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Deep learning acceleration of multiscale superresolution localization photoacoustic imaging

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Light(Science & Applications) 2022年第6期11卷 1166-1177页

作者： Jongbeom Kim Gyuwon Kim Lei Li Pengfei Zhang Jin Young Kim Yeonggeun Kim Hyung Ham Kkim lihong v.wang Seungchul Lee Chulhong Kim Departments of Electrical Engineering Mechanical EngineeringConvergence IT Engineeringand Interdisciplinary Bioscience and BioengineeringGraduate School of Artificial IntelligenceMedical Device Innovation CenterPohang University of Science and Technology(POSTECH)77 Cheongam-roNam-guPohangGyeongbuk 37673Republic of Korea Caltech Optical Imaging Laboratory Andrew and Peggy Cherng Department of Medical EngineeringDepartment of Electrical EngineeringCalifornia Institute of Technology1200 E.California Blvd.MC 138-78PasadenaCA 91125USA School of Precision Instruments and Optoelectronics Engineering Tianjin University92 Weijin RoadNankai DistrictTianjin 300072China Opticho 532CHANGeUP GROUND87 Cheongam-roNam-guPohangGyeongsangbuk 37673Republic of Korea

A superresolution imaging approach that localizes very small targets,such as red blood cells or droplets of injected photoacoustic dye,has significantly improved spatial resolution in various biological and medical imaging ***,this superior spatial resolution is achieved by sacrificing temporal resolution because many raw image frames,each containing the localization target,must be superimposed to form a sufficiently sampled high-density superresolution ***,we demonstrate a computational strategy based on deep neural networks(DNNs)to reconstruct high-density superresolution images from far fewer raw image *** localization strategy can be applied for both 3D label-free localization optical-resolution photoacoustic microscopy(OR-PAM)and 2D labeled localization photoacoustic computed tomography(PACT).For the former,the required number of raw volumetric frames is reduced from tens to fewer than *** the latter,the required number of raw 2D frames is reduced by 12 ***,our proposed method has simultaneously improved temporal(via the DNN)and spatial(via the localization method)resolutions in both label-free microscopy and labeled ***-learning powered localization PA imaging can potentially provide a practical tool in preclinical and clinical studies requiring fast temporal and fine spatial resolutions.

关键词： Deep frames networks

Learning-based super-resolution interpolation for sub-Nyquist sampled laser speckles

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Photonics Research 2023年第4期11卷 631-642页

作者： HUANHAO LI ZHIPENG YU QI ZHAO YUNQI LUO SHENGFU CHENG TIANTING ZHONG CHI MAN WOO HONGLIN LIU lihong v.wang YUANJIN ZHENG PUXIANG LAI Department of Biomedical Engineering Hong Kong Polytechnic UniversityHong KongChina Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518063China School of Electrical and Electronics Engineering Nanyang Technological UniversitySingapore 639798Singapore Key Laboratory for Quantum Optics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Caltech Optical Imaging Laboratory Andrew and Peggy Cherng Department of Medical EngineeringCalifornia Institute of TechnologyPasadenaCalifornia 91125USA Photonics Research Institute Hong Kong Polytechnic UniversityHong KongChina

Information retrieval from visually random optical speckle patterns is desired in many scenarios yet considered *** requires accurate understanding or mapping of the multiple scattering process,or reliable capability to reverse or compensate for the scattering-induced phase *** whatever situation,effective resolving and digitization of speckle patterns are ***,on some occasions,to increase the acquisition speed and/or signal-to-noise ratio(SNR),speckles captured by cameras are inevitably sampled in the sub-Nyquist domain via pixel binning(one camera pixel contains multiple speckle grains)due to finite size or limited bandwidth of *** a down-sampling process is irreversible;it undermines the fine structures of speckle grains and hence the encoded information,preventing successful information *** retrace the lost information,super-resolution interpolation for such sub-Nyquist sampled speckles is *** this work,a deep neural network,namely SpkSRNet,is proposed to effectively up sample speckles that are sampled below 1/10 of the Nyquist criterion to well-resolved ones that not only resemble the comprehensive morphology of original speckles(decompose multiple speckle grains from one camera pixel)but also recover the lost complex information(human face in this study)with high fidelity under normal-and low-light conditions,which is impossible with classic interpolation *** successful speckle super-resolution interpolation demonstrations are essentially enabled by the strong implicit correlation among speckle grains,which is non-quantifiable but could be discovered by the well-trained *** further engineering,the proposed learning platform may benefit many scenarios that are physically inaccessible,enabling fast acquisition of speckles with sufficient SNR and opening up new avenues for seeing big and seeing clearly simultaneously in complex scenarios.

关键词： speckle interpolation hence

Recent Advances in Photoacoustic Tomography

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Biomedical Engineering Frontiers 2021年第1期2卷 27-43页

作者： Lei Li lihong v.wang Caltech Optical Imaging Laboratory Andrew and Peggy Cherng Department of Medical EngineeringDepartment of Electrical EngineeringCalifornia Institute of Technology1200 East California BoulevardMail Code 138-78PasadenaCA 91125USA

Photoacoustic tomography(PAT)that integrates the molecular contrast of optical imaging with the high spatial resolution of ultrasound imaging in deep tissue has widespread applications in basic biological science,preclinical research,and clinical ***,tremendous progress has been made in PAT regarding technical innovations,preclinical applications,and clinical ***,we selectively review the recent progresses and advances in PAT,including the development of advanced PAT systems for small-animal and human imaging,newly engineered optical probes for molecular imaging,broad-spectrum PAT for label-free imaging of biological tissues,high-throughput snapshot photoacoustic topography,and integration of machine learning for image reconstruction and *** envision that PAT will have further technical developments and more impactful applications in biomedicine.

关键词： clinical topography integrate

Harnessing a multi-dimensional fibre laser using genetic wavefront shaping

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Light(Science & Applications) 2020年第1期9卷 593-602页

作者： Xiaoming Wei Joseph C.Jing Yuecheng Shen lihong v.wang Caltech Optical Imaging Laboratory Andrew and Peggy Cherng Department of Medical EngineeringDepartment of Electrical EngineeringCalifornia Institute of Technology1200 East California Boulevard MailCode 138-78Pasadena 91125 CAUSA School of Physics and Optoelectronics/State Key Laboratory of Luminescent Materials and Devices/Guangdong Engineering Technology Research and Development Center of Special Optical Fiber Materials and Devices/Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques South China University of Technology381 Wushan RoadGuangzhou 510640China School of Electronics and Information Technology Sun Yatsen UniversityGuangzhou 510006China

The multi-dimensional laser is a fascinating platform not only for the discovery and understanding of new higherdimensional coherent lightwaves but also for the frontier study of the complex three-dimensional(3D)nonlinear dynamics and solitary waves widely involved in physics,chemistry,biology and materials *** controlling coherent lightwave oscillation in multi-dimensional lasers,however,is challenging and has largely been unexplored;yet,it is crucial for both designing 3D coherent light fields and unveiling any underlying nonlinear ***,for the first time,we genetically harness a multi-dimensional fibre laser using intracavity wavefront shaping technology such that versatile lasing characteristics can be *** demonstrate that the output power,mode profile,optical spectrum and mode-locking operation can be genetically optimized by appropriately designing the objective function of the genetic *** is anticipated that this genetic and systematic intracavity control technology for multi-dimensional lasers will be an important step for obtaining high-performance 3D lasing and presents many possibilities for exploring multi-dimensional nonlinear dynamics and solitary waves that may enable new applications.

关键词： fibre dimensional coherent

Physical picture of the optical memory effect

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Photonics Research 2019年第11期7卷 1323-1330页

作者： Honglin Liu Zhentao Liu Meijun Chen Shensheng Han lihong v.wang Key Laboratory for Quantum Optics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Caltech Optical Imaging Laboratory Andrew and Peggy Cherng Department of Medical EngineeringDepartment of Electrical EngineeringCalifornia Institute of TechnologyPasadenaCalifornia 91125USA

The optical memory effect is an interesting phenomenon that has attracted considerable attention in recent decades. Here, we present a new physical picture of the optical memory effect, in which the memory effect and the conventional spatial shift invariance are united. Based on this picture we depict the role of thickness, scattering times, and anisotropy factor and derive equations to calculate the ranges of the angular memory effect(AME) of different scattering components(ballistic light, singly scattered, doubly scattered, etc.), and hence a more accurate equation for the real AME ranges of volumetric turbid media. A conventional random phase mask model is modified according to the new picture. The self-consistency of the simulation model and its agreement with the experiment demonstrate the rationality of the model and the physical picture, which provide powerful tools for more sophisticated studies of the memory-effect-related phenomena and wavefront-sensitive techniques, such as wavefront shaping, optical phase conjugation, and optical trapping in/through scattering media.

关键词： effect scattered hence

PHOTOACOUSTIC GENERATION OF FOCUSED QUASI-UNIPOLAR PRESSURE PULSES

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Journal of Innovative Optical Health Sciences 2010年第4期3卷 247-253页

作者： KONSTANTIN MASLOv HAO F.ZHANG lihong v.wang Optical Imaging Laboratory Department of Biomedical Engineering Washington University in St.Louis St.LouisMissouri 63130USA Department of Electrical Engineering and Computer Science University of Wisconsin-Milwaukee Milwaukee Wisconsin 53201USA

The photoacoustic effect was employed to generate short-duration quasi-unipolar acoustic pressure pulses in both planar and spherically focused *** the focal region,the temporal profile of a pressure pulse can be approximated by the first derivative of the temporal profile near the front transducer surface,with a time-averaged value equal to *** approximation agreed with experimental results acquired from photoacoustic transducers with both rigid and free *** a free boundary,the acoustic pressure in the focal region is equal to the sum of a positive pressure that follows the spatial profile of the optical energy deposition in the medium and a negative pressure that follows the temporal profile of the laser pulse.

关键词： Photoacoustics optoacoustics ultrasound generation unipolar pulse

PRELIMINARY STUDY ON SKIN CANCER DETECTION IN SENCAR MICE USING MUELLER OPTICAL COHERENCE TOMOGRAPHY

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Journal of Innovative Optical Health Sciences 2009年第3期2卷 289-294页

作者： MILOˇS TODOROvI´C SHULIANG JIAO GEORGE STOICA lihong v.wang Department of Biomedical Engineering Texas A&M University College StationTexas 77843-3120USA Department of Ophthalmology Keck School of Medicine University of Southern CaliforniaLos AngelesCalifornia 90033USA Department of Pathobiology Texas A&M University College StationTexas 77843-5547USA

We report on the use of a fiber-based Mueller-matrix optical coherence tomography(OCT)system with continuous source-polarization modulation for in vivo imaging of early stages of skin cancer in SENCAR mice.A homemade hand-held probe with integrated optical scanning and beam delivering optics was coupled in the sample *** OCT images show the morphological changes in skin resulting from pre-cancerous papilloma formations that are consistent with histology,thus demonstrating the system’s potential for early skin cancer detection.

关键词： Coherence imaging medical and biological imaging optical coherence tomography birefringence polarization turbid media

Single-pulse real-time billion-frames-per-second planar imaging of ultrafast nanoparticle-laser dynamics and temperature in flames

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Light(Science & Applications) 2023年第3期12卷 379-390页

作者： Yogeshwar Nath Mishra Peng wang Florian J.Bauer Yide Zhang Dag Hanstorp Stefan Will lihong v.wang Caltech Optical Imaging Laboratory Andrew and Peggy Cherng Department of Medical EngineeringDepartment of Electrical EngineeringCalifornia Institute of Technology1200 East California BoulevardMail Code 138-78PasadenaCA91125USA NASA-Jet Propulsion Laboratory California Institute of Technology4800 Oak Grove DrivePasadenaCA91109USA Department of Physics University of GothenburgSE 41296GothenburgSweden Institute of Engineering Thermodynamics(LTT)and Erlangen Graduate School in Advanced Optical Technologies(SAOT) Friedrich-Alexander-Universität Erlangen-Nürnberg(FAU)91058ErlangenGermany

Unburnt hydrocarbon flames produce soot,which is the second biggest contributor to global warming and harmful to human *** state-of-the-art high-speed imaging techniques,developed to study non-repeatable turbulent flames,are limited to million-frames-per-second imaging rates,falling short in capturing the dynamics of critical ***,these techniques do not provide a complete picture of flame-laser interactions,important for understanding soot ***,thermal effects induced by multiple consecutive pulses modify the optical properties of soot nanoparticles,thus making single-pulse imaging ***,we report single-shot laser-sheet compressed ultrafast photography(LS-CUP)for billion-frames-per-second planar imaging of flame-laser *** observed laser-induced incandescence,elastic light scattering,and fluorescence of soot precursors-polycyclic aromatic hydrocarbons(PAHs)in real-time using a single nanosecond laser *** spatiotemporal maps of the PAHs emission,soot temperature,primary nanoparticle size,soot aggregate size,and the number of monomers,present strong experimental evidence in support of the theory and modeling of soot inception and growth mechanism in ***-CUP represents a generic and indispensable tool that combines a portfolio of ultrafast combustion diagnostic techniques,covering the entire lifecycle of soot nanoparticles,for probing extremely short-lived(picoseconds to nanoseconds)species in the spatiotemporal domain in non-repeatable turbulent ***,LS-CUP’s unparalleled capability of ultrafast wide-field temperature imaging in real-time is envisioned to unravel mysteries in modern physics such as hot plasma, sonoluminescence, and nuclear fusion.

关键词： dynamics pulse turbulent

Multifocal photoacoustic microscopy using a single-element ultrasonic transducer through an ergodic relay

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Light(Science & Applications) 2020年第1期9卷 717-723页

作者： Yang Li Terence T.W.Wong Junhui Shi Hsun-Chia Hsu lihong v.wang Caltech Optical Imaging Laboratory Andrew and Peggy Cherng Department of Medical EngineeringDepartment of Electrical EngineeringCalifornia Institute of Technology1200 East California BoulevardPasadenaCA 91125USA Department of Biomedical Engineering Washington University in St.LouisCampus Box 1097One Brookings DriveSt.LouisMO 63130-4899USA Translational and Advanced Bioimaging Laboratory Department of Chemical and Biological EngineeringHong Kong University of Science and TechnologyHong KongChina

Optical-resolution photoacoustic microscopy(OR-PAM)has demonstrated high-spatial-resolution imaging of optical absorption in biological *** date,most OR-PAM systems rely on mechanical scanning with confocally aligned optical excitation and ultrasonic detection,limiting the wide-field imaging speed of these *** several multifocal OR-PA(MFOR-PA)systems have attempted to address this limitation,they are hindered by the complex design in a constrained physical ***,we present a two-dimensional(2D)MFOR-PAM system that utilizes a 2D microlens array and an acoustic ergodic *** a single-element ultrasonic transducer,this system can detect PA signals generated from 400 optical foci in parallel and then raster scan the optical foci patterns to form an MFOR-PAM *** system improves the imaging resolution of an acoustic ergodic relay system from 220 to 13μm and enables 400-folds shorter scanning time than that of a conventional OR-PAM system at the same resolution and laser repetition *** demonstrated the imaging ability of the system with both in vitro and in vivo experiments.

关键词： element resolution utilize