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汽车白车身机器人电阻点焊质量常见缺陷分析与改善方法

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时代汽车 2024年第13期 134-136页

作者：刘立华刘德鹏曾令重莫文将广西柳州上汽通用五菱汽车股份有限公司广西柳州545007

在汽车车身制造行业中,电阻点焊是一种高速、经济的连接方式,也是汽车生产中不可缺少的一部分。为提高生产效率及降低生产成本,越来越多机器人出现在各车企的生产线上,其中点焊机器人在汽车制造行业中得到广泛应用,点焊机器人的焊接质... 详细信息

在汽车车身制造行业中,电阻点焊是一种高速、经济的连接方式,也是汽车生产中不可缺少的一部分。为提高生产效率及降低生产成本,越来越多机器人出现在各车企的生产线上,其中点焊机器人在汽车制造行业中得到广泛应用,点焊机器人的焊接质量也随之而来,电阻点焊的质量直接会影响到车身的强度降低及安全性能。因此点焊的质量提升需要越来越受到重视,同时对电阻点焊的质量也提出了更高的要求。本文主要探讨点焊机器人焊接产生的常见缺陷焊穿、脱焊、焊点扭曲、裂纹、毛刺、压痕过深、边缘焊点、漏焊、焊点偏差等原因分析及改善方法。

关键词：机器人点焊焊接缺陷分析改善

肾功能亢进患者美罗培南药动学/药效学达标情况及谷浓度影响因素

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医药导报 2024年第1期43卷 122-126页

作者：陈沈珏李昕伍敏益刘丽华何鑫李美云长沙市第三医院药学部长沙410015 长沙市抗菌药物临床应用研究所长沙410015 长沙市第三医院重症医学科长沙410015

目的探讨肾功能亢进患者美罗培南药动学(PK)/药效学(PD)达标情况及谷浓度影响因素,为肾功能亢进患者合理使用美罗培南提供参考。方法采用回顾性研究方法,收集某院2018年1月-2021年12月使用美罗培南并监测浓度的肾功能亢进患者的资料,... 详细信息

目的探讨肾功能亢进患者美罗培南药动学(PK)/药效学(PD)达标情况及谷浓度影响因素,为肾功能亢进患者合理使用美罗培南提供参考。方法采用回顾性研究方法,收集某院2018年1月-2021年12月使用美罗培南并监测浓度的肾功能亢进患者的资料,分析美罗培南PK/PD达标情况,采用多重线性回归分析探讨美罗培南谷浓度的影响因素。结果共58例患者纳入研究,谷浓度为1.35[0.23,1.86]μg·mL^(-1),以100%fT>最低抑菌浓度(MIC)为PK/PD靶值,达标率为20.69%;日剂量<3 g·d^(-1)的达标率为8.70%,≥3 g·d^(-1)的达标率为31.43%。当MIC为0.5、1、2、4、8μg·mL^(-1)时,PK/PD达标率分别为62.07%、48.28%、20.69%、8.62%、0。多因素分析显示日剂量是美罗培南谷浓度的独立影响因子。结论肾功能亢进患者美罗培南PK/PD达标率较低,即使MIC≤0.5μg·mL^(-1),常规剂量也难以达理想PK/PD,临床应尽早识别肾功能亢进,尽早行治疗药物监测,以指导肾功能亢进患者美罗培南的用药方案。

关键词：美罗培南肾功能亢进血药浓度药动学药效学

重症患者哌拉西林他唑巴坦血药浓度达标情况及影响因素分析

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中国医院药学杂志 2024年第8期44卷 925-928,934页

作者：陈沈珏李美云胡杰曹琴刘丽华伍敏益长沙市第三医院药学部湖南长沙410015 长沙市第三医院重症医学科湖南长沙410015

目的:分析重症患者哌拉西林他唑巴坦药物浓度达标情况,探讨其影响因素,为合理使用哌拉西林他唑巴坦提供依据。方法:回顾性收集长沙市第三医院重症监护病房(ICU)2020年1月至2022年7月使用哌拉西林他唑巴坦并监测了哌拉西林药物浓度的患... 详细信息

目的:分析重症患者哌拉西林他唑巴坦药物浓度达标情况,探讨其影响因素,为合理使用哌拉西林他唑巴坦提供依据。方法:回顾性收集长沙市第三医院重症监护病房(ICU)2020年1月至2022年7月使用哌拉西林他唑巴坦并监测了哌拉西林药物浓度的患者。统计分析哌拉西林药物浓度分布情况及达标情况,采用多重线性回归方法分析其影响因素。结果:共收集191例患者,哌拉西林谷浓度(C_(min))为26.33[11.93,51.77]μg·mL^(–1),以C_(min)16~64μg·mL^(–1)为目标,C_(min)达标率为49.21%;单因素分析显示,年龄、体质量指数(BMI)、给药日剂量、输注时间、肌酐清除率(Ccr)、平均24 h尿量、白蛋白、谷丙转氨酶、谷草转氨酶、总胆红素是哌拉西林药物浓度的影响因素;多重线性回归分析表明,BMI、给药日剂量、输注时间、Ccr、谷丙转氨酶和总胆红素是哌拉西林血药浓度的影响因素。结论:重症患者哌拉西林血药浓度达标率较低,影响因素较多,有必要行治疗药物监测(therapeutical drug monitoring,TDM)以优化重症患者哌拉西林他唑巴坦的给药。

关键词：重症患者哌拉西林他唑巴坦血药浓度影响因素

The effects of <i>astragalus</i>polysaccharide on zebrafish cell apoptosis and senescence

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American Journal of Molecular Biology 2012年第2期2卷 103-109页

作者： Guangqing Xia Xiaojuan Han Jie Qi Wei liu Jinzhi Song Jiamei Qin lihua liu Department of Biology Tonghua Normal University Tonghua City China Department of Life Science North-East Normal University Changchun City China Department of Marine and Science Life Ocean Uinversity of China Qingdao City China

Astragalus polysaccharide (AP) is the extraction of astragalus, which is a plant used in traditional Chinese herb medicine and may increase an orgainism’s resistance to stress. Several earlier studies in vitro have indicated that AP has anti-aging activities, however the mechanism underlyling these activities was unclear and remained to be elucidated. In this study, Using the zebrafish (Danio rerio), we evaluated molecular mechanism of the effect of AP on zebrafish growth, development and apoptosis. 30 zebrafish embryos (24 hours post fertilization (hpf)) were exposed to varying concentrations of AP (from 0.125 mg/ml to 0. 5 mg/ml) continuously for 3 days. The results of β-galactosidase (SA-β-gal) and acridine orange fluorescence showed that AP can delay zebrafish embryos apoptosis under the concentration of 0.125 mg/ml. In addition, the differential gene expression of AP treated zebrafish embryos was examined by RT-PCR analysis. We found that the gene expression of mdm2 and tert were up-regulated while bax, p21 and p53 gene expression were down-regulated during early apoptosis of the zebrafish embryos mediated by AP. These results demonstrated that AP may play a role during the induction of senescence and this function might by p53-mediated pathway.

关键词： Astragalus Polysaccharide Zebrafish Cell Proliferation Senescence

家属参与的多维度护理对乳腺癌根治术患者心理应激和功能恢复的影响

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中国当代医药 2024年第19期31卷 158-162页

作者：叶乐黄胜君刘丽华张琼郑洁江西省上饶市人民医院头颈乳腺外科江西上饶334000

目的探讨家属参与的多维度护理对乳腺癌根治术患者心理应激和功能恢复的影响。方法选取2022年6月至2023年6月上饶市人民医院头颈乳腺外科收治的60例乳腺癌患者作为研究对象。按照随机数字表法分为对照组(30例)与观察组(30例),对照组采... 详细信息

目的探讨家属参与的多维度护理对乳腺癌根治术患者心理应激和功能恢复的影响。方法选取2022年6月至2023年6月上饶市人民医院头颈乳腺外科收治的60例乳腺癌患者作为研究对象。按照随机数字表法分为对照组(30例)与观察组(30例),对照组采用常规护理,观察组采用家属参与的多维度护理。比较两组的心理应激反应、心理状况、上肢功能障碍、上肢活动度、肩关节活动能力恢复情况及生活质量,入院后检查收缩压(SBP)和心率(HR),分别采用心理弹性量表(CD-RISC)、焦虑自评表(SAS)、汉密尔顿焦虑量表(HAMA)、抑郁自评量表(SDS)、汉密尔顿抑郁量表(HAMD)、上肢功能障碍量表(Quick-Dash)、上肢关节活动度量表(ROM)、肩关节功能量表(Constant-Murley)、肿瘤患者生活质量量表(QLQ-C30)及乳腺癌患者特异量表(FACT-B)评估。结果观察组患者干预后CD-RISC评分高于对照组,且SBP、HR低于对照组,差异有统计学意义(P<0.05);观察组患者干预后SAS、HAMA、SDS、HAMD评分低于对照组,差异有统计学意义(P<0.05);观察组患者干预后Quick-Dash评分低于对照组,且ROM、Constant-Murley评分高于对照组,差异有统计学意义(P<0.05);观察组干预后上肢外展、前屈、后伸、内旋、外旋角度、手指爬墙高度高于对照组,差异有统计学意义(P<0.05);观察组患者干预后QLQ-C30、FACT-B评分高于对照组,差异有统计学意义(P<0.05)。结论家属参与的多维度护理能改善乳腺癌根治术患者心理应激情况及心理状况、降低患者上肢功能障碍,提高上肢及肩关节功能恢复,增加上肢活动范围,提高生活质量。

关键词：家属参与多维度护理乳腺癌根治术心理应激功能恢复

Effect of Ethanolic Extract of Pereskia aculeata Miller on Joint Swelling in Rats with Adjuvant-induced Arthritis

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Medicinal Plant 2020年第5期11卷 63-67页

作者： Xuan WU lihua liu Changfu LI Yu CHEN Yifei CHEN Pharmacy School Guilin Medical UniversityGuilin 541000China Guangxi Key Laboratory of Pharmacology Pharmacy School of Guilin Medical UniversityGuilin 541000China

[Objectives]To explore the effect of ethanolic extract of Pereskia aculeata Miller(EEPA)on joint swelling in adjuvant arthritis rats.[Methods]60 SD rats were randomly selected.Except for the blank group,the remaining animals were injected with complete Freund's adjuvant to establish the adjuvant arthritis rat models,which were divided into 6 groups:blank group,positive group,model group,and EEPA high-dose(64 mg/kg),EEPA medium-dose(32 mg/kg),EEPA low-dose(16 mg/kg)groups,10 in each group.The changes of ankle joint swelling diameter and arthritis index score were observed,and the spleen index was calculated.The serum prostaglandin E2(PGE2)level was detected by enzyme-linked immunosorbent assay(ELISA).[Results]The degree of ankle swelling diameter,arthritis index score,expression of serum inflammatory factors,and spleen index in the model group were significantly higher than those in the blank group,indicating that there was an inflammatory reaction and abnormal immune organs,and the modeling was successful.Under the intervention of EEPA drugs,the degree of ankle swelling diameter and arthritis index score of EEPA group with different doses were significantly lower than that of the model group(P<0.05),and the level of serum inflammatory factors was also lower than that of the model group(P<0.05).The index was lower than the model group and close to the normal group(P<0.05),and the higher the EEPA dose,the lower the index expression level(P<0.05).[Conclusions]EEPA can reduce joint swelling and inhibit the level of inflammatory factors to some extent in adjuvant arthritis rats.

关键词： Pereskia aculeata Miller Rheumatoid arthritis PGE2

Investigations on High-Speed Flash Boiling Atomization of Fuel Based on Numerical Simulations

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1427-1453页

作者： Wei Zhong Zhenfang Xin lihua Wang Haiping liu School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai200092China Beijing Mechanical Equipment Research Institute Beijing100854China

Flash boiling atomization(FBA)is a promising approach for enhancing spray atomization,which can generate a fine and more evenly distributed spray by increasing the fuel injection temperature or reducing the ambient pressure.However,when the outlet speed of the nozzle exceeds 400 m/s,investigating high-speed flash boiling atomization(HFBA)becomes quite challenging.This difficulty arises fromthe involvement ofmany complex physical processes and the requirement for a very fine mesh in numerical simulations.In this study,an HFBA model for gasoline direct injection(GDI)is established.This model incorporates primary and secondary atomization,as well as vaporization and boilingmodels,to describe the development process of the flash boiling spray.Compared to lowspeed FBA,these physical processes significantly impact HFBA.In this model,the Eulerian description is utilized for modeling the gas,and the Lagrangian description is applied to model the droplets,which effectively captures the movement of the droplets and avoids excessive mesh in the Eulerian coordinates.Under various conditions,numerical solutions of the Sauter mean diameter(SMD)for GDI show good agreement with experimental data,validating the proposed model’s performance.Simulations based on this HFBA model investigate the influences of fuel injection temperature and ambient pressure on the atomization process.Numerical analyses of the velocity field,temperature field,vapor mass fraction distribution,particle size distribution,and spray penetration length under different superheat degrees reveal that high injection temperature or low ambient pressure significantly affects the formation of small and dispersed droplet distribution.This effect is conducive to the refinement of spray particles and enhances atomization.

关键词： High-speed flash boiling atomization numerical simulations Eulerian description Lagrangian description gasoline direct injection

A review on the aging phenomena of organic components and their mass transfer through the NAPL interfacial phase

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Chinese Journal Of Geochemistry 2013年第3期32卷 252-260页

作者： liu lihua Stefan Haderlein Key Laboratory of Renewable Energy and Gas Hydrate Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Eberhard-Karls-University of Tuebingen Center for Applied Geoscience (ZAG)

It occurs worldwide that the organic components of non-aqueous phase liquid (NAPL) enter the porous medium and become the source of contaminants in the subsurface. The transport of the organic components through NAPL interphase into the aqueous phase and the subsurface determines the extent of contamination, the persistence of residual NAPL phases and the techniques of remediation. During the transport process the NAPL interphase may experience "aging", a physical and chemical change when NAPL is exposed to aqueous and or gaseous phases. This aging process alters vice versa the mass transfer behaviour of the organic contaminants in the porous medium.

关键词：老化现象有机组成传质界面相部分和非水相液体评论污染物源

编程式自动化车门多点涂胶装置及技术的研发与应用

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时代汽车 2024年第13期 113-115页

作者：刘立华莫文将曾令重黄艳丽广西柳州上汽通用五菱汽车股份有限公司广西柳州545007

在汽车车身制造行业,为降低车门钣金之间在行驶过程中产生振动和噪声,往往需要在内外板间进行多位置涂上减震胶,提高行驶舒适性。本文主要提出一种编程式自动多点涂胶装置,即能满足快速对多点位置精确涂胶,又能满足涂胶量、涂胶一致性... 详细信息

在汽车车身制造行业,为降低车门钣金之间在行驶过程中产生振动和噪声,往往需要在内外板间进行多位置涂上减震胶,提高行驶舒适性。本文主要提出一种编程式自动多点涂胶装置,即能满足快速对多点位置精确涂胶,又能满足涂胶量、涂胶一致性稳定的研发方案。分别详细阐述了装置设计方案、技术方案、工作原理及应用效果。

关键词：多级多点涂胶低成本高效率研发应用