检索结果-南通市图书馆

Publication trends in studies examining radix notoginseng as a treatment for ischemic brain injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2014年第17期9卷 1635-1642页

作者： Haiping Li Luo Qiang Chunyang Zhang Chaohui Wang Zhenxing Mu ligang jiang Department of Neurology Affiliated Hospital of Beihua University

Acute ischemic stroke has become a major disease burden with high mortality and morbidity rates. There is a lack of evidence-based medicine confirming the efficacy of common treatments. Panax notoginseng saponins, the main active ingredient of radix notoginseng, have a neuro- protective role in ischemic brain injury, and have been popularized as a maintenance treatment for acute cerebral infarction and its sequelae. We conducted literature searches on the Web of Science, ***, Cochrane Collaboration, CNKI, Wanfang and the China Scientific ＆ Technological Achievements Database and analyzed the experimental and clinical outcomes of studies investigating the use of radix notoginseng in the treatment of ischemic brain injury to improve the understanding of relevant research trends and existing problems. We found that over the past 10 years, China has maintained its interest in Panax notoginseng research, while such studies are scarce on the Web of Science. However, Chinese researchers often focus on the neuroprotective role of radix notoginseng in ischemic brain injury, but there are no large-scale clinical data to confirm its efficacy and safety. There remains a need for more rigorous large-sample randomized controlled clinical trials with long-term follow-up, to determine whether radix notoginseng lowers stroke recurrence and improves patient＇s quality of life.

关键词： nerve regeneration neuroprotection Panax notoginseng cerebral ischemia stroke Panax notoginseng saponins basic clinical neural regeneration

Neuronal apoptosis and interleukin 1-beta converting enzyme expression in the frontal cortex and hippocampus of mice with ischemia/reperfusion injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2010年第11期5卷 864-867页

作者： ligang jiang Xinyu Hu Qiuhui Chen Jie Wu Guohua Hu Wei Li Lijing Cui Department of Neurology the Second Hospital of Jilin University Changchun 130041 Jilin Province China Department of Neurology Jifin Central Hospital Jilin 132011 Jilin Province China Department of Neurology Hospital Affiliated to Beihua University Jilin 132011 Jilin Province China

BACKGROUND： Interleukin 1β-converting enzyme （ICE） gene expression can induce neuronal apoptosis. However, the dynamic changes in ICE gene expression and its effects on neuronal apoptosis under cerebral ischemia/reperfusion conditions remain unclear. OBJECTIVE： To observe neuronal apoptosis and changes in ICE gene expression in the frontal cortex and hippocampus following ischemia/reperfusion injury. DESIGN, TIME AND SETTING： A randomized, controlled animal study was conducted at the Laboratory of Experimental Animal Center, the Second Hospital of Jilin University and Central Laboratory, the Second Hospital of Jilin University, China, from November 2008 to September 2009. MATERIALS： The ICE gene primer sequence （TaKaPa Co., Dalian, China）, FACScan Flow cytometer （Becton Dickinson, Franklin Lakes, N J, USA）, and Perkin Elmer GeneAmp PCR system 2400 （Perkin Elmer, Waltham, MA, USA） were used in this study. METHODS： A total of 45 healthy, adult, male, Kunming mice were randomly assigned to normal control （n = 5）, sham surgery （n = 5）, and model （n = 35） groups. The mice in the model group were equally and randomly subdivided into seven subgroups according to various reperfusion time points （1 hour, 1,3, 7, 14, 28, and 42 days）. Animal models of ischemia/reperfusion injury were established by bilateral carotid artery ligation in the model group. The mice in the sham surgery group only received saline perfusion and surgery for carotid artery exposure. MAIN OUTCOME MEASURES： Neuronal apoptosis in the frontal cortex and hippocampus of mice was measured using flow cytometry. The time course of ICE mRNA levels in the frontal cortex and hippocampus were quantified using reverse transcription-polymerase chain reaction. RESULTS： Neuronal apoptosis in the frontal cortex and hippocampus peaked at 3 days following ischemia/reperfusion injury （P 〈 0.05）. ICE mRNA expression increased in the frontal cortex at 1 day following ischemia/reperfusion injury （P 〈 0.05）, decreased at 3 day

关键词： ischemia/reperfusion injury cell apoptosis interleukin 1β-converting enzyme brain injury neural regeneration

Effects of glucocorticoid dexamethasone on serum nitric oxide synthase activity and nitric oxide levels in a rat model of lung disease-induced brain injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2011年第25期6卷 1971-1976页

作者： Huajun Li ligang jiang Meng Xia Haiping Li Fanhua Meng Wei Li Lifeng Liu Zhaohui Wang Department of Neurology Air Force General Hospital Beijing 100142 China Department of Neurobiology Affiliated Hospital of Beihua University Jilin 132011 Jilin Province China Department of Neurology Beijing Shijingshan Hospital Beijing 100043 China Medical School of Beihua University Jilin 132001 Jilin Province China

In this study, we investigated the effects of dexamethasone, pertussis toxin （a Gi protein inhibitor） and actinomycin （a transcription inhibitor） on serum nitric oxide synthase activity and nitric oxide content in a rat model of lung disease-induced brain injury. High-dose dexamethasone （13 mg/kg） and dexamethasone ＋ actinomycin reduced lung water content, increased serum nitric oxide synthase activity and nitric oxide content, diminished inflammatory cell infiltration in pulmonary alveolar interstitium, attenuated meningeal vascular hyperemia, reduced glial cell infiltration, and decreased cerebral edema. These results demonstrate that high-dose glucocorticoid treatment can reduce the severity of lung disease-induced brain injury by increasing nitric oxide synthase activity and nitric oxide levels.

关键词： glucocorticoid lung disease-induced brain injury nitric oxide nitric oxide synthase dexamethasone actinomycin neural regeneration

Safety and Risk Management of Cosmetic Products

在线全文

学校读者我要写书评

暂无评论

China Detergent & Cosmetics 2019年第3期4卷 23-31页

作者： jiang ligang Proya Cosmetic Co. Ltd.

The safety and risk management of cosmetic products runs through the entire life cycle of the product. The author focuses on the safety of cosmetic products, starting from the three stages of cosmetics research and development, production and sales, pointing out the key control points at each stage, aiming to provide a reference for cosmetics companies to develop products.

关键词： cosmetic safety critical control point risk management

An Overall Thought of Cosmetics R&D System Construction

在线全文

学校读者我要写书评

暂无评论

China Detergent & Cosmetics 2017年第2期2卷 15-17页

作者： jiang ligang Proya Cosmetics Co. Ltd.

Introduction Since it came into the 21^(st) century, great changes have taken place in cosmetics industry. With the emergence and blowout growth of OTO mode, it is obvious to all of us that there will be more challenges and opportunities in next several decades, especially for the development of cosmetic companies in China. As a matter of fact,many foreign companies have learned to improve the enterprise technology innovation ability by combining all innovation resources from all sides in the global *** integration is becoming closer and closer, and with emerging technologies and cross-industry applications continue to emerge, the world is entering a new era full of subversive ideas with rapid development of intensive innovation and electronic information.

关键词：化妆品行业中国发展现状市场分析

The Latest Status and Progress of Domestic and Foreign Regulations on Cosmetic Efficacy Claims

在线全文

学校读者我要写书评

暂无评论

China Detergent & Cosmetics 2021年第3期6卷 46-53页

作者： Li Yanan jiang ligang Research&Innovation Center Proya Cosmetics Co.Ltd.China

The supervision and administration of cosmetics and its two supporting documents related to efficacy,cosmetics classification rules and classification catalogue and evaluation standard of cosmetic efficacy claims,have been successively introduced and implemented,making China’s cosmetics industry officially enter the era of efficacy *** the time window when the new era is coming,the definitions of cosmetics in China and other countries are *** latest status and progress of regulations on cosmetic efficacy claims in China and other countries are summarized,and the standard methods or guidance of cosmetic efficacy evaluation at home and abroad are *** enlightenment from the supervision systems of cosmetic efficacy in other cosmetic consumer markets around the world are *** addition,the opportunities and challenges for cosmetic enterprises under the background of cosmetic law reform in China are also prospected.

关键词： cosmetics efficacy claims laws and regulations China Europe and America standard methods evaluation guidelines

PARK1 gene mutation of autosomal dominant Parkinson's disease family

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2011年第5期6卷 330-334页

作者： ligang jiang Qiuhui Chen Ying Zhang Xinyu Hu Jia Fan Lifeng Liu Rui Guo Yajuan Sun Yizhi Zhang Guohua Hu Department of Neurology Second Hospital of Jilin University Changchun 130041 Jilin Province China Department of Neurology Central Hospital of Jilin Jilin 132011 Jilin Province China Beihua University Jilin 132011 Jilin Province China

Studies have shown that PARK1 gene is associated with the autosomal dominant inheritance of Parkinson＇s disease. PARK1 gene contains two mutation sites, namely Ala30Pro and Ala53Thr, which are located on exons 3 and 4, respectively. However, the genetic loci of the pathogenic genes remain unclear. In this study, blood samples were collected from 11 members of a family with high prevalence of Parkinson＇s disease, including four affected cases, five suspected cases and two non-affected cases. Point mutation screening of common mutation sites on PARK1 gene exon 4 was conducted using PCR, to determine the genetic loci of the causative gene for Parkinson＇s disease. Gene identification and sequencing results showed that a T base deletion mutation was observed in the PARK1 gene exon 4 of all 11 collected samples. It was confirmed that the PARK1 gene exon 4 gene mutation is an important pathogenic mutation for Parkinson＇s disease.

关键词： Parkinson's disease family genetic PARK1 gene mutation neurodegenerative disease

Refutation of Cosmetics Rumors

在线全文

学校读者我要写书评

暂无评论

China Detergent & Cosmetics 2019年第4期4卷 51-55页

作者： jiang ligang Yue Juan Proya Cosmetic Co. Ltd.

With the rapid development of China’s economy,people’s living standards have been gradually improved,and they begin to care more about their *** applications have become more widespread,and the market volume has expanded year by *** overall size of China’s cosmetics market has jumped to second place in the *** Internet and online community platforms are developing *** the one hand,consumers can get access to more cosmetic information which helps to deepen their understanding of cosmetics;on the other hand,wrong and useless information is also wrapped in it,which inevitably increases the difficulty of screening and distinguishing the right information for *** the rumors related to cosmetics are very rampant,and various expressions make consumers *** rumors will have the wrong influence and guidance on consumers’choice,identification and use of *** to crack these rumors and convey the correct cosmetic knowledge to every consumer is a problem that cosmetics practitioners need to solve.

关键词： expanded fused wrong

The Rise of China Cosmetics Original Technology

在线全文

学校读者我要写书评

暂无评论

China Detergent & Cosmetics 2022年第4期7卷 6-16页

作者： Wang Lina jiang ligang Li Yanan Proya Cosmetics Co. Ltd.China

Under the current situation of the cosmetics industry,this paper compares the different technical fields of cosmetics at home and abroad and the development status of cosmetic raw materials,discusses the reasons why foreign cosmetic raw materials still occupy the majority of the country,and summarizes the development status of the number of patent applications,cosmetic safety and efficacy evaluation methods,animal substitution and in vitro evaluation technology for cosmetics,the combination of digital beauty and cosmetics and localization of testing equipment,and suggestions on the development of China’s future cosmetic original technology capabilities.

关键词： Chinese cosmetics original technology patents evaluation methods testing equipment