biology 2017年第5期9卷 422-434页

作者： Yan Luo Bilian Liu Xin yang Xiaoxiao Ma Xing Zhang Denis e. Bragin Xuexian O. yang Wendong Huang Meilian Liu Department of endocrinology and Metabolism Metabolic Syndrome Research Center Key Laboratory of Diabetes Immunology National Clinical ResearchCenter for Metabolic Diseases The Second Xiangya Hospital Central South University Changsha 410011 China Department of Biochemistry and Molecular Biology University of New Mexico Health Sciences Center School of Medicine Albuquerque NM 87131 USA Department of Diabetes Complications & Metabolism Research City of Hope Duarte CA 91010 USA Department of Microbiology and Molecular Genetics University of New Mexico Health Sciences Center School of Medicine Albuquerque NM 87131 USA Department of Neurosurgery University of New Mexico Health Sciences Center School of Medicine Albuquerque NM 87131 USA

Type 2 immune response has been shown to facilitate cold-induced thermogenesis and browning of white fat. However, whether alternatively activated macrophages produce catecholamine and substantially promote adaptive thermogenesis in adipose tissue remains controversial. Here, we show that tyrosine hydroxylase CryrH）, a rate-limiting enzyme of catecholamine biosynthesis, was expressed and phosphorylated in adipose-resident macrophages. In addition, the plasma level of adrenaline was increased by cold stress in mice, and treatment of macrophages with adrenaline stimulated phosphorylation of CaZ＋/calmodulin-dependent protein kinase II （CaMKII） and TyrH. Genetic and pharmacological inhibition of CaMKII or PKA signaling diminished adrenaline- induced phosphorylation of TyrH in primary macrophages. Consistently, overexpression of constitutively active CaMKII upregulated basal TyrH phosphorylation, while suppressing the stimulatory effect of adrenaline on TyrH in macrophages. Myeioid-specific dis- ruption of CaMKIIy suppressed both the cold-induced production of norepinephrine and adipose UCP1 expression in vivo and the stimulatory effect of adrenaline on macrophage-dependent activation of brown adipocytes in vitro. Lack of CaMKII signaling attenu- ated catecholamine production mediated by cytokines IL-4 and IL-13, key inducers of type 2 immune response in primary macro- phages. Taken together, these results suggest a feedforward mechanism of adrenaline in adipose-resident macrophages, and that myeloid CaMKII signaling plays an important role in catecholamine production and subsequent beige fat activation.

关键词： CaMKII adrenaline tyrosine hydroxylase catecholamine UCP1