Effects of glucocorticoid dexamethasone on serum nitric oxide synthase activity and nitric oxide levels in a rat model of lung disease-induced brain injury

作     者：Huajun Li Ligang Jiang Meng Xia Haiping Li Fanhua Meng Wei Li Lifeng Liu Zhaohui Wang 

作者机构：Department of Neurology Air Force General Hospital Beijing 100142 China Department of Neurobiology Affiliated Hospital of Beihua University Jilin 132011 Jilin Province China Department of Neurology Beijing Shijingshan Hospital Beijing 100043 China Medical School of Beihua University Jilin 132001 Jilin Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2011年第6卷第25期

页      面：1971-1976页

核心收录：

学科分类：0710[理学-生物学] 090502[农学-动物营养与饲料科学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 0905[农学-畜牧学] 08[工学] 0817[工学-化学工程与技术] 09[农学] 

主　　题：glucocorticoid lung disease-induced brain injury nitric oxide nitric oxide synthase dexamethasone actinomycin neural regeneration 

摘      要：In this study, we investigated the effects of dexamethasone, pertussis toxin （a Gi protein inhibitor） and actinomycin （a transcription inhibitor） on serum nitric oxide synthase activity and nitric oxide content in a rat model of lung disease-induced brain injury. High-dose dexamethasone （13 mg/kg） and dexamethasone ＋ actinomycin reduced lung water content, increased serum nitric oxide synthase activity and nitric oxide content, diminished inflammatory cell infiltration in pulmonary alveolar interstitium, attenuated meningeal vascular hyperemia, reduced glial cell infiltration, and decreased cerebral edema. These results demonstrate that high-dose glucocorticoid treatment can reduce the severity of lung disease-induced brain injury by increasing nitric oxide synthase activity and nitric oxide levels.