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雌二醇片改善绝经女性下生殖道环境对阴道镜下病变检出率的作用研究

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标记免疫分析与临床 2024年第5期31卷 799-804页

作者：朱修香徐灵王立锋杨宝华夏子茵李航程群仙徐会娣复旦大学附属闵行医院/上海市闵行区中心医院妇产科上海201199

目的观察绝经女性使用雌二醇片对阴道镜下病变检出率的影响。方法前瞻性选取2020年12月至2021年10月在复旦大学附属闵行医院妇科宫颈门诊具有转诊阴道镜指征的患者200例作为研究对象,随机数字法分为试验组和对照组,每组100例。试验组在... 详细信息

目的观察绝经女性使用雌二醇片对阴道镜下病变检出率的影响。方法前瞻性选取2020年12月至2021年10月在复旦大学附属闵行医院妇科宫颈门诊具有转诊阴道镜指征的患者200例作为研究对象,随机数字法分为试验组和对照组,每组100例。试验组在行阴道镜检查前1周开始给予雌二醇片治疗,每次0.5mg,每天1次,连续使用1周;对照组阴道镜检查前未使用任何药物治疗。对比两组患者的临床资料、阴道镜检查结果、患者疼痛、阴道镜满意度、雌激素水平、阴道镜检查总体评价以及用药患者不良反应情况。结果两组患者的年龄、绝经年限以及筛查前合并生殖道症状对比差异无统计学意义(P>0.05)。试验组低度鳞状上皮内病变(LSIL)检出率(75.00%)明显高于对照组(17.00%)(P0.05)。试验组患者的疼痛评分明显低于对照组,阴道镜满意度明显高于对照组,差异均有统计学意义(P0.05);试验组停药1周后血清FSH、LH水平恢复原状,E2下降到原来水平。试验组绝经年限10年的患者阴道镜检查评估为较充分占比明显均高于对照组,宫颈鳞柱交界区部分可见占比均明显高于对照组(P<0.05)。试验组患者治疗期间有轻微的乳房胀、下腹胀及外阴饱满感,停药1周后上述症状消失。结论绝经女性使用雌二醇片能够明显减轻阴道镜活检的疼痛感,提高患者的阴道镜检测满意度,通过改善局部雌激素水平,使得阴道壁及宫颈正常组织雌激素水平提高,碘实验非病变部位着色,凸显病变组织的碘实验不着色,使得阴道镜下活检取材更准确,提高老年女性宫颈癌前病变及早期宫颈癌阴道镜下诊断率。

关键词：绝经女性阴道镜检查雌二醇片检出率

Characterization and developmental expression of AmphiMef2 gene in amphioxus

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Science China(Life Sciences) 2007年第5期50卷 637-641页

作者： ZHANG Ying wang lifeng SHAO Ming ZHANG HongWei Institute of Developmental Biology Life Science College Key Lab of Experimental Teratology of Ministry of Education Shandong University Jinan 250100 China Institute of Developmental Biology Life Science College Key Lab of Experimental Teratology of Ministry of Education Shandong University Jinan 250100 China Institute of Developmental Biology Life Science College Key Lab of Experimental Teratology of Ministry of Education Shandong University Jinan 250100 China Institute of Developmental Biology Life Science College Key Lab of Experimental Teratology of Ministry of Education Shandong University Jinan 250100 China

Myocyte enhancer factor 2 proteins are members of MADS family of transcription factors, which can control the expression of muscle-specific genes in vertebrates. However, not all Mef2 genes are es-sential for muscle development in invertebrates. Here we have isolated a full-length cDNA from am-phioxus, designated AmphiMef2. The predicted amino acid sequence has highly conserved MADS and MEF2 domains, showing higher identity with the corresponding regions of its homologues in verte-brates than those in invertebrates. Results from whole-mount in situ hybridization show that the ex-pression of AmphiMef2 initially appears in the presomitic mesoderm at early neurula stage, then the transcripts are detected in both the somites and the unsegmented presomitic mesoderm. At 36 h larval stage, the expression is only detected in the posterior somites. By 48 h larval stage, the expression is shifted to the preoral pit (a homologous organ to the vertebrate adenohypophysis) and persists until at least 72 h larval stage. The results suggest that AmphiMef2 may be not only involved in the myogenesis but also the development or function of the preoral pit in amphioxus.

关键词： AmphiMef2, amphioxus, developmental expression, myogenesis, preoral pit

Boosting host immune immunity for control of viral persistence in chronic hepatitis B:Lighting the way forward

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Boosting host immune immunity for control of viral persisten...

Agile Supply Chain Reengineering Based on Multi-Objective Global Performance Measurement

2012中国消化系疾病学术大会

作者： Fusheng wang Zheng Zhang Jiyuan Zhang lifeng wang The Institute of Translational Hepatology and The Research Center for Biological Therapy Beijing 302 Hospital

Since the antiviral immunity of the host not only determines the outcome of HBV infection,but also dictates the clinical efficacy of antiviral therapy including the sustained HBV clearance and HBsAg ***,a large amount of HBsAg,in general,specifically or predominantly influences Treg cells in the patients with chronic

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Journal of Systems Engineering and Electronics 2003年第1期14卷 30-35,80页

作者： wang juxiang, Xi lifeng, wang Anlin & Hu ZongwuDepartment of Industrial Engineering, School of Mechanical Engineering,Shanghai Jiaotong University, Shanghai 200030, P. R. China) Department of Industrial Engineering School of Mechanical Engineering Shanghai Jiaotong University Shanghai 200030 P. R. China

The process and related technology of agile supply chain reengineering is discussed in this paper. The process of supply chain reengineering is divided into two parts here: structure reengineering and operation strategy reengineering. Multi-agent concept is adopted in the structure reengineering for the convenience of the modeling. Enterprises in the agile supply chain are expressed as corresponding agents with specified characteristics. Cost and response time are adopted as the main objectives of the global supply chain performance measurement. A virtual simplified supply chain is used to illustrate the role of overall supply chain performance measurement in the reengineering process.

关键词： Agile supply chain reengineering Structure reengineering Strategy reengineering Multi-agent technology

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我国煤气化技术发展与展望

洁净煤技术 2022年第2期28卷 115-121页

作者：王利峰中国煤炭科工集团安标国家矿用产品安全标志中心有限公司北京100013

煤气化技术作为煤炭资源清洁高效利用的关键技术,近年来发展迅速。概述了煤气化技术在我国能源利用和发展中的重要作用,介绍了当前我国煤气化技术应用的发展脉络,对比了常见的固定床气化技术、流化床气化技术和气流床气化技术在我国的... 详细信息

煤气化技术作为煤炭资源清洁高效利用的关键技术,近年来发展迅速。概述了煤气化技术在我国能源利用和发展中的重要作用,介绍了当前我国煤气化技术应用的发展脉络,对比了常见的固定床气化技术、流化床气化技术和气流床气化技术在我国的应用情况,总结了各种气化技术的特点和应用情况,指出我国应用煤气化技术的经验和教训,并对新生的气化技术及常见的煤气化技术未来发展趋势进行了展望。我国煤气化技术已逐步从早期“外延粗放式”进入到了“内涵集约式”的发展阶段,在“双碳”产业政策背景下,煤气化技术应进入精耕细作研究阶段以提质增效,提高气化炉的整体效率、拓宽煤种适应性、提高气化炉单炉生产能力、降低停车风险保障装置的可靠性、降低气化技术对环境影响程度、强化煤气化与新型煤化工的技术集成是煤气化技术的发展方向。

关键词：煤化工煤气化技术双碳提质增效

Genomic insights into the origin, adaptive evolution, and herbicide resistance of Leptochloa chinensis, a devastating tetraploid weedy grass in rice fields

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Molecular Plant 2022年第6期15卷 1045-1058页

作者： lifeng wang Xuepeng Sun Yajun Peng Ke Chen Shan Wu Yanan Guo Jingyuan Zhang Haona Yang Tao Jin Lamei Wu Xiaomao Zhou Bin Liang Zhenghong Zhao Ducai Liu Zhangjun Fei Lianyang Bai State Key Laboratory of Hybrid Rice Hunan Academy of Agricultural SciencesChangsha 410125China Hunan Weed Science Key Laboratory Hunan Academy of Agricultural SciencesChangsha 410125China Boyce Thompson Institute Cornell UniversityIthacaNY 14853USA College of Horticulture Science Zhejiang A&F UniversityHangzhou 311300China Qingdao Kingagroot Compounds Co.Ltd Qingdao 266000China USDA-ARS Robert W.Holley Center for Agriculture and HealthIthacaNY 14853USA

Chinese sprangletop (Leptochloa chinensis), belonging to the grass subfamily Chloridoideae, is one of the most notorious weeds in rice ecosystems. Here, we report a chromosome-scale reference genome assembly and a genomic variation map of the tetraploid L. chinensis. The L. chinensis genome is derived from two diploid progenitors that diverged ∼10.9 million years ago, and its two subgenomes display neither fractionation bias nor overall gene expression dominance. Comparative genomic analyses reveal substantial genome rearrangements in L. chinensis after its divergence from the common ancestor of Chloridoideae and, together with transcriptome profiling, demonstrate the important contribution of tetraploidization to the gene sources for the herbicide resistance of L. chinensis. Population genomic analyses of 89 accessions from China reveal that L. chinensis accessions collected from southern/southwestern provinces have substantially higher nucleotide diversity than those from the middle and lower reaches of the Yangtze River, suggesting that L. chinensis spread in China from the southern/southwestern provinces to the middle and lower reaches of the Yangtze River. During this spread, L. chinensis developed significantly increased herbicide resistance, accompanied by the selection of numerous genes involved in herbicide resistance. Taken together, our study generated valuable genomic resources for future fundamental research and agricultural management of L. chinensis, and provides significant new insights into the herbicide resistance as well as the origin and adaptive evolution of L. chinensis.

关键词： Leptochloa weed sgenome polyploidization genome evolution genetic diversity adaptive selection herbicide resistance

多元正态分布熵的Stein型和Brester-Zidek型估计

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统计与决策 2020年第8期36卷 16-20页

作者：王理峰南京铁道职业技术学院数学系南京210031

基于一些随机样本,在Linex损失下估计期望及方差阵都未知的多元正态分布的熵。在仅依赖于|S|的估计类中,熵的最优仿射同变估计δc*是可容许估计,但在一些范围更大的估计类中,δc*是不可容许估计。文章首先用Stein型估计δ?ST去改进δc*,... 详细信息

基于一些随机样本,在Linex损失下估计期望及方差阵都未知的多元正态分布的熵。在仅依赖于|S|的估计类中,熵的最优仿射同变估计δc*是可容许估计,但在一些范围更大的估计类中,δc*是不可容许估计。文章首先用Stein型估计δ?ST去改进δc*,但Stein型估计不是光滑的,然后用具有光滑性的Brester-Zidek型估计去改进δc*,进一步研究知Brester-Zidek估计是可容许估计,也是Bayes估计。

关键词：多元正态分布熵 Linex损失 Stein型估计 Brester-Zidek型估计 Bayes估计可容许估计

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非饱和裂隙孔隙岩体持水曲线的预测研究

岩石力学与工程学报 2006年第Z2期25卷 3830-3834页

作者：孙树林王利丰河海大学水文水资源与水利工程科学国家重点实验室江苏南京210098 河海大学地质及岩土工程系江苏南京210098

对于大量发育有毛细管通道的渗透性岩体,其持水曲线已经得到一些应用,但用试验方法较准确地测定具有基质孔隙和裂隙双重孔隙介质的岩体持水曲线仍是一个非常困难的问题,目前一般只能采用压汞试验进行转化得到;同时,持水曲线的准确程度... 详细信息

对于大量发育有毛细管通道的渗透性岩体,其持水曲线已经得到一些应用,但用试验方法较准确地测定具有基质孔隙和裂隙双重孔隙介质的岩体持水曲线仍是一个非常困难的问题,目前一般只能采用压汞试验进行转化得到;同时,持水曲线的准确程度将直接关系到岩体中非饱和作用研究结果的准确程度。因此,如何有效且准确地得到岩体持水曲线是值得研究的课题。基于微观结构特征和毛细管理论,讨论裂隙孔隙岩体持水曲线的预测方法;通过室内岩体微观结构的试验,进行持水曲线的预测,并与压汞试验曲线进行对比。对比结果显示,预测曲线与实测曲线吻合较好,准确度较高。由此可见,该预测方法简便、准确、实用性强,是得到孔隙性岩体持水曲线的有效途径。

关键词：岩石力学裂隙孔隙岩体非饱和持水曲线毛细管

Synergetic PVA degradation and H2 evolution in photocatalytic fuel cells using Ag@Fe_(2)O_(3) cathode

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Frontiers of Chemical Science and Engineering 2024年第1期18卷 85-93页

作者： Likun Sun Kesi Xiong Baoning Zhang Jinghong Fang Yingchao He Min wang Zhixing Gan Fanglin Du Qiong Sun Liyan Yu lifeng Dong College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042China Center for Future Optoelectronic Functional Materials School of Computer and Electronic InformationNanjing Normal UniversityNanjing 210023China Department of Physics Hamline UniversitySt.Paul 55104USA

In a dual-chamber photocatalytic fuel cell device,polyvinyl alcohol degradation and H2 evolution were concurrently *** setup involved commercial P25 as the photoanode and Ag@Fe_(2)O_(3) nanoparticles as the ***,the feasibility of a Fentonlike reaction in the cathode,utilizing Fe^(2+)ions and pumped O_(2),was *** cathode materials,polyvinyl alcohol types,and pH values’effects were assessed on device *** tests highlighted photoinduced holes(h+)and OH·radicals as pivotal contributions to polyvinyl alcohol ***-term stability of the device was established through cycling experiments.

关键词： photocatalytic fuel cell PVA Ag@Fe_(2)O_(3) cathode materials Fenton-like reaction