检索结果-南通市图书馆

Hypertonia-linked protein Trakl functions with mitofusins to promote mitochondrial tethering and fusion

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2018年第8期9卷 693-716页

作者： Crystal A. Lee lih-shen chin Lian Li Department of Pharmacology Emory University School of Medicine Atlanta GA 30322 USA Cell Biology Section Neurogenetics Branch National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda MD 20892 USA

Hypertonia is a neurological dysfunction associated with a number of central nervous system disorders, including cerebral palsy, Parkinson＇s disease, dystonia, and epilepsy. Genetic studies have identified a homozygous truncation mutation in Trakl that causes hypertonia in mice. Moreover, elevated Trakl protein expression is associated with several types of cancers and variants in Trakl are linked to childhood absence epilepsy in humans. Despite the importance of Trakl in health and disease, the mechanisms of Trakl action remain unclear and the pathogenic effects of Trakl mutation are unknown. Here we report that Trakl has a crucial function in regulation of mitochondrial fusion. Depletion of Trakl inhibits mitochondrial fusion, result- ing in mitochondrial fragmentation, whereas overex- pression of Trakl elongates and enlarges mitochondria. Our analyses revealed that Trakl interacts and colocal- izes with mitofusins on the outer mitochondrial mem- brane and functions with mitofusins to promote mitochondrial tethering and fusion. Furthermore, Trakl is required for stress-induced mitochondrial hyperfu- sion and pro-survival response. We found that hyper- tonia-associated mutation impairs Trakl mitochondrial localization and its ability to facilitate mitochondrial tethering and fusion. Our findings uncover a novel function of Trakl as a regulator of mitochondrial fusion and provide evidence linking dysregulated mitochon- drial dynamics to hypertonia pathogenesis.

关键词： mitochondria mitochondrial fusion mitochondrial tethering mitofusin hypertonia

Pre-treatment to Improve the Bake-hardening Response in the Naturally Aged Al-Mg-Si Alloy

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2011年第3期27卷 205-212页

作者： chin-Hui shen Department of Mechanical Engineering Army Academy No.750Longdong Rd.Zhongli CityTaoyuan County 320TaiwanChina

This paper describes pre-treatment methods to improve the bake-hardening response of naturally aged AA6022 （Al-0.6Mg-1.0Si）, which is an alloy used in automotive body panels. These methods are used to accelerate the artificial aging process, which proceeds 30-day period of natural aging. The precipitation behavior of the sheets of this aluminum alloy was analyzed by differential scanning calorimetry （DSC） and electrical conductivity measurements, and subsequently confirmed by microstructure observations by transmission electron microscopy （TEM）. Tensile tests and microhardness measurements were performed to determine the mechanical properties of the samples. Under simulated paint-baking conditions （30 min at 170℃）, the microhardness and the yield strength （YS） of the pre-strained ＋ pre-aged samples were found to be I13 HV and 225 MPa, respectively. These values are considerably higher than those of pre-aged samples, and they did not decrease significantly during the initial stage of artificial aging.

关键词： Pre-aging Pre-straining Natural aging and Bake hardening

Antacid effects of chinese herbal prescriptions assessed by a modified artificial stomach model

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第35期16卷 4455-4459页

作者： Tsung-Hsiu Wu I-chin Chen lih-Chi Chen chinese Medicine Pharmacy Department E-Da Hospital School of chinese Medicine for Post-Baccalaureate I-Shou University Department of Pharmacy Taipei City Hospital College of Pharmacy Taipei Medical University

AIM:To assess the antacid effects of the tonic chinese herbal prescriptions,Si-Jun-Zi-Tang(SJZT) and shen-Ling-Bai-Zhu-San(SLBZS).METHODS:Decoctions of the tonic chinese herbal prescriptions,SJZT and SLBZS,were prepared according to chinese original *** pH of the prescription decoctions and their neutralizing effects on artif icial gastric acids were determined and compared with water and the active controls,sodium bicarbonate and colloidal aluminum phosphate.A modified model of Vatier's artificial stomach was used to determine the duration of consistent neutralization effect on artificial gastric *** neutralization capacity in vitro was determined with the titration method of Fordtran's ***:The results showed that both SJZT and SLBZS have antacid effects in *** with the water group,SJZT and SLBZS were found to possess signif icant gastric acid neutralizing *** duration for consistent neutralization of SLBZS was signif icantly longer than that of ***,SLBZS and SJZT exhibited signif icant antacid capacities compared to ***:SJZT and SLBZS were consistently active in the artificial stomach model and are suggested to have antacid effects similar to the active control drugs.

关键词： Traditional chinese medicines Antacid Acid neutralizing capacity Artificial stomach

Polymeric artificial solid/electrolyte interphases for Li-ion batteries

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2015年第6期25卷 563-571页

作者： Nae-lih Wu Yu-Ting Weng Fu-sheng Li Nai-Hsuan Yang chin-Lung Kuo Dong-sheng Li Deprtment of Chemical Engineering National Taiwan University Department of Materials Science and Engineering National Taiwan University

During the operation of Li-ion batteries(LIBs),solvent and electrolyte decomposition takes place at the electrode surface to form a so-called solid-electrode interphase(SEI) *** physical structure and chemical composition of the SEI exert profound effects on various aspects of the electrode performance of the batteries.A new concept of forming polymeric artificial SEIs(A-SEIs) based on rational design of multifunctional polymer-blend coating to achieve favorable electrode/A-SEI/electrolyte interfacial properties is *** examples using binary and ternary polymer blends to form mechanically robust and highly Li-ion permeable surface coatings with selected functionalities in the cases of graphite and silicon–graphite composite electrodes have demonstrated greatly enhanced capacity,rate and cycle *** the rich chemistry available from polymer blends,this surface preconditioning approach holds great promise for improving the performance of various negative electrodes to meet the requirements for advanced LIBs.

关键词： Li ion battery Solid electrolyte interphase Surface modification Polymer blend

The Degradation Rate of Polyanhydride (Poly(sebacic acid), diacetoxy terminated, PSADT)

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2013年第4期28卷 793-797页

作者：崔志香 PENG Yiyan LI Ke PENG Jun ZHAO Haibin TURNG lih-sheng shen Changyu School of Materials Science and Engineering Fujian University of Technology Polymer Engineering Center University of Wisconsin-Madison National Engineering Research Center of Novel Technology South China University of Technology School of Materials Science and Engineering Zhengzhou University

The in vitro degradation rate of polyanhydride （poly（sebacic acid）, diacetoxy terminated）, also known as PSADT, was investigated. PSADT tablets with a circular cross-section were formed using a compression molding device, and then immersed into phosphate buffer saline （PBS） for in vitro degradation experiments. The mechanisms of degradation and the degradation rate were characterized by the change in molecular weight and reduction in specimen mass. In addition, the effects of processing temperature and the geometry of the formed PSADT tablets on the rate of degradation were studied. The surface morphology at different degradation times was observed by scanning electron microscopy （SEM）. The experimental results showed that PSADT exhibited sur^hce erosion due to the fact that near zero-order degradation kinetics was observed during its degradation process. Moreover, it is found that the geometry of tablets played an important role on the rate of degradation, while the processing temperature had no significant effect on the PSADT degradation rate.

关键词： degradation rate polyanhydride biodegradable polymer surface erosion compression molding

Bank Lending and Economic Growth of chinese Cities

在线全文

学校读者我要写书评

暂无评论

china & World Economy 2012年第2期20卷 59-79页

作者： chin Hwa Lu Chung Hua shen Department of Finance China University of Technology Department of Finance National Taiwan University

Using a city-level dataset over the period 2004-2006, the present study investigates the relationship between bank lending and the economic growth of chinese cities. Unlike past studies, we divide bank lending into loans from three types of banks： foreign banks, city banks and other banks. Our findings are threefold. First, the lending of foreign banks exhibits a strong and positive association with the economic growth of chinese cities. Second, foreign direct investment in the sampled cities enhances the lending effects of foreign banks, but reduces the lending effects of other banks on the economy of chinese cities. Third, the effects of city competitiveness are similar to those offoreign direct investment; that is, city competitiveness augments the lending effects of foreign banks but reduces the lending effects of other banks.

关键词： bank lending chinese cities city banks economic growth foreign banksJEL codes: 043 G21

Interaction between microbubble and elastic microvessel in low frequency ultrasound field using finite element method

在线全文

学校读者我要写书评

暂无评论

chinese Science Bulletin 2013年第3期58卷 291-298页

作者： shen YuanYuan WANG TianFu chin ChienTing DIAO XianFen CHEN SiPing Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging National-Regional Key Technology Engineering Laboratory for Medical Ultrasound

The interaction between microbubble and elastic microvessel wall has been hypothesized to be important in the mechanisms of therapeutic ultrasound *** this study,a 2D axisymmetric finite element numerical model is established to study the interaction between elastic microvessel wall and oscillating microbubble in low frequency ultrasound field using fluid solid interaction *** numerical results show that the bubble oscillation induces the vessel wall dilation and *** von Mises stress distribution over the microvessel wall is heterogeneous and the maximum value of the midpoint on the inner vessel wall could reach 0.23 MPa and 1.32 MPa under PNP 0.2 MPa and 0.5 MPa,*** the bubble collapses,the circumferential stress decreases rapidly and the transmural pressure increases ***,the circumferential stress becomes compressive with the maximum magnitude 1.83 MPa under PNP 0.5 MPa,larger than the maximum tension *** is possible that the rapid compression stress during bubble collapse plays important role in mechanical effect on microvessel wall endothelial lining disruption.

关键词：相互作用有限元法超声场微血管弹性微泡低频数值模型

Unconventional topological phase transition in non-symmorphic material KHgX(X=As,Sb,Bi)

在线全文

学校读者我要写书评

暂无评论

npj Computational Materials 2019年第1期5卷 599-605页

作者： chin-shen Kuo Tay-Rong Chang Su-Yang Xu Horng-Tay Jeng Department of Physics National Tsing Hua UniversityHsinchu 30013Taiwan Department of Physics National Cheng Kung UniversityTainan 701Taiwan Center for Quantum Frontiers of Research&Technology(QFort) Tainan 701Taiwan Department of Physics Massachusetts Institute of TechnologyCambridgeMA 02139USA Physics Division National Center for Theoretical SciencesHsinchu 30013Taiwan Institute of Physics Academia SinicaTaipei 11529Taiwan

Traditionally topological phase transition describes an evolution from topological trivial to topological nontrivial *** from the non-symmorphic crystalline symmetry,we propose in this work an unconventional topological phase transition scheme between two topological nontrivial insulating states mediated by a Dirac gapless state,differing from the traditional topological phase *** KHgX(X=As,Sb,Bi)family is the first experimentally realized topological non-symmorphic crystalline insulator(TNCI),where the topological surface states are characterized by the Mobius-twisted *** on first-principles calculations,we present a topological insulator–metal transition from TNCI into a Dirac semimetal(DSM)via applying an external pressure on *** find an unusual mirror Chern number C_(m)=−3 for the DSM phase of KHgX in the non-symmorphic crystal structure,which is topologically distinct from the traditional DSM such as Na_(3)Bi and Cd_(3)As_(2).Furthermore,we predict a new TNCI phase in KHgX via symmetry *** topological surface states in this new TNCI phase display zigzag connectivity,different from the unstressed *** results offer a comprehensive study for understanding how the topological surface states evolve from a quantum phase transition in non-symmorphic system.

关键词： topological transition phase

Study on the Tin Oxide Sol-Gel Membrane as a pH Sensing Electrode

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

稀有金属材料与工程 2006年第A3期35卷 238-239页

作者： chin-Shuen Hung Jung-Chuan Chou Tai-Ping Sun shen-Kan Hsiung Institute of Electronic Engineering Chung Yuan Christian University Chung-Li Taiwan 320China Graduate School of Electronic Engineering National Yunlin University of Science and Technology Douliou Taiwan 640China Department of Electrical Engineering National Chi Nan University Nantou Taiwan 545 China

In this study,tin oxide sensing membrane was derived by sol-gel method and was coated onto indium tin oxide (ITO) glass substrate by spin-coating technique to fabricate a pH sensing ***,the morphology of the tin oxide membrane has been discussed through the instrumental ***,the sensing characteristics of the pH electrode was measured by commercial instrumental amplifier as the readout *** to the sol-gel method has many advantages such as easy fabrication of gel solution,ability to dope other materials without any expensive fabricating ***,it is suitable for the mass production of a disposable sensor.

关键词： tin oxide sensing membrane sol-gel method spin-coating technology pH sensing electrode