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Effects of probiotics， prebiotics and synbiotics supplementation on cardiovascular risk factors in patients with type 2 diabetes mellitus: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials

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Food Science and Human Wellness 2024年

作者： Yanyan Tian Jiayue Xia Lihua Li ligang yang Hua Xiao Guoping Gao Yuanyuan Wang Chen Zhang Tiange Bu Guiju Sun Department of Nutritional Sciences， University of Toronto Key Laboratory of Environmental Medicine and Engineering of Ministry of Education， Department of Nutrition and Food Hygiene， School of Public Health， Southeast University Lianshui People's Hospital Affiliated to Kangda College of Nanjing Medical University Gong'an County People's Hospital

A systematic review and meta-analysis study was conducted to assess the effectiveness of probiotic/prebiotic/synbiotic supplementation on the effects of cardiovascular risk factors in patients with type 2 diabetes mellitus (T2DM) based on data from randomized controlled trials (RCTs). We searched electronic databases including PubMed， Cochrane Library， Embase， and Web of Science to identify clinical trials published up to 31 March 2023. Data was pooled using a random-effects model if significant heterogeneity (I2> 50%)， otherwise use a fixed-effects model. Fifty-six trials that included 3 317 patients were enrolled for analysis. Meta-analysis reported that probiotic/prebiotic/synbiotic supplementation significantly reduced systolic blood pressure (SBP) (weighted mean difference (WMD): -3.57 mmHg， 95% confidence interval (CI): -5.36， -1.78; P = 0.000)， diastolic blood pressure (DBP) (WMD: -2.05 mmHg， 95% CI: -3.07， -1.04; P = 0.000)， triglycerides (TG) (WMD: -16.10 mg/dL， 95% CI: -20.16， -12.05; P = 0.000)， total cholesterol (TC) (WMD: -14.00 mg/dL， 95% CI: -20.46， -7.55; P = 0.000)， low-density lipoprotein cholesterol (LDL-C) (WMD: -7.03 mg/dL， 95% CI: -9.25， -4.81; P = 0.000)， fasting plasma glucose (FPG) (WMD: -16.57 mg/dL， 95% CI: -20.39， -12.74; P = 0.000)， hemoglobin A1c (HbA1c) (WMD: -0.44%， 95% CI: -0.68， -0.20; P = 0.000)， insulin (standardized mean difference (SMD): -0.37， 95% CI: -0.53， -0.21; P = 0.000)， homeostatic model assessment of insulin resistance (HOMA-IR) (WMD: -1.05， 95% CI: -1.56， -0.54; P = 0.000)， C-reactive protein (CRP) (SMD: -0.35， 95% CI: -0.57， -0.13; P = 0.002)， tumor necrosis factor-α (TNF-α) (SMD: -1.07， 95% CI: -1.57， -0.56; P = 0.000)， interleukin-6 (IL-6) (SMD: -0.37 ， 95% CI: -0.61， -0.13; P = 0.003) levels， they also increased the high-density lipoprotein cholesterol (HDL-C) (WMD: 3.70 mg/dL， 95% CI: 1.80， 5.60; P = 0.000) levels in T2DM patients， as compared to the placebo groups. This meta-analysis supports the use of probiotic

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利用扭转双脉冲驱动激光产生偏振方向可控的阿秒脉冲(特邀)

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光子学报 2024年第6期53卷 83-91页

作者：杨立岗杜进旭王国利西北师范大学物理与电子工程学院兰州730070

研究了扭转双脉冲激光参数对产生高次谐波和阿秒脉冲偏振方向的影响。结果表明,当两束同频线偏振激光脉冲偏振方向正交并具有合适的时间延迟(或相位差)时,改变它们之间的强度比,可以在垂直于激光传播方向的平面内得到任意偏振方向的线... 详细信息

研究了扭转双脉冲激光参数对产生高次谐波和阿秒脉冲偏振方向的影响。结果表明,当两束同频线偏振激光脉冲偏振方向正交并具有合适的时间延迟(或相位差)时,改变它们之间的强度比,可以在垂直于激光传播方向的平面内得到任意偏振方向的线极化阿秒脉冲,而激光载波包络相位不会对这种调控产生显著影响。此外,在合适的激光强度比下,利用两束激光脉冲之间的偏振夹角也可以有效控制阿秒脉冲的偏振方向。为产生偏振方向可控阿秒脉冲提供了一种简单易操作的方案。

关键词：双脉冲激光场高次谐波阿秒脉冲偏振方向调控

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非酒精性脂肪性肝病流行现状及危险因素研究进展

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中国全科医学 2024年第30期27卷 3825-3834页

作者：许耀珑赵佳欣杨立刚东南大学公共卫生学院环境医学工程教育部重点实验室营养与食品卫生学系江苏省南京市210003

非酒精性脂肪性肝病是一种进行性疾病,与乙型病毒性肝炎、丙型病毒性肝炎、酒精性肝病共同构成全球慢性肝病的主要病因。非酒精性脂肪性肝病若不进行有效干预,可逐渐恶化为非酒精性脂肪性肝炎、脂肪性肝纤维化、肝硬化甚至肝癌等,并可... 详细信息

非酒精性脂肪性肝病是一种进行性疾病,与乙型病毒性肝炎、丙型病毒性肝炎、酒精性肝病共同构成全球慢性肝病的主要病因。非酒精性脂肪性肝病若不进行有效干预,可逐渐恶化为非酒精性脂肪性肝炎、脂肪性肝纤维化、肝硬化甚至肝癌等,并可能在将来成为终末期肝病的主要原因。世界范围内,非酒精性脂肪性肝病的患病率、发病率正在不断增加,危害日趋显著。本文在进行大量资料搜集与文献阅读后,对非酒精性脂肪性肝病在性别、地区等方面的流行病学特征进行分析,同时针对激素、环境等危险因素对非酒精性脂肪性肝病可能造成的影响进行讨论,为非酒精性脂肪性肝病预防控制提供新的思路。

关键词：非酒精性脂肪性肝病流行病学危险因素综述

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梅毒螺旋体病原学检测方法及研究进展

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皮肤性病诊疗学杂志 2024年第7期31卷 475-478页

作者：杨立刚南方医科大学皮肤病医院广东广州510091

传统的梅毒螺旋体检测方法受限于便捷性及敏感性不足,影响了在梅毒早期诊断的应用。随着核酸扩增技术在传染病病原学诊断方面的发展,核酸扩增技术在梅毒诊断的应用越来越广泛,而且可以用于多种临床标本的检测。与此同时,兔子感染试验在... 详细信息

传统的梅毒螺旋体检测方法受限于便捷性及敏感性不足,影响了在梅毒早期诊断的应用。随着核酸扩增技术在传染病病原学诊断方面的发展,核酸扩增技术在梅毒诊断的应用越来越广泛,而且可以用于多种临床标本的检测。与此同时,兔子感染试验在梅毒螺旋体鉴定、繁殖、分离方面仍然发挥重要作用。本文概述梅毒螺旋体病原学检测方法及研究进展,以期为临床工作者及相关领域研究人员提供参考。

关键词：梅毒梅毒螺旋体核酸扩增兔子感染试验

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Tissue distribution of Lycium barbarum polysaccharides in rat tissue by fluorescein isothiocyanate labeling

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Food Science and Human Wellness 2022年第4期11卷 837-844页

作者： Chao yang Hui Xia Huali Tang ligang yang Guiju Sun Key Laboratory of Environmental Medicine and Engineering of Ministry of Education and Department of Nutrition and Food hygieneSchool of Public HealthSoutheast UniversityChina-DRIs Expert Committee on Other Food SubstancesNanjing 210009China

To date, in vivo investigations of polysaccharide’s pharmacokinetics are significantly restricted by the difficulty in their detection. This study was conducted to establish the quantitative determination of Lycium barbarum polysaccharides(LBPs) based on fluorescein isothiocyanate(FITC) pre-labeling and to investigate their tissue distribution in rat. We obtained the calibration curves linear over the range of 0.0–25 μg/m L in rat tissue samples with correlation coefficients greater than 0.99. The inter-day and intra-day precisions(RSD, %) were within 15%, and the relative recovery ranged 95.2%–102.4%, with RSD range 1.48%–9.58%, indicating that this experiment was suitable for the determination of LBPs. The fluorescence intensity was measured after 24 h storage at room temperature, 3 times of freeze-cycle and cryopreservation at –20 ℃ for 15 day, these results indicated that the stability of the samples was good. LBP-FITC was mainly absorbed by the small intestine and stomach, and mainly excreted in the urine through the kidney;this distinct difference in the tissue distribution of LBPs could be attributed to the size of these LBPs in relation to the pore sizes of the vascular beds in the kidney and liver. Results showed in this study enable us to comprehensively understand the biological effects of LBPs following its oral ingestion.

关键词： Lycium barbarum polysaccharides Fluorescein isothiocyanate Tissue distribution

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Resilient sliding mode control for 2D CPSs under denial-of-service attacks

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Science China(Information Sciences) 2024年第6期67卷 262-278页

作者： Lingling LI Rongni yang Zhiguang FENG ligang WU College of Intelligent Systems Science and Engineering Harbin Engineering University School of Control Science and Engineering Shandong University School of Astronautics Harbin Institute of Technology

This study addresses the resilient sliding mode control(SMC) problem for two-dimensional cyber-physical systems(2D CPSs) characterized by the Roesser model under denial-of-service attack(DoSA), which can interfere with signal transmission over the communication network. First, the DoS-A model is established by introducing constraints on the Do S frequency and duration. Then, based on active or silent attack situations, the considered system is described as a switched mode. Furthermore, together with Lyapunov theory, the average dwell time technique is employed to deduce sufficient criteria that assure the existence of the desired sliding mode controller. Finally, verification examples are provided to show the validity of the established SMC scheme.

关键词： two-dimensional systems cyber-physical systems denial-of-service attack resilient sliding mode control

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Different n-6/n-3 polyunsaturated fatty acid ratios affect postprandial metabolism in normal and hypertriglyceridemic rats

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Food Science and Human Wellness 2023年第4期12卷 1157-1166页

作者： ligang yang Chao yang Zhixiu Song Min Wan Hui Xia Xian yang Dengfeng Xu Da Pan Hechun Liu Shaokang Wang Guiju Sun Key Laboratory of Environmental Medicine and Engineering of Ministry of Education School of Public HealthSoutheast UniversityNanjing 210009China Second Clinical Medical College Nanjing University of Chinese MedicineNanjing 210023China

Postprandial metabolism plays major roles in many pathological *** n-6/n-3 polyunsaturated fatty acid(PUFA)ratio is closely related to various physiological *** study aimed to investigate the effects of high fat meals with different n-6/n-3 PUFA ratios on postprandial metabolism in normal control(NC)and hypertriglyceridemia(HTG)*** postprandial response of triglyceride(TG)in HTG groups was higher than that in NC groups after different n-6/n-3 PUFA ratio *** HTG groups showed higher postprandial total cholesterol(TC)responses than NC groups after 1:1 and 20:1 ratio *** 5:1 n-6/n-3 PUFA ratio elicited lower postprandial responses of tumor necrosis factorα(TNF-α)than 1:1 and 10:1 ratios in HTG *** postprandial malondialdehyde(MDA)response was lower after a 5:1 n-6/n-3 PUFA ratio meal than 1:1 and 20:1 ratio meals in HTG *** 1:1 ratio resulted in a lower postprandial reactive oxygen species(ROS)level than 5:1 and 10:1 n-6/n-3 PUFA ratios in NC *** results showed that a low n-6/n-3 PUFA ratio improved postprandial dysmetabolism induced by a high fat meal in NC and HTG rats.A high n-6/n-3 PUFA ratio increased the difference in postprandial metabolism between NC and HTG rats.

关键词： Polyunsaturated fatty acid n-6 Fatty acids n-3 Fatty acids Postprandial metabolism Hypertriglyceridemia

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Low carbon alcohol fuel electrolysis of hydrogen generation catalyzed by a novel and effective Pt–CoTe/C bifunctional catalyst system

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Green Energy & Environment 2024年第4期9卷 758-770页

作者： yang Zhou Lice Yu Jinfa Chang ligang Feng Jiujun Zhang School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou225002JiangsuChina NanoScience Technology Center University of Central FloridaOrlandoFL32826USA College of Sciences&Institute for Sustainable Energy Shanghai UniversityShanghai200444China

Low carbon alcohol fuels electrolysis under ambient conditions is promising for green hydrogen generation instead of the traditional alcohol fuels steam reforming technique,and highly efficient bifunctional catalysts for membrane electrode fabrication are required to drive the electrolysis ***,the efficient catalytic promotion effect of a novel catalyst promoter,CoTe,on Pt is demonstrated for low carbon alcohol fuels of methanol and ethanol electrolysis for hydrogen *** and density functional theory calculation results indicate that the optimized electronic structure of Pt–CoTe/C resulting from the synergetic effect between Pt and CoTe further regulates the adsorption energies of CO and H*that enhances the catalytic ability for methanol and ethanol ***,the good water activation ability of CoTe and the strong electronic effect of Pt and CoTe increased the tolerance ability to the poisoning species as demonstrated by the CO-stripping *** high catalytic kinetics and stability,as well as the promotion effect,were also carefully ***,71.9%and 75.5%of the initial peak current density was maintained after 1000 CV cycles in acid electrolyte for methanol and ethanol oxidation;and a low overpotential of 30 and 35 mV was required to drive the hydrogen evolution reaction in methanol and ethanol solution at the current density of 10 mA cm^(-2).In the two-electrode system for alcohol fuels electrolysis,using the optimal Pt–CoTe/C catalyst as bi-functional catalysts,the cell potential of 0.66 V(0.67 V)was required to achieve 10 mA cm^(-2) for methanol(ethanol)electrolysis,much smaller than that of water electrolysis(1.76 V).The current study offers a novel platform for hydrogen generation via low carbon alcohol fuel electrolysis,and the result is helpful to the catalysis mechanism understanding of Pt assisted by the novel promoter.

关键词： Methanol electrolysis Ethanol electrolysis Cobalt telluride Pt-based electrocatalyst Hydrogen evolution reaction

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Comparison of the effects of 3 kinds of oils rich in omega-3 polyunsaturated fatty acids on glycolipid metabolism and lipoprotein subfractions

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Food Science and Human Wellness 2023年第6期12卷 2221-2231页

作者： Hechun Liu Feng Wang Hui Xia Da Pan ligang yang Shaokang Wang Feng Zhao Guiju Sun Key Laboratory of Environmental Medicine and Engineering of Ministry of Education Department of Nutrition and Food HygieneSchool of Public HealthSoutheast UniversityNanjing 210009China Department of Endocrinology and Metabolism The First Affi liated Hospital of Nanjing Medical UniversityNanjing 210029China Tianjin Institute of Environmental and Operational Medicine Tianjin 300050China Research Center of Fatty Acid and Human Health Qingdao UniversityQingdao 266000China

Dietary omega-3 polyunsaturated fatty acids(ω-3 PUFAs)can be classifi ed into animal-and plant-derivedω-3 *** with type 2 diabetes(T2DM)are frequently accompanied by dyslipidemia,which is closely related to the high-density lipoprotein(HDL-C)subfractions *** study aimed to determine the effects of different sourcesω-3 PUFAs on glucolipid metabolism and lipoprotein subfractions in T2DM with *** T2DM patients with dyslipidemia were randomly assigned to take 3 g/day fi sh oil(FO,containing eicosapentaenoic acid(EPA)and docosahexaenoic acid(DHA)),3 g/day perilla oil(PO,containingα-linolenic acid(ALA)),or 3 g/day blend oil(BO,containing EPA,DHA and ALA)for 3 months.90 patients completed the *** was a significant reduction of glycated hemoglobin(HbA1c)in all the *** triglycerides(TG)in the FO group were signifi cantly different with a group×time interaction(P=0.043),which was higher compared with the other two *** serum small HDL-C subfractions in the PO group was higher and the serum large HDL-C subfractions in the PO group was lower than those in the BO and FO ***-derivedω-3 PUFAs are more effective at controlling blood glucose than animal-derivedω-3 ***,animal-derivedω-3 PUFAs have a signifi cant lowering effect on TG compared with plant-derivedω-3 ***,large HDL-C subfractions after animal-derivedω-3 PUFAs intake were higher than plant-derivedω-3 PUFAs intake;while small HDL-C subfractions were *** the animal-and plant-derivedω-3 PUFAs have practical value in improving glucose and lipids metabolism in T2DM patients with dyslipidemia.

关键词： Diabetes Omega-3 polyunsaturated fatty acid Lipoprotein subfraction Dyslipidemia

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Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice

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Food Science and Human Wellness 2022年第1期11卷 32-40页

作者： Hui Xia Xiangling Shi Beijia Zhou Jing Sui Chao yang Hechun Liu ligang yang Shaokang Wang Guiju Sun Key Laboratory of Environmental Medicine and Engineering of Ministry of Education and Department of Nutrition and Food HygieneSchool of Public HealthSoutheast UniversityNanjing 210009China Research Institute for Environment and Health School of Law and Public AffairsNanjing University of Information Science and TechnologyNanjingJiangsu210044China

Flaxseed has displayed the potential beneficial as functional ***,most studies focused on effects of flaxseed extracts or ingredients in ***,few studies showed that flaxseed extracts contributed to anti-type 1 diabetes(T1D),yet the underlying mechanism is still *** the present study,16.7% of milled flaxseed(MF)-added diet was given to diabetic mice induced by streptozocin for 6 *** results showed that MF feeding 1)slightly decreased blood glucose levels and improved the ability of glucose tolerance by oral glucose tolerance test,2)decreased liver tumor necrosis factor-αlevels and increased liver glycogen levels with significance via down-regulating TLR4/NF-κB pathways,3)and significantly altered some beneficial bacteria in gut *** conclusion,the present study showed that milled flaxseed showed the potential on anti-T1D through anti-inflammation via TLR4/NF-κB and altering the gut microbiota in STZ-induced diabetic mice.

关键词： Milled flaxseed Type 1 diabetes Gut microbiota TLR4/NF-κB pathway

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